{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:29:36Z","timestamp":1760059776898,"version":"build-2065373602"},"reference-count":125,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Aqua-CLIMADAPT","award":["PTDC\/CTA-AMB\/0592\/2021","UIDB\/04378\/2020","LA\/P\/0140\/2020","2020.04413.BD"],"award-info":[{"award-number":["PTDC\/CTA-AMB\/0592\/2021","UIDB\/04378\/2020","LA\/P\/0140\/2020","2020.04413.BD"]}]},{"name":"FCT\/MCTES","award":["PTDC\/CTA-AMB\/0592\/2021","UIDB\/04378\/2020","LA\/P\/0140\/2020","2020.04413.BD"],"award-info":[{"award-number":["PTDC\/CTA-AMB\/0592\/2021","UIDB\/04378\/2020","LA\/P\/0140\/2020","2020.04413.BD"]}]},{"name":"Associate Laboratory Institute for Health and Bioeconomy\u2014i4HB","award":["PTDC\/CTA-AMB\/0592\/2021","UIDB\/04378\/2020","LA\/P\/0140\/2020","2020.04413.BD"],"award-info":[{"award-number":["PTDC\/CTA-AMB\/0592\/2021","UIDB\/04378\/2020","LA\/P\/0140\/2020","2020.04413.BD"]}]},{"name":"FCT I.P.","award":["PTDC\/CTA-AMB\/0592\/2021","UIDB\/04378\/2020","LA\/P\/0140\/2020","2020.04413.BD"],"award-info":[{"award-number":["PTDC\/CTA-AMB\/0592\/2021","UIDB\/04378\/2020","LA\/P\/0140\/2020","2020.04413.BD"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fishes"],"abstract":"<jats:p>The need to maximize aquaculture production while addressing environmental and food security challenges posed by climate change has driven research towards the development of functional aquafeeds that enhance performance and immunity in farmed species. However, exposure to dietary and environmental stressors affects marine organisms, altering key metabolic pathways best understood through high-throughput \u201comics\u201d tools. This study assessed the effects of Asparagopsis taxiformis supplementation on central metabolic pathways by analyzing changes in primary metabolite levels in the liver of farmed Diplodus sargus under optimal and suboptimal temperature conditions. Results showed that seaweed supplementation had a beneficial effect on the fish\u2019s primary metabolome; however, inclusion levels and rearing conditions played a crucial role in determining outcomes. While 1.5% supplementation maintained a balanced primary metabolome under optimal temperature conditions, 3.0% supplementation most effectively mitigated the adverse effects of acute thermal stress during a marine heatwave. These findings highlight the nutritive and functional potential of A. taxiformis supplementation in aquafeeds for marine omnivorous fish species and emphasize the importance of evaluating functional aquafeeds under suboptimal rearing conditions. Overall, our results demonstrate the value of metabolomics in elucidating the molecular basis underlying biological pathways in farmed marine fish and optimizing production through climate-smart dietary strategies.<\/jats:p>","DOI":"10.3390\/fishes10070350","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T09:45:52Z","timestamp":1752572752000},"page":"350","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asparagopsis taxiformis Feed Supplementation as a Tool to Improve the Resilience of Farmed Diplodus sargus to Marine Heatwave Events\u2014A Metabolomics Approach"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0447-6009","authenticated-orcid":false,"given":"Marta","family":"Dias","sequence":"first","affiliation":[{"name":"CIIMAR\u2014Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Avenida General Norton de Matos S\/N, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5518-5338","authenticated-orcid":false,"given":"Isa","family":"Marmelo","sequence":"additional","affiliation":[{"name":"CIIMAR\u2014Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Avenida General Norton de Matos S\/N, 4450-208 Matosinhos, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"},{"name":"IPMA DivAV\u2014Division of Aquaculture, Upgrading and Bioprospection, Portuguese Institute for the Sea and Atmosphere, Avenida Doutor Alfredo Magalh\u00e3es Ramalho, 6, 1495-165 Alg\u00e9s, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6747-1243","authenticated-orcid":false,"given":"Carla","family":"Ant\u00f3nio","sequence":"additional","affiliation":[{"name":"Plant Metabolomics Lab Portugal, 1349-017 Lisboa, Portugal"},{"name":"Forest Research Centre, Associate Laboratory TERRA, School of Agriculture, University of Lisbon, Tapada da Ajuda, 1349-017 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3257-9777","authenticated-orcid":false,"given":"Ana M.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Plant Metabolomics Lab Portugal, 1349-017 Lisboa, Portugal"},{"name":"Forest Research Centre, Associate Laboratory TERRA, School of Agriculture, University of Lisbon, Tapada da Ajuda, 1349-017 Lisboa, Portugal"},{"name":"iBET\u2014Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, 2781-901 Oeiras, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6745-745X","authenticated-orcid":false,"given":"Ant\u00f3nio","family":"Marques","sequence":"additional","affiliation":[{"name":"CIIMAR\u2014Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Avenida General Norton de Matos S\/N, 4450-208 Matosinhos, Portugal"},{"name":"IPMA DivAV\u2014Division of Aquaculture, Upgrading and Bioprospection, Portuguese Institute for the Sea and Atmosphere, Avenida Doutor Alfredo Magalh\u00e3es Ramalho, 6, 1495-165 Alg\u00e9s, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-0366","authenticated-orcid":false,"given":"M\u00e1rio S.","family":"Diniz","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"}]},{"given":"Ana Lu\u00edsa","family":"Maulvault","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"},{"name":"IPMA DivAV\u2014Division of Aquaculture, Upgrading and Bioprospection, Portuguese Institute for the Sea and Atmosphere, Avenida Doutor Alfredo Magalh\u00e3es Ramalho, 6, 1495-165 Alg\u00e9s, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"ref_1","unstructured":"FAO (2022). 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