{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:55:28Z","timestamp":1774436128020,"version":"3.50.1"},"reference-count":57,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002924","name":"FEDER","doi-asserted-by":"publisher","award":["Opera\u00e7\u00e3o NORTE-01-0145-FEDER-000011\u2013 denominada Qualidade e Seguran\u00e7a Alimentar- uma abordagem (nano)tecnol\u00f3gica"],"award-info":[{"award-number":["Opera\u00e7\u00e3o NORTE-01-0145-FEDER-000011\u2013 denominada Qualidade e Seguran\u00e7a Alimentar- uma abordagem (nano)tecnol\u00f3gica"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FCT\/MEC","award":["UID\/QUI\/50006\/2013 \u2013 POCI\/01\/0145\/FEDER\/007265"],"award-info":[{"award-number":["UID\/QUI\/50006\/2013 \u2013 POCI\/01\/0145\/FEDER\/007265"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cosmetics"],"abstract":"<jats:p>Coffee silverskin, the major coffee-roasting by-product, is currently used as fuel and for soil fertilization. However, there are several studies reporting silverskin as a good source of bioactive compounds that can be extracted and further used by cosmetic industry. Its high antioxidant potential may be due to the synergistic interaction of chlorogenic acids (1\u20136%), caffeine (0.8\u20131.25%), and melanoidins (17\u201323%), among other antioxidant compounds. The bioactive compounds of silverskin can answer to the new fields of cosmetic industry on natural active ingredient resources that improve health skin appearance, counteract skin aging and related diseases, in an environmentally friendly approach. Skin aging is a complex process associated with oxidative metabolism and reactive oxygen species (ROS) generation. ROS production increase matrix metalloproteinases (MMPs), as well as pro-inflammatory mediators, resulting in consequent skin damage and aging. To counteract this process, cosmetic industry is looking for compounds able to increase MMP inhibitory activities, hyaluronidase inhibitory activity, expression of collagen and elastase inhibitory activity, as potential bioactive ingredients with anti-aging purposes. This review focuses on skin aging factors and the potential anti-aging, anti-inflammatory, antimicrobial, anti-cellulite and anti-hair loss activity, as well as protection against UV damage, of coffee silverskin and their bioactive compounds.<\/jats:p>","DOI":"10.3390\/cosmetics5010005","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T12:00:06Z","timestamp":1514980806000},"page":"5","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Coffee Silverskin: A Review on Potential Cosmetic Applications"],"prefix":"10.3390","volume":"5","author":[{"given":"S\u00edlvia","family":"Bessada","sequence":"first","affiliation":[{"name":"REQUIMTE\/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5053-513X","authenticated-orcid":false,"given":"Rita","family":"C. Alves","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-6596","authenticated-orcid":false,"given":"M.","family":"P. P. Oliveira","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"ref_1","unstructured":"Galanakis, C.M. (2017). Handbook of Coffee Processing by-Products, Academic Press. [1st ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1021\/jf034974x","article-title":"Characterization of a new potential functional ingredient: Coffee silverskin","volume":"52","author":"Borrelli","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Costa, A.S., Alves, R.C., Vinha, A.F., Costa, E., Costa, C.S., Nunes, M.A., Almeida, A.A., Santos-Silva, A., and Oliveira, M.B.P.P. (2017). Nutritional, chemical and antioxidant\/pro-oxidant profiles of silverskin, a coffee roasting by-product. Food Chem.","DOI":"10.1016\/j.foodchem.2017.03.106"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.indcrop.2014.01.006","article-title":"Optimization of antioxidants extraction from coffee silverskin, a roasting by-product, having in view a sustainable process","volume":"53","author":"Costa","year":"2014","journal-title":"Ind. Crops Prod."},{"key":"ref_5","unstructured":"Carneiro, L., Silva, J., Mussatto, S., Roberto, I., and Teixeira, J. (2009). Book of Abstracts of the 8th International Meeting of the Portuguese Carbohydrate Group, GLUPOR."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"10499","DOI":"10.1021\/jf071959+","article-title":"Natural occurrence of ochratoxin A and antioxidant activities of green and roasted coffees and corresponding byproducts","volume":"55","author":"Napolitano","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"10836","DOI":"10.1021\/jf503200z","article-title":"Coffee silverskin: Characterization, possible uses, and safety aspects","volume":"62","author":"Toschi","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"12221","DOI":"10.1021\/jf1031229","article-title":"Antiradical activity, phenolics profile, and hydroxymethylfurfural in espresso coffee: Influence of technological factors","volume":"58","author":"Alves","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.foodres.2014.05.058","article-title":"Antiglycative and carbonyl trapping properties of the water soluble fraction of coffee silverskin","volume":"62","author":"Navarro","year":"2014","journal-title":"Food Res. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.foodres.2017.08.012","article-title":"Validation of coffee silverskin extract as a food ingredient by the analysis of cytotoxicity and genotoxicity","volume":"100","author":"Haza","year":"2017","journal-title":"Food Res. Int."},{"key":"ref_11","unstructured":"European Commission (2005). Commission Regulation (EC) No. 123\/2005 of 26 January 2005 amending Regulation (EC) No. 466\/2001 as regards ochratoxin A. Off. J. Eur. Union, L25, 3\u20135."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.foodres.2014.01.023","article-title":"Review on utilization and composition of coffee silverskin","volume":"61","author":"Narita","year":"2014","journal-title":"Food Res. Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1007\/s11947-013-1115-7","article-title":"Selection of the solvent and extraction conditions for maximum recovery of antioxidant phenolic compounds from coffee silverskin","volume":"7","author":"Ballesteros","year":"2014","journal-title":"Food Bioproc. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s11947-011-0565-z","article-title":"Production, composition, and application of coffee and its industrial residues","volume":"4","author":"Mussatto","year":"2011","journal-title":"Food Bioprocess Technol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.lwt.2012.08.001","article-title":"Coffee silverskin as a source of dietary fiber in bread-making: Optimization of chemical treatment using response surface methodology","volume":"50","author":"Pourfarzad","year":"2013","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.foodchem.2013.10.100","article-title":"A novel antioxidant beverage for body weight control based on coffee silverskin","volume":"150","author":"Ullate","year":"2014","journal-title":"Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.indcrop.2014.10.014","article-title":"Are coffee silverskin extracts safe for topical use? An in vitro and in vivo approach","volume":"63","author":"Rodrigues","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/exd.13010","article-title":"In vitro and in vivo comparative study of cosmetic ingredients coffee silverskin and hyaluronic acid","volume":"25","author":"Rodrigues","year":"2016","journal-title":"Exp. Dermatol."},{"key":"ref_19","unstructured":"Galanakis, C.M. (2017). Handbook of Coffee Processing by-Products, Academic Press. [1st ed.]."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1271\/bbb.110106","article-title":"Inhibitory effect of a hot water extract of coffee \u201csilverskin\u201d on hyaluronidase","volume":"75","author":"Furusawa","year":"2011","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3109\/13880209.2014.922589","article-title":"Coffee silverskin: A possible valuable cosmetic ingredient","volume":"53","author":"Rodrigues","year":"2015","journal-title":"Pharm. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1039\/c2fo30048f","article-title":"Coffee melanoidins: Structures, mechanisms of formation and potential health impacts","volume":"3","author":"Moreira","year":"2012","journal-title":"Food Funct."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.arr.2016.08.001","article-title":"Skin aging and oxidative stress: Equol\u2019s anti-aging effects via biochemical and molecular mechanisms","volume":"31","author":"Lephart","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/10715762.2017.1355550","article-title":"Marine algae as attractive source to skin care","volume":"51","author":"Berthon","year":"2017","journal-title":"Free Rad. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ejmech.2015.04.040","article-title":"The role of antioxidants in the chemistry of oxidative stress: A review","volume":"97","author":"Pisoschi","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.indcrop.2015.07.073","article-title":"Asteraceae species with most prominent bioactivity and their potential applications: A review","volume":"76","author":"Bessada","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"ref_27","unstructured":"Martirosyan, D.M. (2016). Functional Foods for Chronic Diseases, CreateSpace Independent Publishing Platform. [1st ed.]."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jtv.2016.03.002","article-title":"Introduction to skin aging","volume":"26","author":"Tobin","year":"2017","journal-title":"J. Tissue Viability"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.freeradbiomed.2010.02.005","article-title":"Degree of roasting is the main determinant of the effects of coffee on NF-\u03bab and epre","volume":"48","author":"Paur","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_30","first-page":"1","article-title":"Anti-hyaluronidase, anti-elastase activity of Garcinia indica","volume":"6","author":"Sahasrabudhe","year":"2010","journal-title":"Int. J. Bot."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/03639045.2015.1035279","article-title":"Application of coffee silverskin in cosmetic formulations: Physical\/antioxidant stability studies and cytotoxicity effects","volume":"42","author":"Rodrigues","year":"2016","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3109\/03639045.2015.1088865","article-title":"Exploring the antioxidant potentiality of two food by-products into a topical cream: Stability, in vitro and in vivo evaluation","volume":"42","author":"Rodrigues","year":"2016","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Iriondo-DeHond, A., Martorell, P., Genov\u00e9s, S., Ram\u00f3n, D., Stamatakis, K., Fresno, M., Molina, A., and del Castillo, M.D. (2016). Coffee silverskin extract protects against accelerated aging caused by oxidative agents. Molecules, 21.","DOI":"10.3390\/molecules21060721"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Martinez, R.M., Pinho-Ribeiro, F.A., Steffen, V.S., Silva, T.C., Caviglione, C.V., Bottura, C., Fonseca, M.J., Vicentini, F.T., Vignoli, J.A., and Baracat, M.M. (2016). Topical formulation containing naringenin: Efficacy against ultraviolet b irradiation-induced skin inflammation and oxidative stress in mice. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0146296"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejpb.2016.04.023","article-title":"Development and characterization of novel 1-(1-naphthyl) piperazine-loaded lipid vesicles for prevention of uv-induced skin inflammation","volume":"104","author":"Menezes","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.foodchem.2014.06.100","article-title":"Anti-inflammatory effect of chlorogenic acid on the IL-8 production in Caco-2 cells and the dextran sulphate sodium-induced colitis symptoms in c57bl\/6 mice","volume":"168","author":"Shin","year":"2015","journal-title":"Food Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"lb256","DOI":"10.1096\/fasebj.30.1_supplement.lb256","article-title":"Anti-inflammatory effect of caffeine by regulating NF-\u03bab activation in murine macrophage","volume":"30","author":"Hwang","year":"2016","journal-title":"FASEB J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/hep.23902","article-title":"Coffee reduces liver damage in a rat model of steatohepatitis: The underlying mechanisms and the role of polyphenols and melanoidins","volume":"52","author":"Vitaglione","year":"2010","journal-title":"Hepatology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.lwt.2014.11.031","article-title":"Revalorization of coffee by-products. Prebiotic, antimicrobial and antioxidant properties","volume":"61","author":"Pastoriza","year":"2015","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1021\/jf8027842","article-title":"Antimicrobial activity of coffee melanoidins: A study of their metal-chelating properties","volume":"57","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.foodchem.2009.05.063","article-title":"Species, roasting degree and decaffeination influence the antibacterial activity of coffee against streptococcus mutans","volume":"118","author":"Antonio","year":"2010","journal-title":"Food Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.biochi.2012.07.012","article-title":"Cholesterol photosensitized oxidation in food and biological systems","volume":"95","author":"Cardenia","year":"2013","journal-title":"Biochimie."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1248\/cpb.59.793","article-title":"Efficient topical delivery of chlorogenic acid by an oil-in-water microemulsion to protect skin against UV-induced damage","volume":"59","author":"Kitagawa","year":"2011","journal-title":"Chem. Pharm. Bull."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/jidsymp.2009.8","article-title":"Matrix-degrading metalloproteinases in photoaging","volume":"14","author":"Quan","year":"2009","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jphotobiol.2017.08.015","article-title":"Potential effect of compounds isolated from Coffea arabica against UV-B induced skin damage by protecting fibroblast cells","volume":"174","author":"Cho","year":"2017","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"12455","DOI":"10.1073\/pnas.182429899","article-title":"Topical applications of caffeine or (\u2212)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice","volume":"99","author":"Lu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/j.1365-2133.2007.07812.x","article-title":"Protection from photodamage by topical application of caffeine after ultraviolet irradiation","volume":"156","author":"Koo","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1039\/c6pp00045b","article-title":"Topical application of spent coffee ground extracts protects skin from ultraviolet B-induced photoaging in hairless mice","volume":"15","author":"Choi","year":"2016","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e36727","DOI":"10.5812\/ijem.36727","article-title":"Review of the mechanisms and effects of noninvasive body contouring devices on cellulite and subcutaneous fat","volume":"14","author":"Alizadeh","year":"2016","journal-title":"Int. J. Endocrinol. Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1467-2494.2006.00318.x","article-title":"Cellulite and its treatment","volume":"28","author":"Rawlings","year":"2006","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_51","unstructured":"Oliveira, M.B.P.P., Mafra, I., and Amaral, J.S. (2017). Current Topics on Food Authetication, Transworld Research Network. [1st ed.]."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000343174","article-title":"Caffeine\u2019s mechanisms of action and its cosmetic use","volume":"26","author":"Herman","year":"2013","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ijpharm.2016.09.059","article-title":"Permeation of topically applied caffeine from a food by-product in cosmetic formulations: Is nanoscale in vitro approach an option?","volume":"513","author":"Rodrigues","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-4632.2007.03119.x","article-title":"Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro","volume":"46","author":"Fischer","year":"2007","journal-title":"Int. J. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/lapl.200710007","article-title":"Investigation of the penetration and storage of a shampoo formulation containing caffeine into the hair follicles by in vivo laser scanning microscopy","volume":"4","author":"Teichmann","year":"2007","journal-title":"Laser Phys. Lett."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1134\/S1054660X10030102","article-title":"Analysis of the penetration of a caffeine containing shampoo into the hair follicles by in vivo laser scanning microscopy","volume":"20","author":"Lademann","year":"2010","journal-title":"Laser Phys."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1365-2125.2007.03065.x","article-title":"The role of hair follicles in the percutaneous absorption of caffeine","volume":"65","author":"Otberg","year":"2008","journal-title":"Br. J. Clin. Pharm."}],"container-title":["Cosmetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-9284\/5\/1\/5\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:49:56Z","timestamp":1760194196000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-9284\/5\/1\/5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,3]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,3]]}},"alternative-id":["cosmetics5010005"],"URL":"https:\/\/doi.org\/10.3390\/cosmetics5010005","relation":{},"ISSN":["2079-9284"],"issn-type":[{"value":"2079-9284","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,3]]}}}