{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T05:17:48Z","timestamp":1762060668011,"version":"build-2065373602"},"reference-count":74,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian Ministry of Health","award":["NUP-25000.023997.2018\/34"],"award-info":[{"award-number":["NUP-25000.023997.2018\/34"]}]},{"name":"PRONON\/MS","award":["NUP-25000.023997.2018\/34"],"award-info":[{"award-number":["NUP-25000.023997.2018\/34"]}]},{"name":"CNPq Productivity Fellowship","award":["NUP-25000.023997.2018\/34"],"award-info":[{"award-number":["NUP-25000.023997.2018\/34"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>The development of new screening methods and diagnostic tests for traits, common diseases, and cancer is linked to the advent of precision genomic medicine, in which health care is individually adjusted based on a person\u2019s lifestyle, environmental influences, and genetic variants. Based on genome-wide association study (GWAS) analysis, rapid and continuing progress in the discovery of relevant single nucleotide polymorphisms (SNPs) for traits or complex diseases has increased interest in the potential application of genetic risk models for routine health practice. The polygenic risk score (PRS) estimates an individual\u2019s genetic risk of a trait or disease, calculated by employing a weighted sum of allele counts combined with non-genetic variables. However, 98.38% of PRS records held in public databases relate to the European population. Therefore, PRSs for multiethnic populations are urgently needed. We performed a systematic review to discuss the role of polygenic risk scores in advancing precision medicine for different cancer types in multiethnic non-European populations.<\/jats:p>","DOI":"10.3390\/curroncol29080436","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T21:52:48Z","timestamp":1659649968000},"page":"5517-5530","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Role of Polygenic Risk Score in Cancer Precision Medicine of Non-European Populations: A Systematic Review"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2431-4779","authenticated-orcid":false,"given":"Howard Lopes Ribeiro","family":"Junior","sequence":"first","affiliation":[{"name":"Molecular Oncology Cancer Center, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil"},{"name":"Center for Research and Drug Development (NPDM), Federal University of Ceara, Fortaleza 60430-275, CE, Brazil"},{"name":"Post-Graduate Program of Pathology, Federal University of Ceara, Fortaleza 60441-750, CE, Brazil"},{"name":"Post-Graduate Program in Translational Medicine, Federal University of Ceara, Fortaleza 14784-400, CE, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8633-2978","authenticated-orcid":false,"given":"L\u00e1zaro Ant\u00f4nio Campanha","family":"Novaes","sequence":"additional","affiliation":[{"name":"Molecular Oncology Cancer Center, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-7517","authenticated-orcid":false,"given":"Jos\u00e9 Guilherme","family":"Datorre","sequence":"additional","affiliation":[{"name":"Molecular Oncology Cancer Center, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil"}]},{"given":"Daniel Antunes","family":"Moreno","sequence":"additional","affiliation":[{"name":"Molecular Oncology Cancer Center, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9639-7940","authenticated-orcid":false,"given":"Rui Manuel","family":"Reis","sequence":"additional","affiliation":[{"name":"Molecular Oncology Cancer Center, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, 4704553 Braga, Portugal"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4704553 Braga, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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