{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:05:59Z","timestamp":1769159159624,"version":"3.49.0"},"reference-count":32,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T00:00:00Z","timestamp":1655510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Background: Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder represented by Crohn\u2019s disease and ulcerative colitis. Currently, there is no cure and pharmacological treatment aims to induce and maintain remission on patients. Because the therapy reveals a relatively high toxicity, during a long-term utilization, it is essential to investigate new pharmacological approaches. Polyphenols, commonly present on red wine, have shown health-beneficial effects related to their antioxidant and anti-inflammatory effects through the inhibition of NF-kB activation, COX-2 and iNOS induction. In this sense, it would be interesting to study their effects in an IBD context. Therefore, this study aims to evaluate the effects of an aqueous extract of phenolic compounds in a 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced model of colitis. Method: Experimental colitis was induced in mice through an intrarectal administration of TNBS and then the mice were treated with an aqueous extract of phenolic compounds intraperitoneally for four days. Results and Discussion: The extract demonstrated an anti-inflammatory effect, reducing TNF-\u03b1 levels in the colon, and had a beneficial effect on the extraintestinal manifestations related to IBD, without any significant side effects. The extract of phenolic compounds demonstrated to be a valuable object of study for the management of IBD in the future.<\/jats:p>","DOI":"10.3390\/cimb44060188","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T09:51:11Z","timestamp":1655545871000},"page":"2745-2758","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Aqueous Extract of Phenolic Compounds Obtained from Red Wine in Experimental Model of Colitis in Mice"],"prefix":"10.3390","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3204-3772","authenticated-orcid":false,"given":"Vanessa","family":"Mateus","sequence":"first","affiliation":[{"name":"H&TRC\u2014Health and Technology Research Center, ESTeSL\u2014Escola Superior de Tecnologia da Sa\u00fade de Lisboa, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisbon, Portugal"},{"name":"iMed.ULisboa, Faculty of Pharmacy of the University of Lisbon, 1600-277 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8283-3174","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Estarreja","sequence":"additional","affiliation":[{"name":"H&TRC\u2014Health and Technology Research Center, ESTeSL\u2014Escola Superior de Tecnologia da Sa\u00fade de Lisboa, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7049-2512","authenticated-orcid":false,"given":"In\u00eas","family":"Silva","sequence":"additional","affiliation":[{"name":"H&TRC\u2014Health and Technology Research Center, ESTeSL\u2014Escola Superior de Tecnologia da Sa\u00fade de Lisboa, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisbon, Portugal"},{"name":"iMed.ULisboa, Faculty of Pharmacy of the University of Lisbon, 1600-277 Lisbon, Portugal"}]},{"given":"Fernando","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Higher Agricultural School of Viseu\u2014Polytechnic Institute of Viseu, 3500-606 Viseu, Portugal"},{"name":"CERNAS Research Centre, Polytechnic Institute of Viseu, 3504-510 Viseu, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6346-8319","authenticated-orcid":false,"given":"Edite","family":"Teixeira-Lemos","sequence":"additional","affiliation":[{"name":"Higher Agricultural School of Viseu\u2014Polytechnic Institute of Viseu, 3500-606 Viseu, Portugal"},{"name":"CERNAS Research Centre, Polytechnic Institute of Viseu, 3504-510 Viseu, Portugal"}]},{"given":"Rui","family":"Pinto","sequence":"additional","affiliation":[{"name":"iMed.ULisboa, Faculty of Pharmacy of the University of Lisbon, 1600-277 Lisbon, Portugal"},{"name":"JCS, Joaquim Chaves, Clinical Laboratory, 1495-068 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1586\/17474124.2015.1002086","article-title":"Dietary anthocyanins as a complementary medicinal approach for management of inflammatory bowel disease","volume":"9","author":"Sodagari","year":"2015","journal-title":"Expert Rev. 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