{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T11:06:13Z","timestamp":1769857573972,"version":"3.49.0"},"publisher-location":"Basel Switzerland","reference-count":22,"publisher":"MDPI","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["LA\/P\/0056\/2020"],"award-info":[{"award-number":["LA\/P\/0056\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["UIDB\/04138\/2020"],"award-info":[{"award-number":["UIDB\/04138\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["UIDP\/04138\/2020"],"award-info":[{"award-number":["UIDP\/04138\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["UIDB\/00645\/2020"],"award-info":[{"award-number":["UIDB\/00645\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["UIDP\/00645\/2020"],"award-info":[{"award-number":["UIDP\/00645\/2020"]}]},{"name":"Institute of Molecular Sciences","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}]},{"name":"Institute of Molecular Sciences","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}]},{"name":"Institute of Molecular Sciences","award":["LA\/P\/0056\/2020"],"award-info":[{"award-number":["LA\/P\/0056\/2020"]}]},{"name":"Institute of Molecular Sciences","award":["UIDB\/04138\/2020"],"award-info":[{"award-number":["UIDB\/04138\/2020"]}]},{"name":"Institute of Molecular Sciences","award":["UIDP\/04138\/2020"],"award-info":[{"award-number":["UIDP\/04138\/2020"]}]},{"name":"Institute of Molecular Sciences","award":["UIDB\/00645\/2020"],"award-info":[{"award-number":["UIDB\/00645\/2020"]}]},{"name":"Institute of Molecular Sciences","award":["UIDP\/00645\/2020"],"award-info":[{"award-number":["UIDP\/00645\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["LA\/P\/0056\/2020"],"award-info":[{"award-number":["LA\/P\/0056\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["UIDB\/04138\/2020"],"award-info":[{"award-number":["UIDB\/04138\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["UIDP\/04138\/2020"],"award-info":[{"award-number":["UIDP\/04138\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["UIDB\/00645\/2020"],"award-info":[{"award-number":["UIDB\/00645\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["UIDP\/00645\/2020"],"award-info":[{"award-number":["UIDP\/00645\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.3390\/ecsoc-28-20168","type":"proceedings-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T04:39:39Z","timestamp":1739767179000},"page":"84","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Potential of Application of Natural Product Nanoparticles in Hypercholesterolemia"],"prefix":"10.3390","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6359-6945","authenticated-orcid":false,"given":"Laura M.","family":"Teixeira","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"},{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"},{"name":"Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-4031","authenticated-orcid":false,"given":"Catarina P.","family":"Reis","sequence":"additional","affiliation":[{"name":"Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, 1649-003 Lisboa, Portugal"},{"name":"Instituto de Biof\u00edsica e Engenharia Biom\u00e9dica (IBEB), Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5192-3006","authenticated-orcid":false,"given":"Rita","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"},{"name":"Departamento de Engenharia Qu\u00edmica, Instituto Superior de Engenharia de Lisboa, 1959-007 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Martinez-Hervas, S., and Ascaso, J.F. (2018). Hypercholesterolemia. Encyclopedia of Endocrine Diseases, Academic Press.","DOI":"10.1016\/B978-0-12-801238-3.65340-0"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Cium\u0103rnean, L., Milaciu, M.V., Negrean, V., Or\u0103\u0219an, O.H., Vesa, S.C., S\u0103l\u0103gean, O., Ilu\u0163, S., and Vlaicu, S.I. (2021). Cardiovascular Risk Factors and Physical Activity for the Prevention of Cardiovascular Diseases in the Elderly. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19010207"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Andr\u00e9, R., Pacheco, R., Bourbon, M., and Serralheiro, M.L. (2021). Brown Algae Potential as a Functional Food against Hypercholesterolemia: Review. Foods, 10.","DOI":"10.3390\/foods10020234"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kim, S.-W., Kang, H.-J., Jhon, M., Kim, J.-W., Lee, J.-Y., Walker, A.J., Agustini, B., Kim, J.-M., and Berk, M. (2019). Statins and Inflammation: New Therapeutic Opportunities in Psychiatry. Front. Psychiatry, 10.","DOI":"10.3389\/fpsyt.2019.00103"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Gu, J., Zhu, N., Li, H.F., Zhang, C.J., Gong, Y.Z., Liao, D.F., and Qin, L. (2022). Ezetimibe and Cancer: Is There a Connection?. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.831657"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Camerino, G.M., Musumeci, O., Conte, E., Musaraj, K., Fonzino, A., Barca, E., Marino, M., Rodolico, C., Tricarico, D., and Camerino, C. (2017). Risk of Myopathy in Patients in Therapy with Statins: Identification of Biological Markers in a Pilot Study. Front. Pharmacol., 8.","DOI":"10.3389\/fphar.2017.00500"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.cgh.2006.04.014","article-title":"Severe Hepatic Side Effects of Ezetimibe","volume":"4","author":"Stolk","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Poli, A., Marangoni, F., Corsini, A., Manzato, E., Marrocco, W., Martini, D., Medea, G., and Visioli, F. (2021). Phytosterols, Cholesterol Control, and Cardiovascular Disease. Nutrients, 13.","DOI":"10.3390\/nu13082810"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Rahman, M.M., Rahaman, M.S., Islam, M.R., Rahman, F., Mithi, F.M., Alqahtani, T., Almikhlafi, M.A., Alghamdi, S.Q., Alruwaili, A.S., and Hossain, M.S. (2022). Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects. Molecules, 27.","DOI":"10.3390\/molecules27010233"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11130-012-0280-6","article-title":"Hypolipidemic Effect of Avocado (Persea americana Mill) Seed in a Hypercholesterolemic Mouse Model","volume":"67","year":"2012","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_11","first-page":"140","article-title":"Inclusion of Avocado (Persea americana) Seeds in the Diet to Improve Carbohydrate and Lipid Metabolism in Rats","volume":"54","author":"Uchenna","year":"2017","journal-title":"Rev. Argent. Endocrinol. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Joudeh, N., and Linke, D. (2022). Nanoparticle Classification, Physicochemical Properties, Characterization, and Applications: A Comprehensive Review for Biologists. J. Nanobiotechnol., 20.","DOI":"10.1186\/s12951-022-01477-8"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Coelho, M., and Pacheco, R. (2023). Anti-Hypercholesterolemia Effects of Edible Seaweed Extracts and Metabolomic Changes in Hep-G2 and Caco-2 Cell Lines. Life, 13.","DOI":"10.20944\/preprints202305.0631.v1"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Santos-Rebelo, A., Garcia, C., Eleut\u00e9rio, C., Bastos, A., Coelho, S.C., Coelho, M.A.N., Molpeceres, J., Viana, A.S., Ascens\u00e3o, L., and Pinto, J.F. (2018). Development of Parvifloron D-Loaded Smart Nanoparticles to Target Pancreatic Cancer. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics10040216"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Pinto, S., Gaspar, M.M., Ascens\u00e3o, L., Fa\u00edsca, P., Reis, C.P., and Pacheco, R. (2022). Nanoformulation of Seaweed Eisenia bicyclis in Albumin Nanoparticles Targeting Cardiovascular Diseases: In Vitro and In Vivo Evaluation. Mar. Drugs, 20.","DOI":"10.3390\/md20100608"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.foodchem.2006.09.017","article-title":"Antioxidant and Antiacetylcholinesterase Activities of Five Plants Used as Portuguese Food Spices","volume":"103","author":"Mata","year":"2007","journal-title":"Food Chem."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Velderrain-Rodr\u00edguez, G.R., Quero, J., Osada, J., Mart\u00edn-Belloso, O., and Rodr\u00edguez-Yoldi, M.J. (2021). Phenolic-rich extracts from avocado fruit residues as functional food ingredients with antioxidant and antiproliferative properties. Biomolecules, 11.","DOI":"10.3390\/biom11070977"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.foodchem.2006.09.034","article-title":"Comparison of Antioxidant Capacities and Cytotoxicities of Certain Fruit Peels","volume":"103","author":"Okonogi","year":"2007","journal-title":"Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Sharifi-Rad, M., Anil Kumar, N.V., Zucca, P., Varoni, E.M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P.V., Azzini, E., and Peluso, I. (2020). Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.00694"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Danaei, M., Dehghankhold, M., Ataei, S., Hasanzadeh Davarani, F., Javanmard, R., Dokhani, A., Khorasani, S., and Mozafari, M.R. (2018). Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics10020057"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8569","DOI":"10.1016\/j.biomaterials.2012.07.063","article-title":"Size-dependent absorption mechanism of polymeric nanoparticles for oral delivery of protein drugs","volume":"33","author":"He","year":"2012","journal-title":"Biomaterials"}],"event":{"name":"ECSOC 2024","acronym":"ECSOC 2024"},"container-title":["ECSOC 2024"],"original-title":[],"link":[{"URL":"https:\/\/www.mdpi.com\/2673-4583\/16\/1\/84\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:58:27Z","timestamp":1760115507000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2673-4583\/16\/1\/84"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":22,"alternative-id":["ecsoc-28-20168"],"URL":"https:\/\/doi.org\/10.3390\/ecsoc-28-20168","relation":{},"subject":[],"published":{"date-parts":[[2024,11,14]]}}}