{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:38:08Z","timestamp":1787027888844,"version":"build-2736575974"},"reference-count":9,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cosmetics"],"abstract":"<jats:p>This report describes a new and simple technique to detect alterations in the rate of turnover in the epidermis without using any toxic chemical, such as a radiolabeled material. The method involves measuring the time course of the decrease of darkening of an ultraviolet A-irradiated site, compared with a non-irradiated control site. The turnover time of the persistent pigmentation on the inner side of the male forearm was 36.2 \u00b1 6.2 days (age: 37.3 \u00b1 11.3 years, mean \u00b1 standard deviation, n = 6), which is in reasonable agreement with the epidermal turnover time previously measured by injecting [3H] thymidine into human skin.<\/jats:p>","DOI":"10.3390\/cosmetics4040047","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T11:12:26Z","timestamp":1510312346000},"page":"47","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["New Method of Measurement of Epidermal Turnover in Humans"],"prefix":"10.3390","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8126-0581","authenticated-orcid":false,"given":"Kazuhisa","family":"Maeda","sequence":"first","affiliation":[{"name":"School of Bioscience and Biotechnology, Tokyo University of Technology, 1404-1 Katakuramachi, Hachioji City, Tokyo 192-0982, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/geronj\/38.2.137","article-title":"Age-associated changes in human epidermal cell renewal","volume":"38","author":"Grove","year":"1983","journal-title":"J. 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