{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:34:14Z","timestamp":1769596454790,"version":"3.49.0"},"reference-count":60,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010067","name":"Gobierno de Arag\u00f3n","doi-asserted-by":"publisher","award":["B56_23D"],"award-info":[{"award-number":["B56_23D"]}],"id":[{"id":"10.13039\/501100010067","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>The main function of interstitial cells of Cajal (ICCs) is to regulate gastrointestinal peristalsis by acting as a \u201cpacemaker\u201d cell by generating spontaneous slow electrical waves. In 2005, electron microscopy revealed a cell type similar to ICCs (ICC-like) outside the gastrointestinal tract, with contractile activity and c-Kit+ immunohistochemistry shared with ICCs. Among the locations where ICC-like cells have been observed, it is in the uterus where they have a significant functional and pathophysiological role. These cells are involved in obstetric phenomena of contractile action, such as ascending sperm transport, embryo implantation, pregnancy, delivery, and the expulsion of menstrual debris. Within the pathophysiology related to these cells, we find obstetric alterations such as recurrent miscarriages, premature deliveries, abolition of uterine contractions, and failures of embryo implantation, in addition to other common conditions in the fertile age, such as endometriosis and leiomyoma.<\/jats:p>","DOI":"10.3390\/cimb45090476","type":"journal-article","created":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T23:57:46Z","timestamp":1694995066000},"page":"7557-7571","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pathophysiological Implications of Interstitial Cajal-like Cells (ICC-like) in Uterus: A Comparative Study with Gastrointestinal ICCs"],"prefix":"10.3390","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2455-680X","authenticated-orcid":false,"given":"Laura","family":"L\u00f3pez-Pingarr\u00f3n","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Physiology and Legal and Forensic Medicine, Faculty of Medicine, University of Zaragoza, 50009 Zaragoza, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-3211","authenticated-orcid":false,"given":"Henrique","family":"Almeida","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Porto University, 4200-135 Porto, Portugal"},{"name":"Department of Biomedicine, Faculty of Medicine, Porto University, 4200-319 Porto, Portugal"},{"name":"Department of Obstetrics and Gynecology, Hospital-CUF Porto, 4100-180 Porto, Portugal"}]},{"given":"Desir\u00e9e","family":"Pereboom-Maicas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Physiology and Legal and Forensic Medicine, Faculty of Medicine, University of Zaragoza, 50009 Zaragoza, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9507-6478","authenticated-orcid":false,"given":"Joaqu\u00edn J.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Physiology and Legal and Forensic Medicine, Faculty of Medicine, University of Zaragoza, 50009 Zaragoza, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"ref_1","unstructured":"Cajal, S.R. 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