{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:11:23Z","timestamp":1772820683870,"version":"3.50.1"},"reference-count":133,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T00:00:00Z","timestamp":1657929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Portuguese Foundation for Science and Technology (FCT)","award":["FCT-NSFC\/0002\/2016"],"award-info":[{"award-number":["FCT-NSFC\/0002\/2016"]}]},{"name":"Portuguese Foundation for Science and Technology (FCT)","award":["PTDC\/BIAANM\/3484\/2014"],"award-info":[{"award-number":["PTDC\/BIAANM\/3484\/2014"]}]},{"name":"Portuguese Foundation for Science and Technology (FCT)","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"Portuguese Foundation for Science and Technology (FCT)","award":["SFRH\/BD\/120040\/2016"],"award-info":[{"award-number":["SFRH\/BD\/120040\/2016"]}]},{"name":"Portuguese Foundation for Science and Technology (FCT)","award":["DL 57\/2016\/CP1361\/CT0005"],"award-info":[{"award-number":["DL 57\/2016\/CP1361\/CT0005"]}]},{"name":"Portuguese Polar Programme FACC PROPOLAR 2016\u20132017","award":["FCT-NSFC\/0002\/2016"],"award-info":[{"award-number":["FCT-NSFC\/0002\/2016"]}]},{"name":"Portuguese Polar Programme FACC PROPOLAR 2016\u20132017","award":["PTDC\/BIAANM\/3484\/2014"],"award-info":[{"award-number":["PTDC\/BIAANM\/3484\/2014"]}]},{"name":"Portuguese Polar Programme FACC PROPOLAR 2016\u20132017","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"Portuguese Polar Programme FACC PROPOLAR 2016\u20132017","award":["SFRH\/BD\/120040\/2016"],"award-info":[{"award-number":["SFRH\/BD\/120040\/2016"]}]},{"name":"Portuguese Polar Programme FACC PROPOLAR 2016\u20132017","award":["DL 57\/2016\/CP1361\/CT0005"],"award-info":[{"award-number":["DL 57\/2016\/CP1361\/CT0005"]}]},{"name":"PhD fellowship","award":["FCT-NSFC\/0002\/2016"],"award-info":[{"award-number":["FCT-NSFC\/0002\/2016"]}]},{"name":"PhD fellowship","award":["PTDC\/BIAANM\/3484\/2014"],"award-info":[{"award-number":["PTDC\/BIAANM\/3484\/2014"]}]},{"name":"PhD fellowship","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"PhD fellowship","award":["SFRH\/BD\/120040\/2016"],"award-info":[{"award-number":["SFRH\/BD\/120040\/2016"]}]},{"name":"PhD fellowship","award":["DL 57\/2016\/CP1361\/CT0005"],"award-info":[{"award-number":["DL 57\/2016\/CP1361\/CT0005"]}]},{"name":"University of Algarve","award":["FCT-NSFC\/0002\/2016"],"award-info":[{"award-number":["FCT-NSFC\/0002\/2016"]}]},{"name":"University of Algarve","award":["PTDC\/BIAANM\/3484\/2014"],"award-info":[{"award-number":["PTDC\/BIAANM\/3484\/2014"]}]},{"name":"University of Algarve","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"University of Algarve","award":["SFRH\/BD\/120040\/2016"],"award-info":[{"award-number":["SFRH\/BD\/120040\/2016"]}]},{"name":"University of Algarve","award":["DL 57\/2016\/CP1361\/CT0005"],"award-info":[{"award-number":["DL 57\/2016\/CP1361\/CT0005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fishes"],"abstract":"<jats:p>The environmental conditions and isolation in the Antarctic have driven the evolution of a unique biodiversity at a macro to microorganism scale. Here, we investigated the possible adaptation of the teleost Nototheniacoriiceps immune system to the cold environment and unique microbial community of the Southern Ocean. The fish immune system was stimulated through an intraperitoneal injection of lipopolysaccharide (LPS 0111:B4 from E. coli) and the tissue transcriptomic response and plasma biochemistry were analyzed 7 days later and compared to a sham injected control. Gene transcription in the head-kidney, intestine and skin was significantly modified by LPS, although tissues showed different responsiveness, with the duodenum most modified and the skin the least modified. The most modified processes in head-kidney, duodenum and skin were related to cell metabolism (up-regulated) and the immune system (comprising 30% of differentially expressed genes). The immune processes identified were mostly down-regulated, particularly interleukins and pattern recognition receptors (PRRs), nucleotide-binding oligomerization domain-like receptors and mannose receptors, unlike the toll-like receptors response commonly described in other teleost fish. The modified transcriptional response was not mirrored by a modified systemic response, as the circulating levels of enzymes of innate immunity, lysozyme and antiproteases, were not significantly different from the untreated and sham control fish. In conclusion, while the N.coriiceps immune system shares many features with other teleosts there are also some specificities. Further studies should better characterize the PRRs and their role in Antarctic teleosts, as well as the importance of the LPS source and its consequences for immune activation in teleosts.<\/jats:p>","DOI":"10.3390\/fishes7040171","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T21:00:28Z","timestamp":1658091628000},"page":"171","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Transcriptomic Down-Regulation of Immune System Components in Barrier and Hematopoietic Tissues after Lipopolysaccharide Injection in Antarctic Notothenia coriiceps"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-1932","authenticated-orcid":false,"given":"C\u00e1rmen S. V.","family":"Sousa","sequence":"first","affiliation":[{"name":"CCMAR-CIMAR LA Centre for Marine Sciences, Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1366-0246","authenticated-orcid":false,"given":"Deborah M.","family":"Power","sequence":"additional","affiliation":[{"name":"CCMAR-CIMAR LA Centre for Marine Sciences, Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal"},{"name":"International Research Centre for Marine Biosciences, Ministry of Science and Technology, Shanghai Ocean University, Shanghai 201306, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5371-7919","authenticated-orcid":false,"given":"Pedro M.","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"CCMAR-CIMAR LA Centre for Marine Sciences, Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8164-581X","authenticated-orcid":false,"given":"Bruno","family":"Louro","sequence":"additional","affiliation":[{"name":"CCMAR-CIMAR LA Centre for Marine Sciences, Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0717-8536","authenticated-orcid":false,"given":"Liangbiao","family":"Chen","sequence":"additional","affiliation":[{"name":"International Research Centre for Marine Biosciences, Ministry of Science and Technology, Shanghai Ocean University, Shanghai 201306, China"},{"name":"Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai 201306, China"},{"name":"National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6244-6468","authenticated-orcid":false,"given":"Adelino V. M.","family":"Can\u00e1rio","sequence":"additional","affiliation":[{"name":"CCMAR-CIMAR LA Centre for Marine Sciences, Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal"},{"name":"International Research Centre for Marine Biosciences, Ministry of Science and Technology, Shanghai Ocean University, Shanghai 201306, China"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1029\/RG024i003p00469","article-title":"The Physics of the Antarctic Circumpolar Current","volume":"24","author":"Nowlin","year":"1986","journal-title":"Rev. Geophys."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1098\/rstb.2006.1958","article-title":"Climate Change and the Marine Ecosystem of the Western Antarctic Peninsula","volume":"362","author":"Clarke","year":"2007","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Rintoul, S.R. (2009). Antarctic Circumpolar Current. Encyclopedia of Ocean Sciences, Elsevier.","DOI":"10.1016\/B978-012374473-9.00603-2"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1186\/s13059-014-0468-1","article-title":"The Genome Sequence of the Antarctic Bullhead Notothen Reveals Evolutionary Adaptations to a Cold Environment","volume":"15","author":"Shin","year":"2014","journal-title":"Genome Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1126\/science.163.3871.1073","article-title":"Freezing Resistance in Some Antarctic Fishes","volume":"163","author":"DeVries","year":"1969","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1546-5098(04)22004-0","article-title":"Antifreeze Proteins and Organismal Freezing Avoidance in Polar Fishes","volume":"22","author":"DeVries","year":"2005","journal-title":"Fish Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/46721","article-title":"Evolution of an Antifreeze Glycoprotein","volume":"401","author":"Cheng","year":"1999","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41559-019-0812-7","article-title":"Antarctic Blackfin Icefish Genome Reveals Adaptations to Extreme Environments","volume":"3","author":"Kim","year":"2019","journal-title":"Nat. Ecol. Evol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Albertson, R.C., Yan, Y.L., Titus, T.A., Pisano, E., Vacchi, M., Yelick, P.C., Detrich, H.W., and Postlethwait, J.H. (2010). Molecular Pedomorphism Underlies Craniofacial Skeletal Evolution in Antarctic Notothenioid Fishes. BMC Evol. Biol., 10.","DOI":"10.1186\/1471-2148-10-4"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"10085","DOI":"10.1021\/bi00452a031","article-title":"Polymerization of Antarctic Fish Tubulins at Low Temperatures: Energetic Aspects","volume":"28","author":"Detrich","year":"1989","journal-title":"Biochemistry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"37038","DOI":"10.1074\/jbc.M005699200","article-title":"Cold Adaptation of Microtubule Assembly and Dynamics. Structural Interpretation of Primary Sequence Changes Present in the \u03b1- and \u03b2-Tubulins of Antarctic Fishes","volume":"275","author":"Detrich","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1242\/jeb.203.8.1287","article-title":"The Interplay among Cardiac Ultrastructure, Metabolism and the Expression of Oxygen-Binding Proteins in Antarctic Fishes","volume":"203","author":"Sidell","year":"2000","journal-title":"J. Exp. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"R1195","DOI":"10.1152\/ajpregu.00660.2004","article-title":"Comparison of Hsc70 Orthologs from Polar and Temperate Notothenioid Fishes: Differences in Prevention of Aggregation and Refolding of Denatured Proteins","volume":"288","author":"Place","year":"2005","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1242\/jeb.203.15.2331","article-title":"Heat-Shock Protein Expression Is Absent in the Antarctic Fish Trematomus bernacchii (Family Nototheniidae)","volume":"203","author":"Hofmann","year":"2000","journal-title":"J. Exp. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00248-014-0374-9","article-title":"Diversity Patterns, Ecology and Biological Activities of Fungal Communities Associated with the Endemic Macroalgae Across the Antarctic Peninsula","volume":"67","author":"Furbino","year":"2014","journal-title":"Microb. Ecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00300-014-1632-5","article-title":"Infectious Diseases of Antarctic Penguins: Current Status and Future Threats","volume":"38","author":"Grimaldi","year":"2015","journal-title":"Polar Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/ddi.12593","article-title":"Barriers to Globally Invasive Species Are Weakening across the Antarctic","volume":"23","author":"Duffy","year":"2017","journal-title":"Divers. Distrib."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.tim.2011.07.008","article-title":"Non-Indigenous Microorganisms in the Antarctic: Assessing the Risks","volume":"19","author":"Cowan","year":"2011","journal-title":"Trends Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0145-305X(01)00029-5","article-title":"Evolution of Effectors and Receptors of Innate Immunity","volume":"25","author":"Magor","year":"2001","journal-title":"Dev. Comp. Immunol."},{"key":"ref_20","first-page":"277","article-title":"Fish Immune System. A Crossroads between Innate and Adaptive Responses","volume":"22","author":"Tort","year":"2003","journal-title":"Inmunologia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1365-2761.2006.00701.x","article-title":"Immunostimulation of Larvae and Juveniles of Cod, Gadus Morhua L.","volume":"29","author":"Magnadottir","year":"2006","journal-title":"J. Fish Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.fsi.2013.09.032","article-title":"The Mucosal Immune System of Fish: The Evolution of Tolerating Commensals While Fighting Pathogens","volume":"35","author":"Gomez","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ni.2549","article-title":"Fishing for Mammalian Paradigms in the Teleost Immune System","volume":"14","author":"Sunyer","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.dci.2012.04.001","article-title":"Advances in Research of Fish Immune-Relevant Genes: A Comparative Overview of Innate and Adaptive Immunity in Teleosts","volume":"39","author":"Zhu","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Bonneaud, C., Wilson, R.S., and Seebacher, F. (2016). Immune-Challenged Fish up-Regulate Their Metabolic Scope to Support Locomotion. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0166028"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Abram, Q.H., Dixon, B., and Katzenback, B.A. (2017). Impacts of Low Temperature on the Teleost Immune System. Biology, 6.","DOI":"10.3390\/biology6040039"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1050-4648(05)80056-7","article-title":"Temperature and Teleost Immune Functions","volume":"2","author":"Bly","year":"1992","journal-title":"Fish Shellfish Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1242\/jeb.201.2.165","article-title":"Differential Effects of Temperature on Specific and Nonspecific Immune Defences in Fish","volume":"201","author":"Troutaud","year":"1998","journal-title":"J. Exp. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"MacKenzie, S., Balasch, J.C., Novoa, B., Ribas, L., Roher, N., Krasnov, A., and Figueras, A. (2008). Comparative Analysis of the Acute Response of the Trout, O. mykiss, Head Kidney to in Vivo Challenge with Virulent and Attenuated Infectious Hematopoietic Necrosis Virus and LPS-Induced Inflammation. BMC Genom., 9.","DOI":"10.1186\/1471-2164-9-141"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s10695-015-0167-1","article-title":"Chemokine Receptor CXCR3 in Turbot (Scophthalmus maximus): Cloning, Characterization and Its Responses to Lipopolysaccharide","volume":"42","author":"Chen","year":"2016","journal-title":"Fish Physiol. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/biology4010067","article-title":"In Vivo Molecular Responses of Fast and Slow Muscle Fibers to Lipopolysaccharide in a Teleost Fish, the Rainbow Trout (Oncorhynchus mykiss)","volume":"4","author":"Magnoni","year":"2015","journal-title":"Biology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0145-305X(94)00057-M","article-title":"Effects of Temperature on Carp Leukocyte Mitogen-Induced Proliferation and Nonspecific Cytotoxic Activity","volume":"19","author":"Troutaud","year":"1995","journal-title":"Dev. Comp. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/fsim.1996.0075","article-title":"Effects of Environmental Temperature on Macrophage Activities in Carp","volume":"7","author":"Clerton","year":"1997","journal-title":"Fish Shellfish Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/0300-9629(91)90314-3","article-title":"Effect of Temperature on the Immune System of Channel Catfish (Ictalurus punctatus)\u2014II. Adaptation of Anterior Kidney Phagocytes to 10 \u00b0C","volume":"100","author":"Dexiang","year":"1991","journal-title":"Comp. Biochem. Physiol. Part A Physiol."},{"key":"ref_35","first-page":"466","article-title":"Phagocytosis and Giant Cell Formation at 0 \u00b0C by Macrophage (M\u00d8) of Notothenia coriiceps","volume":"60","author":"Silva","year":"2002","journal-title":"J. Fish Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s003000050297","article-title":"Induced Inflammatory Process in the Antarctic Fish Notothenia neglecta","volume":"20","author":"Silva","year":"1998","journal-title":"Polar Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s003000050436","article-title":"Experimental Studies on the Response of the Fish (Notothenia coriiceps Richardson, 1844) to Parasite (Pseudoterranova decipiens Krabbe, 1878) and Other Irritant Stimuli at Antarctic Temperatures","volume":"22","author":"Silva","year":"1999","journal-title":"Polar Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1095-8649.1987.tb05319.x","article-title":"The Inflammatory Response of the Antarctic Silverfish, Pleuragramma antarcticum Boulenger, 1902, to a Plerocercoid (Species Unknown) Infestation","volume":"31","author":"White","year":"1987","journal-title":"J. Fish Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00441-005-1139-z","article-title":"Microscopical Study of Experimental Wound Healing in Notothenia coriiceps (Cabe\u00e7uda) at 0 Degrees C","volume":"321","author":"Cooper","year":"2005","journal-title":"Cell Tissue Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00251-014-0792-3","article-title":"Characterization of Toll-like Receptor Gene Expression and the Pathogen Agonist Response in the Antarctic Bullhead Notothen Notothenia coriiceps","volume":"66","author":"Ahn","year":"2014","journal-title":"Immunogenetics"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fimmu.2022.812890","article-title":"Toll-Like Receptor Evolution: Does Temperature Matter?","volume":"13","author":"Sousa","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3389\/fphys.2020.00102","article-title":"LPS Modulates the Expression of Iron-Related Immune Genes in Two Antarctic Notothenoids","volume":"11","author":"Sousa","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1093\/molbev\/msn056","article-title":"Adaptive Evolution of Hepcidin Genes in Antarctic Notothenioid Fishes","volume":"25","author":"Xu","year":"2008","journal-title":"Mol. Biol. Evol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.fsi.2016.06.004","article-title":"Transcriptome Analysis of Immune Response Genes Induced by Pathogen Agonists in the Antarctic Bullhead Notothen Notothenia coriiceps","volume":"55","author":"Ahn","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00227-022-04043-w","article-title":"Comparative Proteomic Analysis of Head Kidney among Three Antarctic Fishes","volume":"169","author":"Jia","year":"2022","journal-title":"Mar. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Nilsson, C., Skoglund, A., Moran, A.P., Annuk, H., Engstrand, L., and Normark, S. (2008). Lipopolysaccharide Diversity Evolving in Helicobacter Pylori Communities through Genetic Modifications in Fucosyltransferases. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003811"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Araya, M.A., Valenzuela, T., Inostroza, N.G., Maruyama, F., Jorquera, M.A., and Acu\u00f1a, J.J. (2020). Isolation and Characterization of Cold-Tolerant Hyper-ACC-Degrading Bacteria from the Rhizosphere, Endosphere, and Phyllosphere of Antarctic Vascular Plants. Microorganisms, 8.","DOI":"10.3390\/microorganisms8111788"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1021\/cb0500015","article-title":"Redefining the Requisite Lipopolysaccharide Structure in Escherichia coli","volume":"1","author":"Meredith","year":"2006","journal-title":"ACS Chem. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000081687","article-title":"Fundamentals of Endotoxin Structure and Function","volume":"Volume 12","author":"Bishop","year":"2004","journal-title":"Concepts in Bacterial Virulence"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.fsi.2008.04.009","article-title":"Biological Effects of Bacterial Lipopolysaccharide (Endotoxin) in Fish: A Review","volume":"25","author":"Swain","year":"2008","journal-title":"Fish Shellfish Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1006\/fsim.2000.0319","article-title":"The Kinetics of the Hypoferraemic Response and Changes in Levels of Alternative Complement Activity in Diploid and Triploid Atlantic Salmon, Following Injection of Lipopolysaccharide","volume":"11","author":"Langston","year":"2001","journal-title":"Fish Shellfish Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s11427-020-1777-y","article-title":"MicroRNA Negatively Regulates NF-\u039aB-Mediated Immune Responses by Targeting NOD1 in the Teleost Fish Miichthys miiuy","volume":"64","author":"Chu","year":"2021","journal-title":"Sci. China Life Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/j.1095-8649.2004.00354.x","article-title":"Characterization of the Cortisol Response Following an Acute Challenge with Lipopolysaccharide in Yellow Perch and the Influence of Rearing Density","volume":"64","author":"Haukenes","year":"2004","journal-title":"J. Fish Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fsi.2020.03.024","article-title":"Liver Transcriptome Analysis and Cortisol Immune-Response Modulation in Lipopolysaccharide-Stimulated in Channel Catfish (Ictalurus punctatus)","volume":"101","author":"Jiang","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_56","unstructured":"Stolen, J.S., Fletcher, T.C., Anderson, D.P., Roberson, B.S., and Van Muiswinkel, W.B. (1990). Lysozyme Assays. Techniques in Fish Immunology, SOS Publications."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0145-305X(01)00038-6","article-title":"Innate Host Defense Mechanisms of Fish against Viruses and Bacteria","volume":"25","author":"Ellis","year":"2001","journal-title":"Dev. Comp. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1210\/en.2004-0644","article-title":"Stimulation of Cortisol Release by the N Terminus of Teleost Parathyroid Hormone-Related Protein in Interrenal Cells in Vitro","volume":"146","author":"Rotllant","year":"2005","journal-title":"Endocrinology"},{"key":"ref_59","unstructured":"Andrews, S. (2015). FASTQC A Quality Control Tool for High Throughput Sequence Data. Babraham Inst., Available online: https:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/."},{"key":"ref_60","unstructured":"Krueger, F. (2015). Trim Galore: A Wrapper Tool around Cutadapt and FastQC. Babraham Inst., Available online: https:\/\/www.bioinformatics.babraham.ac.uk\/projects\/trim_galore\/."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and Memory-Efficient Alignment of Short DNA Sequences to the Human Genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Li, B., and Dewey, C.N. (2011). RSEM: Accurate Transcript Quantification from RNA-Seq Data with or without a Reference Genome. BMC Bioinform., 12.","DOI":"10.1186\/1471-2105-12-323"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"W537","DOI":"10.1093\/nar\/gky379","article-title":"The Galaxy Platform for Accessible, Reproducible and Collaborative Biomedical Analyses: 2018 Update","volume":"46","author":"Afgan","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: A Fast Spliced Aligner with Low Memory Requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie Enables Improved Reconstruction of a Transcriptome from RNA-Seq Reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated Estimation of Fold Change and Dispersion for RNA-Seq Data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/nprot.2013.084","article-title":"De Novo Transcript Sequence Reconstruction from RNA-Seq Using the Trinity Platform for Reference Generation and Analysis","volume":"8","author":"Haas","year":"2013","journal-title":"Nat. Protoc."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1101\/gr.196469.115","article-title":"TransRate: Reference-Free Quality Assessment of de Novo Transcriptome Assemblies","volume":"26","author":"Boursnell","year":"2016","journal-title":"Genome Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"EdgeR: A Bioconductor Package for Differential Expression Analysis of Digital Gene Expression Data","volume":"26","author":"Robinson","year":"2009","journal-title":"Bioinformatics"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.celrep.2016.12.063","article-title":"A Tissue-Mapped Axolotl De Novo Transcriptome Enables Identification of Limb Regeneration Factors","volume":"18","author":"Bryant","year":"2017","journal-title":"Cell Rep."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Eden, E., Navon, R., Steinfeld, I., Lipson, D., and Yakhini, Z. (2009). GOrilla: A Tool for Discovery and Visualization of Enriched GO Terms in Ranked Gene Lists. BMC Bioinform., 10.","DOI":"10.1186\/1471-2105-10-48"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"W316","DOI":"10.1093\/nar\/gkr483","article-title":"KOBAS 2.0: A Web Server for Annotation and Identification of Enriched Pathways and Diseases","volume":"39","author":"Xie","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Supek, F., Bo\u0161njak, M., \u0160kunca, N., and \u0160muc, T. (2011). REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0021800"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1093\/molbev\/msab199","article-title":"BUSCO Update: Novel and Streamlined Workflows along with Broader and Deeper Phylogenetic Coverage for Scoring of Eukaryotic, Prokaryotic, and Viral Genomes","volume":"38","author":"Manni","year":"2021","journal-title":"Mol. Biol. Evol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s11160-018-9535-0","article-title":"Effects of Short-Term Thermal Stress on the Plasma Biochemical Profiles of Two Antarctic Nototheniid Species","volume":"28","author":"Kandalski","year":"2018","journal-title":"Rev. Fish Biol. Fish."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.fsi.2004.12.009","article-title":"The Effect of Sea Bream (Sparus aurata) Broodstock and Larval Vaccination on the Susceptibility by Photobacterium damsela Subsp. Piscicida and on the Humoral Immune Parameters","volume":"19","author":"Hanif","year":"2005","journal-title":"Fish Shellfish Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.fsi.2007.09.005","article-title":"Effect of Endotoxin on the Immunity of Indian Major Carp, Labeo rohita","volume":"24","author":"Nayak","year":"2008","journal-title":"Fish Shellfish Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.4049\/jimmunol.0801755","article-title":"Evolution of Lipopolysaccharide (LPS) Recognition and Signaling: Fish TLR4 Does Not Recognize LPS and Negatively Regulates NF-\u039aB Activation","volume":"182","author":"Sepulcre","year":"2009","journal-title":"J. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1139\/m66-143","article-title":"Comparative Studies on the Toxicity of Escherichia Coli Lipopolysaccharide Endotoxin in Various Animal Species","volume":"12","author":"Berczi","year":"1966","journal-title":"Can. J. Microbiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1038\/emm.2013.97","article-title":"Recognition of Lipopolysaccharide Pattern by TLR4 Complexes","volume":"45","author":"Park","year":"2013","journal-title":"Exp. Mol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3354\/dao015175","article-title":"Effects of Alpha-Tocopherol and Dietary Oxidized Fish Oil on the Immune Response of Sea Bass Dicentrarchus labrax","volume":"15","author":"Obach","year":"1993","journal-title":"Dis. Aquat. Org."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s10695-010-9440-5","article-title":"Physiological Stress and Innate Immune Response in Gilthead Sea Bream (Sparus aurata) and Sea Bass (Dicentrarchus labrax) Exposed to Combination of Trimethoprim and Sulfamethoxazole (TMP-SMX)","volume":"37","author":"Yildiz","year":"2011","journal-title":"Fish Physiol. Biochem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.fsi.2007.03.010","article-title":"Oral Administration of Eclipta Alba Leaf Aqueous Extract Enhances the Non-Specific Immune Responses and Disease Resistance of Oreochromis mossambicus","volume":"23","author":"Christybapita","year":"2007","journal-title":"Fish Shellfish Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3354\/dao006001","article-title":"Study on Lysozyme Activity in Some Fish Species","volume":"6","author":"Lie","year":"1989","journal-title":"Dis. Aquat. Org."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s40071-016-0128-z","article-title":"Assessment of the Accuracy of Physiological Blood Indicators for the Evaluation of Stress, Health Status and Welfare in Siberian Sturgeon (Acipenser baerii) Subject to Chronic Heat Stress and Dietary Supplementation","volume":"8","author":"Simide","year":"2016","journal-title":"Int. Aquat. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/prot.24223","article-title":"Lipid a from Lipopolysaccharide Recognition: Structure, Dynamics and Cooperativity by Molecular Dynamics Simulations","volume":"81","author":"Garate","year":"2013","journal-title":"Proteins Struct. Funct. Bioinform."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1574-6976.2002.tb00597.x","article-title":"O-Antigen Structural Variation: Mechanisms and Possible Roles in Animal\/Plant\u2013Microbe Interactions","volume":"26","author":"Lerouge","year":"2002","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"6746","DOI":"10.1128\/JB.184.23.6746-6749.2002","article-title":"Low-Temperature-Induced Changes in Composition and Fluidity of Lipopolysaccharides in the Antarctic Psychrotrophic Bacterium Pseudomonas syringae","volume":"184","author":"Kumar","year":"2002","journal-title":"J. Bacteriol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.bpj.2013.08.002","article-title":"Molecular Dynamics and NMR Spectroscopy Studies of E. Coli Lipopolysaccharide Structure and Dynamics","volume":"105","author":"Wu","year":"2013","journal-title":"Biophys. J."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF02705244","article-title":"Mechanism of Bacterial Adaptation to Low Temperature","volume":"31","author":"Chattopadhyay","year":"2006","journal-title":"J. Biosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen Recognition and Innate Immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1432-1033.1989.tb15253.x","article-title":"Lipopolysaccharide Interactions with Lysozyme Differentially Affect Lipopolysaccharide Immunostimulatory Activity","volume":"186","author":"Ohno","year":"1989","journal-title":"Eur. J. Biochem."},{"key":"ref_93","first-page":"514","article-title":"Susceptibility of Zebrafish (Danio rerio) to a Model Pathogen, Spring Viremia of Carp Virus","volume":"53","author":"Sanders","year":"2003","journal-title":"Comp. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.fsi.2009.03.011","article-title":"Effects of Temperature Change on the Innate Cellular and Humoral Immune Responses of Orange-Spotted Grouper Epinephelus coioides and Its Susceptibility to Vibrio alginolyticus","volume":"26","author":"Cheng","year":"2009","journal-title":"Fish Shellfish Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.fsi.2006.08.015","article-title":"The Immune Response of Tilapia Oreochromis mossambicus and Its Susceptibility to Streptococcus iniae under Stress in Low and High Temperatures","volume":"22","author":"Ndong","year":"2007","journal-title":"Fish Shellfish Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.fsi.2013.02.012","article-title":"Impaired TLR2 and TLR7 Response in Olive Flounder Infected with Viral Haemorrhagic Septicaemia Virus at Host Susceptible 15 \u00b0C but High at Non-Susceptible 20 \u00b0C","volume":"34","author":"Avunje","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.fsi.2019.06.030","article-title":"Overwinter Mortality in Yellow Drum (Nibea albiflora): Insights from Growth and Immune Responses to Cold and Starvation Stress","volume":"92","author":"Song","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.fsi.2011.02.010","article-title":"The Acute Phase Response of Atlantic Cod (Gadus morhua): Humoral and Cellular Response","volume":"30","author":"Magnadottir","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3389\/fphys.2018.00625","article-title":"Immunomodulatory Effects of Dietary Seaweeds in LPS Challenged Atlantic Salmon Salmo salar as Determined by Deep RNA Sequencing of the Head Kidney Transcriptome","volume":"9","author":"Palstra","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.3389\/fimmu.2018.02758","article-title":"A Novel Lipopolysaccharide Recognition Mechanism Mediated by Internalization in Teleost Macrophages","volume":"9","author":"Lu","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.molimm.2017.01.010","article-title":"Immune Transcriptome Reveals the Mincle C-Type Lectin Receptor Acts as a Partial Replacement for TLR4 in Lipopolysaccharide-Mediated Inflammatory Response in Barramundi (Lates calcarifer)","volume":"83","author":"Zoccola","year":"2017","journal-title":"Mol. Immunol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/bs.mie.2019.10.004","article-title":"Isolation of mononuclear phagocytes from the mouse gut","volume":"632","author":"Chiaranunt","year":"2020","journal-title":"Methods in Enzymology"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1177\/09680519050110060301","article-title":"How Toll-like Receptors and Nod-like Receptors Contribute to Innate Immunity in Mammals","volume":"11","author":"Fritz","year":"2005","journal-title":"J. Endotoxin Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"13337","DOI":"10.1038\/s41598-020-70390-7","article-title":"Lipopolysaccharide Administration for a Mouse Model of Cerebellar Ataxia with Neuroinflammation","volume":"10","author":"Hong","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1534\/genetics.109.107540","article-title":"Identification of Novel Genes That Mediate Innate Immunity Using Inbred Mice","volume":"183","author":"Yang","year":"2009","journal-title":"Genetics"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.fsi.2017.05.014","article-title":"Characterization and Expression Profiling of NOD-like Receptor C3 (NLRC3) in Mucosal Tissues of Turbot (Scophthalmus maximus L.) Following Bacterial Challenge","volume":"66","author":"Hou","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.fsi.2016.04.006","article-title":"Anti-Infective Mannose Receptor Immune Mechanism in Large Yellow Croaker (Larimichthys crocea)","volume":"54","author":"Dong","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"ref_108","first-page":"680","article-title":"Molecular cloning and functional analysis of nucleotide-binding oligomerization domain 1 (NOD1) in olive flounder, Paralichthys olivaceus","volume":"36","author":"Hikima","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s12038-013-9330-y","article-title":"NOD1 and NOD2 Receptors in Mrigal (Cirrhinus mrigala): Inductive Expression and Downstream Signalling in Ligand Stimulation and Bacterial Infections","volume":"38","author":"Swain","year":"2013","journal-title":"J. Biosci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.fsi.2015.09.024","article-title":"Characterization of NLR-A Subfamily Members in Miiuy Croaker and Comparative Genomics Revealed NLRX1 Underwent Duplication and Lose in Actinopterygii","volume":"47","author":"Li","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10456-013-9384-3","article-title":"Regulation of Angiogenesis, Mural Cell Recruitment and Adventitial Macrophage Behavior by Toll-like Receptors","volume":"17","author":"Aplin","year":"2014","journal-title":"Angiogenesis"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000354770","article-title":"Celastrol Inhibits Lipopolysaccharide-Induced Angiogenesis by Suppressing TLR4-Triggered Nuclear Factor-Kappa B Activation","volume":"131","author":"Ni","year":"2014","journal-title":"Acta Haematol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3389\/fimmu.2020.00502","article-title":"Interleukin-1 Ligands and Receptors in Lumpfish (Cyclopterus lumpus L.): Molecular Characterization, Phylogeny, Gene Expression, and Transcriptome Analyses","volume":"11","author":"Lunde","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/cyto.2001.0949","article-title":"Interleukin-1\u03b2 Isolated from a Marine Fish Reveals up-Regulated Expression in Macrophages Following Activation with Lipopolysaccharide and Lymphokines","volume":"16","author":"Mulero","year":"2001","journal-title":"Cytokine"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"30004","DOI":"10.1038\/srep30004","article-title":"Distinct Differentiation Programs Triggered by IL-6 and LPS in Teleost IgM+ B Cells in the Absence of Germinal Centers","volume":"6","author":"Abos","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.dci.2005.03.004","article-title":"Characterization and Expression Analysis of Bactericidal Permeability-Increasing Protein (BPI) Antimicrobial Peptide Gene from Channel Catfish Ictalurus punctatus","volume":"29","author":"Xu","year":"2005","journal-title":"Dev. Comp. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.fsi.2015.05.013","article-title":"Identification and Expression Analysis on Bactericidal Permeability-Increasing Protein\/Lipopolysaccharide-Binding Protein of Blunt Snout Bream, Megalobrama amblycephala","volume":"45","author":"Tang","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.immuni.2007.07.020","article-title":"Zebrafish Peptidoglycan Recognition Proteins Are Bactericidal Amidases Essential for Defense against Bacterial Infections","volume":"27","author":"Li","year":"2007","journal-title":"Immunity"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Zhang, F., Shan, S., Xu, X., Wang, Y., Zhang, Y., Yin, M., and Yang, G. (2019). Molecular Characterization and Expression Analysis of Two Peptidoglycan Recognition Proteins (CcPGRP5, CcPGRP6) in Larvae Ontogeny of Common Carp Cyprinus carpio L. and upon Immune Stimulation by Bacteria. BMC Vet. Res., 15.","DOI":"10.1186\/s12917-018-1744-1"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.4049\/jimmunol.1302611","article-title":"Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes","volume":"192","author":"Briolat","year":"2014","journal-title":"J. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.dci.2018.08.012","article-title":"Interleukin-6 Gets Involved in Response to Bacterial Infection and Promotes Antibody Production in Nile Tilapia (Oreochromis niloticus)","volume":"89","author":"Wei","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.fsi.2016.05.019","article-title":"Characterization of Immune-Related Genes in the Yellow Catfish Pelteobagrus fulvidraco in Response to LPS Challenge","volume":"56","author":"Liu","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"eabe0531","DOI":"10.1126\/sciimmunol.abe0531","article-title":"Deep-Sea Microbes as Tools to Refine the Rules of Innate Immune Pattern Recognition","volume":"6","author":"Gauthier","year":"2021","journal-title":"Sci. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molmed.2014.11.008","article-title":"Mitochondria: Diversity in the Regulation of the NLRP3 Inflammasome","volume":"21","author":"Gurung","year":"2015","journal-title":"Trends Mol. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/S0021-9258(17)49920-0","article-title":"The Zebrafish NLRP3 Inflammasome Has Functional Roles in ASC-Dependent Interleukin-1\u03b2 Maturation and Gasdermin E\u2013Mediated Pyroptosis","volume":"295","author":"Li","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Reyes-Cerpa, S., Maisey, K., Reyes-Lpez, F., Toro-Ascuy, D., Mara, A., and Imarai, M. (2012). Fish Cytokines and Immune Response. New Advances and Contributions to Fish Biology, IntechOpen.","DOI":"10.5772\/53504"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.fsi.2019.09.003","article-title":"In Vitro Immune Response of Chinook Salmon (Oncorhynchus tshawytscha) Peripheral Blood Mononuclear Cells Stimulated by Bacterial Lipopolysaccharide","volume":"94","author":"Lulijwa","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.fsi.2017.07.041","article-title":"The Roles of NF-\u039aB and ROS in Regulation of pro-Inflammatory Mediators of Inflammation Induction in LPS-Stimulated Zebrafish Embryos","volume":"68","author":"Ko","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.fsi.2020.11.009","article-title":"Transcriptome Analysis of Immune- and Iron-Related Genes after Francisella noatunensis Subsp. Orientalis Infection in Nile Tilapia (Oreochromis niloticus)","volume":"111","author":"Maekawa","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"735501","DOI":"10.1016\/j.aquaculture.2020.735501","article-title":"Effects of Glucose, Insulin, Glucagon, LPS and Poly (I:C) on Adiponectin Receptors Expression in Grass Carp (Ctenophcuyngodon idellus)","volume":"528","author":"Qin","year":"2020","journal-title":"Aquaculture"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"100527","DOI":"10.1016\/j.aqrep.2020.100527","article-title":"Cloning and Expression Analysis of Keap1 of Golden Pompano (Trachinotus ovatus) and Response to Oxidized Fish Oil and LPS Administration","volume":"18","author":"Xie","year":"2020","journal-title":"Aquac. Rep."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0300-9629(91)90519-I","article-title":"Acute-Phase Hypoferremic Response to Lipopolysaccharide in Rainbow Trout (Oncorhynchus mykiss)","volume":"98","author":"Congleton","year":"1991","journal-title":"Comp. Biochem. Physiol.-Part A Physiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/1755-0998.13156","article-title":"Error, Noise and Bias in de Novo Transcriptome Assemblies","volume":"21","author":"Freedman","year":"2021","journal-title":"Mol. Ecol. Resour."}],"container-title":["Fishes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2410-3888\/7\/4\/171\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:51:57Z","timestamp":1760140317000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2410-3888\/7\/4\/171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,16]]},"references-count":133,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["fishes7040171"],"URL":"https:\/\/doi.org\/10.3390\/fishes7040171","relation":{},"ISSN":["2410-3888"],"issn-type":[{"value":"2410-3888","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,16]]}}}