{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:05:56Z","timestamp":1758931556844,"version":"3.44.0"},"reference-count":64,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"The Foundation for Science and Technology","doi-asserted-by":"publisher","award":["PTDC\/LLT-LIN\/1115\/2021","PTDC\/LLT-LIN\/29338\/2017","PTDC\/MHC-LIN\/3901\/2014"],"award-info":[{"award-number":["PTDC\/LLT-LIN\/1115\/2021","PTDC\/LLT-LIN\/29338\/2017","PTDC\/MHC-LIN\/3901\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["EJIHPE"],"abstract":"<jats:p>Language difficulties have been highlighted as a cornerstone of the developmental profile in Down Syndrome (DS), but very few studies have examined early language abilities in children with DS to determine the initial strengths and weaknesses that might inform early language interventions to support language development in this population. This study focused on the early perception of intonation and examined whether it differed between infants with DS and typically developing (TD) peers. Using a visual habituation paradigm from a previous study on TD infants\u2019 ability to perceive the intonation of statements and questions, infants with DS were able to successfully discriminate statement and question intonation, similarly to TD infants. However, unlike for TD infants, an age group effect was found, with older infants with DS being unable to discriminate the intonation contrast. Our findings highlight the importance of prosody in early development also in infants with DS. Moreover, the unexpected decrease in early sensitivity to intonation in older infants with DS pinpoints a crucial developmental window\u2014the first semester of life\u2014for early interventions using intonation to support language learning in these infants.<\/jats:p>","DOI":"10.3390\/ejihpe15100194","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T06:02:52Z","timestamp":1758866572000},"page":"194","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Perception of Intonation in Down Syndrome: Implications for Language Intervention"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8376-2419","authenticated-orcid":false,"given":"C\u00e1tia","family":"Severino","sequence":"first","affiliation":[{"name":"Center of Linguistics, School of Arts and Humanities, University of Lisbon, 1600-214 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7640-4798","authenticated-orcid":false,"given":"Marina","family":"Vig\u00e1rio","sequence":"additional","affiliation":[{"name":"Center of Linguistics, School of Arts and Humanities, University of Lisbon, 1600-214 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6102-0772","authenticated-orcid":false,"given":"S\u00f3nia","family":"Frota","sequence":"additional","affiliation":[{"name":"Center of Linguistics, School of Arts and Humanities, University of Lisbon, 1600-214 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/mrdd.20158","article-title":"Language development in down syndrome: From the prelinguistic period to the acquisition of literacy","volume":"13","author":"Abbeduto","year":"2007","journal-title":"Mental Retardation and Developmental Disabilities Research Reviews"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bandl.2016.08.002","article-title":"Prosodic grouping at birth","volume":"162","author":"Abboub","year":"2016","journal-title":"Brain and Language"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12929-015-0138-y","article-title":"Down syndrome: An insight of the disease","volume":"22","author":"Asim","year":"2015","journal-title":"Journal of Biomedical Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ijdevneu.2011.11.005","article-title":"Impaired myelination of the human hippocampal formation in down syndrome","volume":"30","author":"Vincze","year":"2012","journal-title":"International Journal of Developmental Neuroscience"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Best, C. T. (2019). The diversity of tone languages and the roles of pitch variation in non-tone languages: Considerations for tone perception research. Frontiers in Psychology, 10.","DOI":"10.3389\/fpsyg.2019.00364"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3104\/reviews.5","article-title":"Language development in children with down syndrome\u2014Reasons for optimism","volume":"1","author":"Buckley","year":"1993","journal-title":"Down Syndrome Research and Practice"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1017\/S0305000918000181","article-title":"Emerging word segmentation abilities in European Portuguese-learning infants: New evidence for the rhythmic unit and the edge factor","volume":"45","author":"Butler","year":"2018","journal-title":"Journal of Child Language"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/(SICI)1098-2779(1997)3:4<307::AID-MRDD5>3.0.CO;2-K","article-title":"Language development in children and adolescents with down syndrome","volume":"3","author":"Chapman","year":"1997","journal-title":"Mental Retardation and Developmental Disabilities Research Reviews"},{"key":"ref_9","unstructured":"Czeke, N., Zahner, K., Rimpler, J., Braun, B., and Frota, S. (, January June). German infants do not discriminate Portuguese rising vs. falling contours. Workshop on Infant Language Development (WILD), Potsdam, Germany."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e12961","DOI":"10.1111\/desc.12961","article-title":"Attentional abilities constrain language development: A cross-syndrome infant\/toddler study","volume":"23","author":"Jones","year":"2020","journal-title":"Developmental Science"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/wcs.1221","article-title":"Cognition in Down syndrome: A developmental cognitive neuroscience perspective","volume":"4","author":"Edgin","year":"2013","journal-title":"WIREs Cognitive Science"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Fal\u00e9, I., and Hub Faria, I. (, January September). Intonational contrasts in EP: A categorical perception approach. INTERSPEECH 2005-EUROSPEECH, Lisbon, Portugal.","DOI":"10.21437\/Interspeech.2005-279"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1080\/02699206.2023.2226302","article-title":"Development and validation of a parental report of toddlers\u2019 prosodic skills","volume":"38","author":"Filipe","year":"2023","journal-title":"Clinical Linguistics & Phonetics"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1017\/S0305000912000207","article-title":"Discriminating down syndrome and fragile X syndrome based on language ability","volume":"40","author":"Finestack","year":"2013","journal-title":"Journal of Child Language"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1515\/prbs.2002.001","article-title":"Nuclear falls and rises in European Portuguese: A phonological analysis of declarative and question intonation","volume":"14","author":"Frota","year":"2002","journal-title":"Probus"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1075\/tilar.23.08fro","article-title":"Early development of intonation: Perception and production","volume":"Vol. 23","author":"Prieto","year":"2018","journal-title":"Trends in language acquisition research"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/infa.12037","article-title":"Infants\u2019 perception of intonation: Is it a statement or a question?","volume":"19","author":"Frota","year":"2014","journal-title":"Infancy"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Frota, S., Pejovic, J., Severino, C., and Vig\u00e1rio, M. (2020). Looking for the edge: Emerging segmentation abilities in atypical development. Speech Prosody 2020, 814\u2013818.","DOI":"10.21437\/SpeechProsody.2020-166"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Gussenhhoven, C., and Chen, A. (2020). Prosodic Bootstrapping. The oxford handbook of language prosody, Oxford University Press.","DOI":"10.1093\/oxfordhb\/9780198832232.001.0001"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"211855","DOI":"10.1098\/rsos.211855","article-title":"Language acquisition and speech rhythm patterns: An auditory neuroscience perspective","volume":"9","author":"Goswami","year":"2022","journal-title":"Royal Society Open Science"},{"key":"ref_21","first-page":"296","article-title":"Communicative and sensorimotor development of down\u2019s syndrome children","volume":"84","author":"Greenwald","year":"1979","journal-title":"American Journal of Mental Deficiency"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Gussenhoven, C. (2004). The phonology of tone and intonation, Cambridge University Press.","DOI":"10.1017\/CBO9780511616983"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Gussenhoven, C. (2015). Suprasegmentals. International encyclopedia of the social & behavioral sciences, Elsevier.","DOI":"10.1016\/B978-0-08-097086-8.52024-8"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/tops.12197","article-title":"Foundations of intonational meaning: Anatomical and physiological factors","volume":"8","author":"Gussenhoven","year":"2016","journal-title":"Topics in Cognitive Science"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3109\/02699206.2013.777121","article-title":"Pursuing prosody interventions","volume":"27","author":"Hargrove","year":"2013","journal-title":"Clinical Linguistics & Phonetics"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bandl.2007.07.023","article-title":"Is there an impairment of language-specific attentional processing in aphasia?","volume":"103","author":"Hula","year":"2007","journal-title":"Brain and Language"},{"key":"ref_27","unstructured":"IBM Corp. (2024). IBM SPSS statistics for Windows (Version 29.0.2.0 (20)) [Computer software], IBM Corp."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.12688\/f1000research.16315.1","article-title":"The genetics of intellectual disability: Advancing technology and gene editing","volume":"9","author":"Ilyas","year":"2020","journal-title":"F1000Research"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Johnson, E. K., Seidl, A., and Tyler, M. D. (2014). The edge factor in early word segmentation: Utterance-level prosody enables word form extraction by 6-month-olds. PLoS ONE, 9, (1).","DOI":"10.1371\/journal.pone.0083546"},{"key":"ref_30","unstructured":"Jusczyk, P. W. (1997). The discovery of spoken language, MIT Press."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1044\/1092-4388(2012\/12-0148)","article-title":"Speech impairment in down syndrome: A review","volume":"56","author":"Kent","year":"2013","journal-title":"Journal of Speech, Language, and Hearing Research: JSLHR"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10803-009-0896-z","article-title":"Brief report: Question-asking and collateral language acquisition in children with Autism","volume":"40","author":"Koegel","year":"2010","journal-title":"Journal of Autism and Developmental Disorders"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1044\/1092-4388(2011\/11-0075)","article-title":"Effects of sampling context on spontaneous expressive language in males with fragile X syndrome or Down syndrome","volume":"55","author":"Kover","year":"2012","journal-title":"Journal of Speech, Language, and Hearing Research"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"F13","DOI":"10.1111\/j.1467-7687.2006.00468.x","article-title":"Infants show a facilitation effect for native language phonetic perception between 6 and 12 months","volume":"9","author":"Kuhl","year":"2006","journal-title":"Developmental Science"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Ladd, D. R. (2008). Intonational phonology, Cambridge University Press. [2nd ed.].","DOI":"10.1017\/CBO9780511808814"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Liu, L., G\u00f6tz, A., Lorette, P., and Tyler, M. D. (2022). How tone, intonation and emotion shape the development of infants\u2019 fundamental frequency perception. Frontiers in Psychology, 13.","DOI":"10.3389\/fpsyg.2022.906848"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Liu, L., and Kager, R. (2018). Monolingual and bilingual infants\u2019 ability to use non-native tone for word learning deteriorates by the second year after birth. Frontiers in Psychology, 9.","DOI":"10.3389\/fpsyg.2018.00117"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Mandke, K., Flanagan, S., Macfarlane, A., Feltham, G., Gabrielczyk, F., Wilson, A. M., Gross, J., and Goswami, U. (2023). Neural responses to natural and enhanced speech edges in children with and without dyslexia. Frontiers in Human Neuroscience, 17.","DOI":"10.3389\/fnhum.2023.1200950"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/TLD.0b013e3181a71fe1","article-title":"Language characteristics of individuals with down syndrome","volume":"29","author":"Martin","year":"2009","journal-title":"Topics in Language Disorders"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ridd.2017.12.021","article-title":"Longitudinal predictors of early language in infants with down syndrome: A preliminary study","volume":"81","author":"Stojanovik","year":"2018","journal-title":"Research in Developmental Disabilities"},{"key":"ref_41","unstructured":"McDuffie, A., and Abbeduto, L. (2009). Language disorders in children with mental retardation of genetic origin: Down syndrome, fragile X syndrome, and Williams syndrome. Handbook of child language disorders, Psychology Press."},{"key":"ref_42","unstructured":"Meints, K., and Woodford, A. (2020, March 02). Lincoln infant lab package 1.0: A new programme package for IPL, preferential listening, habituation and eyetracking, Available online: https:\/\/www.lincoln.ac.uk\/media\/responsive2017\/collegeofsocialscience\/schoolofpsychology\/Handbook_08-12-2009.pdf."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Moraleda-Sep\u00falveda, E., L\u00f3pez-Resa, P., Pulido-Garc\u00eda, N., Delgado-Matute, S., and Sim\u00f3n-Medina, N. (2022). Language intervention in down syndrome: A systematic literature review. International Journal of Environmental Research and Public Health, 19, (10).","DOI":"10.3390\/ijerph19106043"},{"key":"ref_44","first-page":"756","article-title":"Language discrimination by newborns: Toward an understanding of the role of rhythm","volume":"24","author":"Nazzi","year":"1998a","journal-title":"Journal of Experimental Psychology: Human Perception and Performance"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0163-6383(98)90044-3","article-title":"Discrimination of pitch contours by neonates","volume":"21","author":"Nazzi","year":"1998b","journal-title":"Infant Behavior and Development"},{"key":"ref_46","unstructured":"Snow, C. E., and Ferguson, C. A. (1977). Mother, Id rather do it myself: Some effects and non-effects of maternal speech style. Talking to children: Language input and acquisition, Cambridge University Press."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.3758\/s13428-019-01244-y","article-title":"Habit2: A stand-alone software solution for presenting stimuli and recording infant looking times in order to study infant development","volume":"51","author":"Oakes","year":"2019","journal-title":"Behavior Research Methods"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Gussenhoven, C., and Chen, A. (2020). Prosody in children with atypical development. The oxford handbook of language prosody, Oxford University Press.","DOI":"10.1093\/oxfordhb\/9780198832232.001.0001"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1075\/tilar.23.17pep","article-title":"Prosodic development in atypical populations","volume":"Vol. 23","author":"Prieto","year":"2018","journal-title":"Trends in language acquisition research"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1121\/1.1362689","article-title":"A cross-language comparison of\/d\/\u2013\/\u00f0\/perception: Evidence for a new developmental pattern","volume":"109","author":"Polka","year":"2001","journal-title":"Journal of the Acoustical Society of America"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0028-2243(88)90030-5","article-title":"Fetal hearing","volume":"28","author":"Querleu","year":"1988","journal-title":"European Journal of Obstetrics & Gynecology and Reproductive Biology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.clinph.2007.09.144","article-title":"Sleeping newborns extract prosody from continuous speech","volume":"119","author":"Sambeth","year":"2008","journal-title":"Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1037\/0012-1649.33.1.3","article-title":"Newborns discriminate the rhythm of multisyllabic stressed words","volume":"33","author":"Sansavini","year":"1997","journal-title":"Developmental Psychology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1162\/jocn.2009.21377","article-title":"Development of hemispheric specialization for lexical pitch\u2013accent in Japanese infants","volume":"22","author":"Sato","year":"2010","journal-title":"Journal of Cognitive Neuroscience"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/1460-6984.12699","article-title":"A systematic review of speech, language and communication interventions for children with Down syndrome from 0 to 6 years","volume":"57","author":"Seager","year":"2022","journal-title":"International Journal of Language & Communication Disorders"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"6038","DOI":"10.1073\/pnas.1017617108","article-title":"Prosody guides the rapid mapping of auditory word forms onto visual objects in 6-mo-old infants","volume":"108","author":"Shukla","year":"2011","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3104\/reviews.118","article-title":"Down syndrome phonology: Developmental patterns and intervention strategies","volume":"7","year":"2001","journal-title":"Down Syndrome Research and Practice"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jneuroling.2010.01.004","article-title":"Prosodic deficits in children with down syndrome","volume":"24","author":"Stojanovik","year":"2011","journal-title":"Journal of Neurolinguistics"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Sundara, M., and Frota, S. (2025). English-learning infants\u2019 developing sensitivity to intonation contours. Languages, 10, (7).","DOI":"10.3390\/languages10070148"},{"key":"ref_60","unstructured":"Sundara, M., Molnar, M., and Frota, S. (2015). The perception of boundary tones in infancy. Proceedings of the 18th international congress of phonetic sciences, International Phonetic Association. Available online: https:\/\/www.internationalphoneticassociation.org\/icphs-proceedings\/ICPhS2015\/Papers\/ICPHS0361.pdf."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Watson, L. A., and Meharena, H. S. (2023). From neurodevelopment to neurodegeneration: Utilizing human stem cell models to gain insight into down syndrome. Frontiers in Genetics, 14.","DOI":"10.3389\/fgene.2023.1198129"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1017\/S0142716418000152","article-title":"Perceptual beginnings to language acquisition","volume":"39","author":"Werker","year":"2018","journal-title":"Applied Psycholinguistics"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"101935","DOI":"10.1016\/j.infbeh.2024.101935","article-title":"Phonetic perceptual reorganization across the first year of life: Looking back","volume":"75","author":"Werker","year":"2024","journal-title":"Infant Behavior and Development"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1017\/S0305000915000744","article-title":"The limits of metrical segmentation: Intonation modulates infants\u2019 extraction of embedded trochees","volume":"43","author":"Zahner","year":"2016","journal-title":"Journal of Child Language"}],"container-title":["European Journal of Investigation in Health, Psychology and Education"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2254-9625\/15\/10\/194\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T08:12:17Z","timestamp":1758874337000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2254-9625\/15\/10\/194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":64,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["ejihpe15100194"],"URL":"https:\/\/doi.org\/10.3390\/ejihpe15100194","relation":{},"ISSN":["2254-9625"],"issn-type":[{"type":"electronic","value":"2254-9625"}],"subject":[],"published":{"date-parts":[[2025,9,26]]}}}