{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:30:02Z","timestamp":1768692602665,"version":"3.49.0"},"reference-count":78,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>The chemical composition and biological properties correlation in several medicinal and aromatic plants is still underexplored, especially in its most common form of consumption as tisane. The present study aims to characterize the organic acids and vitamin E composition of five tisanes and their extracts by High-Performance Liquid Chromatography coupled to a diode-array detector (HPLC-DAD) and HPLC coupled to a fluorescence detector techniques, respectively, and the phenolic composition by HPLC-DAD-ESI\/MS (mass spectrometry by electrospray ionization). It also focuses on their bioactive properties, namely antioxidant, antimicrobial, anti-inflammatory, cytotoxic, anti-tyrosinase, and anti-diabetic activities. A Principal Component Analysis (PCA) was performed in order to understand the correlation between the chemical composition and bioactive properties of the tisanes. The tisane 5 (T5) composed by lemon thyme, tutsan, cloves, and cinnamon, was the most promising mixture, presenting the lowest values for the lipid peroxidation inhibition, anti-inflammatory, and anti-diabetic activity. It also presented the highest concentration of phenolic acids (caffeoylquinic acids derivatives), and flavan-3-ols (catechin derivatives). Only the dry plants presented tocopherols. For the antihemolytic, antimicrobial, and cytotoxic activity, T2 and T4 (with lemon thyme) were highlighted as the best herbal mixtures. The PCA proved to be a valid tool to select the most promising tisane according to the bioactivity. These results suggest that the studied tisanes can be source of high added-value bioactive compounds with health-promoting effects and potential for application in the food and nutraceutical industries, among others.<\/jats:p>","DOI":"10.3390\/foods10020475","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T14:23:27Z","timestamp":1614003807000},"page":"475","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Phytochemical Characterization and Evaluation of Bioactive Properties of Tisanes Prepared from Promising Medicinal and Aromatic Plants"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5813-4453","authenticated-orcid":false,"given":"Beatriz H.","family":"Paschoalinotto","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Universidade Tecnol\u00f3gica Federal do Paran\u00e1, Campus Campo Mour\u00e3o (UTFPR-CM), Campo Mour\u00e3o 87301-899, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8744-7814","authenticated-orcid":false,"given":"Maria In\u00eas","family":"Dias","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7523-1637","authenticated-orcid":false,"given":"Jos\u00e9","family":"Pinela","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3954-3833","authenticated-orcid":false,"given":"T\u00e2nia C.S.P.","family":"Pires","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"given":"Maria Jos\u00e9","family":"Alves","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5848-8457","authenticated-orcid":false,"given":"Andrei","family":"Mocan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 8 Victor Babe\u0219 Street, 400012 Cluj-Napoca, Romania"},{"name":"Laboratory of Chromatography, Institute of Advanced Horticulture Research of Transylvania, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6801-4578","authenticated-orcid":false,"given":"Ricardo C.","family":"Calhelha","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-5189","authenticated-orcid":false,"given":"Lillian","family":"Barros","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"given":"Rafael P.","family":"Ineu","sequence":"additional","affiliation":[{"name":"Universidade Tecnol\u00f3gica Federal do Paran\u00e1, Campus Campo Mour\u00e3o (UTFPR-CM), Campo Mour\u00e3o 87301-899, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-4882","authenticated-orcid":false,"given":"Isabel C.F.R.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.foodres.2014.11.047","article-title":"Gamma irradiation as a practical alternative to preserve the chemical and bioactive wholesomeness of widely used aromatic plants","volume":"67","author":"Pereira","year":"2015","journal-title":"Food Res. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jpba.2016.01.042","article-title":"The determination of elements in herbal teas and medicinal plant formulations and their tisanes","volume":"130","author":"Pohl","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.fct.2012.09.021","article-title":"A review on antioxidants, prooxidants and related controversy: Natural and synthetic compounds, screening and analysis methodologies and future perspectives","volume":"51","author":"Carocho","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.foodchem.2005.07.042","article-title":"Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses","volume":"99","author":"Balasundram","year":"2006","journal-title":"Food Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.lwt.2013.08.017","article-title":"Mediterranean non-cultivated vegetables as dietary sources of compounds with antioxidant and biological activity","volume":"55","author":"Morales","year":"2014","journal-title":"LWT Food Sci. Technol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/(SICI)1097-0010(20000515)80:7<985::AID-JSFA572>3.0.CO;2-7","article-title":"Phenols in the plant and in man. The potential for possible nutritional enhancement of the diet by modifying the phenols content or profile","volume":"80","author":"Parr","year":"2000","journal-title":"J. Sci. Food Agric."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.carbpol.2009.01.030","article-title":"Polyphenolic-polysaccharide compounds from selected medicinal plants of Asteraceae and Rosaceae families: Chemical characterization and blood anticoagulant activity","volume":"77","author":"Pawlaczyk","year":"2009","journal-title":"Carbohydr. Polym."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0955-2863(01)00155-3","article-title":"A review of latest research findings on the health promotion properties of tea","volume":"12","author":"Dufresne","year":"2001","journal-title":"J. Nutr. Biochem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1016\/j.phytochem.2007.09.014","article-title":"Nutraceuticals: Facts and fiction","volume":"68","year":"2007","journal-title":"Phytochemistry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.foodchem.2015.03.136","article-title":"Scientific validation of synergistic antioxidant effects in commercialised mixtures of Cymbopogon citratus and Pterospartum tridentatum or Gomphrena globosa for infusions preparation","volume":"185","author":"Roriz","year":"2015","journal-title":"Food Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.bse.2004.01.005","article-title":"Comparative chemical composition of Agastache mexicana subsp. mexicana and A. mexicana subsp. xolocotziana","volume":"32","author":"Linares","year":"2004","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/ptr.4807","article-title":"Chamomile and marigold tea: Chemical characterization and evaluation of anticancer activity","volume":"27","author":"Nadvinski","year":"2013","journal-title":"Phyther. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jep.2018.02.001","article-title":"Phytochemical characterization and biological activity evaluation of ethanolic extract of Cinnamomum zeylanicum","volume":"219","author":"Husain","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_14","first-page":"58","article-title":"Biological potential and phytopharmacological screening of Gomphrena species","volume":"3","author":"Ilyas","year":"2014","journal-title":"Glob. J. Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1039\/C5FO01342A","article-title":"A comparison of the bioactivity and phytochemical profile of three different cultivars of globe amaranth: Red, white, and pink","volume":"7","author":"Liberal","year":"2016","journal-title":"Food Funct."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.foodres.2016.08.040","article-title":"Bioactive properties and functional constituents of Hypericum androsaemum L.: A focus on the phenolic profile","volume":"89","author":"Jabeur","year":"2016","journal-title":"Food Res. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.phytol.2016.12.034","article-title":"Three new isobenzofurans from Lavandula angustifolia and their bioactivities","volume":"19","author":"Zhou","year":"2017","journal-title":"Phytochem. Lett."},{"key":"ref_18","first-page":"52","article-title":"Vegetative, physiological, nutritional and antioxidant behavior of spearmint (Mentha spicata L.) in response to different nitrogen supply in hydroponics","volume":"6","author":"Chrysargyris","year":"2017","journal-title":"J. Appl. Res. Med. Aromat. Plants"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.foodres.2013.02.015","article-title":"Commercial peppermint (Mentha\u00d7piperita L.) teas: Antichlamydial effect and polyphenolic composition","volume":"53","author":"Kapp","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.foodchem.2014.05.061","article-title":"Effect of cultivar on phenolic levels, anthocyanin composition, and antioxidant properties in purple basil (Ocimum basilicum L.)","volume":"164","author":"Flanigan","year":"2014","journal-title":"Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0308-8146(03)00151-1","article-title":"Antioxidant activity and total phenolic content of Iranian Ocimum accessions","volume":"83","author":"Javanmardi","year":"2003","journal-title":"Food Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.foodchem.2011.04.011","article-title":"Variations in phenolic composition and antioxidant properties among 15 basil (Ocimum basilicum L.) cultivars","volume":"128","author":"Kwee","year":"2011","journal-title":"Food Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1039\/C7FO01928A","article-title":"Water soluble compounds of: Rosmarinus officinalis L. improve the oxidative and inflammatory states of rats with adjuvant-induced arthritis","volume":"9","author":"Comar","year":"2018","journal-title":"Food Funct."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.foodres.2013.09.016","article-title":"Simultaneous characterization and quantification of phenolic compounds in Thymus x citriodorus using a validated HPLC-UV and ESI-MS combined method","volume":"54","author":"Pereira","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s11130-015-0476-7","article-title":"A Comparison of the nutritional contribution of thirty-nine aromatic plants used as condiments and\/or herbal infusions","volume":"70","author":"Pereira","year":"2015","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.indcrop.2016.04.065","article-title":"Phenolic profile and antioxidant activity of Coleostephus myconis (L.) Rchb.f.: An underexploited and highly disseminated species","volume":"89","author":"Bessada","year":"2016","journal-title":"Ind. Crops Prod."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s12161-012-9443-1","article-title":"Optimized Analysis of Organic Acids in Edible Mushrooms from Portugal by Ultra Fast Liquid Chromatography and Photodiode Array Detection","volume":"6","author":"Barros","year":"2013","journal-title":"Food Anal. Methods"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.foodchem.2017.03.026","article-title":"Wild mushrooms and their mycelia as sources of bioactive compounds: Antioxidant, anti-inflammatory and cytotoxic properties","volume":"230","author":"Souilem","year":"2017","journal-title":"Food Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.indcrop.2018.11.059","article-title":"Chemical features and bioactivities of cornflower (Centaurea cyanus L.) capitula: The blue flowers and the unexplored non-edible part","volume":"128","author":"Lockowandt","year":"2019","journal-title":"Ind. Crops Prod."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.foodchem.2017.08.010","article-title":"Antioxidant and antimicrobial properties of dried Portuguese apple variety (Malus domestica Borkh. cv Bravo de Esmolfe)","volume":"240","author":"Pires","year":"2018","journal-title":"Food Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/14756366.2016.1178247","article-title":"Comparative study of biological activities and multicomponent pattern of two wild Turkish species: Asphodeline anatolica and Potentilla speciosa","volume":"31","author":"Zengin","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.phytochem.2017.07.006","article-title":"Evaluation of Asteraceae herbal extracts in the management of diabetes and obesity. Contribution of caffeoylquinic acids on the inhibition of digestive enzymes activity and formation of advanced glycation end-products (in vitro)","volume":"143","author":"Castilho","year":"2017","journal-title":"Phytochemistry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.indcrop.2017.06.043","article-title":"Everlasting flower (Helichrysum stoechas Moench) as a potential source of bioactive molecules with antiproliferative, antioxidant, antidiabetic and neuroprotective properties","volume":"108","author":"Les","year":"2017","journal-title":"Ind. Crops Prod."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.sajb.2015.08.018","article-title":"Identification of hydroxylcinnamoyl tartaric acid esters in Bidens pilosa by UPLC-tandem mass spectrometry","volume":"103","author":"Khoza","year":"2016","journal-title":"S. Afr. J. Bot."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/pca.935","article-title":"Profiling the chlorogenic acids of aster by HPLC\u2013MSn","volume":"17","author":"Clifford","year":"2006","journal-title":"Phytochem. Anal."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1021\/jf026187q","article-title":"Hierarchical scheme for LC-MSnidentification of chlorogenic acids","volume":"51","author":"Clifford","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Souilem, F., Dias, M.I., Barros, L., Calhelha, R.C., Alves, M.J., Harzallah-Skhiri, F., and Ferreira, I.C.F.R. (2019). Phenolic profile and bioactive properties of carissa macrocarpa (Eckl.) A.DC.: An in vitro comparative study between leaves, stems, and flowers. Molecules, 24.","DOI":"10.3390\/molecules24091696"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.foodres.2017.11.014","article-title":"Edible flowers as sources of phenolic compounds with bioactive potential","volume":"105","author":"Pires","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.fitote.2013.09.012","article-title":"Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain","volume":"91","author":"Ozarowski","year":"2013","journal-title":"Fitoterapia"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.arabjc.2015.06.026","article-title":"Winter wild fennel leaves as a source of anti-inflammatory and antioxidant polyphenols","volume":"11","author":"Pacifico","year":"2018","journal-title":"Arab. J. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"11201","DOI":"10.1021\/jf303267e","article-title":"Characterization of apigenin and luteolin derivatives from oil palm (Elaeis guineensis Jacq.) Leaf using LC-ESI-MS\/MS","volume":"60","author":"Tahir","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jff.2015.04.044","article-title":"A bioactive formulation based on Fragaria vesca L. vegetative parts: Chemical characterisation and application in \u03ba-carrageenan gelatin","volume":"16","author":"Dias","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Majdi, C., Pereira, C., Dias, M.I., Calhelha, R.C., Alves, M.J., Frih, B., Charrouf, Z., Barros, L., Amaral, J.S., and Ferreira, I.C.F.R. (2020). Phytochemical characterization and bioactive properties of cinnamon basil (Ocimum basilicum cv. \u2018cinnamon\u2019) and lemon basil (ocimum x citriodorum). Antioxidants, 9.","DOI":"10.3390\/antiox9050369"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.foodres.2018.08.041","article-title":"Phenolic compounds characterization by LC-DAD- ESI\/MSn and bioactive properties of Thymus algeriensis Boiss. & Reut. and Ephedra alata Decne","volume":"116","author":"Ziani","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1039\/C6FO00270F","article-title":"Rosemary extracts in functional foods: Extraction, chemical characterization and incorporation of free and microencapsulated forms in cottage cheese","volume":"7","author":"Ribeiro","year":"2016","journal-title":"Food Funct."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1039\/C6FO00841K","article-title":"Mentha spicata L. infusions as sources of antioxidant phenolic compounds: Emerging reserve lots with special harvest requirements","volume":"7","author":"Rita","year":"2016","journal-title":"Food Funct."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.phytochem.2011.02.027","article-title":"Determination of the hydroxycinnamate profile of 12 members of the Asteraceae family","volume":"72","author":"Jaiswal","year":"2011","journal-title":"Phytochemistry"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Grzegorczyk-Karolak, I., and Kiss, A.K. (2018). Determination of the phenolic profile and antioxidant properties of Salvia viridis L. Shoots: A comparison of aqueous and hydroethanolic extracts. Molecules, 23.","DOI":"10.3390\/molecules23061468"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jff.2016.01.028","article-title":"Characterization of active constituents in Pyracantha fortuneana fruit extract and their effects on hyperlipidaemia, obesity, and oxidative stress in rodents","volume":"22","author":"Xu","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_50","first-page":"319","article-title":"Foeniculum vulgare essential oils: Chemical composition, antioxidant and antimicrobial activities","volume":"5","author":"Miguel","year":"2010","journal-title":"Nat. Prod. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.foodchem.2018.03.006","article-title":"Exploring reserve lots of Cymbopogon citratus, Aloysia citrodora and Thymus \u00d7 citriodorus as improved sources of phenolic compounds","volume":"257","author":"Rita","year":"2018","journal-title":"Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.foodres.2014.04.036","article-title":"Pterospartum tridentatum, Gomphrena globosa and Cymbopogon citratus: A phytochemical study focused on antioxidant compounds","volume":"62","author":"Roriz","year":"2014","journal-title":"Food Res. Int."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.indcrop.2017.01.007","article-title":"Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: Effects on phenolic composition, cytotoxicity, antibacterial and virucidal activities","volume":"97","author":"Pereira","year":"2017","journal-title":"Ind. Crops Prod."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.1021\/jf020121d","article-title":"Antiproliferative activities of citrus flavonoids against six human cancer cell lines","volume":"50","author":"Manthey","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.2174\/092986709787909587","article-title":"Antioxidants in Wild Mushrooms","volume":"16","author":"Ferreira","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jep.2005.05.024","article-title":"Oleanolic acid and ursolic acid: Research perspectives","volume":"100","author":"Liu","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jep.2006.04.029","article-title":"Antioxidant activity of caffeoyl quinic acid derivatives from the roots of Dipsacus asper Wall","volume":"108","author":"Hung","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.foodcont.2008.02.009","article-title":"Antimicrobial activity of malic acid against Listeria monocytogenes, Salmonella Enteritidis and Escherichia coli O157:H7 in apple, pear and melon juices","volume":"20","year":"2009","journal-title":"Food Control"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.fct.2013.01.031","article-title":"Analysis of organic acids in electron beam irradiated chestnuts (Castanea sativa Mill.): Effects of radiation dose and storage time","volume":"55","author":"Carocho","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s13105-013-0253-8","article-title":"Hypoglycemic and hepatoprotective activity of Rosmarinus officinalis extract in diabetic rats","volume":"69","author":"Ramadan","year":"2013","journal-title":"J. Physiol. Biochem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.livsci.2014.05.006","article-title":"Effects of different levels of clove bud (Syzygium aromaticum) on performance, intestinal microbial colonization, jejunal morphology, and immunocompetence of laying hens fed different n-6 to n-3 ratios","volume":"167","author":"Mahdavi","year":"2014","journal-title":"Livest. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"S2736","DOI":"10.1016\/j.arabjc.2013.10.019","article-title":"Fatty acid composition and tocopherol content in four Tunisian Hypericum species: Hypericum perforatum, Hypericum tomentosum, Hypericum perfoliatum and Hypericum ericoides Ssp. Roberti","volume":"10","author":"Hosni","year":"2017","journal-title":"Arab. J. Chem."},{"key":"ref_63","unstructured":"Instituto Nacional de Sa\u00fade Doutor Ricardo Jorge, IP, and Instituto Nacional de Estat\u00edstica, IP (2005). INSA-Inqu\u00e9rito Nacional de Sa\u00fade, Instituto Nacional de Estat\u00edstica."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cbi.2009.06.007","article-title":"Comparison of quercetin and dihydroquercetin: Antioxidant-independent actions on erythrocyte and platelet membrane","volume":"182","author":"Chen","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijantimicag.2005.09.002","article-title":"Antimicrobial activity of flavonoids","volume":"26","author":"Cushnie","year":"2005","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.foodchem.2012.05.015","article-title":"Phytochemical investigations and biological potential screening with cellular and non-cellular models of globe amaranth (Gomphrena globosaL.) inflorescences","volume":"135","author":"Silva","year":"2012","journal-title":"Food Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.indcrop.2014.11.029","article-title":"Contribution of the main polyphenols of Thymus mastichina subsp: Mastichina to its antioxidant properties","volume":"66","author":"Sponza","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"FSO283","DOI":"10.4155\/fsoa-2017-0124","article-title":"Rosmarinus officinalis L.: An update review of its phytochemistry and biological activity","volume":"4","author":"Andrade","year":"2018","journal-title":"Futur. Sci. OA"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.fitote.2016.09.021","article-title":"A new acetophenone glycoside from the flower buds of Syzygium aromaticum (cloves)","volume":"115","author":"Ryu","year":"2016","journal-title":"Fitoterapia"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/jmf.2014.3262","article-title":"Anti-inflammatory activity of butein and luteolin through suppression of NF\u03baB activation and induction of heme oxygenase-1","volume":"18","author":"Sung","year":"2015","journal-title":"J. Med. Food"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Correa, V.G., Gon\u00e7alves, G.A., de S\u00e1-Nakanishi, A.B., Ferreira, I.C.F.R., Barros, L., Dias, M.I., Koehnlein, E.A., de Souza, C.G.M., Bracht, A., and Peralta, R.M. (2017). Effects of in vitro digestion and in vitro colonic fermentation on stability and functional properties of yerba mate (Ilex paraguariensis A. St. Hil.) beverages. Food Chem., 237.","DOI":"10.1016\/j.foodchem.2017.05.125"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.canlet.2015.07.005","article-title":"Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity","volume":"367","author":"Petiwala","year":"2015","journal-title":"Cancer Lett."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1021\/jf020826f","article-title":"Mushroom tyrosinase: Recent prospects","volume":"51","author":"Seo","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1248\/bpb.30.595","article-title":"Inhibitory compound of tyrosinase activity from the sprout of Polygonum hydropiper L. (Benitade)","volume":"30","author":"Miyazawa","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.phytochem.2004.04.016","article-title":"Chalcones as potent tyrosinase inhibitors: The effect of hydroxyl positions and numbers","volume":"65","author":"Nerya","year":"2004","journal-title":"Phytochemistry"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.jff.2013.03.010","article-title":"\u03b1-Glucosidase inhibitory terpenoids from Potentilla fulgens and their quantitative estimation by validated HPLC method","volume":"5","author":"Kumar","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3109\/09637480903455963","article-title":"Evaluation of \u03b1-glucosidase, \u03b1-amylase and protein glycation inhibitory activities of edible plants","volume":"61","author":"Adisakwattana","year":"2010","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1515\/jbcpp-2013-0141","article-title":"Caffeic and chlorogenic acids inhibit key enzymes linked to type 2 diabetes (in vitro): A comparative study","volume":"26","author":"Oboh","year":"2015","journal-title":"J. Basic Clin. Physiol. Pharmacol."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/10\/2\/475\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:27:57Z","timestamp":1760160477000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/10\/2\/475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,22]]},"references-count":78,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["foods10020475"],"URL":"https:\/\/doi.org\/10.3390\/foods10020475","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,22]]}}}