{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T12:06:59Z","timestamp":1778328419969,"version":"3.51.4"},"reference-count":44,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-016385"],"award-info":[{"award-number":["POCI-01-0145-FEDER-016385"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/00051\/2020"],"award-info":[{"award-number":["UIDP\/00051\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Aims: This study aimed to evaluate the association of GDF-15 and NT-pro-BNP in two different biological matrices with AF in severe aortic stenosis patients undergoing aortic valve replacement surgery (AVR), its association with atrial matrix remodeling, as well as with 30-day postoperative outcomes. Main Methods: One hundred and twenty-six patients between 2009 and 2019 with severe aortic stenosis undergoing AVR surgery in a tertiary hospital were assessed. Key Findings: pericardial fluid GDF-15 and pericardial fluid and serum NT-pro-BNP were increased in AF patients with aortic stenosis. COL1A1 and COL3A1 gene expression increased when pericardial fluid NT-pro-BNP values were higher. TIMP4 was positively correlated with pericardial fluid GDF-15. Significance: GDF-15 and NT-pro-BNP in the pericardial fluid are biomarkers of atrial fibrillation in aortic stenosis and correlate with atrial matrix remodeling. AKI is predicted by both serum and pericardial fluid GDF-15.<\/jats:p>","DOI":"10.3390\/diagnostics11081422","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T21:43:53Z","timestamp":1628199833000},"page":"1422","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pericardial NT-Pro-BNP and GDF-15 as Biomarkers of Atrial Fibrillation and Atrial Matrix Remodeling in Aortic Stenosis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1236-0233","authenticated-orcid":false,"given":"Mariana","family":"Frag\u00e3o-Marques","sequence":"first","affiliation":[{"name":"Cardiovascular Research and Development Center, Faculty of Medicine of the University of Porto, 4200 Porto, Portugal"},{"name":"Department of Clinical Pathology, S\u00e3o Jo\u00e3o University Hospital Centre, 4200 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-4069","authenticated-orcid":false,"given":"Isaac","family":"Barroso","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, S\u00e3o Jo\u00e3o University Hospital Centre, 4200 Porto, Portugal"},{"name":"EPIUnit, Instituto de Sa\u00fade P\u00fablica, University of Porto, 4200 Porto, Portugal"}]},{"given":"Rui","family":"Farinha","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, S\u00e3o Jo\u00e3o University Hospital Centre, 4200 Porto, Portugal"},{"name":"EPIUnit, Instituto de Sa\u00fade P\u00fablica, University of Porto, 4200 Porto, Portugal"}]},{"given":"Isabel M","family":"Miranda","sequence":"additional","affiliation":[{"name":"Cardiovascular Research and Development Center, Faculty of Medicine of the University of Porto, 4200 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4536-2315","authenticated-orcid":false,"given":"Diana","family":"Martins","sequence":"additional","affiliation":[{"name":"Cardiovascular Research and Development Center, Faculty of Medicine of the University of Porto, 4200 Porto, Portugal"}]},{"given":"Jennifer","family":"Mancio","sequence":"additional","affiliation":[{"name":"Cardiovascular Research and Development Center, Faculty of Medicine of the University of Porto, 4200 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2656-8935","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Rocha-Neves","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, University of Porto, 4200 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4836-6311","authenticated-orcid":false,"given":"Jo\u00e3o T","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, S\u00e3o Jo\u00e3o University Hospital Centre, 4200 Porto, Portugal"},{"name":"EPIUnit, Instituto de Sa\u00fade P\u00fablica, University of Porto, 4200 Porto, Portugal"}]},{"given":"Adelino","family":"Leite-Moreira","sequence":"additional","affiliation":[{"name":"Cardiovascular Research and Development Center, Faculty of Medicine of the University of Porto, 4200 Porto, Portugal"}]},{"given":"In\u00eas","family":"Falc\u00e3o-Pires","sequence":"additional","affiliation":[{"name":"Cardiovascular Research and Development Center, Faculty of Medicine of the University of Porto, 4200 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1177\/0267659120949210","article-title":"Adverse remodeling in atrial fibrillation following isolated aortic valve replacement surgery","volume":"36","author":"Oliveira","year":"2021","journal-title":"Perfusion"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Benjamin, E.J., Muntner, P., Alonso, A., Bittencourt, M.S., Callaway, C.W., Carson, A.P., Chamberlain, A.M., Chang, A.R., Cheng, S., and Das, S.R. 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