{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T16:03:00Z","timestamp":1765382580616,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Scientific Research at Northern Border University","award":["NBU-FFR-2025-2578-01","UIDB\/04564\/2020","UIDP\/04564\/2020"],"award-info":[{"award-number":["NBU-FFR-2025-2578-01","UIDB\/04564\/2020","UIDP\/04564\/2020"]}]},{"name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["NBU-FFR-2025-2578-01","UIDB\/04564\/2020","UIDP\/04564\/2020"],"award-info":[{"award-number":["NBU-FFR-2025-2578-01","UIDB\/04564\/2020","UIDP\/04564\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Crystals"],"abstract":"<jats:p>In this work, we synthesized the Co0.85Bi0.15Fe1.9X0.1O4 (X = Ce3+, Sm3+, Ho3+, and Er3+) nanoparticles via the auto-combustion method. The cell viability against two breast cancer cells (MDA-MB-231 and T-47D cells) and the PC3 prostate cancer cells were carefully analyzed and correlated with the structural parameters and particle size values as well as the chemical composition. The produced compounds\u2019 morphological and structural characteristics were performed using scanning transmission microscopy (TEM) and X-ray Diffraction (XRD). For all compounds, the analyses of the XRD experimental data revealed a structurally reversed cubic spinel with space group Fd-3m. All of the compounds had crystallites smaller than 45 nm which concorded well with the particle size values deduced from TEM images. Co0.85Bi0.15Fe1.9Ho0.1O4 nanoparticles induced a high mortality of breast and prostate cancer cells (MDA-MB-231, T-47D, and PC3) while the Co0.85Bi0.15Fe1.9Sm0.1O4 compound (higher particle size) reduced almost 35% of MDA-MB-231 cancer cells. With very low cytotoxicity against normal human cells, the Co0.85Bi0.15Fe1.9Ho0.1O4 nanoparticles play a significant role in the elimination of cancer cells.<\/jats:p>","DOI":"10.3390\/cryst15050482","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T06:10:46Z","timestamp":1747721446000},"page":"482","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Co0.85Bi0.15Fe1.9X0.1O4 (X = Ce4+, Sm3+, Ho3+, and Er3+) Nanoparticles with Selective Anticancer Activity: A Structural and Morphological Approach"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5989-5003","authenticated-orcid":false,"given":"Liza","family":"Saher","sequence":"first","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques CRAPC, BP384, Bou-Ismail, Tipaza 42004, Algeria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6861-3976","authenticated-orcid":false,"given":"Adel","family":"Benali","sequence":"additional","affiliation":[{"name":"I3N, Physics Department, Campus de Santiago, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Laboratoire de Physique Appliqu\u00e9e, Facult\u00e9 des Sciences, Universit\u00e9 de Sfax, B.P. 1171, Sfax 3000, Tunisia"},{"name":"University of Coimbra, CFisUC, Physics Department, 3400-516 Coimbra, Portugal"}]},{"given":"Saoussen","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Northern Border University, Arar 91431, Saudi Arabia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6919-8778","authenticated-orcid":false,"given":"Essebti","family":"Dhahri","sequence":"additional","affiliation":[{"name":"Laboratoire de Physique Appliqu\u00e9e, Facult\u00e9 des Sciences, Universit\u00e9 de Sfax, B.P. 1171, Sfax 3000, Tunisia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6858-9507","authenticated-orcid":false,"given":"Manuel P. F.","family":"Gra\u00e7a","sequence":"additional","affiliation":[{"name":"I3N, Physics Department, Campus de Santiago, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8737-4851","authenticated-orcid":false,"given":"Benilde F. O.","family":"Costa","sequence":"additional","affiliation":[{"name":"University of Coimbra, CFisUC, Physics Department, 3400-516 Coimbra, Portugal"}]},{"given":"Luisa A.","family":"Helguero","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Artur M. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.physb.2009.12.035","article-title":"Structural, electrical and dielectric properties of yttrium substituted nickel ferrites","volume":"405","author":"Ishaque","year":"2010","journal-title":"Phys. B Condens. Matter"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.matchemphys.2011.10.030","article-title":"Magnesium ferrite nanoparticles inserted in a glass matrix\u2014Microstructure and magnetic properties","volume":"132","author":"Valente","year":"2012","journal-title":"Mater. Chem. Phys."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1039\/b209391j","article-title":"Magnetic Nanoparticles as a Catalyst Vehicle for Simple and Easy Recycling","volume":"27","author":"Yoon","year":"2003","journal-title":"New J. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"21752","DOI":"10.1021\/am502693t","article-title":"Design of Functional Nanoparticles and Assemblies for Theranostic Applications","volume":"6","author":"Skeete","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/anie.200602866","article-title":"Magnetic Nanoparticles: Synthesis, Protection, Functionalization, and Application","volume":"46","author":"Lu","year":"2007","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/jbm.b.30630","article-title":"Comparative Evaluation of Heating Ability and Biocompatibility of Different Ferrite-based Magnetic Fluids for Hyperthermia Application","volume":"81B","author":"Pradhan","year":"2007","journal-title":"J. Biomed. Mater. Res. Part B"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1088\/0957-0233\/14\/8\/314","article-title":"Tunable Optical Filter","volume":"14","author":"Philip","year":"2003","journal-title":"Meas. Sci. Technol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1021\/ja067457e","article-title":"Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia","volume":"129","author":"Fortin","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.mseb.2007.06.005","article-title":"Influence of additives on the magnetic proper-ties, microstructure and densification of Mn\u2212Zn soft ferrites","volume":"141","author":"Shokrollahi","year":"2007","journal-title":"Mater. Sci. Eng. B"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00339-009-5256-5","article-title":"Nanostructures and magnetic properties of cobaltferrite (CoFe2O4) fabricated by electro spinning","volume":"97","author":"Sangmanee","year":"2009","journal-title":"Appl. Phys. A"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jallcom.2009.12.115","article-title":"Effect of preparation conditions on physicochemical, surface and catalytic properties of cobalt ferrite prepared by coprecipitation","volume":"493","author":"Turky","year":"2010","journal-title":"J. Alloys Compd."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10854-022-09398-w","article-title":"CoFe2O4 spinel ferrite studies on permanent magnet application and cytotoxic effects on breast and prostate cancer cell lines","volume":"34","author":"Benali","year":"2023","journal-title":"J. Mater. Sci. Mater. Electron."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jmmm.2013.05.030","article-title":"Magnetic and structural properties of RE doped Co-ferrite (R = Nd, Eu, and Gd) nano-particles synthesized by co-precipitation","volume":"345","author":"Amiri","year":"2013","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1063\/1.1377621","article-title":"Synthesis and magnetic properties of CoFe2O4 spinel ferrite nanoparticles doped with lanthanide ions","volume":"78","author":"Kahn","year":"2001","journal-title":"Appl. Phys. Lett."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1140\/epjp\/s13360-022-02754-z","article-title":"Synthesis and physico-chemical characterization of Bi-doped Cobalt ferrite nanoparticles: Cytotoxic effects against breast and prostate cancer cell lines","volume":"137","author":"Benali","year":"2022","journal-title":"Eur. Phys. J. Plus"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1038\/s41598-017-02784-z","article-title":"The structural and magnetic properties of dual phase cobalt ferrite","volume":"7","author":"Gore","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Young, R.A. (1993). The Rietveld Method, Oxford University Press.","DOI":"10.1093\/oso\/9780198555773.001.0001"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1021\/acs.chemmater.5b01034","article-title":"Exploring the magnetic properties of cobalt-ferrite nanoparticles for the development of a rare-earth-free permanent magnet","volume":"27","author":"Lottini","year":"2015","journal-title":"Chem. Mater."},{"key":"ref_19","first-page":"483","article-title":"Bi-doped cobalt ferrite nanoparticles for electromagnetic interference (EMI) shielding applications","volume":"36","author":"Kalia","year":"2025","journal-title":"J. Mater. Sci: Mater. Electron"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"20905","DOI":"10.1021\/jp205572m","article-title":"Autocombustion High-Temperature Synthesis, Structural, and Magnetic Properties of CoCrxFe2\u2212xO4 (0 \u2264 x \u2264 1.0)","volume":"115","author":"Toksha","year":"2011","journal-title":"J. Phys. Chem. C"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"166624","DOI":"10.1016\/j.jmmm.2020.166624","article-title":"Neutron diffraction and M\u00f6ssbauer spectroscopy studies for Ce doped CoFe2O4 nanoparticles","volume":"503","author":"Hashhash","year":"2020","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jmatprotec.2007.07.012","article-title":"Magnetic properties of nanocrystalline Sm-substituted CoFe2O4 synthesized by citrate precursor method","volume":"198","author":"Rashad","year":"2008","journal-title":"J. Mater. Process. Technol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1016\/j.jmmm.2008.06.031","article-title":"Magnetic properties of CoFe1.9RE0.1O4 nanoparticles (RE = La, Ce, Nd, Sm, Eu, Gd, Tb, Ho) prepared in polyol","volume":"320","author":"Tahar","year":"2008","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.spmi.2018.03.048","article-title":"Effect of annealing temperature on structural, morphology and dielectric properties of La0.75Ba0.25FeO3 perovskite","volume":"117","author":"Abdallah","year":"2018","journal-title":"Superlatt. Microstruct."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"39830","DOI":"10.1021\/acsami.7b13103","article-title":"Employing Calcination as a Facile Strategy to Reduce the Cytotoxicity in CoFe2O4 and NiFe2O4 Nanoparticles","volume":"9","author":"Lima","year":"2017","journal-title":"ACS Appl. Mater. 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