{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:51:22Z","timestamp":1772898682383,"version":"3.50.1"},"publisher-location":"Basel Switzerland","reference-count":16,"publisher":"MDPI","license":[{"start":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T00:00:00Z","timestamp":1636848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT","award":["PTDC\/ASP-AGR\/30154\/2017"],"award-info":[{"award-number":["PTDC\/ASP-AGR\/30154\/2017"]}]},{"name":"FCT","award":["PO-CI-01-0145-FEDER-030154"],"award-info":[{"award-number":["PO-CI-01-0145-FEDER-030154"]}]},{"name":"FCT","award":["UIDB\/00686\/2020"],"award-info":[{"award-number":["UIDB\/00686\/2020"]}]},{"name":"FCT","award":["UIDB\/04650\/2020"],"award-info":[{"award-number":["UIDB\/04650\/2020"]}]},{"name":"FCT","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"FEDER","award":["PTDC\/ASP-AGR\/30154\/2017"],"award-info":[{"award-number":["PTDC\/ASP-AGR\/30154\/2017"]}]},{"name":"FEDER","award":["PO-CI-01-0145-FEDER-030154"],"award-info":[{"award-number":["PO-CI-01-0145-FEDER-030154"]}]},{"name":"FEDER","award":["UIDB\/00686\/2020"],"award-info":[{"award-number":["UIDB\/00686\/2020"]}]},{"name":"FEDER","award":["UIDB\/04650\/2020"],"award-info":[{"award-number":["UIDB\/04650\/2020"]}]},{"name":"FEDER","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"EU","award":["PTDC\/ASP-AGR\/30154\/2017"],"award-info":[{"award-number":["PTDC\/ASP-AGR\/30154\/2017"]}]},{"name":"EU","award":["PO-CI-01-0145-FEDER-030154"],"award-info":[{"award-number":["PO-CI-01-0145-FEDER-030154"]}]},{"name":"EU","award":["UIDB\/00686\/2020"],"award-info":[{"award-number":["UIDB\/00686\/2020"]}]},{"name":"EU","award":["UIDB\/04650\/2020"],"award-info":[{"award-number":["UIDB\/04650\/2020"]}]},{"name":"EU","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"FCT-Portugal and FEDER-COMPETE\/QREN-EU","award":["PTDC\/ASP-AGR\/30154\/2017"],"award-info":[{"award-number":["PTDC\/ASP-AGR\/30154\/2017"]}]},{"name":"FCT-Portugal and FEDER-COMPETE\/QREN-EU","award":["PO-CI-01-0145-FEDER-030154"],"award-info":[{"award-number":["PO-CI-01-0145-FEDER-030154"]}]},{"name":"FCT-Portugal and FEDER-COMPETE\/QREN-EU","award":["UIDB\/00686\/2020"],"award-info":[{"award-number":["UIDB\/00686\/2020"]}]},{"name":"FCT-Portugal and FEDER-COMPETE\/QREN-EU","award":["UIDB\/04650\/2020"],"award-info":[{"award-number":["UIDB\/04650\/2020"]}]},{"name":"FCT-Portugal and FEDER-COMPETE\/QREN-EU","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"FCT","award":["PTDC\/ASP-AGR\/30154\/2017"],"award-info":[{"award-number":["PTDC\/ASP-AGR\/30154\/2017"]}]},{"name":"FCT","award":["PO-CI-01-0145-FEDER-030154"],"award-info":[{"award-number":["PO-CI-01-0145-FEDER-030154"]}]},{"name":"FCT","award":["UIDB\/00686\/2020"],"award-info":[{"award-number":["UIDB\/00686\/2020"]}]},{"name":"FCT","award":["UIDB\/04650\/2020"],"award-info":[{"award-number":["UIDB\/04650\/2020"]}]},{"name":"FCT","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.3390\/ecsoc-25-11689","type":"proceedings-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T04:50:01Z","timestamp":1663303801000},"page":"105","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cytotoxicity Studies of Eugenol Amino Alcohols Derivatives"],"prefix":"10.3390","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9139-090X","authenticated-orcid":false,"given":"Cl\u00e1udia","family":"Teixeira","sequence":"first","affiliation":[{"name":"Centre of Chemistry (CQ\/UM), University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal"},{"name":"REQUIMTE\/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}]},{"given":"Nuno F. S.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Centre of Chemistry (CQ\/UM), University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0384-7592","authenticated-orcid":false,"given":"David M.","family":"Pereira","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-7364","authenticated-orcid":false,"given":"Renato B.","family":"Pereira","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}]},{"given":"Maria Jos\u00e9 G.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Centre of Chemistry (CQ\/UM), University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5829-6081","authenticated-orcid":false,"given":"Elisabete M. S.","family":"Castanheira","sequence":"additional","affiliation":[{"name":"Centre of Physics of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Ant\u00f3nio Gil","family":"Fortes","sequence":"additional","affiliation":[{"name":"Centre of Chemistry (CQ\/UM), University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2048-1190","authenticated-orcid":false,"given":"Maria Sameiro T.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Centre of Chemistry (CQ\/UM), University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s11101-009-9123-y","article-title":"Nature: A vital source of leads for anticancer drug development","volume":"8","author":"Cragg","year":"2009","journal-title":"Phytochem. Rev."},{"key":"ref_2","first-page":"59","article-title":"Medicinal plants, human health and biodiversity: A broad review","volume":"147","author":"Sen","year":"2015","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3149362","DOI":"10.1155\/2018\/3149362","article-title":"Anticancer properties of essential oils and other natural products","volume":"2018","author":"Blowman","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Nehme, R., Andr\u00e9s, S., Pereira, R.B., Jemaa, M.B., Bouhallab, S., Ceciliani, F., L\u00f3pez, S., Rahali, F.Z., Ksouri, R., and Pereira, D.M. (2021). Essential oils in livestock: From health to food quality. Antioxidants, 10.","DOI":"10.3390\/antiox10020330"},{"key":"ref_6","first-page":"1055","article-title":"The multiple faces of eugenol. A versatile starting material and building block for organic and bio-organic synthesis and a convenient precursor toward bio-based fine chemicals","volume":"26","author":"Kaufman","year":"2015","journal-title":"J. Braz. Chem. Soc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.18632\/aging.100934","article-title":"Apoptosis as anticancer mechanism: Function and dysfunction of its modulators and targeted therapeutic strategies","volume":"8","author":"Pistritto","year":"2016","journal-title":"Aging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: A review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2184.2012.00845.x","article-title":"Programmed cell death pathways in cancer: A review of apoptosis, autophagy and programmed necrosis","volume":"45","author":"Ouyang","year":"2012","journal-title":"Cell Prolif."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: A review of the major forms of apoptosis, necrosis and autophagy","volume":"43","year":"2019","journal-title":"Cell Biol. Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6290","DOI":"10.3390\/molecules17066290","article-title":"Antiproliferative and molecular mechanism of eugenol-induced apoptosis in cancer cells","volume":"17","author":"Jaganathan","year":"2012","journal-title":"Molecules"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13065-018-0407-4","article-title":"Eugenol derivatives: Synthesis, characterization, and evaluation of antibacterial and antioxidant activities","volume":"12","author":"Silva","year":"2018","journal-title":"Chem. Cent. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1021\/ol051220q","article-title":"Highly chemoselective addition of amines to epoxides in water","volume":"7","author":"Azizi","year":"2015","journal-title":"Org. Lett."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6616","DOI":"10.3390\/molecules26216616","article-title":"Amino alcohols from eugenol as potential semisynthetic insecticides: Chemical, biological and computational insights","volume":"26","author":"Pinto","year":"2021","journal-title":"Molecules"}],"event":{"name":"International Electronic Conference on Synthetic Organic Chemistry","acronym":"ECSOC-25"},"container-title":["The 25th International Electronic Conference on Synthetic Organic Chemistry"],"original-title":[],"link":[{"URL":"https:\/\/www.mdpi.com\/2673-4583\/8\/1\/105\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:57:39Z","timestamp":1760169459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2673-4583\/8\/1\/105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,14]]},"references-count":16,"alternative-id":["ecsoc-25-11689"],"URL":"https:\/\/doi.org\/10.3390\/ecsoc-25-11689","relation":{},"subject":[],"published":{"date-parts":[[2021,11,14]]}}}