{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:06:11Z","timestamp":1761897971287,"version":"build-2065373602"},"reference-count":107,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"national funds","award":["UIDB\/00709\/2020","UIDP\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020","UIDP\/00709\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Hypertensive disorders of pregnancy (HDP) represent a substantial risk to maternal and fetal health. Emerging evidence suggests an association between testosterone and pre-eclampsia (PE), potentially mediated through androgen receptors (AR). Nevertheless, the mechanism driving this association is yet to be elucidated. On the other hand, reports of transgender men\u2019s pregnancies offer a limited and insightful opportunity to understand the role of high androgen levels in the development of HDP. In this sense, a literature review was performed from a little over 2 decades (1998\u20132022) to address the association of testosterone levels with the development of HDP. Furthermore, this review addresses the case of transgender men for the first time. The main in vitro outcomes reveal placenta samples with greater AR mRNA expression. Moreover, ex vivo studies show that testosterone-induced vasorelaxation impairment promotes hypertension. Epidemiological data point to greater testosterone levels in blood samples during PE. Studies with transgender men allow us to infer that exogenous testosterone administration can be considered a risk factor for PE and that the administration of testosterone does not affect fetal development. Overall, all studies analyzed suggested that high testosterone levels are associated with PE.<\/jats:p>","DOI":"10.3390\/cimb46030108","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T08:43:48Z","timestamp":1708505028000},"page":"1668-1693","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Relationship between Androgens and Vascular and Placental Function during Pre-eclampsia"],"prefix":"10.3390","volume":"46","author":[{"given":"Lara M.","family":"Fernandes","sequence":"first","affiliation":[{"name":"CICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilh\u00e3, Portugal"},{"name":"FCS-UBI, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-6398","authenticated-orcid":false,"given":"Margarida","family":"Lorigo","sequence":"additional","affiliation":[{"name":"CICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilh\u00e3, Portugal"},{"name":"FCS-UBI, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4823-5701","authenticated-orcid":false,"given":"Elisa","family":"Cairrao","sequence":"additional","affiliation":[{"name":"CICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilh\u00e3, Portugal"},{"name":"FCS-UBI, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilh\u00e3, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"ref_1","unstructured":"Felig, P., and Frohman, L.A. (2001). Endocrinology & Metabolism, McGraw-Hill. [4th ed.]."},{"key":"ref_2","unstructured":"Melmed, S., Koenig, R., Rosen, C., Auchus, R.J., and Goldfine, A. (2015). Williams Textbook of Endocrinology, Elsevier Health Sciences. [14th ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mce.2017.08.016","article-title":"Intracrine androgen biosynthesis, metabolism and action revisited","volume":"465","author":"Schiffer","year":"2018","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Parsons, A.M., and Bouma, G.J. (2021). A Potential Role and Contribution of Androgens in Placental Development and Pregnancy. Life, 11.","DOI":"10.3390\/life11070644"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1210\/endo-126-2-1165","article-title":"Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone","volume":"126","author":"Grino","year":"1990","journal-title":"Endocrinology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1210\/edrv.23.2.0460","article-title":"Androgen receptor (AR) coregulators: An overview","volume":"23","author":"Heinlein","year":"2002","journal-title":"Endocr. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4103\/1008-682X.122590","article-title":"Human androgen deficiency: Insights gained from androgen receptor knockout mouse models","volume":"16","author":"Rana","year":"2014","journal-title":"Asian J. Androl."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.yfrne.2007.10.005","article-title":"Non-genomic actions of androgens","volume":"29","author":"Foradori","year":"2008","journal-title":"Front. Neuroendocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lorigo, M., Mariana, M., Lemos, M.C., and Cairrao, E. (2020). Vascular mechanisms of testosterone: The non-genomic point of view. J. Steroid Biochem. Mol. Biol., 196.","DOI":"10.1016\/j.jsbmb.2019.105496"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Perusqu\u00eda, M. (2022). Androgens and Non-Genomic vascular responses in hypertension. Biochem. Pharmacol., 203.","DOI":"10.1016\/j.bcp.2022.115200"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Stallone, J.N., and Oloyo, A.K. (2023). Cardiovascular and metabolic actions of the androgens: Is testosterone a Janus-faced molecule?. Biochem. Pharmacol., 208.","DOI":"10.1016\/j.bcp.2022.115347"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ceca.2006.11.003","article-title":"Molecular requirements for L-type Ca2+ channel blockade by testosterone","volume":"42","author":"Scragg","year":"2007","journal-title":"Cell Calcium"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.vph.2012.01.008","article-title":"Regional differences in the vasorelaxing effects of testosterone and its 5-reduced metabolites in the canine vasculature","volume":"56","author":"Espinoza","year":"2012","journal-title":"Vasc. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1093\/humrep\/deu198","article-title":"The striking similarities in the metabolic associations of female androgen excess and male androgen deficiency","volume":"29","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/oby.21033","article-title":"The role of androgens in metabolism, obesity, and diabetes in males and females","volume":"23","author":"Navarro","year":"2015","journal-title":"Obesity"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"R125","DOI":"10.1530\/EJE-17-0124","article-title":"Mechanisms in endocrinology: The sexually dimorphic role of androgens in human metabolic disease","volume":"177","author":"Schiffer","year":"2017","journal-title":"Eur. J. Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"R155","DOI":"10.1530\/REP-18-0278","article-title":"Androgens in maternal vascular and placental function: Implications for preeclampsia pathogenesis","volume":"156","author":"Kumar","year":"2018","journal-title":"Reproduction"},{"key":"ref_18","first-page":"630","article-title":"Elevated gestational testosterone impacts vascular and uteroplacental function","volume":"67","author":"Kumar","year":"2023","journal-title":"Placenta"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/humupd\/dmu008","article-title":"Androgens in pregnancy: Roles in parturition","volume":"20","author":"Makieva","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1095\/biolreprod.104.036954","article-title":"Androgens induce relaxation of contractile activity in pregnant human myometrium at term: A nongenomic action on L-type calcium channels","volume":"73","author":"Navarrete","year":"2005","journal-title":"Biol. Reprod."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1210\/jc.2010-2504","article-title":"The human placenta expresses CYP17 and generates androgens de novo","volume":"96","author":"Escobar","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.placenta.2023.05.005","article-title":"The preeclampsia condition alters external potassium-evoked contraction of human umbilical vessels","volume":"138","author":"Silva","year":"2023","journal-title":"Placenta"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/1440-1681.12047","article-title":"Long- and short-term effects of androgens in human umbilical artery smooth muscle","volume":"40","author":"Saldanha","year":"2013","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s12265-019-09939-5","article-title":"Vascular Pathways of Testosterone: Clinical Implications","volume":"13","author":"Lorigo","year":"2020","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00210-007-0213-3","article-title":"Potassium channels are involved in testosterone-induced vasorelaxation of human umbilical artery","volume":"376","author":"Alvarez","year":"2008","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s11515-018-1517-z","article-title":"Androgen and estrogen receptors in placental physiology and dysfunction","volume":"13","author":"McWhorter","year":"2018","journal-title":"Front. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S1028-4559(09)60301-6","article-title":"Expression of androgen receptor in human placentas from normal and preeclamptic pregnancies","volume":"48","author":"Hsu","year":"2009","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/jp.2011.101","article-title":"Fetal sex-related dysregulation in testosterone production and their receptor expression in the human placenta with preeclampsia","volume":"32","author":"Sathishkumar","year":"2012","journal-title":"J. Perinatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"18415","DOI":"10.1038\/s41598-021-97799-y","article-title":"Oxidative stress-induced impairment of trophoblast function causes preeclampsia through the unfolded protein response pathway","volume":"11","author":"Mukherjee","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"D\u2019Arrigo, G., Gianquinto, E., Rossetti, G., Cruciani, G., Lorenzetti, S., and Spyrakis, F. (2021). Binding of Androgen- and Estrogen-Like Flavonoids to Their Cognate (Non)Nuclear Receptors: A Comparison by Computational Prediction. Molecules, 26.","DOI":"10.3390\/molecules26061613"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.steroids.2019.01.006","article-title":"Membrane androgen receptors (OXER1, GPRC6A AND ZIP9) in prostate and breast cancer: A comparative study of their expression","volume":"142","author":"Kalyvianaki","year":"2019","journal-title":"Steroids"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1210\/me.2015-1161","article-title":"Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues","volume":"29","author":"Pi","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.molmet.2016.12.006","article-title":"GPRC6A: Jack of all metabolism (or master of none)","volume":"6","author":"Pi","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3390\/pathophysiology28020013","article-title":"Preeclampsia Status Controls Interleukin-6 and Soluble IL-6 Receptor Release from Neutrophils and Endothelial Cells: Relevance to Increased Inflammatory Responses","volume":"28","author":"Wang","year":"2021","journal-title":"Pathophysiology"},{"key":"ref_35","unstructured":"(2013). Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists\u2019 Task Force on Hypertension in Pregnancy. Obstet. Gynecol., 122, 1122\u20131131."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1093\/eurheartj\/ehy340","article-title":"2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy: The Task Force for the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC)","volume":"39","author":"Bauersachs","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/AOG.0000000000000564","article-title":"Pregnancy-related mortality in the United States, 2006\u20132010","volume":"125","author":"Creanga","year":"2015","journal-title":"Obs. Gynecol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/10641950802000943","article-title":"Prevalence of hypertension during pregnancy in Portugal","volume":"27","author":"Costa","year":"2008","journal-title":"Hypertens. Pregnancy"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.ajog.2005.10.813","article-title":"Preeclampsia, gestational hypertension and intrauterine growth restriction, related or independent conditions?","volume":"194","author":"Villar","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"105918","DOI":"10.1155\/2012\/105918","article-title":"A comprehensive review of hypertension in pregnancy","volume":"2012","author":"Mustafa","year":"2012","journal-title":"J. Pregnancy"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.2174\/138161207781663019","article-title":"Hypertension in Pregnancy: Pathophysiology & Management Strategies","volume":"13","author":"Karthikeyan","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"23905","DOI":"10.3390\/ijms161023905","article-title":"Cardiovascular complications of pregnancy","volume":"16","author":"Gongora","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_43","unstructured":"(2019). ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia. Obstet. Gynecol., 133, 1."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"(2000). Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am. J. Obstet. Gynecol., 183, s1\u2013s22.","DOI":"10.1016\/S0002-9378(00)40820-3"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/01.hjh.0000431740.32696.cc","article-title":"2013 ESH\/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"31","author":"Mancia","year":"2013","journal-title":"J. Hypertens."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/hr.2016.126","article-title":"Epidemiology of hypertensive disorders in pregnancy: Prevalence, risk factors, predictors and prognosis","volume":"40","author":"Umesawa","year":"2017","journal-title":"Hypertens. Res."},{"key":"ref_48","first-page":"332","article-title":"Intrauterine growth retardation (IUGR): Epidemiology and etiology","volume":"6","author":"Romo","year":"2009","journal-title":"Pediatr. Endocrinol. Rev. PER"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1067\/mob.2001.111719","article-title":"The risks of spontaneous preterm delivery and perinatal mortality in relation to size at birth according to fetal versus neonatal growth standards","volume":"184","author":"Lackman","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8","DOI":"10.21037\/jlpm.2019.11.04","article-title":"Diagnosis of hypertensive disorders in pregnancy: An update","volume":"5","author":"Tagetti","year":"2019","journal-title":"J. Lab. Precis. Med."},{"key":"ref_51","first-page":"1","article-title":"Hypertensive disorders of pregnancy","volume":"3","author":"Mammaro","year":"2009","journal-title":"J. Prenat. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/17402520600876903","article-title":"Immunology and genetic of preeclampsia","volume":"13","author":"Serrano","year":"2006","journal-title":"Clin. Dev. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0002-9378(99)70150-X","article-title":"Androgens in preeclampsia","volume":"180","author":"Acromite","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejogrb.2005.07.007","article-title":"Androgen levels in the third trimester of pregnancy in patients with preeclampsia","volume":"126","author":"Salamalekis","year":"2006","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"S6.e1","DOI":"10.1016\/j.ajog.2015.07.050","article-title":"What is the placenta?","volume":"213","author":"Burton","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Burton, G.J., and Fowden, A.L. (2015). The placenta: A multifaceted, transient organ. Philos. Trans. R. Soc. Lond. B Biol. Sci., 370.","DOI":"10.1098\/rstb.2014.0066"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Keelan, J.A., Mattes, E., Tan, H., Dinan, A., Newnham, J.P., Whitehouse, A.J., Jacoby, P., and Hickey, M. (2012). Androgen concentrations in umbilical cord blood and their association with maternal, fetal and obstetric factors. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0042827"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3892\/mmr.2021.11891","article-title":"Comparison of steroid hormones in three different preeclamptic models","volume":"23","author":"Shin","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1161\/HYPERTENSIONAHA.111.00486","article-title":"Testosterone alters maternal vascular adaptations: Role of the endothelial NO system","volume":"61","author":"Chinnathambi","year":"2013","journal-title":"Hypertension"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Chinnathambi, V., More, A.S., Hankins, G.D., Yallampalli, C., and Sathishkumar, K. (2014). Gestational Exposure to Elevated Testosterone Levels Induces Hypertension via Heightened Vascular Angiotensin II Type 1 Receptor Signaling in Rats1. Biol. Reprod., 91.","DOI":"10.1095\/biolreprod.114.118968"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1161\/HYPERTENSIONAHA.114.03283","article-title":"Elevated testosterone levels during rat pregnancy cause hypersensitivity to angiotensin II and attenuation of endothelium-dependent vasodilation in uterine arteries","volume":"64","author":"Chinnathambi","year":"2014","journal-title":"Hypertension"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jsbmb.2017.11.001","article-title":"Antihypertensive responses of vasoactive androgens in an in vivo experimental model of preeclampsia","volume":"178","author":"Hanson","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/biolre\/ioab051","article-title":"Activation of angiotensin type 2 receptor attenuates testosterone-induced hypertension and uterine vascular resistance in pregnant rats\u2020","volume":"105","author":"Mishra","year":"2021","journal-title":"Biol. Reprod."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1093\/oxfordjournals.humrep.a019209","article-title":"Regulation of vascular adaptation during pregnancy and post-partum: Effects of nitric oxide inhibition and steroid hormones","volume":"11","author":"Liao","year":"1996","journal-title":"Hum. Reprod."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"R499","DOI":"10.1152\/ajpregu.00355.2017","article-title":"Animal models of preeclampsia: Translational failings and why","volume":"314","author":"Marshall","year":"2018","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11906-023-01233-9","article-title":"The Clinical Value of Rodent Models in Understanding Preeclampsia Development and Progression","volume":"25","author":"Ramdin","year":"2023","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Lan, K.C., Lai, Y.J., Cheng, H.H., Tsai, N.C., Su, Y.T., Tsai, C.C., and Hsu, T.Y. (2020). Levels of sex steroid hormones and their receptors in women with preeclampsia. Reprod. Biol. Endocrinol., 18.","DOI":"10.1186\/s12958-020-0569-5"},{"key":"ref_68","first-page":"344","article-title":"Evidence of high circulating testosterone in women with prior preeclampsia","volume":"83","author":"Laivuori","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1034\/j.1600-0412.2001.801107.x","article-title":"Androgen levels of preeclamptic patients in the third trimester of pregnancy and six weeks after delivery","volume":"80","author":"Serin","year":"2001","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1210\/jcem.87.4.8405","article-title":"First trimester insulin resistance and subsequent preeclampsia: A prospective study","volume":"87","author":"Wolf","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_71","first-page":"552","article-title":"Human chorionic gonadotropin and testosterone in normal and preeclamptic pregnancies in relation to fetal sex","volume":"100","author":"Steier","year":"2002","journal-title":"Obstet. Gynecol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/0144361031000074637","article-title":"The role of androgens in the aetiology and pathology of pre-eclampsia","volume":"23","author":"Kutlu","year":"2003","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/BF03040303","article-title":"Elevated serum concentrations of androgens in women with pregnancy-induced hypertension","volume":"115","author":"Jirecek","year":"2003","journal-title":"Wien. Klin. Wochenschr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/ije\/dyg094","article-title":"Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies","volume":"32","author":"Troisi","year":"2003","journal-title":"Int. J. Epidemiol."},{"key":"ref_75","first-page":"1268","article-title":"Estrogen and Androgen Concentrations Are Not Lower in the Umbilical Cord Serum of Pre-eclamptic Pregnancies","volume":"12","author":"Troisi","year":"2003","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0020-7292(03)00318-7","article-title":"Androgen levels in pre-eclamptic pregnant women","volume":"84","author":"Baksu","year":"2004","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.0001-6349.2004.00276.x","article-title":"The relationship between plasma levels of leptin and androgen in healthy and preeclamptic pregnant women","volume":"83","author":"Atamer","year":"2004","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.0001-6349.2005.00493.x","article-title":"Early second-trimester maternal hyperandrogenemia and subsequent preeclampsia: A prospective study","volume":"84","author":"Carlsen","year":"2005","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_79","first-page":"186","article-title":"Evaluation of Androgen and Progesterone Levels in Women with Preeclampsia","volume":"30","author":"Salari","year":"2005","journal-title":"Iran. J. Med. Sci."},{"key":"ref_80","first-page":"228","article-title":"[High plasmatic androgen levels in women affected with pregnancy-induced hypertension]","volume":"58","author":"Camero","year":"2006","journal-title":"Rev. Investig. Clin."},{"key":"ref_81","first-page":"33","article-title":"Testosterona s\u00e9rica en trastornos hipertensivos del embarazo","volume":"72","author":"Irribarra","year":"2007","journal-title":"Rev. Chil. Obstet. Y Ginecol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.3109\/00016349.2010.505638","article-title":"Hormonal and metabolic characteristics of premenopausal women with a history of preeclamptic pregnancy","volume":"89","author":"Tuuri","year":"2010","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e471","DOI":"10.1016\/j.ajog.2010.06.011","article-title":"Steroid profiling in preeclamptic women: Evidence for aromatase deficiency","volume":"203","author":"Hertig","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3109\/00365513.2011.580858","article-title":"Serum testosterone levels during early pregnancy in patients developing preeclampsia","volume":"71","author":"Tuutti","year":"2011","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"834","DOI":"10.3109\/09513590.2012.683061","article-title":"A comparison of serum androgens in pre-eclamptic and normotensive pregnant women during the third trimester of pregnancy","volume":"28","author":"Sharifzadeh","year":"2012","journal-title":"Gynecol. Endocrinol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s10552-012-9934-9","article-title":"Maternal and cord steroid sex hormones, angiogenic factors, and insulin-like growth factor axis in African-American preeclamptic and uncomplicated pregnancies","volume":"23","author":"Wang","year":"2012","journal-title":"Cancer Causes Control"},{"key":"ref_87","first-page":"817","article-title":"Association between fetal sex and maternal serum testosterone levels in normotensive and preeclamptic pregnancies","volume":"6","author":"Ashraf","year":"2012","journal-title":"Pak. J. Med. Health Sci."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Perez-Sepulveda, A., Monteiro, L.J., Dobierzewska, A., Espa\u00f1a-Perrot, P.P., Venegas-Araneda, P., Guzm\u00e1n-Rojas, A.M., Gonz\u00e1lez, M.I., Palominos-Rivera, M., Irarrazabal, C.E., and Figueroa-Diesel, H. (2015). Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139682"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1161\/HYPERTENSIONAHA.116.08468","article-title":"Testosterone Represses Estrogen Signaling by Upregulating miR-22: A Mechanism for Imbalanced Steroid Hormone Production in Preeclampsia","volume":"69","author":"Shao","year":"2017","journal-title":"Hypertension"},{"key":"ref_90","first-page":"2681","article-title":"Regulation of steroid hormones in the placenta and serum of women with preeclampsia","volume":"17","author":"Shin","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.placenta.2018.07.004","article-title":"Abnormal steroidogenesis and aromatase activity in preeclampsia","volume":"69","author":"Berkane","year":"2018","journal-title":"Placenta"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3329\/bsmmuj.v13i1.45052","article-title":"Maternal serum progesterone level in preeclampsia","volume":"13","author":"Chowdhury","year":"2020","journal-title":"Bangabandhu Sheikh Mujib Med. Univ. J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1080\/10641955.2020.1765174","article-title":"Fetal gender, serum human chorionic gonadotropin, and testosterone in women with preeclampsia","volume":"39","author":"Ibrahim","year":"2020","journal-title":"Hypertens. Pregnancy"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/2305-0500.275522","article-title":"Testosterone is a surrogate and proxy biomarker for severity of late-onset preeclampsia: A cross-sectional study","volume":"9","year":"2020","journal-title":"Asian Pac. J. Reprod."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Eckstein, M.L., Moser, O., R\u00f6ssler, A., Moertl, M.G., Jantscher, A., Papousek, I., Wagner, J., Schmid-Zalaudek, K., Sourij, H., and Treiber, G. (2021). Differences in Hemodynamic, Hormonal and Heart Rate Variability Parameters in Complication-Free Pregnancies Compared to Individuals with Gestational Diabetes Mellitus and Preeclampsia: An Observational Retrospective Analysis. Life, 11.","DOI":"10.1055\/s-0041-1727390"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/jch.14601","article-title":"Serum estradiol to testosterone ratio as a novel predictor of severe preeclampsia in the first trimester","volume":"25","author":"Shen","year":"2022","journal-title":"J. Clin. Hypertens."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1210\/jc.2013-3399","article-title":"Hyperandrogenemia Predicts Metabolic Phenotype in Polycystic Ovary Syndrome: The Utility of Serum Androstenedione","volume":"99","author":"Taylor","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1027164","DOI":"10.3389\/fendo.2022.1027164","article-title":"A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization","volume":"13","author":"Shaw","year":"2022","journal-title":"Front. Endocrinol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Peres, G.M., Mariana, M., and Cairr\u00e3o, E. (2018). Pre-Eclampsia and Eclampsia: An Update on the Pharmacological Treatment Applied in Portugal. J. Cardiovasc. Dev. Dis., 5.","DOI":"10.3390\/jcdd5010003"},{"key":"ref_100","first-page":"7","article-title":"Risk factors and effective management of preeclampsia","volume":"8","author":"English","year":"2015","journal-title":"Integr. Blood Press. Control"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41581-019-0119-6","article-title":"Pre-eclampsia: Pathogenesis, novel diagnostics and therapies","volume":"15","author":"Phipps","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0735-1097(98)00416-1","article-title":"Vascular reactivity is impaired in genetic females taking high-dose androgens","volume":"32","author":"McCredie","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/andr.12382","article-title":"Effects of testosterone therapy on BMI, blood pressure, and laboratory profile of transgender men: A systematic review","volume":"5","author":"Velho","year":"2017","journal-title":"Andrology"},{"key":"ref_104","first-page":"921","article-title":"The efficacy, safety, and outcomes of testosterone use among transgender men patients: A review of the literature","volume":"45","author":"Mwamba","year":"2022","journal-title":"Neurourol. Urodyn."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1097\/AOG.0000000000000540","article-title":"Transgender men who experienced pregnancy after female-to-male gender transitioning","volume":"124","author":"Light","year":"2014","journal-title":"Obstet. Gynecol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/jog.15145","article-title":"Transgender man receiving testosterone treatment became pregnant and delivered a girl: A case report","volume":"48","author":"Yoshida","year":"2022","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1055\/s-0038-1657788","article-title":"Recommendations for the Use of Testosterone in Male Transgender","volume":"40","author":"Costa","year":"2018","journal-title":"Rev. Bras. Ginecol. 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