{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:45:09Z","timestamp":1760147109896,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CIDMA","award":["UIDB\/04106\/2020","IDP\/04106\/2020"],"award-info":[{"award-number":["UIDB\/04106\/2020","IDP\/04106\/2020"]}]},{"name":"The Center for Research and Development in Mathematics and Applications of University of Aveiro","award":["UIDB\/04106\/2020","IDP\/04106\/2020"],"award-info":[{"award-number":["UIDB\/04106\/2020","IDP\/04106\/2020"]}]},{"name":"Portuguese Foundation for Science and Technology (FCT\u2013Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia)","award":["UIDB\/04106\/2020","IDP\/04106\/2020"],"award-info":[{"award-number":["UIDB\/04106\/2020","IDP\/04106\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EBJ"],"abstract":"<jats:p>Background: Infections by multidrug-resistant (MDR) microorganisms are associated with increased morbidity and mortality in burn patients. This study aimed to analyze the evolution of MDR bacteria over a five-year period at Coimbra Burns Unit (CBU) in Portugal, seeking to assess the possible associations of specific bacteria with presumed risk factors. Methods: The data obtained consisted of identified bacteria present in any microbiological sample from each patient (including blood, central venous catheter, urine, tracheal aspirate and\/or wound exudate). Univariate models and a multivariate model were constructed for each of the MDR bacteria species that infected at least 50 patients or that had five or more MDR strains. Statistical hypothesis tests with a p-value less than 0.05 were considered significant. Results: Of a total of 341 samples obtained, 107 were MDR, corresponding to 10 species. Globally, there was no significant variation in MDR bacteria frequency over the period under analysis. Some risk factors and\/or trends were identified for some species, but none was linked to all of them. Conclusions: The risks for the development of MDR in bacteria in burn patients are multifactorial, mainly linked to longer hospital stays, the use of invasive devices and inadequate antimicrobial treatment. However, the influence of these risks regarding specific bacterial species is not straightforward and may rely on individual characteristics, type of treatment and\/or local prevalent flora. Due to the severity of multidrug-resistant infections, continued microbiological surveillance with the aid of rapid diagnostic tests and prompt institution of appropriate antimicrobial therapy are crucial to improving outcomes for burn patients.<\/jats:p>","DOI":"10.3390\/ebj4010002","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T04:29:38Z","timestamp":1673497778000},"page":"9-17","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of Potential Risk Factors for Multidrug-Resistance at a Burn Unit"],"prefix":"10.3390","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6820-5251","authenticated-orcid":false,"given":"Lu\u00eds","family":"Cabral","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery and Burns Unit, Coimbra University Hospital Centre (CHUC), 3000-075 Coimbra, Portugal"}]},{"given":"Leonor","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Mathematics, CIDMA\u2014Center for Research and Development in Mathematics and Applications, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-3561","authenticated-orcid":false,"given":"Ana H.","family":"Tavares","sequence":"additional","affiliation":[{"name":"Center for Research and Development in Mathematics and Applications\u2014School of Technology and Management (ESTGA), 3750-127 \u00c1gueda, Portugal"}]},{"given":"Gon\u00e7alo","family":"Tom\u00e9","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Burns Unit, Coimbra University Hospital Centre (CHUC), 3000-075 Coimbra, Portugal"}]},{"given":"Marisa","family":"Caetano","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Coimbra University Hospital Centre (CHUC), 3000-561 Coimbra, Portugal"}]},{"given":"Catarina","family":"Chaves","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Coimbra University Hospital Centre (CHUC), 3000-561 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1051-8084","authenticated-orcid":false,"given":"Vera","family":"Afreixo","sequence":"additional","affiliation":[{"name":"Department of Mathematics, CIDMA\u2014Center for Research and Development in Mathematics and Applications, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1128\/CMR.19.2.403-434.2006","article-title":"Burn wound infections","volume":"19","author":"Church","year":"2006","journal-title":"Clin. 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