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This study aimed to characterise a nanoemulsion formulated with a\u00e7a\u00ed seed oil and explore its cytotoxic effects on HeLa and SiHa cervical cancer cell lines, alongside assessing its antioxidant and toxicity properties both in vitro and in vivo. Extracted from fruits sourced in Brazil, the oil underwent thorough chemical characterization using gas chromatography\u2013mass spectrometry. The resulting nanoemulsion was prepared and evaluated for stability, particle size, and antioxidant properties. The nanoemulsion exhibited translucency, fluidity, and stability post centrifugation and temperature tests, with a droplet size of 238.37, PDI -9.59, pH 7, and turbidity 0.267. In vitro assessments on cervical cancer cell lines revealed antitumour effects, including inhibition of cell proliferation, migration, and colony formation. Toxicity tests conducted in cell cultures and female Swiss mice demonstrated no adverse effects of both a\u00e7a\u00ed seed oil and nanoemulsion. Overall, a\u00e7a\u00ed seed oil, particularly when formulated into a nanoemulsion, presents potential for cancer treatment due to its bioactive properties and safety profile.<\/jats:p>","DOI":"10.3390\/cimb46050235","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T05:28:06Z","timestamp":1713850086000},"page":"3763-3793","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A\u00e7a\u00ed (Euterpe oleracea Mart.) Seed Oil and Its Nanoemulsion: Chemical Characterisation, Toxicity Evaluation, Antioxidant and Anticancer Activities"],"prefix":"10.3390","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8642-5418","authenticated-orcid":false,"given":"Katia Regina Assun\u00e7\u00e3o","family":"Borges","sequence":"first","affiliation":[{"name":"Northeast Biotechnology Postgraduate Program, Renorbio, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Sa\u00f5 Luis 65080-085, Maranhao, Brazil"}]},{"given":"Lais Ara\u00fajo Souza","family":"Wolff","sequence":"additional","affiliation":[{"name":"Adult Health Master\u2019s Postgraduate Program\u2014PPGSAD, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Sa\u00f5 Luis 65080-085, Maranhao, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2748-1564","authenticated-orcid":false,"given":"Marcos Antonio Cust\u00f3dio Neto","family":"da Silva","sequence":"additional","affiliation":[{"name":"Medicine Course, Federal University of Maranhao, Imperatriz 65915-060, Maranhao, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-8486","authenticated-orcid":false,"given":"Allysson Kayron","family":"de Carvalho Silva","sequence":"additional","affiliation":[{"name":"Northeast Biotechnology Postgraduate Program, Renorbio, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Sa\u00f5 Luis 65080-085, Maranhao, Brazil"}]},{"given":"Carmem Duarte Lima","family":"Campos","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Sa\u00f5 Luis 65080-085, Maranhao, Brazil"}]},{"given":"Franscristhiany Silva","family":"Souza","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biodiversity and Biotechnology of the Bionorte Network, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Sa\u00f5 Luis 65080-085, Maranhao, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5068-4696","authenticated-orcid":false,"given":"Amanda Mara","family":"Teles","sequence":"additional","affiliation":[{"name":"Professional Postgradualte Program in Animal Health Defense, State University of Maranh\u00e3o, Av. Oeste Externa, 2220-S\u00e3o Crist\u00f3v\u00e3o, S\u00e3o Lu\u00eds 65010-120, Maranhao, Brazil"}]},{"given":"Andr\u00e9 \u00c1lvares Marques","family":"Vale","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Sa\u00f5 Luis 65080-085, Maranhao, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2542-6879","authenticated-orcid":false,"given":"Henrique","family":"Pascoa","sequence":"additional","affiliation":[{"name":"Farmatec Laboratory at the Federal University of Goi\u00e1s, Campus Samambaia da UFG, Goi\u00e2nia 74690-631, Goi\u00e1s, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-5803","authenticated-orcid":false,"given":"Eliana Martins","family":"Lima","sequence":"additional","affiliation":[{"name":"Farmatec Laboratory at the Federal University of Goi\u00e1s, Campus Samambaia da UFG, Goi\u00e2nia 74690-631, Goi\u00e1s, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2506-169X","authenticated-orcid":false,"given":"Eduardo Martins","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Graduate Program in Biosciences Applied to Health, CEUMA Universitity, S\u00e3o Lu\u00eds 65075-120, Maranh\u00e3o, Brazil"}]},{"given":"Ana Clara Silva","family":"Nunes","sequence":"additional","affiliation":[{"name":"Coordination of the Chemical Engineering course, Center for Exact Sciences and Technology, Federal University of Maranhao (UFMA), S\u00e3o Lu\u00eds 65080-085, Maranh\u00e3o, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2151-2449","authenticated-orcid":false,"given":"Rui M.","family":"Gil da Costa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Sa\u00f5 Luis 65080-085, Maranhao, Brazil"},{"name":"Centre for the Research and Technology of Agro-Environmental and Biological Sciences, Universidade de Tr\u00e1s-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal"},{"name":"Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)\/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto), Porto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal"},{"name":"Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE), Faculty of Engineering, University of Porto (FEUP), 4200-465 Porto, Portugal"},{"name":"Associate Laboratory in Chemical Engineering (ALiCE), University of Porto (FEUP), 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-6317","authenticated-orcid":false,"given":"Ana Isabel","family":"Faustino-Rocha","sequence":"additional","affiliation":[{"name":"Centre for the Research and Technology of Agro-Environmental and Biological Sciences, Universidade de Tr\u00e1s-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal"},{"name":"Comprehensive Health Research Center (CHRC), 7006-554 \u00c9vora, Portugal"},{"name":"Department of Zootechnics, School of Sciences and Technology, University of \u00c9vora, 7002-554 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7073-8308","authenticated-orcid":false,"given":"Rafael","family":"Cardoso Carvalho","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Sa\u00f5 Luis 65080-085, Maranhao, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2783-362X","authenticated-orcid":false,"given":"Maria do Desterro Soares Brand\u00e3o","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Northeast Biotechnology Postgraduate Program, Renorbio, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Sa\u00f5 Luis 65080-085, Maranhao, Brazil"},{"name":"Adult Health Master\u2019s Postgraduate Program\u2014PPGSAD, Federal University of Maranhao (UFMA), Avenida dos Portugueses, 1966 Bacanga, Sa\u00f5 Luis 65080-085, Maranhao, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.foodchem.2015.01.055","article-title":"Amazon acai: Chemistry and biological activities: A review","volume":"179","author":"Pereira","year":"2015","journal-title":"Food Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e08422","DOI":"10.1590\/fst.08422","article-title":"Jussa\u00ed (Euterpe edulis): A review","volume":"42","author":"Carvalho","year":"2022","journal-title":"Food Sci. 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