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Madeira","award":["M1420-09-5369-FSE-000001"],"award-info":[{"award-number":["M1420-09-5369-FSE-000001"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia and Madeira","award":["M1420-01-0145-FEDER-000008"],"award-info":[{"award-number":["M1420-01-0145-FEDER-000008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Prostate cancer (PCa) continues to be the second most common malignant tumour and the main cause of oncological death in men. Investigating endogenous volatile organic metabolites (VOMs) produced by various metabolic pathways is emerging as a novel, effective, and non-invasive source of information to establish the volatilomic biosignature of PCa. In this study, headspace solid-phase microextraction combined with gas chromatography\u2013mass spectrometry (HS-SPME\/GC-MS) was used to establish the urine volatilomic profile of PCa and identify VOMs that can discriminate between the two investigated groups. This non-invasive approach was applied to oncological patients (PCa group, n = 26) and cancer-free individuals (control group, n = 30), retrieving a total of 147 VOMs from various chemical families. This included terpenes, norisoprenoid, sesquiterpenes, phenolic, sulphur and furanic compounds, ketones, alcohols, esters, aldehydes, carboxylic acid, benzene and naphthalene derivatives, hydrocarbons, and heterocyclic hydrocarbons. The data matrix was subjected to multivariate analysis, namely partial least-squares discriminant analysis (PLS-DA). Accordingly, this analysis showed that the group under study presented different volatomic profiles and suggested potential PCa biomarkers. Nevertheless, a larger cohort of samples is required to boost the predictability and accuracy of the statistical models developed.<\/jats:p>","DOI":"10.3390\/curroncol30050370","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T04:26:29Z","timestamp":1683692789000},"page":"4904-4921","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Differences in the Volatilomic Urinary Biosignature of Prostate Cancer Patients as a Feasibility Study for the Detection of Potential Biomarkers"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8396-7054","authenticated-orcid":false,"given":"Giulia","family":"Riccio","sequence":"first","affiliation":[{"name":"Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Univesit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"},{"name":"Unity of Chemistry, Biochemistry and Clinical Molecular Biology, Department of Diagnostic and Laboratory Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1762-1175","authenticated-orcid":false,"given":"Cristina V.","family":"Berenguer","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, NPRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"}]},{"given":"Rosa","family":"Perestrelo","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, NPRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"}]},{"given":"Ferdinando","family":"Pereira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Urologia, Hospital Dr. N\u00e9lio Mendon\u00e7a, SESARAM, EPERAM\u2014Servi\u00e7o de Sa\u00fade da Regi\u00e3o Aut\u00f3noma da Madeira, Avenida Lu\u00eds de Cam\u00f5es, n\u00ba57, 9004-514 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8305-2938","authenticated-orcid":false,"given":"Pedro","family":"Berenguer","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o Dra Maria Isabel Mendon\u00e7a, Hospital Dr. N\u00e9lio Mendon\u00e7a, SESARAM, EPERAM, Avenida Lu\u00eds de Cam\u00f5es, n\u00ba57, 9004-514 Funchal, Portugal"},{"name":"RO-RAM\u2014Registo Oncol\u00f3gico da Regi\u00e3o Aut\u00f3noma da Madeira, Hospital Dr. N\u00e9lio Mendon\u00e7a, SESARAM, EPERAM, Avenida Lu\u00eds de Cam\u00f5es, n\u00ba57, 9004-514 Funchal, Portugal"}]},{"given":"Cristina P.","family":"Ornelas","sequence":"additional","affiliation":[{"name":"Centro de Sa\u00fade do Bom Jesus, SESARAM, EPERAM, Rua das Hortas, n\u00ba67, 9050-024 Funchal, Portugal"}]},{"given":"Ana C\u00e9lia","family":"Sousa","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o Dra Maria Isabel Mendon\u00e7a, Hospital Dr. N\u00e9lio Mendon\u00e7a, SESARAM, EPERAM, Avenida Lu\u00eds de Cam\u00f5es, n\u00ba57, 9004-514 Funchal, Portugal"}]},{"given":"Jo\u00e3o Arag\u00e3o","family":"Vital","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Urologia, Hospital Dr. N\u00e9lio Mendon\u00e7a, SESARAM, EPERAM\u2014Servi\u00e7o de Sa\u00fade da Regi\u00e3o Aut\u00f3noma da Madeira, Avenida Lu\u00eds de Cam\u00f5es, n\u00ba57, 9004-514 Funchal, Portugal"}]},{"given":"Maria do Carmo","family":"Pinto","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Urologia, Hospital Dr. N\u00e9lio Mendon\u00e7a, SESARAM, EPERAM\u2014Servi\u00e7o de Sa\u00fade da Regi\u00e3o Aut\u00f3noma da Madeira, Avenida Lu\u00eds de Cam\u00f5es, n\u00ba57, 9004-514 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0316-5348","authenticated-orcid":false,"given":"Jorge A. M.","family":"Pereira","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, NPRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4521-0020","authenticated-orcid":false,"given":"Viviana","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Univesit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"},{"name":"Unity of Chemistry, Biochemistry and Clinical Molecular Biology, Department of Diagnostic and Laboratory Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1965-3151","authenticated-orcid":false,"given":"Jos\u00e9 S.","family":"C\u00e2mara","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, NPRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"},{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias Exatas e Engenharia, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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