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Optimization of Nanoencapsulation of Codium Tomentosum Extract and Its Potential Application in Yogurt Fortification. Mar. Drugs, 24.","DOI":"10.3390\/md23040147"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Kumar, S., Baldi, A., and Sharma, D.K. (2022). Characterization and In Vitro Investigation of Antiscabietic Effect of Phytosomes Assimilating Quercetin and Naringenin Rich Fraction of Pistacia Integerrima Galls Extract against Sarcoptes Scabiei. J. Drug Deliv. Sci. Technol., 67.","DOI":"10.1016\/j.jddst.2021.102851"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1080\/17425247.2019.1690452","article-title":"In Vivo Biodistribution of Venlafaxine-PLGA Nanoparticles for Brain Delivery: Plain vs. Functionalized Nanoparticles","volume":"16","author":"Gomes","year":"2019","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Soliman, T.N., Negm El-Dein, A., Abd Al-Daim, S., Allayeh, A., Awad, H., and Flefil, N.S. (2024). Characterization of C-Phycocyanin Antioxidant, Anti-Inflammatory, Anti-Tumour, and Anti-HCoV-229E Activities and Encapsulation for Implementation in an Innovative Functional Yogurt. Heliyon, 10.","DOI":"10.1016\/j.heliyon.2024.e31642"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Mittal, P., Singla, M., Kapoor, R., Kumar, D., Gupta, S., Gupta, G., and Bhattacharya, T. (2024). Paclitaxel Loaded Capmul MCM and Tristearin Based Nanostructured Lipid Carriers (NLCs) for Glioblastoma Treatment: Screening of Formulation Components by Quality by Design (QbD) Approach. Discov. Nano, 19.","DOI":"10.1186\/s11671-024-04132-3"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Direito, R., Reis, C., Roque, L., Gon\u00e7alves, M., Sanches-Silva, A., Gaspar, M.M., Pinto, R., Rocha, J., Sepodes, B., and Ros\u00e1rio Bronze, M. (2019). Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11060296"},{"key":"ref_38","first-page":"46","article-title":"Phosphatidylcholine Complex in Improving Oral Drug Delivery of Epicatechin: Preparation and Characterization","volume":"1","author":"Semalty","year":"2014","journal-title":"Drug Discov. Dev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jconrel.2014.04.017","article-title":"Assessment of PEG on Polymeric Particles Surface, a Key Step in Drug Carrier Translation","volume":"185","author":"Rabanel","year":"2014","journal-title":"J. Control. 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