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de Pesquisa e Inova\u00e7\u00e3o (VDPI) from ENSP-Fiocruz","award":["E-26\/210.949\/2021"],"award-info":[{"award-number":["E-26\/210.949\/2021"]}]},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade P\u00fablica e Meio Ambiente and the Vice Dire\u00e7\u00e3o de Pesquisa e Inova\u00e7\u00e3o (VDPI) from ENSP-Fiocruz","award":["E-26\/210.626\/2024"],"award-info":[{"award-number":["E-26\/210.626\/2024"]}]},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade P\u00fablica e Meio Ambiente and the Vice Dire\u00e7\u00e3o de Pesquisa e Inova\u00e7\u00e3o (VDPI) from ENSP-Fiocruz","award":["309065\/2021-6"],"award-info":[{"award-number":["309065\/2021-6"]}]},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade P\u00fablica e Meio Ambiente and the Vice Dire\u00e7\u00e3o de Pesquisa e Inova\u00e7\u00e3o (VDPI) from ENSP-Fiocruz","award":["2020.08969.BD"],"award-info":[{"award-number":["2020.08969.BD"]}]},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade P\u00fablica e Meio Ambiente and the Vice Dire\u00e7\u00e3o de Pesquisa e Inova\u00e7\u00e3o (VDPI) from ENSP-Fiocruz","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Tendon structure is predominantly composed of the extracellular matrix (ECM), and genetic variants in non-collagenous ECM components may influence susceptibility to tendinopathy. We investigated the potential influence of single nucleotide polymorphisms (SNPs) in fibrillin-2 (FBN2), tenascin-C (TNC), and matrix metalloproteinase-3 (MMP3) on the tendon regeneration failure phenotype and impact on the susceptibility to tendinopathy in Brazilian high-performance athletes. Methods: This case\u2013control study was conducted with 397 high-performance athletes from different sports modalities (197 tendinopathy cases and 200 controls), and they were analyzed by validated TaqManTM SNP genotyping assays of the SNPs FBN2 (rs331079), TNC (rs2104772), and MMP3 (rs591058). Results: Out of the 197 tendinopathy cases, 63% suffered from chronic tendon pain and 22% experienced more than three episodes of disease manifestation. The TNC-rs2104772-A allele was significantly associated with tendinopathy (OR: 1.4; 95% CI: 1.1\u20131.8), while athletes carrying the MMP3-rs591058-T allele were linked to an increased risk of more episodes of disease manifestation (OR: 1.7; 95% CI: 1.1\u20132.8). The TNC-MMP3 tendon regeneration failure phenotype (TNC-A\/MMP3-T) was associated with an increased risk of tendinopathy (OR: 1.4; 95% CI: 1.1\u20132.0) and episodes of disease manifestation (OR: 2.0; 95% CI: 1.2\u20133.5). Athletes with tendinopathy who had the TNC-A\/MMP3-T interaction were more prone to experiencing more than three disease exacerbations (OR: 4.3; 95% CI: 1.8\u201310.5) compared to TNC-A\/TNC-C. Conclusions: This study suggests that rs2104772 and rs591058 SNPs could be involved in the tendon regeneration failure phenotype and may influence the molecular mechanism related to the regulation of the tendon ECM during training workload.<\/jats:p>","DOI":"10.3390\/diagnostics14222469","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T06:30:48Z","timestamp":1730788248000},"page":"2469","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tenascin-C-Matrix Metalloproteinase-3 Phenotype and the Risk of Tendinopathy in High-Performance Athletes: A Case\u2013Control Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Lucas Rafael","family":"Lopes","sequence":"first","affiliation":[{"name":"Research Laboratory of Pharmaceutical Science (LAPESF), Rio de Janeiro State University (UERJ), Av. Manuel Caldeira de Alvarenga, 1203\u2014Campo Grande, Rio de Janeiro 23070-200, RJ, Brazil"},{"name":"Program of Post-Graduation in Public Health and Environment, National School of Public Health, Oswald Cruz Foundation, Rio de Janeiro 21041-210, RJ, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7301-3644","authenticated-orcid":false,"given":"Marcus Vin\u00edcius Galv\u00e3o","family":"Amaral","sequence":"additional","affiliation":[{"name":"Research Division, National Institute of Traumatology and Orthopaedics, Rio de Janeiro 20940-070, RJ, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1209-4425","authenticated-orcid":false,"given":"Rodrigo Araujo","family":"Goes","sequence":"additional","affiliation":[{"name":"Research Division, National Institute of Traumatology and Orthopaedics, Rio de Janeiro 20940-070, RJ, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3680-7757","authenticated-orcid":false,"given":"Val\u00e9ria","family":"Tavares","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)\/Pathology and Laboratory Medicine Department, Clinical Pathology SV\/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Centre (Porto CCC), 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4993-4467","authenticated-orcid":false,"given":"Francisca","family":"Dias","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)\/Pathology and Laboratory Medicine Department, Clinical Pathology SV\/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Centre (Porto CCC), 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3010-8373","authenticated-orcid":false,"given":"Rui","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)\/Pathology and Laboratory Medicine Department, Clinical Pathology SV\/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Centre (Porto CCC), 4200-072 Porto, Portugal"},{"name":"Faculty of Medicine, University of Porto (FMUP), 4200-072 Porto, Portugal"},{"name":"ICBAS\u2014Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal"},{"name":"Research Department, Portuguese League Against Cancer (NRNorte), 4200-172 Porto, Portugal"},{"name":"Faculty of Health Sciences, Fernando Pessoa University, 4200-150 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-8579","authenticated-orcid":false,"given":"Daniel Escorsim","family":"Machado","sequence":"additional","affiliation":[{"name":"Research Laboratory of Pharmaceutical Science (LAPESF), Rio de Janeiro State University (UERJ), Av. Manuel Caldeira de Alvarenga, 1203\u2014Campo Grande, Rio de Janeiro 23070-200, RJ, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7683-0698","authenticated-orcid":false,"given":"Jamila Alessandra","family":"Perini","sequence":"additional","affiliation":[{"name":"Research Laboratory of Pharmaceutical Science (LAPESF), Rio de Janeiro State University (UERJ), Av. Manuel Caldeira de Alvarenga, 1203\u2014Campo Grande, Rio de Janeiro 23070-200, RJ, Brazil"},{"name":"Program of Post-Graduation in Public Health and Environment, National School of Public Health, Oswald Cruz Foundation, Rio de Janeiro 21041-210, RJ, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Goes, R.A., Lopes, L.R., Cossich, V.R.A., de Miranda, V.A.R., Coelho, O.N., Bastos, R.D.C., Domenis, L.A.M., Guimar\u00e3es, J.A.M., Grangeiro-Neto, J.A., and Perini, J.A. (2020). 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