{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:37:55Z","timestamp":1761395875041,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T00:00:00Z","timestamp":1604102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electronics"],"abstract":"<jats:p>The study of the optical properties of biological tissues for a wide spectral range is necessary for the development and planning of noninvasive optical methods to be used in clinical practice. In this study, we propose a new method to calculate almost all optical properties of tissues as a function of wavelength directly from spectral measurements. Using this method, and with the exception of the reduced scattering coefficient, which was obtained by traditional simulation methods, all the other optical properties were calculated in a simple and fast manner for human and pathological colorectal tissues. The obtained results are in good agreement with previous published data, both in magnitude and in wavelength dependence. Since this method is based on spectral measurements and not on discrete-wavelength experimental data, the calculated optical properties contain spectral signatures that correspond to major tissue chromophores such as DNA and hemoglobin. Analysis of the absorption bands of hemoglobin in the wavelength dependence of the absorption spectra of normal and pathological colorectal mucosa allowed to identify differentiated accumulation of a pigment in these tissues. The increased content of this pigment in the pathological mucosa may be used for the future development of noninvasive diagnostic methods for colorectal cancer detection.<\/jats:p>","DOI":"10.3390\/electronics9111805","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T21:39:56Z","timestamp":1604180396000},"page":"1805","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lipofuscin-Type Pigment as a Marker of Colorectal Cancer"],"prefix":"10.3390","volume":"9","author":[{"given":"S\u00f3nia","family":"Carvalho","sequence":"first","affiliation":[{"name":"Department of Pathology and Cancer Biology, and Epigenetics Group-Research Center, Portuguese Oncology Institute of Porto, 4200-072 Porto, Portugal"}]},{"given":"Isa","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cancer Biology, and Epigenetics Group-Research Center, Portuguese Oncology Institute of Porto, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3171-4666","authenticated-orcid":false,"given":"Rui","family":"Henrique","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cancer Biology, and Epigenetics Group-Research Center, Portuguese Oncology Institute of Porto, 4200-072 Porto, Portugal"},{"name":"Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar-University of Porto (ICBAS-UP), 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7479-2694","authenticated-orcid":false,"given":"Valery","family":"Tuchin","sequence":"additional","affiliation":[{"name":"Research-Educational Institute of Optics and Biophotonics, Saratov State University, Saratov 410012, Russia"},{"name":"Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, Tomsk 634050, Russia"},{"name":"Laboratory of Laser Diagnostics of Technical and Living Systems, Institute of Precision Mechanics and Control of the Russian Academy of Sciences, Saratov 410028, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0667-3428","authenticated-orcid":false,"given":"Lu\u00eds","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Physics Department-Polytechnic Institute of Porto, School of Engineering, 4249-015 Porto, Portugal"},{"name":"Centre of Innovation in Engineering and Industrial Technology (CIETI), School of Engineering, Polytechnic of Porto, 4249-015 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/S0140-6736(13)61649-9","article-title":"Colorectal cancer","volume":"383","author":"Brenner","year":"2014","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Oliveira, L.M., and Tuchin, V.V. 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