{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:38:09Z","timestamp":1778636289151,"version":"3.51.4"},"reference-count":82,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T00:00:00Z","timestamp":1639785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Santa Casa da Miseric\u00f3rdia","award":["MB37-2017"],"award-info":[{"award-number":["MB37-2017"]}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["IF\/01227\/2015"],"award-info":[{"award-number":["IF\/01227\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>The increasing consumption of sugar and fat seen over the last decades and the consequent overweight and obesity, were recently linked with a deleterious effect on cognition and synaptic function. A major question, which remains to be clarified, is whether obesity in the elderly is an additional risk factor for cognitive impairment. We aimed at unravelling the impact of a chronic high caloric diet (HCD) on memory performance and synaptic plasticity in aged rats. Male rats were kept on an HCD or a standard diet (control) from 1 to 24 months of age. The results showed that under an HCD, aged rats were obese and displayed significant long-term recognition memory impairment when compared to age-matched controls. Ex vivo synaptic plasticity recorded from hippocampal slices from HCD-fed aged rats revealed a reduction in the magnitude of long-term potentiation, accompanied by a decrease in the levels of the brain-derived neurotrophic factor receptors TrkB full-length (TrkB-FL). No alterations in neurogenesis were observed, as quantified by the density of immature doublecortin-positive neurons in the hippocampal dentate gyrus. This study highlights that obesity induced by a chronic HCD exacerbates age-associated cognitive decline, likely due to impaired synaptic plasticity, which might be associated with deficits in TrkB-FL signaling.<\/jats:p>","DOI":"10.3390\/cimb43030162","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T02:40:32Z","timestamp":1639968032000},"page":"2305-2319","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats"],"prefix":"10.3390","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7668-2173","authenticated-orcid":false,"given":"Sara L.","family":"Paulo","sequence":"first","affiliation":[{"name":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"},{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9633-7999","authenticated-orcid":false,"given":"Catarina","family":"Miranda-Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"},{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"}]},{"given":"Rita F.","family":"Belo","sequence":"additional","affiliation":[{"name":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"},{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9343-745X","authenticated-orcid":false,"given":"Rui S.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"},{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"}]},{"given":"Jo\u00e3o","family":"Fonseca-Gomes","sequence":"additional","affiliation":[{"name":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"},{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9151-7149","authenticated-orcid":false,"given":"Sara R.","family":"Tanqueiro","sequence":"additional","affiliation":[{"name":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"},{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"}]},{"given":"Vera","family":"Geraldes","sequence":"additional","affiliation":[{"name":"Instituto de Fisiologia, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"},{"name":"Centro Cardiovascular da Universidade de Lisboa, 1649-028 Lisboa, Portugal"}]},{"given":"Isabel","family":"Rocha","sequence":"additional","affiliation":[{"name":"Instituto de Fisiologia, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"},{"name":"Centro Cardiovascular da Universidade de Lisboa, 1649-028 Lisboa, Portugal"}]},{"given":"Ana M.","family":"Sebasti\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"},{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6854-2509","authenticated-orcid":false,"given":"Sara","family":"Xapelli","sequence":"additional","affiliation":[{"name":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"},{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"}]},{"given":"Maria J.","family":"Di\u00f3genes","sequence":"additional","affiliation":[{"name":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"},{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.3389\/fimmu.2017.01745","article-title":"Aging, obesity, and inflammatory age-related diseases","volume":"8","author":"Frasca","year":"2017","journal-title":"Front. 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