{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:38:25Z","timestamp":1762079905080,"version":"build-2065373602"},"reference-count":49,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/16169-0","305250\/2019-1","001","88887.371188\/2019-00","UIDB\/04567\/2020","UIDP\/04567\/2020"],"award-info":[{"award-number":["2019\/16169-0","305250\/2019-1","001","88887.371188\/2019-00","UIDB\/04567\/2020","UIDP\/04567\/2020"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2019\/16169-0","305250\/2019-1","001","88887.371188\/2019-00","UIDB\/04567\/2020","UIDP\/04567\/2020"],"award-info":[{"award-number":["2019\/16169-0","305250\/2019-1","001","88887.371188\/2019-00","UIDB\/04567\/2020","UIDP\/04567\/2020"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["2019\/16169-0","305250\/2019-1","001","88887.371188\/2019-00","UIDB\/04567\/2020","UIDP\/04567\/2020"],"award-info":[{"award-number":["2019\/16169-0","305250\/2019-1","001","88887.371188\/2019-00","UIDB\/04567\/2020","UIDP\/04567\/2020"]}]},{"DOI":"10.13039\/501100001871","name":"FCT-Foundation for Science and Technology","doi-asserted-by":"publisher","award":["2019\/16169-0","305250\/2019-1","001","88887.371188\/2019-00","UIDB\/04567\/2020","UIDP\/04567\/2020"],"award-info":[{"award-number":["2019\/16169-0","305250\/2019-1","001","88887.371188\/2019-00","UIDB\/04567\/2020","UIDP\/04567\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cosmetics"],"abstract":"<jats:p>The skin acts as a protective barrier, guarding the body against microorganisms, chemicals, and several environmental factors. Accordingly, this all-important organ must be kept healthy to maintain its optimal functionality. One approach to maintain skin health is the application of multifunction bioactive sunscreens containing antioxidant molecule(s). Rosmarinic acid (RA), a phenolic compound, is known for its antioxidant activity. Herein, the safety and efficacy of a multifunction prototype sunscreen were investigated, aiming to evaluate the performance of this polyphenol with two known and widely used UV filters (bemotrizinol and octyl p-methoxycinnamate). Samples protected the DNA fragmentation compared to UV control, by the comet assay, and showed good skin compatibility in subjects. Formulations F1 and F3 were able to increase skin hydration, and, possibly, the RA interfered with this attribute. An increase in transepidermal water loss was observed for formulations F1, F2, and F4, which may be related to the vehicle, containing the RA or not. No decreases were observed in the inflammatory reaction caused by the ethyl nicotinate with any of the samples. As a perspective, we suggest trials with a greater number of subjects or protocol modifications. Altering the vehicle qualitative and quantitative composition is also a pertinent perspective.<\/jats:p>","DOI":"10.3390\/cosmetics9060141","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T01:56:06Z","timestamp":1670896566000},"page":"141","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rosmarinic Acid Multifunctional Sunscreen: Comet Assay and In Vivo Establishment of Cutaneous Attributes"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3072-3587","authenticated-orcid":false,"given":"Thalita Marc\u00edlio","family":"C\u00e2ndido","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]},{"given":"Ma\u00edra Bueno","family":"Ariede","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0066-1840","authenticated-orcid":false,"given":"Claudin\u00e9ia Aparecida Sales de Oliveira","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3563-4105","authenticated-orcid":false,"given":"Fabiana Vieira","family":"Lima","sequence":"additional","affiliation":[{"name":"Division of Pharmacy, Department of Health Science, Federal University of Esp\u00edrito Santo, S\u00e3o Mateus 29932-540, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-2785","authenticated-orcid":false,"given":"Wagner Vidal","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Research and Development Department, Chemyunion Ltd., Sorocaba 18087-101, Brazil"}]},{"given":"Nat\u00e1lia Mencacci Esteves","family":"Pedro","sequence":"additional","affiliation":[{"name":"Research and Development Department, Chemyunion Ltd., Sorocaba 18087-101, Brazil"}]},{"given":"Giovana","family":"Padovani","sequence":"additional","affiliation":[{"name":"Research and Development Department, Chemyunion Ltd., Sorocaba 18087-101, Brazil"}]},{"given":"Bianca da Silva","family":"Sufi","sequence":"additional","affiliation":[{"name":"Research and Development Department, Chemyunion Ltd., Sorocaba 18087-101, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7992-8343","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Rijo","sequence":"additional","affiliation":[{"name":"CBIOS, Universidade Lus\u00f3fona\u2019s Research Center for Biosciences & Health Technologies, 1749-024 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4950-8510","authenticated-orcid":false,"given":"Maria Val\u00e9ria Robles","family":"Velasco","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6429-6213","authenticated-orcid":false,"given":"Catarina","family":"Rosado","sequence":"additional","affiliation":[{"name":"CBIOS, Universidade Lus\u00f3fona\u2019s Research Center for Biosciences & Health Technologies, 1749-024 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-3024","authenticated-orcid":false,"given":"Andr\u00e9 Rolim","family":"Baby","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.redox.2015.01.006","article-title":"Oxidative Stress in Severe Acute Illness","volume":"4","author":"Rael","year":"2015","journal-title":"Redox Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0973-7847.70902","article-title":"Free Radicals, Antioxidants and Functional Foods: Impact on Human Health","volume":"4","author":"Lobo","year":"2010","journal-title":"Pharmacogn. 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Molecules, 27.","DOI":"10.3390\/molecules27082423"}],"container-title":["Cosmetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-9284\/9\/6\/141\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:39:53Z","timestamp":1760146793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-9284\/9\/6\/141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,12]]},"references-count":49,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["cosmetics9060141"],"URL":"https:\/\/doi.org\/10.3390\/cosmetics9060141","relation":{},"ISSN":["2079-9284"],"issn-type":[{"type":"electronic","value":"2079-9284"}],"subject":[],"published":{"date-parts":[[2022,12,12]]}}}