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Local hemodynamics may play a crucial role in its manifestation and progression. To evaluate choroidal and retinal vascular parameters, a total of 134 eyes were analyzed, 100 with intermediate AMD and 34 age matched healthy controls. 131 eyes of 104 patients were eligible for complete image assessment and 3 eyes were excluded for insufficient image quality: Group 1: intermediate AMD (n = 97) and Group 2: healthy controls (n = 34). Spectral domain optic coherence tomography (SD-OCT) with enhanced depth imaging (EDI) and optic coherence tomography angiography (OCT-A) were acquired using Spectralis (Heidelberg Engineering). Choroid and retinal capillary plexus were evaluated and image binarization was used to obtain quantitative data. Mean age was 77.67 years old (YO) and 67.2% were women. Total subfoveal choroidal area and luminal area were significantly reduced in Group 1 compared with Group 2 (0.88 mm2 and 0.40 mm2 vs. 1.24 mm2 and 0.55 mm2, respectively) (p &lt; 0.05). Regarding choriocapillary flow density, AMD eyes recorded reduced values (34.83%) compared with controls (36.25%) (p &lt; 0.05). Chorioretinal vasculature is impaired in intermediate AMD patients and vascular parameters could be attractive new prognostic biomarkers. Future therapeutic approaches may target this vascular dysfunction and delay disease progression.<\/jats:p>","DOI":"10.3390\/diagnostics12051290","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T02:57:02Z","timestamp":1653274622000},"page":"1290","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Choroidal Vascular Impairment in Intermediate Age-Related Macular Degeneration"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7523-2418","authenticated-orcid":false,"given":"Rita","family":"Flores","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar de Lisboa Central EPE, 1169-050 Lisbon, Portugal"},{"name":"NOVA Medical School, Universidade Nova de Lisboa, 1169-056 Lisbon, Portugal"}]},{"given":"\u00c2ngela","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, 4099-002 Porto, Portugal"},{"name":"Faculty of Medicine, University of Porto, 4099-002 Porto, Portugal"}]},{"given":"Guilherme","family":"Neri","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar de Lisboa Central EPE, 1169-050 Lisbon, Portugal"}]},{"given":"Ana C.","family":"Fradinho","sequence":"additional","affiliation":[{"name":"NOVA Medical School, Universidade Nova de Lisboa, 1169-056 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1387-9953","authenticated-orcid":false,"given":"Bruno","family":"Quenderra","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar de Lisboa Central EPE, 1169-050 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0889-4809","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Barata","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar de Lisboa Central EPE, 1169-050 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7272-5842","authenticated-orcid":false,"given":"Sandra","family":"Tenreiro","sequence":"additional","affiliation":[{"name":"NOVA Medical School, Universidade Nova de Lisboa, 1169-056 Lisbon, Portugal"}]},{"given":"Miguel C.","family":"Seabra","sequence":"additional","affiliation":[{"name":"NOVA Medical School, Universidade Nova de Lisboa, 1169-056 Lisbon, Portugal"},{"name":"UCL Institute of Ophthalmology, London EC1V 9EL, UK"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,22]]},"reference":[{"key":"ref_1","first-page":"1041","article-title":"Age-related macular degeneration: Nonneovascular early AMD, intermediate AMD, and geographic atrophy","volume":"Volume II","author":"Ryan","year":"2006","journal-title":"Retina"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0161-6420(92)31871-8","article-title":"Prevalence of age-related maculopathy. 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