{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:09:04Z","timestamp":1777619344300,"version":"3.51.4"},"reference-count":97,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB 50006\/2020"],"award-info":[{"award-number":["UIDB 50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Citrinin (CIT) deserves attention due to its known toxic effects in mammalian species and its widespread occurrence in food commodities, often along with ochratoxin A, another nephrotoxic mycotoxin. Human exposure, a key element in assessing risk related to food contaminants, depends upon mycotoxin contamination levels in food and on food consumption. Commercial supplements, commonly designated as red rice, usually used in daily diets in Asiatic countries due to their medicinal properties, may pose a health problem as a result of high CIT levels. In addition to the worldwide occurrence of CIT in foods and supplements, a wide range of several analytical and detection techniques with high sensitivity, used for evaluation of CIT, are reviewed and discussed in this manuscript. This review addresses the scientific literature regarding the presence of CIT in foods of either vegetable or animal origin, as well as in supplements. On what concerns analytical methodologies, sample extraction methods, such as shaking extraction and ultrasonic assisted extraction (UAE), clean-up methods, such as liquid-liquid extraction (LLE), solid phase extraction (SPE) and Quick, Easy, Cheap, Effective, Rugged and Safe (QuECHERS), and detection and quantification methods, such as thin layer chromatography (TLC), high performance liquid chromatography (HPLC), capillary electrophoresis (CE), biosensors, and ELISA, are also reviewed.<\/jats:p>","DOI":"10.3390\/foods10010014","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T08:38:43Z","timestamp":1608712723000},"page":"14","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Citrinin in Foods and Supplements: A Review of Occurrence and Analytical Methodologies"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2372-1874","authenticated-orcid":false,"given":"Liliana J. G.","family":"Silva","sequence":"first","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Bromatology and Pharmacognosy, Faculty of Pharmacy, University of Coimbra, Polo III, Azinhaga de Sta Comba, 3000-548 Coimbra, Portugal"}]},{"given":"Andr\u00e9 M. P. T.","family":"Pereira","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Bromatology and Pharmacognosy, Faculty of Pharmacy, University of Coimbra, Polo III, Azinhaga de Sta Comba, 3000-548 Coimbra, Portugal"}]},{"given":"Angelina","family":"Pena","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Bromatology and Pharmacognosy, Faculty of Pharmacy, University of Coimbra, Polo III, Azinhaga de Sta Comba, 3000-548 Coimbra, Portugal"}]},{"given":"Celeste M.","family":"Lino","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Bromatology and Pharmacognosy, Faculty of Pharmacy, University of Coimbra, Polo III, Azinhaga de Sta Comba, 3000-548 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.fct.2018.08.025","article-title":"Assessing the mycotoxicological risk from consumption of complementary foods by infants and young children in Nigeria","volume":"121","author":"Ojuri","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1080\/19440049.2015.1010185","article-title":"Recent mycotoxin survey data and advanced mycotoxin detection techniques reported from China: A review","volume":"32","author":"Selvaraj","year":"2015","journal-title":"Food Addit. Contam. Part A"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF02980928","article-title":"Natural occurrence of citrinin in rice grains and its biocontrol byTrichoderma hamatum","volume":"33","author":"Ezzat","year":"2005","journal-title":"Phytoparasitica"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tifs.2019.08.014","article-title":"The occurrence of mycotoxins in breast milk, fruit products and cereal-based infant formula: A review","volume":"92","author":"Coppa","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1128\/CMR.16.3.497-516.2003","article-title":"Mycotoxins","volume":"5","author":"Bennett","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.3390\/toxins5091574","article-title":"Producers and Important Dietary Sources of Ochratoxin A and Citrinin","volume":"5","author":"Ostry","year":"2013","journal-title":"Toxins"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2478\/10004-1254-60-2009-1992","article-title":"Toxicological properties of citrinin","volume":"60","author":"Flajs","year":"2009","journal-title":"Arh. Hig. Rada Toksikol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1383-5718(99)00095-9","article-title":"Mutagenicity of commercial Monascus fermentation products and the role of citrinin contamination","volume":"444","author":"Maas","year":"1999","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3892\/or.2017.5424","article-title":"Effects of different mycotoxins on humans, cell genome and their involvement in cancer","volume":"37","author":"Adam","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0168-1605(98)00112-3","article-title":"Mycotoxin production by Aspergillus, Fusarium and Penicillium species","volume":"43","author":"Sweeney","year":"1998","journal-title":"Int. J. Food Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.foodcont.2015.10.051","article-title":"Worldwide occurrence of mycotoxins in rice","volume":"62","author":"Ferre","year":"2016","journal-title":"Food Control"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/1541-4337.12367","article-title":"Mycotoxin Biomarkers of Exposure: A Comprehensive Review","volume":"17","author":"Vidal","year":"2018","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.toxlet.2017.10.006","article-title":"Preliminary data on citrinin kinetics in humans and their use to estimate citrinin exposure based on biomarkers","volume":"282","author":"Degen","year":"2018","journal-title":"Toxicol. Lett."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Magan, N., and Olsen, M. (2004). Other mycotoxins. Mycotoxins in Food: Detection and Control, Woodhead Publishing Limited.","DOI":"10.1201\/9781439823361"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.aca.2012.06.038","article-title":"A direct assessment of mycotoxin biomarkers in human urine samples by liquid chromatography tandem mass spectrometry","volume":"741","author":"Ediage","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.foodchem.2012.10.104","article-title":"Simultaneous determination of lovastatin and citrinin in red yeast rice supplements by micellar electrokinetic capillary chromatography","volume":"138","author":"Mornar","year":"2013","journal-title":"Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1080\/21501203.2020.1727578","article-title":"Occurrence and analysis of mycotoxins in domestic Chinese herbal medicines","volume":"11","author":"Qin","year":"2020","journal-title":"Mycology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"272","DOI":"10.17508\/CJFST.2019.11.2.05","article-title":"Toxicogenic fungi and the occurrence of mycotoxins in traditional meat products","volume":"11","author":"Zadravec","year":"2019","journal-title":"Croat. J. Food Sci. Technol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Patial, V., Asrani, R.K., and Thakur, M. (2018). Food-Borne Mycotoxicoses: Pathologies and Public Health Impact, Elsevier Inc.","DOI":"10.1016\/B978-0-12-811444-5.00009-9"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s12550-017-0299-5","article-title":"Blood plasma biomarkers of citrinin and ochratoxin A exposure in young adults in Bangladesh","volume":"34","author":"Ali","year":"2018","journal-title":"Mycotoxin Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.3390\/toxins5111965","article-title":"Deleterious Effects of Mycotoxin Combinations Involving Ochratoxin A","volume":"5","author":"Peraica","year":"2013","journal-title":"Toxins"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.3390\/nu6052077","article-title":"Toxicity mechanisms of the food contaminant citrinin: Application of a quantitative yeast model","volume":"6","author":"Proft","year":"2014","journal-title":"Nutrients"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Doughari, J. (2015). The Occurrence, Properties and Significance of Citrinin Mycotoxin. J. Plant Pathol. Microbiol., 6.","DOI":"10.4172\/2157-7471.1000321"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1080\/02652030210121320","article-title":"Co-occurrence of patulin and citrinin in Portuguese apples with rotten spots","volume":"19","author":"Martins","year":"2002","journal-title":"Food Addit. Contam."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Viegas, S., Assun\u00e7\u00e3o, R., Nunes, C., Osteresch, B., Twaru\u017cek, M., Kosicki, R., Grajewski, J., Martins, C., Alvito, P., and Almeida, A. (2018). Exposure assessment to mycotoxins in a Portuguese fresh bread dough company by using a multi-biomarker approach. Toxins, 10.","DOI":"10.3390\/toxins10090342"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1007\/s00216-016-9402-6","article-title":"A fully automated and fast method using direct sample injection combined with fused-core column on-line SPE-HPLC for determination of ochratoxin A and citrinin in lager beers","volume":"408","author":"Solich","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.4315\/0362-028X-65.8.1317","article-title":"Citrinin Production and Stability in Cheese","volume":"65","author":"Bailly","year":"2002","journal-title":"J. Food Prot."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00204-014-1363-y","article-title":"Occurrence of the mycotoxin citrinin and its metabolite dihydrocitrinone in urines of German adults","volume":"89","author":"Ali","year":"2015","journal-title":"Arch. Toxicol."},{"key":"ref_29","first-page":"179","article-title":"Introduction and Safety Evaluation of Citrinin in Foods","volume":"5","author":"Huiqin","year":"2017","journal-title":"J. Food Nutr. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.foodcont.2004.10.012","article-title":"Review on the qualitative and quantitative analysis of the mycotoxin citrinin","volume":"17","author":"Xu","year":"2006","journal-title":"Food Control"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1039\/b600960c","article-title":"Citrinin revisited: From monomers to dimers and beyond","volume":"4","author":"Clark","year":"2006","journal-title":"Org. Biomol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"EFSA (2012). Scientific Opinion on the risks for public and animal health related to the presence of citrinin in food and feed. EFSA J., 10, 1\u201382.","DOI":"10.2903\/j.efsa.2012.2605"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3920\/QAS2018.1398","article-title":"Comparative analysis of notifications regarding mycotoxins in the rapid alert system for food and feed (RASFF)","volume":"11","year":"2019","journal-title":"Qual. Assur. Saf. Crop. Foods"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.foodchem.2007.03.040","article-title":"Occurrence of aflatoxin B1, citrinin and ochratoxin A in rice in five provinces of the central region of Vietnam","volume":"105","author":"Nguyen","year":"2007","journal-title":"Food Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1080\/19440049.2015.1055522","article-title":"High-throughput determination of citrinin in rice by ultra-high-performance liquid chromatography and fluorescence detection (UHPLC-FL)","volume":"32","year":"2015","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control. Expo. Risk Assess."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1002\/jsfa.8667","article-title":"Co-occurrence of citrinin and ochratoxin A in rice in Asia and its implications for human health","volume":"98","author":"Ali","year":"2018","journal-title":"J. Sci. Food Agric."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"T1438","DOI":"10.1111\/1750-3841.12900","article-title":"Citrinin Determination in Red Fermented Rice Products by Optimized Extraction Method Coupled to Liquid Chromatography Tandem Mass Spectrometry (LC-MS\/MS)","volume":"80","author":"Ji","year":"2015","journal-title":"J. Food Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1021\/jf304881g","article-title":"Development of a rapid LC\/DAD\/FLD\/MSn method for the simultaneous determination of monacolins and citrinin in red fermented rice products","volume":"61","author":"Mornar","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s12550-012-0154-7","article-title":"A preliminary survey on the occurrence of mycotoxigenic fungi and mycotoxins contaminating red rice at consumer level in Selangor, Malaysia","volume":"29","author":"Samsudin","year":"2013","journal-title":"Mycotoxin Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.foodchem.2011.11.051","article-title":"Natural occurrence of citrinin in widely consumed traditional Chinese food red yeast rice, medicinal plants and their related products","volume":"132","author":"Li","year":"2012","journal-title":"Food Chem."},{"key":"ref_41","first-page":"206","article-title":"A Validated RP-HPLC Method for the Determination of Citrinin in Xuezhikang Capsule and other Monascus-Fermented Products","volume":"9","author":"Lan","year":"2012","journal-title":"J. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/jaoac\/94.1.179","article-title":"Synchronous high-performance liquid chromatography with a photodiode array detector and mass spectrometry for the determination of citrinin, monascin, ankaflavin, and the lactone and acid forms of monacolin K in red mold rice","volume":"94","author":"Wu","year":"2011","journal-title":"J. AOAC Int."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.foodcont.2012.04.015","article-title":"Natural occurrence of citrinin in Tunisian wheat grains","volume":"28","author":"Zaied","year":"2012","journal-title":"Food Control"},{"key":"ref_44","first-page":"1","article-title":"Occurrence of Penicillium verrucosum, ochratoxin A, ochratoxin B and citrinin in on-farm stored winter wheat from the Canadian Great Lakes Region","volume":"12","author":"Miller","year":"2017","journal-title":"PLoS ONE"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"9352","DOI":"10.1021\/jf302003n","article-title":"Quantitation of mycotoxins in food and feed from burkina faso and mozambique using a modern LC-MS\/MS multitoxin method","volume":"60","author":"Warth","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Hajnal, E.J., Kos, J., Malachov\u00e1, A., Steiner, D., Stranska, M., Krska, R., and Sulyok, M. (2020). Mycotoxins in maize harvested in Serbia in the period 2012\u20132015. Part 2: Non-regulated mycotoxins and other fungal metabolites. Food Chem., 317.","DOI":"10.1016\/j.foodchem.2020.126409"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"22","DOI":"10.21010\/ajtcam.v14i3.3","article-title":"Presence of Citrinin in Grains and Its Possible Health Effects","volume":"14","author":"Bevardi","year":"2017","journal-title":"Afr. J. Tradit. Complement. Altern. Med. AJTCAM"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s00217-003-0858-1","article-title":"New method of citrinin determination by HPLC after polyamide column clean-up","volume":"218","author":"Meister","year":"2004","journal-title":"Eur. Food Res. Technol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.foodchem.2004.06.035","article-title":"Analysis of some breakfast cereals on the French market for their contents of ochratoxin A, citrinin and fumonisin B1: Development of a method for simultaneous extraction of ochratoxin A and citrinin","volume":"92","author":"Faucet","year":"2005","journal-title":"Food Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.foodcont.2018.11.049","article-title":"Mycotoxin co-exposures in infants and young children consuming household- and industrially-processed complementary foods in Nigeria and risk management advice","volume":"98","author":"Ojuri","year":"2019","journal-title":"Food Control"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/mnfr.200600055","article-title":"Preliminary data on the presence of mycotoxins (ochratoxin A, citrinin and aflatoxin B1) in black table olives \u201cGreek style\u201d of Moroccan origin","volume":"50","author":"Tozlovanu","year":"2006","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_52","first-page":"371","article-title":"Mycobiota, mycotoxigenic fungi, and citrinin production in black olives","volume":"Volume 571","author":"Hocking","year":"2006","journal-title":"Advances in Experimental Medicine and Biology: Advances in Food Mycology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.foodcont.2013.05.002","article-title":"Natural occurrence of aflatoxin B1, ochratoxin A and citrinin in Croatian fermented meat products","volume":"34","author":"Markov","year":"2013","journal-title":"Food Control"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Jeswal, P., and Kumar, D. (2015). Mycobiota and Natural Incidence of Aflatoxins, Ochratoxin A, and Citrinin in Indian Spices Confirmed by LC-MS\/MS. Int. J. Microbiol., 2015.","DOI":"10.1155\/2015\/242486"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10661-010-1688-9","article-title":"Mycotoxin levels and incidence of mould in Turkish rice","volume":"178","author":"Aydin","year":"2011","journal-title":"Environ. Monit. Assess."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.fct.2017.10.002","article-title":"A comprehensive review on biological properties of citrinin","volume":"110","author":"Islam","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"7634","DOI":"10.1021\/jf101194f","article-title":"Anti-diabetic effects of monascus purpureus NTU 568 fermented products on streptozotocin-induced diabetic rats","volume":"58","author":"Shi","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.foodchem.2014.02.060","article-title":"Comparison of extraction methods for analysis of citrinin in red fermented rice","volume":"157","author":"Wang","year":"2014","journal-title":"Food Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2018.01374","article-title":"Investigation of citrinin and pigment biosynthesis mechanisms in monascus purpureus by Transcriptomic Analysis","volume":"9","author":"Liang","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jnutbio.2007.05.012","article-title":"Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells","volume":"19","author":"Hong","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/02652030500391911","article-title":"Ochratoxin A and citrinin loads in stored wheat grains: Impact of grain dust and possible prediction using ergosterol measurement","volume":"23","author":"Tangni","year":"2005","journal-title":"Food Addit. Contam."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.foodcont.2008.07.002","article-title":"Occurrence and legislation of mycotoxins in food and feed from Morocco","volume":"20","author":"Zinedine","year":"2009","journal-title":"Food Control"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1128\/aem.33.4.1004-1006.1977","article-title":"Produciton and biological activity of patulin and citrinin from Penicillium expansum","volume":"33","author":"Ciegler","year":"1977","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.4315\/0362-028X-68.7.1516","article-title":"Production and Stability of Patulin, Ochratoxin A, Citrinin, and Cyclopiazonic Acid on Dry Cured Ham","volume":"68","author":"Bailly","year":"2005","journal-title":"J. Food Prot."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.foodcont.2015.05.013","article-title":"Ochratoxin A contamination of the autochthonous dry-cured meat product \u201cSlavonski Kulen\u201d during a six-month production process","volume":"57","author":"Pleadin","year":"2015","journal-title":"Food Control"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1080\/15321819.2015.1032306","article-title":"Impact of casing damaging on aflatoxin B 1 concentration during the ripening of dry-fermented meat sausages","volume":"36","author":"Pleadin","year":"2015","journal-title":"J. Immunoass. Immunochem."},{"key":"ref_67","unstructured":"European Commission (2014). COMMISSION REGULATION (EU) No 212\/2014 of 6 March 2014 amending Regulation (EC) No 1881\/2006 as regards maximum levels of the contaminant citrinin in food supplements based on rice fermented with red yeast Monascus purpureus. EFSA J., 67, 3\u20134."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1007\/s00216-016-9348-8","article-title":"Development of magnetic molecularly imprinted polymers for selective extraction: Determination of citrinin in rice samples by liquid chromatography with UV diode array detection","volume":"408","author":"Urraca","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s00216-007-1542-2","article-title":"A liquid chromatography\/tandem mass spectrometric multi-mycotoxin method for the quantification of 87 analytes and its application to semi-quantitative screening of moldy food samples","volume":"389","author":"Sulyok","year":"2007","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1002\/rcm.6255","article-title":"Development and validation of a rapid multi-biomarker liquid chromatography\/tandem mass spectrometry method to assess human exposure to mycotoxins","volume":"26","author":"Warth","year":"2012","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1080\/09540105.2017.1312293","article-title":"Development of ic-ELISA and lateral-flow immunochromatographic assay strip for the detection of citrinin in cereals","volume":"28","author":"Kong","year":"2017","journal-title":"Food Agric. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Kos, J., Jani\u0107 Hajnal, E., Malachov\u00e1, A., Steiner, D., Stranska, M., Krska, R., Poschmaier, B., and Sulyok, M. (2020). Mycotoxins in maize harvested in Republic of Serbia in the period 2012\u20132015. Part 1: Regulated mycotoxins and its derivatives. Food Chem., 312.","DOI":"10.1016\/j.foodchem.2019.126034"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.chroma.2014.08.037","article-title":"Optimization and validation of a quantitative liquid chromatography-tandem mass spectrometric method covering 295 bacterial and fungal metabolites including all regulated mycotoxins in four model food matrices","volume":"1362","author":"Sulyok","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"ref_74","first-page":"85","article-title":"Rapid thin layer chromatographic determination of patulin, citrinin and aflatoxin in apples and pears, and their juices and jams","volume":"66","author":"Gimeno","year":"1983","journal-title":"J. Assoc. Off. Anal. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.chroma.2015.12.004","article-title":"A single-step solid phase extraction for the simultaneous determination of 8 mycotoxins in fruits by ultra-high performance liquid chromatography tandem mass spectrometry","volume":"1429","author":"Wang","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.aca.2008.11.010","article-title":"Analytical methods for determination of mycotoxins: A review","volume":"632","author":"Turner","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3920\/WMJ2017.2250","article-title":"Developments in mycotoxin analysis: An update for 2016-2017","volume":"11","author":"Berthiller","year":"2018","journal-title":"World Mycotoxin J."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Zhang, L., Dou, X.W., Zhang, C., Logrieco, A.F., and Yang, M.H. (2018). A review of current methods for analysis of mycotoxins in herbal medicines. Toxins, 10.","DOI":"10.3390\/toxins10020065"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1002\/jssc.200900652","article-title":"Citrinin selective molecularly imprinted polymers for SPE","volume":"33","author":"Guo","year":"2010","journal-title":"J. Sep. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.bios.2014.09.017","article-title":"A disposable evanescent wave fiber optic sensor coated with a molecularly imprinted polymer as a selective fluorescence probe","volume":"64","author":"Ton","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.talanta.2010.11.007","article-title":"Citrinin (CIT) determination in rice samples using a micro fluidic electrochemical immunosensor","volume":"83","author":"Granero","year":"2011","journal-title":"Talanta"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00204-013-1010-z","article-title":"Methods for analysis of citrinin in human blood and urine","volume":"87","author":"Blaszkewicz","year":"2013","journal-title":"Arch. Toxicol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1007\/s00204-014-1358-8","article-title":"Fast and sensitive LC\u2013MS\/MS method measuring human mycotoxin exposure using biomarkers in urine","volume":"89","author":"Huybrechts","year":"2015","journal-title":"Arch. Toxicol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.aca.2018.02.036","article-title":"Ultra-sensitive, stable isotope assisted quantification of multiple urinary mycotoxin exposure biomarkers","volume":"1019","author":"Ezekiel","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"ref_85","first-page":"51","article-title":"Review of Sample Treatments and the State-of-the-art of Analytical Techniques for Mycotoxins in Food","volume":"Volume 1\u20132","year":"2017","journal-title":"Analysis of Food Toxins and Toxicants"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1016\/j.foodchem.2012.04.072","article-title":"Microsphere-based flow cytometric immunoassay for the determination of citrinin in red yeast rice","volume":"134","author":"Li","year":"2012","journal-title":"Food Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/19440049.2012.743042","article-title":"Preparation of an immunoaffinity column for the clean-up of fermented food samples contaminated with citrinin","volume":"30","author":"Zhu","year":"2013","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control. Expo. Risk Assess."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.snb.2016.02.053","article-title":"Quartz crystal microbalance sensor based on molecularly imprinted polymer membrane and three-dimensional Au nanoparticles@mesoporous carbon CMK-3 functional composite for ultrasensitive and specific determination of citrinin","volume":"230","author":"Fang","year":"2016","journal-title":"Sens. Actuators B Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.apsusc.2015.11.222","article-title":"Sensitive determination of citrinin based on molecular imprinted electrochemical sensor","volume":"362","author":"Atar","year":"2016","journal-title":"Appl. Surf. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.foodchem.2015.03.065","article-title":"A molecular imprinted SPR biosensor for sensitive determination of citrinin in red yeast rice","volume":"184","author":"Atar","year":"2015","journal-title":"Food Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1002\/elan.201400174","article-title":"Mycotoxins: Simultaneous detection of zearalenone and citrinin by voltammetry on edge plane pyrolytic graphite electrode","volume":"26","author":"Nasir","year":"2014","journal-title":"Electroanalysis"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.chroma.2012.10.071","article-title":"Development and application of salting-out assisted liquid\/liquid extraction for multi-mycotoxin biomarkers analysis in pig urine with high performance liquid chromatography\/tandem mass spectrometry","volume":"1292","author":"Song","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00216-007-1717-x","article-title":"Stable isotope dilution assays in mycotoxin analysis","volume":"390","author":"Rychlik","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1002\/jssc.201000423","article-title":"A reliable isotope dilution method for simultaneous determination of fumonisins B1, B2 and B3 in traditional Chinese medicines by ultra-high-performance liquid chromatography-tandem mass spectrometry","volume":"33","author":"Han","year":"2010","journal-title":"J. Sep. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.aca.2010.02.009","article-title":"An ultra-high-performance liquid chromatography-tandem mass spectrometry method for simultaneous determination of aflatoxins B1, B2, G1, G2, M1 and M2 in traditional Chinese medicines","volume":"664","author":"Han","year":"2010","journal-title":"Anal. Chim. Acta"},{"key":"ref_96","first-page":"1240","article-title":"Occurrence of enniatins and beauvericin in 60 Chinese medicinal herbs","volume":"31","author":"Hu","year":"2014","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control. Expo. Risk Assess."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Ouhibi, S., Vidal, A., Martins, C., Gali, R., Hedhili, A., De Saeger, S., and De Boevre, M. (2020). LC-MS\/MS methodology for simultaneous determination of patulin and citrinin in urine and plasma applied to a pilot study in colorectal cancer patients. Food Chem. 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