{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:54:14Z","timestamp":1768434854196,"version":"3.49.0"},"reference-count":42,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Portuguese Foundation for Science and Technology (FCT","award":["FCT-UIDB\/05704\/2020"],"award-info":[{"award-number":["FCT-UIDB\/05704\/2020"]}]},{"name":"Portuguese Foundation for Science and Technology (FCT","award":["PTDC\/EMD-EMD\/6588\/2020"],"award-info":[{"award-number":["PTDC\/EMD-EMD\/6588\/2020"]}]},{"name":"Portuguese Foundation for Science and Technology (FCT","award":["CEECINST\/00060\/2021"],"award-info":[{"award-number":["CEECINST\/00060\/2021"]}]},{"name":"Institutional Scientific Employment Stimulus","award":["FCT-UIDB\/05704\/2020"],"award-info":[{"award-number":["FCT-UIDB\/05704\/2020"]}]},{"name":"Institutional Scientific Employment Stimulus","award":["PTDC\/EMD-EMD\/6588\/2020"],"award-info":[{"award-number":["PTDC\/EMD-EMD\/6588\/2020"]}]},{"name":"Institutional Scientific Employment Stimulus","award":["CEECINST\/00060\/2021"],"award-info":[{"award-number":["CEECINST\/00060\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eng"],"abstract":"<jats:p>Sudden cardiac death (SCD) represents a critical public health challenge, emphasizing the need for predictive techniques that model complex physiological dynamics. Studies indicate that the \u201cV-trough\u201d pattern in sympathetic nerve activity (SNA) could act as an early indicator of potentially fatal cardiac events, which can be effectively modeled using a modified version of Chua\u2019s chaotic system, incorporating the variables of heart rate (HR), SNA, and blood pressure (BP). This paper introduces a Chua circuit with delay, and proposes a novel control design technique based on Lurie-type control systems theory combined with mixed-sensitivity H\u221e (S\/KS\/T) methodology. The proposed controller enables precise regulation of HR in Chua\u2019s circuit, both with and without delay, paving the way for the development of advanced devices capable of preventing SCD. Furthermore, the developed theory allows for the project of robust controllers for delayed Lurie systems within the single-input\u2013single-output (SISO) framework. The presented theoretical framework, supported by numerical simulations, demonstrates the effectiveness of the conceptualization, marking a considerable advance in the understanding and early intervention of SCD through robust and nonlinear control systems.<\/jats:p>","DOI":"10.3390\/eng6050089","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T11:47:41Z","timestamp":1745581661000},"page":"89","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lurie Control Systems Applied to the Sudden Cardiac Death Problem Based on Chua Circuit Dynamics"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2369-9016","authenticated-orcid":false,"given":"Rafael F.","family":"Pinheiro","sequence":"first","affiliation":[{"name":"Center for Innovative Care and Health Technology (ciTechCare), School of Health Sciences (ESSLei), Polytechnic University of Leiria, 2414-016 Leiria, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3709-6790","authenticated-orcid":false,"given":"Diego","family":"Col\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratory of Automation and Control (LAC), Telecommunications and Control Department, Polytechnic School, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-010, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9339-3728","authenticated-orcid":false,"given":"Alexandre","family":"Antunes","sequence":"additional","affiliation":[{"name":"Center for Innovative Care and Health Technology (ciTechCare), School of Health Sciences (ESSLei), Polytechnic University of Leiria, 2414-016 Leiria, Portugal"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6774-5363","authenticated-orcid":false,"given":"Rui","family":"Fonseca-Pinto","sequence":"additional","affiliation":[{"name":"Center for Innovative Care and Health Technology (ciTechCare), School of Health Sciences (ESSLei), Polytechnic University of Leiria, 2414-016 Leiria, Portugal"},{"name":"Instituto de Telecomunica\u00e7\u00f5es (IT), 2411-901 Leiria, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhao, S., Ching, C.K., Huang, D., Liu, Y.B., Rodriguez-Guerrero, D.A., and Hussin, A. 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