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Sensor selection is typically performed empirically, with sensors picked up either by analyzing their characteristics or through trial and error, which does not guarantee an optimized sensor array composition. This study focuses on developing a method for sensor selection for an electronic tongue using simulated sensor data and Lasso regularization. Simulated sensor responses were calculated using sensor parameters such as sensitivity and selectivity, which were determined in the individual analyte solutions. Sensor selection was carried out using Lasso regularization, which removes redundant or highly correlated variables without much loss of information. The objective of the optimization of the sensor array was twofold, aiming to minimize both quantification errors and the number of sensors in the array. The quantification of toxins belonging to one of the groups of marine toxins\u2014paralytic shellfish toxins (PSTs)\u2014using arrays of potentiometric chemical sensors was used as a case study. Eight PSTs corresponding to the toxin profiles in bivalves due to the two common toxin-producing phytoplankton species, G. catenatum (dcSTX, GTX5, GTX6, and C1+2) and A. minitum (STX, GTX2+3), as well as total sample toxicity, were included in the study. Experimental validation with mixed solutions of two groups of toxins confirmed the suitability of the proposed method of sensor array optimization with better performance obtained for the a priori optimized sensor arrays. The results indicate that the use of simulated sensor responses and Lasso regularization is a rapid and efficient method for the selection of an optimized sensor array.<\/jats:p>","DOI":"10.3390\/chemosensors12060115","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T08:06:06Z","timestamp":1718784366000},"page":"115","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sensor Selection for an Electronic Tongue for the Rapid Detection of Paralytic Shellfish Toxins: A Case Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4764-5044","authenticated-orcid":false,"given":"Mariana","family":"Raposo","sequence":"first","affiliation":[{"name":"CESAM and Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3240-2883","authenticated-orcid":false,"given":"Maria Teresa S. R.","family":"Gomes","sequence":"additional","affiliation":[{"name":"CESAM and Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-5876","authenticated-orcid":false,"given":"Sara T.","family":"Costa","sequence":"additional","affiliation":[{"name":"IPMA, Portuguese Institute for the Sea and Atmosphere, 1449-006 Lisbon, Portugal"},{"name":"CIIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4050-123 Porto, Portugal"},{"name":"ICBAS, Abel Salazar Biomedical Sciences Institute, University of Porto, Largo Prof. Abel Salazar, 2, 4099-003 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9330-9979","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Botelho","sequence":"additional","affiliation":[{"name":"IPMA, Portuguese Institute for the Sea and Atmosphere, 1449-006 Lisbon, Portugal"},{"name":"CIIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4050-123 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7963-3892","authenticated-orcid":false,"given":"Alisa","family":"Rudnitskaya","sequence":"additional","affiliation":[{"name":"CESAM and Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1021\/ac00290a049","article-title":"Model Studies on Multiple Channel Analysis of Free Magnesium, Calcium, Sodium, and Potassium at Physiological Concentration Levels with Ion-Selective Electrodes","volume":"57","author":"Otto","year":"1985","journal-title":"Anal. 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