{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:54:51Z","timestamp":1778802891712,"version":"3.51.4"},"reference-count":32,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["Project No. 582PED\u20442022, New hybrid protein nanostructures for targeting specific in colon tumor cells (Prot-Col-Target), PN-III-P2-2.1-PED-2021-1323\/01.08.2022."],"award-info":[{"award-number":["Project No. 582PED\u20442022, New hybrid protein nanostructures for targeting specific in colon tumor cells (Prot-Col-Target), PN-III-P2-2.1-PED-2021-1323\/01.08.2022."]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Coatings"],"abstract":"<jats:p>The bioavailability of the administered drugs that reach the systemic circulation is the first point in resolving the pathology of patients. Albumin-based nanoparticles represent an increasingly used strategy to deliver cancer drugs into cells that otherwise cannot overcome biological barriers. In this work, rutin (Ru), a flavonoid with anticancer and antioxidant potential, was incorporated into bovine serum albumin nanoparticles (BSA-Ru NPs), developed using the desolvation method, and the entire system was characterized and evaluated by scanning electron microscopy (SEM), atomic force microscopy (AFM), and UV\u2013Vis absorption spectroscopy. The results showed that BSA and BSA\u2013Ru NPs are uniformly distributed, have relatively large sizes, and have a time stability of more than 60%. Furthermore, the effect of these nanohybrids on the thermal stability of liposomal membranes was evaluated by surface plasmon resonance (SPR), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The viability evaluation was assessed by the tetrazolium salt (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) (MTS) protocol in the fibroblast L929 line and a high level of biocompatibility, confirmed by SEM results, was found.<\/jats:p>","DOI":"10.3390\/coatings14020220","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T04:47:45Z","timestamp":1707713265000},"page":"220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Albumin\u2013Rutin Nanoparticles: Design, Characterization, and Biophysical Evaluation"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3662-9268","authenticated-orcid":false,"given":"Claudia G.","family":"Chilom","sequence":"first","affiliation":[{"name":"Faculty of Physics, University of Bucharest Magurele, 077125 Magurele, Romania"}]},{"given":"Adriana Elena","family":"Balan","sequence":"additional","affiliation":[{"name":"Faculty of Physics, University of Bucharest Magurele, 077125 Magurele, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1848-6753","authenticated-orcid":false,"given":"Teodor Adrian","family":"Enache","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, 077125 Magurele, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4104-2990","authenticated-orcid":false,"given":"Daniela","family":"Oprea","sequence":"additional","affiliation":[{"name":"Faculty of Physics, University of Bucharest Magurele, 077125 Magurele, Romania"},{"name":"National Institute of Materials Physics, 077125 Magurele, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-5545","authenticated-orcid":false,"given":"Monica","family":"Enculescu","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, 077125 Magurele, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1467-3113","authenticated-orcid":false,"given":"Monica","family":"Florescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Transilvania University of Brasov, 500039 Brasov, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2971-4547","authenticated-orcid":false,"given":"Melinda","family":"David","sequence":"additional","affiliation":[{"name":"Faculty of Electrical Engineering and Computer Science, Transilvania University of Brasov, 500039 Brasov, Romania"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,10]]},"reference":[{"key":"ref_1","first-page":"930","article-title":"Albumin-based nanoparticles: A promising strategy to overcome cancer drug resistance","volume":"3","author":"Hassanin","year":"2020","journal-title":"Cancer Drug Resist."},{"key":"ref_2","first-page":"9285854","article-title":"Protein based nanostructures for drug delivery","volume":"2018","author":"Verma","year":"2018","journal-title":"J. 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