{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:22:27Z","timestamp":1774671747024,"version":"3.50.1"},"reference-count":63,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Colon capsule endoscopy (CCE) enables a comprehensive, non-invasive, and painless evaluation of the colon, although it still has limited indications. The lengthy reading times hinder its wider implementation, a drawback that could potentially be overcome through the integration of artificial intelligence (AI) models. Studies employing AI, particularly convolutional neural networks (CNNs), demonstrate great promise in using CCE as a viable option for detecting certain diseases and alterations in the colon, compared to other methods like colonoscopy. Additionally, employing AI models in CCE could pave the way for a minimally invasive panenteric or even panendoscopic solution. This review aims to provide a comprehensive summary of the current state-of-the-art of AI in CCE while also addressing the challenges, both technical and ethical, associated with broadening indications for AI-powered CCE. Additionally, it also gives a brief reflection of the potential environmental advantages of using this method compared to alternative ones.<\/jats:p>","DOI":"10.3390\/diagnostics14182072","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T03:34:20Z","timestamp":1726716860000},"page":"2072","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A Comprehensive Review of Artificial Intelligence and Colon Capsule Endoscopy: Opportunities and Challenges"],"prefix":"10.3390","volume":"14","author":[{"given":"Joana","family":"Mota","sequence":"first","affiliation":[{"name":"Precision Medicine Unit, Department of Gastroenterology, S\u00e3o Jo\u00e3o University Hospital, 4200-427 Porto, Portugal"},{"name":"WGO Gastroenterology and Hepatology Training Center, 4200-427 Porto, Portugal"}]},{"given":"Maria","family":"Jo\u00e3o Almeida","sequence":"additional","affiliation":[{"name":"Precision Medicine Unit, Department of Gastroenterology, S\u00e3o Jo\u00e3o University Hospital, 4200-427 Porto, Portugal"},{"name":"WGO Gastroenterology and Hepatology Training Center, 4200-427 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5890-7049","authenticated-orcid":false,"given":"Francisco","family":"Mendes","sequence":"additional","affiliation":[{"name":"Precision Medicine Unit, Department of Gastroenterology, S\u00e3o Jo\u00e3o University Hospital, 4200-427 Porto, Portugal"},{"name":"WGO Gastroenterology and Hepatology Training Center, 4200-427 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0484-4804","authenticated-orcid":false,"given":"Miguel","family":"Martins","sequence":"additional","affiliation":[{"name":"Precision Medicine Unit, Department of Gastroenterology, S\u00e3o Jo\u00e3o University Hospital, 4200-427 Porto, Portugal"},{"name":"WGO Gastroenterology and Hepatology Training Center, 4200-427 Porto, Portugal"}]},{"given":"Tiago","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Precision Medicine Unit, Department of Gastroenterology, S\u00e3o Jo\u00e3o University Hospital, 4200-427 Porto, Portugal"},{"name":"WGO Gastroenterology and Hepatology Training Center, 4200-427 Porto, Portugal"}]},{"given":"Jo\u00e3o","family":"Afonso","sequence":"additional","affiliation":[{"name":"Precision Medicine Unit, Department of Gastroenterology, S\u00e3o Jo\u00e3o University Hospital, 4200-427 Porto, Portugal"},{"name":"WGO Gastroenterology and Hepatology Training Center, 4200-427 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9427-5635","authenticated-orcid":false,"given":"Pedro","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Precision Medicine Unit, Department of Gastroenterology, S\u00e3o Jo\u00e3o University Hospital, 4200-427 Porto, Portugal"},{"name":"WGO Gastroenterology and Hepatology Training Center, 4200-427 Porto, Portugal"}]},{"given":"Helder","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Precision Medicine Unit, Department of Gastroenterology, S\u00e3o Jo\u00e3o University Hospital, 4200-427 Porto, Portugal"},{"name":"WGO Gastroenterology and Hepatology Training Center, 4200-427 Porto, Portugal"},{"name":"Faculty of Medicine, University of Porto, 4200-427 Porto, Portugal"}]},{"given":"Patricia","family":"Andrade","sequence":"additional","affiliation":[{"name":"Precision Medicine Unit, Department of Gastroenterology, S\u00e3o Jo\u00e3o University Hospital, 4200-427 Porto, Portugal"},{"name":"WGO Gastroenterology and Hepatology Training Center, 4200-427 Porto, Portugal"},{"name":"Faculty of Medicine, University of Porto, 4200-427 Porto, Portugal"}]},{"given":"Jo\u00e3o","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal"},{"name":"Digestive Artificial Intelligence Development, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9387-9872","authenticated-orcid":false,"given":"Guilherme","family":"Macedo","sequence":"additional","affiliation":[{"name":"Precision Medicine Unit, Department of Gastroenterology, S\u00e3o Jo\u00e3o University Hospital, 4200-427 Porto, Portugal"},{"name":"WGO Gastroenterology and Hepatology Training Center, 4200-427 Porto, Portugal"},{"name":"Faculty of Medicine, University of Porto, 4200-427 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-0830","authenticated-orcid":false,"given":"Miguel","family":"Mascarenhas","sequence":"additional","affiliation":[{"name":"Precision Medicine Unit, Department of Gastroenterology, S\u00e3o Jo\u00e3o University Hospital, 4200-427 Porto, Portugal"},{"name":"WGO Gastroenterology and Hepatology Training Center, 4200-427 Porto, Portugal"},{"name":"Faculty of Medicine, University of Porto, 4200-427 Porto, Portugal"},{"name":"ManopH 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