{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:53:48Z","timestamp":1775487228259,"version":"3.50.1"},"reference-count":51,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Science and Technology (FCT, Portugal)","award":["FCT\/MCTES (PIDDAC)"],"award-info":[{"award-number":["FCT\/MCTES (PIDDAC)"]}]},{"name":"Foundation for Science and Technology (FCT, Portugal)","award":["UIDB\/00690\/2020"],"award-info":[{"award-number":["UIDB\/00690\/2020"]}]},{"name":"Foundation for Science and Technology (FCT, Portugal)","award":["UIDP\/00690\/2020"],"award-info":[{"award-number":["UIDP\/00690\/2020"]}]},{"name":"Foundation for Science and Technology (FCT, Portugal)","award":["EXPL2021CIMO_06"],"award-info":[{"award-number":["EXPL2021CIMO_06"]}]},{"name":"Foundation for Science and Technology (FCT, Portugal)","award":["LA\/P\/0007\/2020"],"award-info":[{"award-number":["LA\/P\/0007\/2020"]}]},{"DOI":"10.13039\/501100001871","name":"CIMO","doi-asserted-by":"publisher","award":["FCT\/MCTES (PIDDAC)"],"award-info":[{"award-number":["FCT\/MCTES (PIDDAC)"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIMO","doi-asserted-by":"publisher","award":["UIDB\/00690\/2020"],"award-info":[{"award-number":["UIDB\/00690\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIMO","doi-asserted-by":"publisher","award":["UIDP\/00690\/2020"],"award-info":[{"award-number":["UIDP\/00690\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIMO","doi-asserted-by":"publisher","award":["EXPL2021CIMO_06"],"award-info":[{"award-number":["EXPL2021CIMO_06"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIMO","doi-asserted-by":"publisher","award":["LA\/P\/0007\/2020"],"award-info":[{"award-number":["LA\/P\/0007\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SusTEC","award":["FCT\/MCTES (PIDDAC)"],"award-info":[{"award-number":["FCT\/MCTES (PIDDAC)"]}]},{"name":"SusTEC","award":["UIDB\/00690\/2020"],"award-info":[{"award-number":["UIDB\/00690\/2020"]}]},{"name":"SusTEC","award":["UIDP\/00690\/2020"],"award-info":[{"award-number":["UIDP\/00690\/2020"]}]},{"name":"SusTEC","award":["EXPL2021CIMO_06"],"award-info":[{"award-number":["EXPL2021CIMO_06"]}]},{"name":"SusTEC","award":["LA\/P\/0007\/2020"],"award-info":[{"award-number":["LA\/P\/0007\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cosmetics"],"abstract":"<jats:p>Hops (Humulus lupulus L.) are known worldwide as a raw material in beer production due their flavor and preservative values. The beneficial properties of the plant have been mostly associated with the female hop inflorescences (cones), which is also the part used in the brewing industry. However, some studies indicate the presence of compounds associated with health benefits in the vegetative parts of hops or small-caliber cones, which discarded in hop collection. Moreover, large quantities of by-products remain in the forms of spent grains and spent hops\/hot trub and are produced by breweries raising environmental and economic sustainability concerns. This review focuses on the phytochemicals and biological and pharmacological activities of hop and their potential use in skin care products and also intends to explore the potential of the hop\u2019 discarded parts and brewery industry by-products for production in the cosmetics industry.<\/jats:p>","DOI":"10.3390\/cosmetics9060139","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T01:42:27Z","timestamp":1670809347000},"page":"139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Hop By-Products: Pharmacological Activities and Potential Application as Cosmetics"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6275-3134","authenticated-orcid":false,"given":"Ol\u00edvia R.","family":"Pereira","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"given":"Gleiciara","family":"Santos","sequence":"additional","affiliation":[{"name":"School of Health Science, Polytechnic Institute of Bragan\u00e7a, Av. D. Afonso V, 5300-121 Bragan\u00e7a, Portugal"}]},{"given":"Maria Jo\u00e3o","family":"Sousa","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"ref_1","unstructured":"(2014). Committee on Herbal Medicinal Products Assessment report on Humulus lupulus L., flos. Eur. Med. Agency, 44, 1\u201338."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Astray, G., Gull\u00f3n, P., Gull\u00f3n, B., Munekata, P.E.S., and Lorenzo, J.M. (2020). Humulus lupulus L. as a natural source of functional biomolecules. Appl. 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