{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T07:46:36Z","timestamp":1775461596409,"version":"3.50.1"},"reference-count":118,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"FCT, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04378\/2020"],"award-info":[{"award-number":["UIDP\/04378\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04378\/2020"],"award-info":[{"award-number":["UIDB\/04378\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0140\/2020"],"award-info":[{"award-number":["LA\/P\/0140\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Associate Laboratory Institute for Health and Bioeconomy","doi-asserted-by":"publisher","award":["UIDP\/04378\/2020"],"award-info":[{"award-number":["UIDP\/04378\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Associate Laboratory Institute for Health and Bioeconomy","doi-asserted-by":"publisher","award":["UIDB\/04378\/2020"],"award-info":[{"award-number":["UIDB\/04378\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Associate Laboratory Institute for Health and Bioeconomy","doi-asserted-by":"publisher","award":["LA\/P\/0140\/2020"],"award-info":[{"award-number":["LA\/P\/0140\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environments"],"abstract":"<jats:p>The One Health approach recognizes the interconnectedness between human, animal, and environmental health. Honeybees (Apis mellifera) embody this framework due to their crucial role in ecosystems, food production, and susceptibility to contaminants. Despite their suitability for a One Health approach, there is a lack of research showcasing the multidisciplinary impacts and contributions of bees. The objective of this work is to explore the application of the One Health approach to bees through a narrative review. This work highlights the contribution of bees to history and culture, economy, medicine, nutrition, food security, and the functioning of ecosystems. It also demonstrates that bee health is affected by land management, agricultural practices, environmental contaminants, nutritional resource availability, predators and diseases, weather, climate patterns, and beekeeping practices. This complex system is highly influenced by policy and beekeeping practices, which will benefit animal health directly and environmental and human health indirectly. Thus, the protection of bees should be prioritized.<\/jats:p>","DOI":"10.3390\/environments11080161","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T13:04:59Z","timestamp":1721999099000},"page":"161","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Honeybees and the One Health Approach"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7814-3659","authenticated-orcid":false,"given":"Joana C.","family":"Prata","sequence":"first","affiliation":[{"name":"School of Medicine and Biomedical Sciences, University of Porto (ICBAS-UP), Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB, Institute for Health and Bioeconomy, University Institute of Health Sciences, CESPU, 4585-116 Gandra, Portugal"},{"name":"UCIBIO, Applied Molecular Biosciences Unit, Translational Toxicology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), 4585-116 Gandra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6115-8811","authenticated-orcid":false,"given":"Paulo","family":"Martins da Costa","sequence":"additional","affiliation":[{"name":"School of Medicine and Biomedical Sciences, University of Porto (ICBAS-UP), Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"},{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto, de Leix\u00f5es, Av. General Norton de Matos s\/n, 4450-208 Matosinhos, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Prata, J.C., Ribeiro, A.I., and Rocha-Santos, T. (2022). An Introduction to the Concept of One Health. One Health, Elsevier.","DOI":"10.1016\/B978-0-12-822794-7.00004-6"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"fny085","DOI":"10.1093\/femsle\/fny085","article-title":"Climate Change and One Health","volume":"365","author":"Zinsstag","year":"2018","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/01.EE9.0000607496.00506.4e","article-title":"The One Health Approach","volume":"3","author":"Heederik","year":"2019","journal-title":"Environ. Epidemiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s10393-004-0151-1","article-title":"Animals as Sentinels of Human Environmental Health Hazards: An Evidence-Based Analysis","volume":"2","author":"Rabinowitz","year":"2005","journal-title":"Ecohealth"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"20180530","DOI":"10.1098\/rsbl.2018.0530","article-title":"Pollinivory and the Diversification Dynamics of Bees","volume":"14","author":"Murray","year":"2018","journal-title":"Biol. Lett."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Evans, J.D., and Chen, Y. (2021). Colony Collapse Disorder and Honey Bee Health. Honey Bee Medicine for the Veterinary Practitioner, Wiley.","DOI":"10.1002\/9781119583417.ch19"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Papa, G., Maier, R., Durazzo, A., Lucarini, M., Karabagias, I.K., Plutino, M., Bianchetto, E., Aromolo, R., Pignatti, G., and Ambrogio, A. (2022). The Honey Bee Apis Mellifera: An Insect at the Interface between Human and Ecosystem Health. Biology, 11.","DOI":"10.3390\/biology11020233"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.tree.2016.12.009","article-title":"Why Bees Are So Vulnerable to Environmental Stressors","volume":"32","author":"Klein","year":"2017","journal-title":"Trends Ecol. Evol."},{"key":"ref_9","first-page":"175","article-title":"Honey Bees and Their Products as Indicators of Environmental Pollution: A Review","volume":"8","author":"Salkova","year":"2016","journal-title":"Agric. Sci. Technol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"108457","DOI":"10.1016\/j.ecolind.2021.108457","article-title":"Honey Bees as Biomonitors of Environmental Contaminants, Pathogens, and Climate Change","volume":"134","author":"Cunningham","year":"2022","journal-title":"Ecol. Indic."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Muhammad-Bashir, B., and Halimah, B.A. (2022). Challenges and Future Perspectives for the Application of One Health. One Health, Elsevier.","DOI":"10.1016\/B978-0-12-822794-7.00007-1"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s11829-017-9528-2","article-title":"Insights from Measuring Pollen Deposition: Quantifying the Pre-Eminence of Bees as Flower Visitors and Effective Pollinators","volume":"11","author":"Willmer","year":"2017","journal-title":"Arthropod. Plant Interact."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1600-0706.2010.18644.x","article-title":"How Many Flowering Plants Are Pollinated by Animals?","volume":"120","author":"Ollerton","year":"2011","journal-title":"Oikos"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"20172140","DOI":"10.1098\/rspb.2017.2140","article-title":"The Worldwide Importance of Honey Bees as Pollinators in Natural Habitats","volume":"285","author":"Hung","year":"2018","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3375\/043.036.0413","article-title":"The Role of Honey Bees as Pollinators in Natural Areas","volume":"36","author":"Aslan","year":"2016","journal-title":"Nat. Areas J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"9308","DOI":"10.1038\/s41598-018-27591-y","article-title":"Controlling the Impact of the Managed Honeybee on Wild Bees in Protected Areas","volume":"8","author":"Henry","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1038\/s41598-022-05603-2","article-title":"Honey Bees and Climate Explain Viral Prevalence in Wild Bee Communities on a Continental Scale","volume":"12","author":"Piot","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_18","unstructured":"European Commission (2024, June 18). Honey Bees. Available online: https:\/\/food.ec.europa.eu\/animals\/live-animal-movements\/honey-bees_en."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Khalifa, S.A.M., Elshafiey, E.H., Shetaia, A.A., El-Wahed, A.A.A., Algethami, A.F., Musharraf, S.G., AlAjmi, M.F., Zhao, C., Masry, S.H.D., and Abdel-Daim, M.M. (2021). Overview of Bee Pollination and Its Economic Value for Crop Production. Insects, 12.","DOI":"10.3390\/insects12080688"},{"key":"ref_20","first-page":"205","article-title":"Effect of Honeybee Pollination on Seed and Fruit Yield of Agricultural Crops in Ethiopia","volume":"4","author":"Bareke","year":"2019","journal-title":"MOJ Ecol. Environ. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/S0140-6736(15)61085-6","article-title":"Effects of Decreases of Animal Pollinators on Human Nutrition and Global Health: A Modelling Analysis","volume":"386","author":"Smith","year":"2015","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.cub.2009.03.071","article-title":"The Global Stock of Domesticated Honey Bees Is Growing Slower Than Agricultural Demand for Pollination","volume":"19","author":"Aizen","year":"2009","journal-title":"Curr. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"20200922","DOI":"10.1098\/rspb.2020.0922","article-title":"Crop Production in the USA Is Frequently Limited by a Lack of Pollinators","volume":"287","author":"Reilly","year":"2020","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"R1125","DOI":"10.1016\/j.cub.2008.10.038","article-title":"Honeybee Buzz Attenuates Plant Damage by Caterpillars","volume":"18","author":"Tautz","year":"2008","journal-title":"Curr. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"18280","DOI":"10.1038\/s41598-022-23310-w","article-title":"Honey Compositional Convergence and the Parallel Domestication of Social Bees","volume":"12","author":"Noiset","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1046\/j.1365-2435.2000.00443.x","article-title":"Long-range Foraging by the Honey-bee, Apis mellifera L","volume":"14","author":"Beekman","year":"2000","journal-title":"Funct. Ecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/00387010.2019.1615957","article-title":"Rapid Detection of Sucrose Adulteration in Honey Using Fourier Transform Infrared Spectroscopy","volume":"52","author":"Cengiz","year":"2019","journal-title":"Spectrosc. Lett."},{"key":"ref_28","unstructured":"European Commission (2024, June 18). EU Coordinated Action \u201cFrom the Hives\u201d (Honey 2021\u20132022). Available online: https:\/\/food.ec.europa.eu\/safety\/eu-agri-food-fraud-network\/eu-coordinated-actions\/honey-2021-2022_en."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Kumar, N., Ranjan, R., Kumar, Y., Patel, S.S., Sai Krishna, V., Appaiah, A., Gupta, K., and Panchariya, P. (2021, January 19\u201320). Discrimination of Various Pure Honey Samples and Its Adulterants Using FTIR Spectroscopy Coupled with Chemometrics. Proceedings of the 2021 7th International Conference on Advanced Computing and Communication Systems (ICACCS), Coimbatore, India.","DOI":"10.1109\/ICACCS51430.2021.9441971"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Pauliuc, D., Dranca, F., Ropciuc, S., and Oroian, M. (2022). Advanced Characterization of Monofloral Honeys from Romania. Agriculture, 12.","DOI":"10.3390\/agriculture12040526"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/MJT.0b013e318293b09b","article-title":"Antimicrobial Properties of Honey","volume":"21","author":"Israili","year":"2014","journal-title":"Am. J. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.tifs.2021.11.012","article-title":"Honey Antibacterial Activity: A Neglected Aspect of Honey Quality Assurance as Functional Food","volume":"118","author":"Majtan","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Mustar, S., and Ibrahim, N. (2022). A Sweeter Pill to Swallow: A Review of Honey Bees and Honey as a Source of Probiotic and Prebiotic Products. Foods, 11.","DOI":"10.3390\/foods11142102"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Hills, S.P., Mitchell, P., Wells, C., and Russell, M. (2019). Honey Supplementation and Exercise: A Systematic Review. Nutrients, 11.","DOI":"10.3390\/nu11071586"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.tifs.2020.02.001","article-title":"Composition and Functionality of Bee Pollen: A Review","volume":"98","author":"Thakur","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_36","unstructured":"Ch\u00e9zeries, J.-F. (1984). A Sa\u00fade Pelo Mel e Produtos Da Colmeia, Litexa Editora."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Zullkiflee, N., Taha, H., and Usman, A. (2022). Propolis: Its Role and Efficacy in Human Health and Diseases. Molecules, 27.","DOI":"10.3390\/molecules27186120"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/med.21866","article-title":"The Antiviral and Immunomodulatory Activities of Propolis: An Update and Future Perspectives for Respiratory Diseases","volume":"42","author":"Magnavacca","year":"2022","journal-title":"Med. Res. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"100239","DOI":"10.1016\/j.phyplu.2022.100239","article-title":"An Overview about Apitherapy and Its Clinical Applications","volume":"2","author":"Weis","year":"2022","journal-title":"Phytomed. Plus"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/ACI.0b013e32830638c5","article-title":"Epidemiology of Insect-Venom Anaphylaxis","volume":"8","author":"Bonifazi","year":"2008","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"599080","DOI":"10.3389\/fphar.2020.599080","article-title":"The Potential Use of Honey as a Remedy for Allergic Diseases: A Mini Review","volume":"11","author":"Islam","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6833","DOI":"10.1021\/acs.jafc.1c05822","article-title":"Bee Products: An Emblematic Example of Underutilized Sources of Bioactive Compounds","volume":"70","author":"Giampieri","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_43","first-page":"17143","article-title":"Investigating the Protein-Based Therapeutic Relationship between Honey Protein SHP-60 and Bevacizumab on Angiogenesis: Exploring the Synergistic Effect through In Vitro and in Silico Analysis","volume":"9","author":"Wahid","year":"2024","journal-title":"ACS Omega"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Qanash, H., Bazaid, A.S., Binsaleh, N.K., Patel, M., Althomali, O.W., and Sheeha, B. (2023). Bin In Vitro Antiproliferative Apoptosis Induction and Cell Cycle Arrest Potential of Saudi Sidr Honey against Colorectal Cancer. Nutrients, 15.","DOI":"10.3390\/nu15153448"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Mart\u00edn, V., Morales, P., Iriondo-DeHond, A., Hospital, X.F., Fern\u00e1ndez, M., Hierro, E., and Haza, A.I. (2023). Differential Apoptotic Effects of Bee Product Mixtures on Normal and Cancer Hepatic Cells. Antioxidants, 12.","DOI":"10.3390\/antiox12030615"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s42690-023-01070-y","article-title":"Antimicrobial Properties of Honeys Produced by Stingless Bees (Hymenoptera, Apidae, Meliponini) from Different Vegetation Zones of Tanzania","volume":"43","author":"Mduda","year":"2023","journal-title":"Int. J. Trop. Insect Sci."},{"key":"ref_47","first-page":"100622","article-title":"Seasons and Bee Foraging Plant Species Strongly Influence Honey Antimicrobial Activity","volume":"12","author":"Rikohe","year":"2023","journal-title":"J. Agric. Food Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Skadi\u0146\u0161, I., Labsv\u0101rds, K.D., Grava, A., Amirian, J., Tomsone, L.E., Ru\u0161ko, J., Viksna, A., Bandere, D., and Brangule, A. (2023). Antimicrobial and Antibiofilm Properties of Latvian Honey against Causative Agents of Wound Infections. Antibiotics, 12.","DOI":"10.3390\/antibiotics12050816"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.2147\/IDR.S410159","article-title":"Effects of Repeated In-Vitro Exposure to Saudi Honey on Bacterial Resistance to Antibiotics and Biofilm Formation","volume":"16","author":"Aldarhami","year":"2023","journal-title":"Infect. Drug Resist."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Clare, J., Lindley, M.R., and Ratcliffe, E. (2024). The Antimicrobial and Antibiofilm Abilities of Fish Oil Derived Polyunsaturated Fatty Acids and Manuka Honey. Microorganisms, 12.","DOI":"10.3390\/microorganisms12040778"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1157506","DOI":"10.3389\/fimmu.2023.1157506","article-title":"Castanea Crenata Honey Reduces Influenza Infection by Activating the Innate Immune Response","volume":"14","author":"Kwon","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Lin, B., Nair, S., Fellner, D.M.J., Nasef, N.A., Singh, H., Negron, L., Goldstone, D.C., Brimble, M.A., Gerrard, J.A., and Domigan, L. (2023). The Leptospermum Scoparium (M\u0101nuka)-Specific Nectar and Honey Compound 3,6,7-Trimethyllumazine (LepteridineTM) That Inhibits Matrix Metalloproteinase 9 (MMP-9) Activity. Foods, 12.","DOI":"10.3390\/foods12224072"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"110700","DOI":"10.1016\/j.vetimm.2023.110700","article-title":"Impact of Apitherapy on Canine, Equine, and Chicken Lymphocytes, In Vitro","volume":"268","author":"Turn","year":"2024","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s12906-023-04129-y","article-title":"The Anti-Allergic Potential of Stingless Bee Honey from Different Botanical Sources via Modulation of Mast Cell Degranulation","volume":"23","author":"Yong","year":"2023","journal-title":"BMC Complement Med. Ther."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"128937","DOI":"10.1016\/j.ijbiomac.2023.128937","article-title":"Structural Characterization of a Polysaccharide from Alhagi Honey and Its Protective Effect against Inflammatory Bowel Disease by Modulating Gut Microbiota Dysbiosis","volume":"259","author":"Song","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"117552","DOI":"10.1016\/j.jep.2023.117552","article-title":"A Polysaccharide from Alhagi Honey Protects the Intestinal Barrier and Regulates the Nrf2\/HO-1-TLR4\/MAPK Signaling Pathway to Treat Alcoholic Liver Disease in Mice","volume":"321","author":"Song","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_57","first-page":"153","article-title":"Administration Safety of Medical-Grade Honey (MGH) in Septic Synovial Structures in Horses: 3 Cases","volume":"87","author":"Terschuur","year":"2023","journal-title":"Can. J. Vet. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bjorl.2021.08.007","article-title":"The Effect of Honey on Post-Tonsillectomy Pain Relief: A Randomized Clinical Trial","volume":"89","author":"Lubis","year":"2023","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Juri\u010d, A., Br\u010di\u0107 Kara\u010donji, I., Ga\u0161i\u0107, U., Milojkovi\u0107 Opsenica, D., Pr\u0111un, S., Bubalo, D., Lu\u0161i\u0107, D., Vah\u010di\u0107, N., and Kopjar, N. (2023). Protective Effects of Arbutus unedo L. Honey in the Alleviation of Irinotecan-Induced Cytogenetic Damage in Human Lymphocytes\u2014An In Vitro Study. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24031903"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.47836\/ifrj.30.6.11","article-title":"A 28-Day Subacute Oral Toxicity Study of Apis cerana (Fabricius) Honey in Wistar Rats","volume":"30","author":"Du","year":"2023","journal-title":"Int. Food Res. J."},{"key":"ref_61","first-page":"1835","article-title":"SOD2 and HIF-1\u03b1 Expression in Rat Ovaries (Rattus norvegicus) Administered with Forest Bee Honey (Apis dorsata) Following Physical Stress","volume":"12","author":"Plumeriastuti","year":"2023","journal-title":"Bali Med. J."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Gouletsou, P.G., Zacharopoulou, T., Skampardonis, V., Georgiou, S.G., Doukas, D., Galatos, A.D., Flouraki, E., Dermisiadou, E., Margeti, C., and Barbagianni, M. (2024). First-Intention Incisional Wound Healing in Dogs and Cats: A Controlled Trial of Dermapliq and Manuka Honey. Vet. Sci., 11.","DOI":"10.3390\/vetsci11020064"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Di Noi, A., Casini, S., Campani, T., Cai, G., and Caliani, I. (2021). Review on Sublethal Effects of Environmental Contaminants in Honey Bees (Apis mellifera), Knowledge Gaps and Future Perspectives. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18041863"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Martinello, M., Manzinello, C., Dainese, N., Giuliato, I., Gallina, A., and Mutinelli, F. (2021). The Honey Bee: An Active Biosampler of Environmental Pollution and a Possible Warning Biomarker for Human Health. Appl. Sci., 11.","DOI":"10.3390\/app11146481"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"122257","DOI":"10.1016\/j.envpol.2023.122257","article-title":"Tracing Nickel Smelter Emissions Using European Honey Bees","volume":"335","author":"Taylor","year":"2023","journal-title":"Environ. Pollut."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev-ento-031616-035115","article-title":"Beekeeping from Antiquity through the Middle Ages","volume":"62","author":"Kritsky","year":"2017","journal-title":"Annu. Rev. Entomol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/0268580919870454","article-title":"The Deep Origins of Society: An Assessment of E.O. Wilson\u2019s Genesis","volume":"34","author":"Turner","year":"2019","journal-title":"Int. Sociol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"13367","DOI":"10.1073\/pnas.0505858102","article-title":"Eusociality: Origin and Consequences","volume":"102","author":"Wilson","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"jeb193888","DOI":"10.1242\/jeb.193888","article-title":"Effects of Group Size on Learning and Memory in the Honey Bee Apis mellifera","volume":"222","author":"Tsvetkov","year":"2019","journal-title":"J. Exp. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/pan3.10206","article-title":"Beekeeping in, of or for the City? A Socioecological Perspective on Urban Apiculture","volume":"3","author":"Sponsler","year":"2021","journal-title":"People Nat."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nrn3357","article-title":"The Honeybee as a Model for Understanding the Basis of Cognition","volume":"13","author":"Menzel","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.aar4975","article-title":"Numerical Ordering of Zero in Honey Bees","volume":"360","author":"Howard","year":"2018","journal-title":"Science"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e0247294","DOI":"10.1371\/journal.pone.0247294","article-title":"A Model of Infection in Honeybee Colonies with Social Immunity","volume":"16","author":"Laomettachit","year":"2021","journal-title":"PLoS ONE"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e23019","DOI":"10.1002\/dvg.23019","article-title":"The Honeybee as a Model Insect for Developmental Genetics","volume":"55","author":"Cridge","year":"2017","journal-title":"Genesis"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41430-021-00991-6","article-title":"Role of the Gut Microbiome in Chronic Diseases: A Narrative Review","volume":"76","author":"Vijay","year":"2022","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fevo.2020.00022","article-title":"Understanding the Effects of Sublethal Pesticide Exposure on Honey Bees: A Role for Probiotics as Mediators of Environmental Stress","volume":"8","author":"Chmiel","year":"2020","journal-title":"Front. Ecol. Evol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e02164","DOI":"10.1128\/mBio.02164-15","article-title":"The Bee Microbiome: Impact on Bee Health and Model for Evolution and Ecology of Host-Microbe Interactions","volume":"7","author":"Engel","year":"2016","journal-title":"mBio"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41684-018-0173-x","article-title":"Honey Bees as Models for Gut Microbiota Research","volume":"47","author":"Zheng","year":"2018","journal-title":"Lab. Anim."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1111\/j.1748-5967.2008.00170.x","article-title":"Perspectives of Multi-modal Contribution of Honeybee Resources to Our Life","volume":"38","author":"Hoshiba","year":"2008","journal-title":"Entomol. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1152\/physrev.00005.2010","article-title":"Honeybees as a Model for the Study of Visually Guided Flight, Navigation, and Biologically Inspired Robotics","volume":"91","author":"Srinivasan","year":"2011","journal-title":"Physiol. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Sabo, C., Yavuz, E., Cope, A., Gurney, K., Vasilaki, E., Nowotny, T., and Marshall, J.A.R. (2017, January 14\u201319). An Inexpensive Flying Robot Design for Embodied Robotics Research. Proceedings of the 2017 International Joint Conference on Neural Networks (IJCNN), Anchorage, AK, USA.","DOI":"10.1109\/IJCNN.2017.7966383"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1109\/MC.2004.119","article-title":"BEES: Exploring Mars with Bioinspired Technologies","volume":"37","author":"Thakoor","year":"2004","journal-title":"Computer"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Hoogendoorn, M., Schut, M.C., and Treur, J. (2007). Modeling Decentralized Organizational Change in Honeybee Societies. Advances in Artificial Life, Springer.","DOI":"10.1007\/978-3-540-74913-4_62"},{"key":"ref_84","unstructured":"Hewlett Packard Enterprise (2024, June 18). Swarm Intelligence. Available online: https:\/\/www.hpe.com\/pt\/en\/what-is\/swarm-intelligence.html."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e21354","DOI":"10.1371\/journal.pone.0021354","article-title":"Analysis of the Waggle Dance Motion of Honeybees for the Design of a Biomimetic Honeybee Robot","volume":"6","author":"Landgraf","year":"2011","journal-title":"PLoS ONE"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/0005772X.1999.11099453","article-title":"Recent Research on the World History of Beekeeping","volume":"80","author":"Crane","year":"1999","journal-title":"Bee World"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2993\/0278-0771-40.3.386","article-title":"The Origins of Maya Stingless Beekeeping","volume":"40","author":"Paris","year":"2020","journal-title":"J. Ethnobiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/0005772X.1983.11097916","article-title":"Experiences with Plastic Combs and Foundation","volume":"64","author":"Weiss","year":"1983","journal-title":"Bee World"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e0216286","DOI":"10.1371\/journal.pone.0216286","article-title":"Reduced Density and Visually Complex Apiaries Reduce Parasite Load and Promote Honey Production and Overwintering Survival in Honey Bees","volume":"14","author":"Dynes","year":"2019","journal-title":"PLoS ONE"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e2001861","DOI":"10.1371\/journal.pbio.2001861","article-title":"Antibiotic Exposure Perturbs the Gut Microbiota and Elevates Mortality in Honeybees","volume":"15","author":"Raymann","year":"2017","journal-title":"PLoS Biol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Rodet, G. (2019). The Man and the Bees: A Coviability Issue\u2014Beekeeping Can It Be Intensively Farmed?. Coviability of Social and Ecological Systems: Reconnecting Mankind to the Biosphere in an Era of Global Change, Springer International Publishing.","DOI":"10.1007\/978-3-319-78111-2_16"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e0172591","DOI":"10.1371\/journal.pone.0172591","article-title":"A Pan-European Epidemiological Study Reveals Honey Bee Colony Survival Depends on Beekeeper Education and Disease Control","volume":"12","author":"Jacques","year":"2017","journal-title":"PLoS ONE"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Sonmez Oskay, G., Uygur, G.S., Oskay, D., and Arda, N. (2023). Impact of Stress Factors Internal and External to the Hive on Honey Bees and Their Reflection on Honey Bee Products: A Review. J. Apic. Res., 1\u201316.","DOI":"10.1080\/00218839.2023.2247840"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Hristov, P., Shumkova, R., Palova, N., and Neov, B. (2020). Factors Associated with Honey Bee Colony Losses: A Mini-Review. Vet. Sci., 7.","DOI":"10.3390\/vetsci7040166"},{"key":"ref_95","unstructured":"Chauzat, M.-P., Laurent, M., Riviere, M.-P., Saugeon, C., Hendrikx, P., and Ribiere-Chabert, M. (2024, June 18). A Pan-European Epidemiological Study on Honeybee Colony Losses 2012\u20132013. Available online: https:\/\/food.ec.europa.eu\/system\/files\/2017-04\/la_bees_epilobee-report_2012-2013.pdf."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Laurino, D., Lioy, S., Carisio, L., Manino, A., and Porporato, M. (2019). Vespa Velutina: An Alien Driver of Honey Bee Colony Losses. Diversity, 12.","DOI":"10.3390\/d12010005"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Peck, D.T. (2021). The Parasitic Mite Varroa destructor. Honey Bee Medicine for the Veterinary Practitioner, Wiley.","DOI":"10.1002\/9781119583417.ch20"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e0242393","DOI":"10.1371\/journal.pone.0242393","article-title":"One Health, One Hive: A Scoping Review of Honey Bees, Climate Change, Pollutants, and Antimicrobial Resistance","volume":"17","author":"Harper","year":"2022","journal-title":"PLoS ONE"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"107506","DOI":"10.1016\/j.jip.2020.107506","article-title":"One Health Implications of Infectious Diseases of Wild and Managed Bees","volume":"186","author":"Wilfert","year":"2021","journal-title":"J. Invertebr. Pathol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Negri, P., Villalobos, E., Szawarski, N., Damiani, N., Gende, L., Garrido, M., Maggi, M., Quintana, S., Lamattina, L., and Eguaras, M. (2019). Towards Precision Nutrition: A Novel Concept Linking Phytochemicals, Immune Response and Honey Bee Health. Insects, 10.","DOI":"10.3390\/insects10110401"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1007\/s00248-020-01538-1","article-title":"Impact of Nutritional Stress on Honeybee Gut Microbiota, Immunity, and Nosema Ceranae Infection","volume":"80","author":"Castelli","year":"2020","journal-title":"Microb. Ecol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s13593-015-0302-5","article-title":"Weeds for Bees? A Review","volume":"35","author":"Bretagnolle","year":"2015","journal-title":"Agron. Sustain. Dev."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"144116","DOI":"10.1016\/j.scitotenv.2020.144116","article-title":"Neonicotinoids in the Agroecosystem: In-Field Long-Term Assessment on Honeybee Colony Strength and Microbiome","volume":"762","author":"Alberoni","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.scitotenv.2018.11.004","article-title":"Effect of the Climate Change on Honey Bee Colonies in a Temperate Mediterranean Zone Assessed through Remote Hive Weight Monitoring System in Conjunction with Exhaustive Colonies Assessment","volume":"653","author":"Flores","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Tilocca, B., Greco, V., Piras, C., Ceniti, C., Paonessa, M., Musella, V., Bava, R., Palma, E., Morittu, V.M., and Spina, A.A. (2024). The Bee Gut Microbiota: Bridging Infective Agents Potential in the One Health Context. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073739"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"17285","DOI":"10.1007\/s11356-017-9240-x","article-title":"The Environmental Risks of Neonicotinoid Pesticides: A Review of the Evidence Post 2013","volume":"24","author":"Wood","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nature14414","article-title":"Bees Prefer Foods Containing Neonicotinoid Pesticides","volume":"521","author":"Kessler","year":"2015","journal-title":"Nature"},{"key":"ref_108","first-page":"3295","article-title":"Revised Guidance on the Risk Assessment of Plant Protection Products on Bees (Apis mellifera, Bombus spp. and Solitary bees)","volume":"21","author":"Adriaanse","year":"2023","journal-title":"EFSA J."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"15217","DOI":"10.1038\/s41598-017-15581-5","article-title":"Field-Relevant Doses of the Systemic Insecticide Fipronil and Fungicide Pyraclostrobin Impair Mandibular and Hypopharyngeal Glands in Nurse Honeybees (Apis mellifera)","volume":"7","author":"Zaluski","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"10305","DOI":"10.1073\/pnas.1803880115","article-title":"Glyphosate Perturbs the Gut Microbiota of Honey Bees","volume":"115","author":"Motta","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Kasiotis, K.M., Zafeiraki, E., Manea-Karga, E., Anastasiadou, P., and Machera, K. (2023). Pesticide Residues and Metabolites in Greek Honey and Pollen: Bees and Human Health Risk Assessment. Foods, 12.","DOI":"10.3390\/foods12040706"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.foodchem.2016.09.001","article-title":"Application of Analytical Methods in Authentication and Adulteration of Honey","volume":"217","author":"Siddiqui","year":"2017","journal-title":"Food Chem."},{"key":"ref_113","unstructured":"Food and Agriculture Organization of the United Nations (2024, June 18). SDG Indicators Data Portal. Available online: https:\/\/www.fao.org\/sustainable-development-goals-data-portal\/data\/indicators\/2.1.1-prevalence-of-undernourishment\/en#:~:text=Global%20hunger%20remained%20relatively%20unchanged,world%20faced%20hunger%20in%202022."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/1749-4877.12714","article-title":"The Honeybee Gut Resistome and Its Role in Antibiotic Resistance Dissemination","volume":"18","author":"Sun","year":"2023","journal-title":"Integr. Zool."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"125","DOI":"10.12688\/openreseurope.17664.1","article-title":"Antibiotics in Honey: A Comprehensive Review on Occurrence and Analytical Methodologies","volume":"4","author":"Rodrigues","year":"2024","journal-title":"Open Res. Eur."},{"key":"ref_116","first-page":"265","article-title":"Impact of Legislation on Antibiotic Use and Awareness of Beekeepers","volume":"65","author":"Croppi","year":"2021","journal-title":"J. Apic. Sci."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Donkersley, P., Elsner-Adams, E., and Maderson, S. (2020). A One-Health Model for Reversing Honeybee (Apis mellifera L.) Decline. Vet. Sci., 7.","DOI":"10.3390\/vetsci7030119"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"437","DOI":"10.24099\/vet.arhiv.1444","article-title":"Veterinarians and Beekeeping: What Roles, Expectations and Future Perspectives?\u2014A Review Paper","volume":"91","author":"Formato","year":"2021","journal-title":"Vet. Arh."}],"container-title":["Environments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3298\/11\/8\/161\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:24:19Z","timestamp":1760109859000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3298\/11\/8\/161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,26]]},"references-count":118,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["environments11080161"],"URL":"https:\/\/doi.org\/10.3390\/environments11080161","relation":{},"ISSN":["2076-3298"],"issn-type":[{"value":"2076-3298","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,26]]}}}