{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:00:46Z","timestamp":1770512446402,"version":"3.49.0"},"reference-count":83,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemosensors"],"abstract":"<jats:p>The present work aimed to determine the nutritional composition (ash, protein, fat, carbohydrate content and energy value), phenolic compounds, pigments and organic acids content of three typical red algae from the Northwest of Spain: Chondrus crispus, Mastocarpus stellatus, and Gigartina pistillata; as well as their antioxidant and antimicrobial activities. Furthermore, the present work compared two extraction techniques: conventional heat assisted extraction (HAE) and high pressure assisted extraction (HPAE) to maximize the yield and the concentration of target compounds. Different independent variables were considered for the response study. Time (t) and percentage of ethanol of the solvent (S) were chosen for both techniques and temperature (T) and pressure (P) were used for HAE and HPAE, respectively. The experiments were designed following a response surface methodology (RSM) approach. The obtained results showed a similar nutritional composition between algae samples: low-fat content and high content of proteins, carbohydrates and energy. All tested algae showed good antioxidant and antimicrobial properties. Finally, HEA demonstrated to be the most efficient extraction technique. This study confirms the potential of red algae to be part of the human diet as a source of non-animal protein, due to its nutritional content, phenolic profile, pigments concentration and bioactive properties, which proves that HAE is the optimum technique for the extraction maximization.<\/jats:p>","DOI":"10.3390\/chemosensors9060132","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T12:08:55Z","timestamp":1623154135000},"page":"132","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Red Seaweeds as a Source of Nutrients and Bioactive Compounds: Optimization of the Extraction"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-7856","authenticated-orcid":false,"given":"Maria","family":"Carpena","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Nutrition and Bromatology Group, Ourense Campus, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo, E-32004 Ourense, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5769-8484","authenticated-orcid":false,"given":"Cristina","family":"Caleja","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"given":"Eliana","family":"Pereira","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0093-771X","authenticated-orcid":false,"given":"Carla","family":"Pereira","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9478-5448","authenticated-orcid":false,"given":"Ana","family":"\u0106iri\u0107","sequence":"additional","affiliation":[{"name":"Institute for Biological Research \u201cSini\u0161a Stankovi\u0107\u201d, National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7381-756X","authenticated-orcid":false,"given":"Marina","family":"Sokovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Biological Research \u201cSini\u0161a Stankovi\u0107\u201d, National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia"}]},{"given":"Anton","family":"Soria-Lopez","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5663-9239","authenticated-orcid":false,"given":"Maria","family":"Fraga-Corral","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Nutrition and Bromatology Group, Ourense Campus, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo, E-32004 Ourense, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9215-9737","authenticated-orcid":false,"given":"Jesus","family":"Simal-Gandara","sequence":"additional","affiliation":[{"name":"Nutrition and Bromatology Group, Ourense Campus, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo, E-32004 Ourense, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-4882","authenticated-orcid":false,"given":"Isabel C. 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(2007). Red Algae. eLS.","DOI":"10.1002\/9780470015902.a0000335"},{"key":"ref_2","unstructured":"FAO (2020). El Estado Mundial de la Pesca y la Acuicuiltura 2020. La Sostenibilidad en Acci\u00f3n, FAO."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.rser.2018.03.100","article-title":"An overview of marine macroalgae as bioresource","volume":"91","author":"Sudhakar","year":"2018","journal-title":"Renew. Sustain. Energy Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.foodchem.2018.12.023","article-title":"Marine prebiotics: Polysaccharides and oligosaccharides obtained by using microbial enzymes","volume":"280","author":"Gurpilhares","year":"2019","journal-title":"Food Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.3390\/md13085358","article-title":"Proteins and Carbohydrates from Red Seaweeds: Evidence for Beneficial Effects on Gut Function and Microbiota","volume":"13","author":"Cian","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.foodchem.2012.04.138","article-title":"Effect of the red seaweed Mastocarpus stellatus intake on lipid metabolism and antioxidant status in healthy Wistar rats","volume":"135","year":"2012","journal-title":"Food Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cbpc.2006.05.007","article-title":"Metabolites from algae with economical impact","volume":"146","author":"Cardozo","year":"2007","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.marenvres.2019.04.001","article-title":"Photo-protective compounds in red macroalgae from Brittany: Considerable diversity in mycosporine-like amino acids (MAAs)","volume":"147","author":"Lalegerie","year":"2019","journal-title":"Mar. Environ. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.tifs.2016.01.019","article-title":"Marine bioactive compounds and health promoting perspectives; innovation pathways for drug discovery","volume":"50","author":"Suleria","year":"2016","journal-title":"Trends Food Sci. Technol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.biotechadv.2012.03.006","article-title":"Marine biotechnology advances towards applications in new functional foods","volume":"30","author":"Freitas","year":"2012","journal-title":"Biotechnol. Adv."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10811-010-9632-5","article-title":"Bioactive compounds in seaweed: Functional food applications and legislation","volume":"23","author":"Holdt","year":"2011","journal-title":"J. Appl. Phycol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/raq.12241","article-title":"Macroalgae as a sustainable aquafeed ingredient","volume":"11","author":"Wan","year":"2019","journal-title":"Rev. Aquac."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.algal.2017.08.001","article-title":"In-depth metabolic profiling of marine macroalgae confirms strong biochemical differences between brown, red and green algae","volume":"26","author":"Belghit","year":"2017","journal-title":"Algal Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tifs.2011.09.001","article-title":"Seaweeds: A sustainable functional food for complementary and alternative therapy","volume":"23","author":"Mohamed","year":"2012","journal-title":"Trends Food Sci. Technol."},{"key":"ref_15","unstructured":"Naylor, J. (1976). Production, Trade and Utilization of Seaweeds and Seaweed Products, FAO. Available online: http:\/\/www.fao.org\/3\/AC860E\/AC860E00.htm."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Torres, M.D., Fl\u00f3rez-Fern\u00e1ndez, N., and Dom\u00ednguez, H. (2019). Integral Utilization of Red Seaweed for Bioactive Production. Mar. Drugs, 17.","DOI":"10.3390\/md17060314"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/jsfa.9143","article-title":"Marine macroalgae as sources of protein and bioactive compounds in feed for monogastric animals","volume":"99","author":"Mydland","year":"2019","journal-title":"J. Sci. Food Agric."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1039\/c3np70057g","article-title":"Biogeography and biodiscovery hotspots of macroalgal marine natural products","volume":"30","author":"Leal","year":"2013","journal-title":"Nat. Prod. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.fsi.2018.02.014","article-title":"Assessment of the effects of sulfated polysaccharides extracted from the red seaweed Irish moss Chondrus crispus on the immune-stimulant activity in mussels Mytilus spp","volume":"75","author":"Rudtanatip","year":"2018","journal-title":"Fish Shellfish. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.4161\/biom.22947","article-title":"Marine algae sulfated polysaccharides for tissue engineering and drug delivery approaches","volume":"2","author":"Silva","year":"2012","journal-title":"Biomatter"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.carbpol.2011.09.073","article-title":"Antihyperlipidemic activity of high sulfate content derivative of polysaccharide extracted from Ulva pertusa (Chlorophyta)","volume":"87","author":"Qi","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"ref_22","first-page":"116","article-title":"Explotaci\u00f3n de las macroalgas marinas: Galicia como caso de estudio hacia una gesti\u00f3n sostenible de los recursos","volume":"111","author":"Tasende","year":"2015","journal-title":"Ambienta"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.foodchem.2012.10.078","article-title":"Phenolic compounds and antioxidant activities of selected species of seaweeds from Danish coast","volume":"138","author":"Farvin","year":"2013","journal-title":"Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/j.foodres.2010.08.005","article-title":"Dietary fibre and physicochemical properties of several edible seaweeds from the northwestern Spanish coast","volume":"43","year":"2010","journal-title":"Food Res. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bcdf.2014.01.002","article-title":"Bioactivity of sulfated polysaccharides from the edible red seaweed Mastocarpus stellatus","volume":"3","year":"2014","journal-title":"Bioact. Carbohydr. Diet. Fibre"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.lwt.2013.08.006","article-title":"An evaluation of edible red seaweed (Chondrus crispus) components and their modification during the cooking process","volume":"56","author":"Pina","year":"2014","journal-title":"LWT Food Sci. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Cotas, J., Marques, V., Afonso, M.B., Rodrigues, C.M.P., and Pereira, L. (2020). Antitumour Potential of Gigartina pistillata Carrageenans against Colorectal Cancer Stem Cell-Enriched Tumourspheres. Mar. Drugs, 18.","DOI":"10.3390\/md18010050"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.jff.2013.04.001","article-title":"Bioactive components of the edible strain of red alga, Chondrus crispus, enhance oxidative stress tolerance in Caenorhabditis elegans","volume":"5","author":"Sangha","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"21757","DOI":"10.3390\/ijms141121757","article-title":"Anti-Biofilm Performance of Three Natural Products against Initial Bacterial Attachment","volume":"14","author":"Salta","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_30","first-page":"3337","article-title":"Antimicrobial activity and lipid profile of seaweed extracts from the North Portuguese Coast","volume":"20","author":"Mendes","year":"2013","journal-title":"Int. Food Res. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3390\/md13010558","article-title":"Enzyme-Assisted Extraction of Bioactive Material from Chondrus crispus and Codium fragile and Its Effect on Herpes simplex Virus (HSV-1)","volume":"13","author":"Kulshreshtha","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0021-9673(01)01212-2","article-title":"Pressurized liquid extraction for the determination of polyphenols in apple","volume":"933","author":"Salces","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7313","DOI":"10.3390\/molecules15107313","article-title":"Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties","volume":"15","author":"Dai","year":"2010","journal-title":"Molecules"},{"key":"ref_34","first-page":"69","article-title":"Extraction of phenolic compounds from melissa using microwave and ultrasound","volume":"37","author":"Ince","year":"2013","journal-title":"Turk. J. Agric. For."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ifset.2008.11.007","article-title":"Effects of high pressure extraction on the extraction yield, total phenolic content and antioxidant activity of longan fruit pericarp","volume":"10","author":"Prasad","year":"2009","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jfoodeng.2019.02.014","article-title":"Effects of high hydrostatic pressure and polysaccharidases on the extraction of antioxidant compounds from red macroalgae, Palmaria palmata and Solieria chordalis","volume":"252","author":"Suwal","year":"2019","journal-title":"J. Food Eng."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ijpharm.2009.08.023","article-title":"Characterization of polyphenols from green tea leaves using a high hydrostatic pressure extraction","volume":"382","author":"Xi","year":"2009","journal-title":"Int. J. Pharm."},{"key":"ref_38","unstructured":"AOAC International (1975). Official Methods of Analysis of AOAC International, Association of Official Analytical Chemists."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/j.jff.2013.07.019","article-title":"Bioactivity and chemical characterization in hydrophilic and lipophilic compounds of Chenopodium ambrosioides L","volume":"5","author":"Barros","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.seppur.2017.10.007","article-title":"Cold extraction of phenolic compounds from watercress by high hydrostatic pressure: Process modelling and optimization","volume":"192","author":"Pinela","year":"2018","journal-title":"Sep. Purif. Technol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.fbp.2016.06.006","article-title":"Optimization of microwave-assisted extraction of ergosterol from Agaricus bisporus L. by-products using response surface methodology","volume":"100","author":"Heleno","year":"2016","journal-title":"Food Bioprod. Process."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.indcrop.2017.06.012","article-title":"Optimization and comparison of maceration and microwave extraction systems for the production of phenolic compounds from Juglans regia L. for the valorization of walnut leaves","volume":"107","author":"Vieira","year":"2017","journal-title":"Ind. Crop. Prod."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.indcrop.2016.04.065","article-title":"Phenolic profile and antioxidant activity of Coleostephus myconis (L.) Rchb.f.: An underexploited and highly disseminated species","volume":"89","author":"Bessada","year":"2016","journal-title":"Ind. Crop. Prod."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.indcrop.2018.11.059","article-title":"Chemical features and bioactivities of cornflower (Centaurea cyanus L.) capitula: The blue flowers and the unexplored non-edible part","volume":"128","author":"Lockowandt","year":"2019","journal-title":"Ind. Crop. Prod."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"7532","DOI":"10.3390\/molecules15117532","article-title":"Antibacterial Effects of the Essential Oils of Commonly Consumed Medicinal Herbs Using an In Vitro Model","volume":"15","author":"Marin","year":"2010","journal-title":"Molecules"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10658-006-9053-0","article-title":"Antimicrobial activity of essential oils and their components against the three major pathogens of the cultivated button mushroom, Agaricus bisporus","volume":"116","year":"2006","journal-title":"Eur. J. Plant Pathol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.scitotenv.2013.04.098","article-title":"NOEC and LOEC as merely concessive expedients: Two unambiguous alternatives and some criteria to maximize the efficiency of dose\u2013response experimental designs","volume":"461\u2013462","author":"Murado","year":"2013","journal-title":"Sci. Total Environ."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.foodchem.2014.06.114","article-title":"Crocin bleaching antioxidant assay revisited: Application to microplate to analyse antioxidant and pro-oxidant activities","volume":"167","author":"Prieto","year":"2015","journal-title":"Food Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.foodres.2014.05.030","article-title":"In vitro determination of the lipophilic and hydrophilic antioxidant capacity of unroasted coffee bean extracts and their synergistic and antagonistic effects","volume":"62","author":"Prieto","year":"2014","journal-title":"Food Res. Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3989\/arbor.2001.i661.824","article-title":"Aditivos naturales","volume":"168","year":"2001","journal-title":"Arbor"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.foodchem.2005.11.029","article-title":"Comparison of nutritive chemistry of a range of temperate seaweeds","volume":"100","author":"Marsham","year":"2007","journal-title":"Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0308-8146(02)00171-1","article-title":"Mineral content of edible marine seaweeds","volume":"79","author":"Ruperez","year":"2002","journal-title":"Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s002170000264","article-title":"Dietary fibre and physicochemical properties of edible Spanish seaweeds","volume":"212","author":"Calixto","year":"2001","journal-title":"Eur. Food Res. Technol."},{"key":"ref_54","first-page":"774","article-title":"Evaluation of the proximate, fatty acid and mineral composition of representative green, brown and red seaweeds from the Persian Gulf of Iran as potential food and feed resources","volume":"49","author":"Abdulalian","year":"2011","journal-title":"J. Food Sci. Technol."},{"key":"ref_55","first-page":"73","article-title":"Seasonal changes in growth, biochemical constituents and phycocolloid of some marine algae of Mandapam coast","volume":"24","author":"Kaliaperumal","year":"2002","journal-title":"Seaweed Res. Util."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tifs.2020.05.003","article-title":"Germination as a bioprocess for enhancing the quality and nutritional prospects of legume proteins","volume":"101","author":"Ohanenye","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.tifs.2019.08.011","article-title":"An overview of extraction and purification techniques of seaweed dietary fibers for immunomodulation on gut microbiota","volume":"92","author":"Praveen","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"ref_58","unstructured":"Pomin, V.H. (2011). A review of the nutrient composition of selected edible seaweeds. Seaweed: Ecology, Nutrient Composition and Medicinal Uses, Nova Science Publishers."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.jksus.2019.11.009","article-title":"A comparison of nutritional value of underexploited edible seaweeds with recommended dietary allowances","volume":"32","author":"Ganesan","year":"2020","journal-title":"J. King Saud Univ. Sci."},{"key":"ref_60","first-page":"2427","article-title":"Biochemical composition, nutritional value, and antioxidant properties of seven seaweed species from the Madeira Archipelago","volume":"29","author":"Nunes","year":"2017","journal-title":"Environ. Boil. Fishes"},{"key":"ref_61","first-page":"1123","article-title":"Brown and red seaweeds as potential sources of antioxidant nutraceuticals","volume":"24","year":"2011","journal-title":"Environ. Boil. Fishes"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Fleurence, J. (2016). Seaweeds as Food, Elsevier.","DOI":"10.1016\/B978-0-12-802772-1.00005-1"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.tifs.2017.11.008","article-title":"Antioxidants: Reviewing the chemistry, food applications, legislation and role as preservatives","volume":"71","author":"Carocho","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"ref_64","first-page":"279","article-title":"Inhibitory impacts of natural antioxidants (ascorbic and citric acid) and vacuum packaging on lipid oxidation in frozen Persian sturgeon fillets","volume":"9","author":"Rostamzad","year":"2010","journal-title":"Iran. J. Fish. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0308-8146(96)00067-2","article-title":"Antioxidants in lipid foods and their impact on food quality","volume":"57","author":"Frankel","year":"1996","journal-title":"Food Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.algal.2018.10.019","article-title":"Metabolite profiling, antioxidant, scavenging and anti-proliferative activities of selected tropical green seaweeds reveal the nutraceutical potential of Caulerpa spp","volume":"36","author":"Tanna","year":"2018","journal-title":"Algal Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1080\/10408398.2015.1087963","article-title":"Anthocyanin extraction from plant tissues: A review","volume":"57","author":"Silva","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.fbp.2016.12.005","article-title":"Natural deep eutectic solvents and ultrasound-assisted extraction: Green approaches for extraction of wine lees anthocyanins","volume":"102","author":"Bosiljkov","year":"2017","journal-title":"Food Bioprod. Process."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.foodchem.2006.02.060","article-title":"Antioxidant assessment of an anthocyanin-enriched blackberry extract","volume":"101","author":"Elisia","year":"2007","journal-title":"Food Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"113603","DOI":"10.1016\/j.jep.2020.113603","article-title":"Hydroalcoholic extract of Tagetes minuta L. inhibits inflammatory bowel disease through the activity of pheophytins on the NF-\u03baB signalling pathway","volume":"268","author":"Ticona","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1080\/10498850.2019.1664693","article-title":"Biochemical and Nutritional Composition of Industrial Red Seaweed Used in Carrageenan Production","volume":"28","author":"Naseri","year":"2019","journal-title":"J. Aquat. Food Prod. Technol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jpba.2009.03.027","article-title":"Bioactive phenols in algae: The application of pressurized-liquid and solid-phase extraction techniques","volume":"51","author":"Klejdus","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jep.2009.12.037","article-title":"Anti-inflammatory properties of phenolic compounds and crude extract from Porphyra dentata","volume":"128","author":"Hsu","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.foodchem.2011.07.054","article-title":"Polyphenol-rich seaweed (Eucheuma cottonii) extract suppresses breast tumour via hormone modulation and apoptosis induction","volume":"130","author":"Namvar","year":"2012","journal-title":"Food Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1021\/jf504220e","article-title":"Impact of Enzyme- and Ultrasound-Assisted Extraction Methods on Biological Properties of Red, Brown, and Green Seaweeds from the Central West Coast of Portugal","volume":"63","author":"Rodrigues","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3389\/fpls.2018.00427","article-title":"Low-Molecular-Weight Polysaccharides From Pyropia yezoensis Enhance Tolerance of Wheat Seedlings (Triticum aestivum L.) to Salt Stress","volume":"9","author":"Zou","year":"2018","journal-title":"Front. Plant Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1016\/j.carbpol.2011.10.026","article-title":"Ultrasonic degradation, purification and analysis of structure and antioxidant activity of polysaccharide from Porphyra yezoensis Udea","volume":"87","author":"Zhou","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"ref_78","first-page":"1029","article-title":"Biochemical and antiviral activities of enzymatic hydrolysates from different invasive French seaweeds","volume":"26","author":"Hardouin","year":"2013","journal-title":"Environ. Boil. Fishes"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.lwt.2010.05.010","article-title":"Enzyme-enhanced extraction of antioxidant ingredients from red algae Palmaria palmata","volume":"43","author":"Wang","year":"2010","journal-title":"LWT Food Sci. Technol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.foodres.2017.07.037","article-title":"Fractionation and identification of antioxidant peptides from an enzymatically hydrolysed Palmaria palmata protein isolate","volume":"100","author":"Harnedy","year":"2017","journal-title":"Food Res. Int."},{"key":"ref_81","first-page":"1609","article-title":"Characteristics of functional materials recovered from Solomon Islands red seaweed (Kappaphycus alvarezii) using pressurized hot water extraction","volume":"29","author":"Gereniu","year":"2017","journal-title":"Environ. Boil. Fishes"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.ibiod.2011.07.002","article-title":"Investigation of Chondrus crispus as a potential source of new antifouling agents","volume":"65","author":"Chambers","year":"2011","journal-title":"Int. Biodeterior. Biodegrad."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.aquaculture.2007.11.029","article-title":"Extracts of Ceramium rubrum, Mastocarpus stellatus and Laminaria digitata inhibit growth of marine and fish pathogenic bacteria at ecologically realistic concentrations","volume":"274","author":"Dubber","year":"2008","journal-title":"Aquaculture"}],"container-title":["Chemosensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9040\/9\/6\/132\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:12:08Z","timestamp":1760163128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9040\/9\/6\/132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,8]]},"references-count":83,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["chemosensors9060132"],"URL":"https:\/\/doi.org\/10.3390\/chemosensors9060132","relation":{},"ISSN":["2227-9040"],"issn-type":[{"value":"2227-9040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,8]]}}}