{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:54:02Z","timestamp":1762642442153,"version":"build-2065373602"},"reference-count":77,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["PN-III-P1-1.1-TE-2016-1501"],"award-info":[{"award-number":["PN-III-P1-1.1-TE-2016-1501"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/CTM\/50011\/2019"],"award-info":[{"award-number":["UID\/CTM\/50011\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Coatings"],"abstract":"<jats:p>Silica-based bioactive glasses (SBG) hold great promise as bio-functional coatings of metallic endo-osseous implants, due to their osteoproductive potential, and, in the case of designed formulations, suitable mechanical properties and antibacterial efficacy. In the framework of this study, the FastOs\u00aeBG alkali-free SBG system (mol%: SiO2\u201438.49, CaO\u201436.07, P2O5\u20145.61, MgO\u201419.24, CaF2\u20140.59), with CuO (2 mol%) and Ga2O3 (3 mol%) antimicrobial agents, partially substituting in the parent system CaO and MgO, respectively, was used as source material for the fabrication of intentionally silica-enriched implant-type thin coatings (~600 nm) onto titanium (Ti) substrates by radio-frequency magnetron sputtering. The physico-chemical and mechanical characteristics, as well as the in vitro preliminary cytocompatibility and antibacterial performance of an alkali-free silica-rich bio-active glass coating designs was further explored. The films were smooth (RRMS &lt; 1 nm) and hydrophilic (water contact angle of ~65\u00b0). The SBG coatings deposited from alkali-free copper-gallium co-doped FastOs\u00aeBG-derived exhibited improved wear performance, with the coatings eliciting a bonding strength value of ~53 MPa, Lc3 critical load value of ~4.9 N, hardness of ~6.1 GPa and an elastic modulus of ~127 GPa. The Cu and Ga co-doped SBG layers had excellent cytocompatibility, while reducing after 24 h the Staphylococcus aureus bacterial development with 4 orders of magnitude with respect to the control situations (i.e., nutritive broth and Ti substrate). Thereby, such SBG constructs could pave the road towards high-performance bio-functional coatings with excellent mechanical properties and enhanced biological features (e.g., by coupling cytocompatibility with antimicrobial properties), which are in great demand nowadays.<\/jats:p>","DOI":"10.3390\/coatings10111119","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T09:46:18Z","timestamp":1605865578000},"page":"1119","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Beneficial Mechanical and Biological Outcomes of Thin Copper-Gallium Doped Silica-Rich Bio-Active Glass Implant-Type Coatings"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0289-8988","authenticated-orcid":false,"given":"George E.","family":"Stan","sequence":"first","affiliation":[{"name":"National Institute for Materials Physics, RO-077125 Magurele, Romania"}]},{"given":"Teddy","family":"Tite","sequence":"additional","affiliation":[{"name":"National Institute for Materials Physics, RO-077125 Magurele, Romania"}]},{"given":"Adrian-Claudiu","family":"Popa","sequence":"additional","affiliation":[{"name":"National Institute for Materials Physics, RO-077125 Magurele, Romania"}]},{"given":"Iuliana Maria","family":"Chirica","sequence":"additional","affiliation":[{"name":"National Institute for Materials Physics, RO-077125 Magurele, Romania"}]},{"given":"Catalin C.","family":"Negrila","sequence":"additional","affiliation":[{"name":"National Institute for Materials Physics, RO-077125 Magurele, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0537-5509","authenticated-orcid":false,"given":"Cristina","family":"Besleaga","sequence":"additional","affiliation":[{"name":"National Institute for Materials Physics, RO-077125 Magurele, Romania"}]},{"given":"Irina","family":"Zgura","sequence":"additional","affiliation":[{"name":"National Institute for Materials Physics, RO-077125 Magurele, Romania"}]},{"given":"Any Cristina","family":"Sergentu","sequence":"additional","affiliation":[{"name":"National Institute for Materials Physics, RO-077125 Magurele, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3871-1436","authenticated-orcid":false,"given":"Gianina","family":"Popescu-Pelin","sequence":"additional","affiliation":[{"name":"National Institute for Lasers, Plasma and Radiation Physics, RO-077125 Magurele, Romania"}]},{"given":"Daniel","family":"Cristea","sequence":"additional","affiliation":[{"name":"Faculty of Materials Science and Engineering, Transilvania University of Brasov, 500068 Brasov, Romania"}]},{"given":"Lucia E.","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Army Centre for Medical Research, RO-020012 Bucharest, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9689-3127","authenticated-orcid":false,"given":"Marius","family":"Necsulescu","sequence":"additional","affiliation":[{"name":"Army Centre for Medical Research, RO-020012 Bucharest, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7520-2809","authenticated-orcid":false,"given":"Hugo R.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Materials and Ceramics Engineering, CICECO, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Jos\u00e9 M. F.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Materials and Ceramics Engineering, CICECO, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kawaguchi, K., Iijima, M., Endo, K., and Mizoguchi, I. (2017). Electrophoretic deposition as a new bioactive glass coating process for orthodontic stainless steel. Coatings, 7.","DOI":"10.3390\/coatings7110199"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Baino, F., Hamzehlou, S., and Kargozar, S. (2018). Bioactive glasses: Where are we and where are we going?. J. Funct. Biomater., 9.","DOI":"10.3390\/jfb9010025"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Brunello, G., Elsayed, H., and Biasetto, L. (2019). Bioactive glass and silicate-based ceramic coatings on metallic implants: Open challenge or outdated topic?. 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