{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T08:39:07Z","timestamp":1775723947379,"version":"3.50.1"},"reference-count":145,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>According to the WHO, cancer was responsible for an estimated 9.6 million deaths in 2018, making it the second global leading cause of death. The main risk factors that lead to the development of this disease include poor behavioral and dietary habits, such as tobacco use, alcohol use and lack of fruit and vegetable intake, or physical inactivity. In turn, it is well known that polyphenols are deeply implicated with the lower rates of cancer in populations that consume high levels of plant derived foods. In this field, phlorotannins have been under the spotlight in recent years since they have shown exceptional bioactive properties, with great interest for application in food and pharmaceutical industries. Among their multiple bioactive properties, phlorotannins have revealed the capacity to interfere with several biochemical mechanisms that regulate oxidative stress, inflammation and tumorigenesis, which are central aspects in the pathogenesis of cancer. This versatility and ability to act either directly or indirectly at different stages and mechanisms of cancer growth make these compounds highly appealing for the development of new therapeutical strategies to address this world scourge. The present manuscript revises relevant studies focusing the effects of phlorotannins to counteract the oxidative stress\u2013inflammation network, emphasizing their potential for application in cancer prevention and\/or treatment.<\/jats:p>","DOI":"10.3390\/foods10071478","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T11:07:40Z","timestamp":1624619260000},"page":"1478","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Brown Algae Phlorotannins: A Marine Alternative to Break the Oxidative Stress, Inflammation and Cancer Network"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6571-7975","authenticated-orcid":false,"given":"Marcelo D.","family":"Catarino","sequence":"first","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3218-9197","authenticated-orcid":false,"given":"S\u00f3nia J.","family":"Amarante","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9318-9732","authenticated-orcid":false,"given":"Nuno","family":"Mateus","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Artur M. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7882-737X","authenticated-orcid":false,"given":"Susana M.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Catarino, M.D., Silva, A.M.S., and Cardoso, S.M. (2018). Phycochemical Constituents and Biological Activities of Fucus spp. Mar. Drugs, 16.","DOI":"10.3390\/md16080249"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1089\/jmf.2008.0151","article-title":"Characteristics and nutritional and cardiovascular-health properties of seaweeds","volume":"12","author":"Bocanegra","year":"2009","journal-title":"J. Med. Food"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s10499-017-0120-7","article-title":"Seaweed aquaculture in Norway: Recent industrial developments and future perspectives","volume":"25","author":"Rebours","year":"2017","journal-title":"Aquac. Int."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Gomez-Zavaglia, A., Prieto Lage, M.A., Jimenez-Lopez, C., Mejuto, J.C., and Simal-Gandara, J. (2019). The potential of seaweeds as a source of functional ingredients of prebiotic and antioxidant value. Antioxidants, 8.","DOI":"10.3390\/antiox8090406"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/chromsci\/bmt045","article-title":"Preparation and chromatographic analysis of phlorotannins","volume":"51","year":"2013","journal-title":"J. Chromatogr. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1039\/b600518g","article-title":"Phloroglucinol compounds of natural origin","volume":"23","author":"Bharate","year":"2006","journal-title":"Nat. Prod. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Catarino, D.M., Silva, M.A., and Cardoso, M.S. (2017). Fucaceae: A Source of Bioactive Phlorotannins. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18061327"},{"key":"ref_8","unstructured":"(2021, May 06). WHO Cancer. Available online: https:\/\/www.who.int\/health-topics\/cancer#tab=tab_1."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00217-006-0510-y","article-title":"Antioxidant activities of phlorotannins purified from Ecklonia cava on free radical scavenging using ESR and H2O2-mediated DNA damage","volume":"226","author":"Ahn","year":"2007","journal-title":"Eur. Food Res. Technol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Catarino, M.D., Silva, A., Cruz, M.T., Mateus, N., Silva, A.M.S., and Cardoso, S.M. (2020). Phlorotannins from Fucus vesiculosus: Modulation of inflammatory response by blocking NF-\u03baB signaling pathway. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186897"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1745-4514.2012.00663.x","article-title":"Antimicrobial, antioxidant and free radical-scavenging capacity of brown seaweed Himanthalia elongata from western coast of Ireland","volume":"37","author":"Rajauria","year":"2013","journal-title":"J. Food Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.foodchem.2010.11.111","article-title":"Anti-proliferative and potential anti-diabetic effects of phenolic-rich extracts from edible marine algae","volume":"126","author":"Nwosu","year":"2011","journal-title":"Food Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/187221309787158371","article-title":"Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer","volume":"3","author":"Khansari","year":"2009","journal-title":"Recent Pat. Inflamm. Allergy Drug Discov."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","year":"2002","journal-title":"Physiol. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s12291-011-0166-7","article-title":"Evaluation of luteolin in the prevention of N-nitrosodiethylamine-induced hepatocellular carcinoma using animal model system","volume":"27","author":"Balamurugan","year":"2012","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1046\/j.1365-2036.2002.01378.x","article-title":"Review article: Oxidative stress as a pathogenic factor in inflammatory bowel disease\u2014Radicals or ridiculous?","volume":"16","author":"Kruidenier","year":"2002","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/1568026615666141209144506","article-title":"Antioxidant Capacities of Flavones and Benefits in Oxidative-Stress Related Diseases","volume":"15","author":"Catarino","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/j.1440-1746.2012.07108.x","article-title":"Oxidative stress in inflammation-based gastrointestinal tract diseases: Challenges and opportunities","volume":"27","author":"Kim","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.canlet.2008.02.026","article-title":"Oxidative stress, DNA methylation and carcinogenesis","volume":"266","author":"Franco","year":"2008","journal-title":"Cancer Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1002\/ijc.23192","article-title":"Chronic inflammation and oxidative stress in human carcinogenesis","volume":"121","author":"Federico","year":"2007","journal-title":"Int. J. Cancer"},{"key":"ref_21","unstructured":"Pollard, T.D., Earnshaw, W.C., Lippincott-Schwartz, J., and Johnson, G.T. (2017). Programmed Cell Death. Cell Biology, Elsevier."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"a006080","DOI":"10.1101\/cshperspect.a006080","article-title":"Cell death signaling","volume":"7","author":"Green","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_23","first-page":"459","article-title":"Some current insights into oxidative stress","volume":"59","year":"2010","journal-title":"Physiol. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ccr.2012.11.014","article-title":"Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors","volume":"23","author":"Schwitalla","year":"2013","journal-title":"Cancer Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"a001008","DOI":"10.1101\/cshperspect.a001008","article-title":"TP53 mutations in human cancers: Origins, consequences, and clinical use","volume":"2","author":"Olivier","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Aranda, M., P\u00e9rez-Ruiz, E., and Redondo, M. (2018). Bcl-2 inhibition to overcome resistance to chemo-and immunotherapy. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19123950"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.foodchem.2012.11.005","article-title":"Protective effect of marine algae phlorotannins against AAPH-induced oxidative stress in zebrafish embryo","volume":"138","author":"Kang","year":"2013","journal-title":"Food Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1007\/s12272-012-1116-5","article-title":"Neuroprotective effect of edible brown alga Eisenia bicyclis on amyloid beta peptide-induced toxicity in PC12 cells","volume":"35","author":"Ahn","year":"2012","journal-title":"Arch. Pharm. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"956","DOI":"10.4103\/0366-6999.154316","article-title":"Phloroglucinol protects the urinary bladder via inhibition of oxidative stress and inflammation in a rat model of cyclophosphamide-induced interstitial cystitis","volume":"128","author":"He","year":"2015","journal-title":"Chin. Med. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"15638","DOI":"10.3390\/molecules191015638","article-title":"Eckol enhances heme oxygenase-1 expression through activation of Nrf2\/JNK pathway in HepG2 Cells","volume":"19","author":"Jun","year":"2014","journal-title":"Molecules"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.foodchem.2014.11.090","article-title":"Dieckol enhances the expression of antioxidant and detoxifying enzymes by the activation of Nrf2-MAPK signalling pathway in HepG2 cells","volume":"174","author":"Lee","year":"2015","journal-title":"Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.fct.2012.12.012","article-title":"Dieckol isolated from brown seaweed Ecklonia cava attenuates type II diabetes in db\/db mouse model","volume":"53","author":"Kang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1016\/j.bmc.2009.01.031","article-title":"Chemical components and its antioxidant properties in vitro: An edible marine brown alga, Ecklonia cava","volume":"17","author":"Li","year":"2009","journal-title":"Bioorgan. Med. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"25738","DOI":"10.1039\/C5RA00338E","article-title":"Protective effect of marine brown algal polyphenols against oxidative stressed zebrafish with high glucose","volume":"5","author":"Kim","year":"2015","journal-title":"RSC Adv."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5340","DOI":"10.1021\/jf300157w","article-title":"Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and hepatoprotective properties in tacrine-treated HepG2 cells","volume":"60","author":"Lee","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.seppur.2016.05.003","article-title":"In vitro bioactive properties of phlorotannins recovered from hydrothermal treatment of Sargassum muticum","volume":"167","author":"Casas","year":"2016","journal-title":"Sep. Purif. Technol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1021\/jf900820x","article-title":"Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties","volume":"57","author":"Kim","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_39","first-page":"184","article-title":"Van Antioxidant activity of phlorotannins from brown algae","volume":"10","author":"Liu","year":"2017","journal-title":"Int. J. Agric. Biol. Eng."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.1021\/jf3003653","article-title":"Antioxidant capacities of phlorotannins extracted from the brown algae Fucus vesiculosus","volume":"60","author":"Wang","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10126-005-6168-9","article-title":"Phlorotannins as radical scavengers from the extract of Sargassum ringgoldianum","volume":"8","author":"Nakai","year":"2006","journal-title":"Mar. Biotechnol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s10811-007-9254-8","article-title":"Antioxidant activities of phlorotannins isolated from Japanese Laminariaceae","volume":"20","author":"Shibata","year":"2008","journal-title":"J. Appl. Phycol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"7773","DOI":"10.1021\/jf8007053","article-title":"Toxicity and antioxidant activity in vitro and in vivo of two Fucus vesiculosus extracts","volume":"56","author":"Poquet","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1007\/s12010-012-9761-1","article-title":"Antioxidant, anti-inflammatory, and anti-senescence activities of a phlorotannin-rich natural extract from Brown Seaweed Ascophyllum nodosum","volume":"167","author":"Dutot","year":"2012","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10811-012-9832-2","article-title":"Effect of phlorotannin-rich extracts of Ascophyllum nodosum and Himanthalia elongata (Phaeophyceae) on cellular oxidative markers in human HepG2 cells","volume":"25","author":"Goya","year":"2013","journal-title":"J. Appl. Phycol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Lee, S., Youn, K., Kim, D.H., Ahn, M.R., Yoon, E., Kim, O.Y., and Jun, M. (2019). Anti-Neuroinflammatory Property of Phlorotannins from Ecklonia cava on A\u03b225\u201335-Induced Damage in PC12 Cells. Mar. Drugs, 17.","DOI":"10.3390\/md17010007"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4490\/algae.2015.30.4.313","article-title":"Evaluation of phlorofucofuroeckol-A isolated from Ecklonia cava (Phaeophyta) on anti-lipid peroxidation in vitro and in vivo","volume":"30","author":"Lee","year":"2015","journal-title":"Algae"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/phpp.12010","article-title":"Phloroglucinol protects human keratinocytes from ultraviolet B radiation by attenuating oxidative stress","volume":"28","author":"Kim","year":"2012","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.etap.2012.08.003","article-title":"Photo-oxidative stress by ultraviolet-B radiation and antioxidative defense of eckstolonol in human keratinocytes","volume":"34","author":"Jang","year":"2012","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jff.2013.02.007","article-title":"The effect of solvents on the antioxidant activity in Caco-2 cells of Irish brown seaweed extracts prepared using accelerated solvent extraction (ASE\u00ae)","volume":"5","author":"Hayes","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.foodchem.2010.11.127","article-title":"In vitro and cellular antioxidant activities of seaweed extracts prepared from five brown seaweeds harvested in spring from the west coast of Ireland","volume":"126","author":"Queguineur","year":"2011","journal-title":"Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.foodchem.2012.02.205","article-title":"Assessment of the ability of seaweed extracts to protect against hydrogen peroxide and tert-butyl hydroperoxide induced cellular damage in Caco-2 cells","volume":"134","author":"Queguineur","year":"2012","journal-title":"Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Corona, G., Coman, M.M., Guo, Y., Hotchkiss, S., Gill, C., Yaqoob, P., Spencer, J.P.E., and Rowland, I. (2017). Effect of simulated gastrointestinal digestion and fermentation on polyphenolic content and bioactivity of brown seaweed phlorotannin-rich extracts. Mol. Nutr. Food Res., 61.","DOI":"10.1002\/mnfr.201700223"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1016\/j.fct.2010.07.029","article-title":"Effect of phloroglucinol on oxidative stress and inflammation","volume":"48","author":"Kim","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jff.2011.10.001","article-title":"Isolation and identification of new compound, 2,7\u2032-phloroglucinol-6,6\u2032-bieckol from brown algae, Ecklonia cava and its antioxidant effect","volume":"4","author":"Kang","year":"2012","journal-title":"J. Funct. Foods"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1021\/jf801133h","article-title":"Antioxidant effects of phlorotannins isolated from Ishige okamurae in free radical mediated oxidative systems","volume":"56","author":"Zou","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.fct.2012.01.004","article-title":"In vivo UVB-photoprotective activity of extracts from commercial marine macroalgae","volume":"50","author":"Guinea","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.etap.2013.09.018","article-title":"Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebrafish model","volume":"36","author":"Kang","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s10811-010-9565-z","article-title":"Protective effect of Ecklonia cava on UVB-induced oxidative stress: In Vitro and in vivo zebrafish model","volume":"23","author":"Ko","year":"2011","journal-title":"J. Appl. Phycol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1023\/B:JAPH.0000004344.45697.0f","article-title":"Inhibition of mouse liver lipid peroxidation by high molecular weight phlorotannins from Sargassum kjellmanianum","volume":"15","author":"Wei","year":"2003","journal-title":"J. Appl. Phycol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1134\/S1063074017060098","article-title":"The Influence of an Extract from the Marine Brown Alga Sargassum pallidum on the Metabolic Reactions in the Liver under Experimental Toxic Hepatitis","volume":"43","author":"Sprygin","year":"2017","journal-title":"Russ. J. Mar. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/ajcn\/nqy147","article-title":"Impact of a (poly)phenol-rich extract from the brown algae Ascophyllum nodosum on DNA damage and antioxidant activity in an overweight or obese population: A randomized controlled trial","volume":"108","author":"Baldrick","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.foodchem.2011.06.019","article-title":"Effects of diet enriched with restructured meats, containing Himanthalia elongata, on hypercholesterolaemic induction, CYP7A1 expression and antioxidant enzyme activity and expression in growing rats","volume":"129","author":"Bastida","year":"2011","journal-title":"Food Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1248\/bpb.27.1037","article-title":"Preventive effects of Laminaria japonica aqueous extract on the oxidative stress and xanthine oxidase activity in streptozotocin-induced diabetic rat liver","volume":"27","author":"Jin","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00210-019-01652-z","article-title":"Radioprotective efficacy of dieckol against gamma radiation-induced cellular damage in hepatocyte cells","volume":"392","author":"Sadeeshkumar","year":"2019","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.etap.2013.02.013","article-title":"Protective effect of a marine polyphenol, dieckol against carbon tetrachloride-induced acute liver damage in mouse","volume":"35","author":"Kang","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Li, S., Liu, J., Zhang, M., Chen, Y., Zhu, T., and Wang, J. (2018). Protective Effect of Eckol against Acute Hepatic injury Induced by Carbon Tetrachloride in Mice. Mar. Drugs, 16.","DOI":"10.3390\/md16090300"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/jcb.24790","article-title":"Cytoprotective effect of eckol against oxidative stress-induced mitochondrial dysfunction: Involvement of the FoxO3a\/AMPK pathway","volume":"115","author":"Kim","year":"2014","journal-title":"J. Cell. Biochem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/jcb.20668","article-title":"Cytoprotective effect of phloroglucinol on oxidative stress induced cell damage via catalase activation","volume":"97","author":"Kang","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1080\/10715760500161165","article-title":"Triphlorethol-A from Ecklonia cava protects V79-4 lung fibroblast against hydrogen peroxide induced cell damage","volume":"39","author":"Kang","year":"2005","journal-title":"Free Radic. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.3390\/md9122793","article-title":"Inhibitory effects of Ecklonia cava extract on high glucose-induced hepatic stellate cell activation","volume":"9","author":"Yokogawa","year":"2011","journal-title":"Mar. Drugs"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1016\/j.fct.2012.05.026","article-title":"Phloroglucinol: Antioxidant properties and effects on cellular oxidative markers in human HepG2 cell line","volume":"50","author":"Goya","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of Nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.biocel.2009.11.009","article-title":"Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K\/Akt","volume":"42","author":"Kim","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Yang, E.-J., Ahn, S., Ryu, J., Choi, M.-S., Choi, S., Chong, Y.H., Hyun, J.-W., Chang, M.-J., and Kim, H.-S. (2013). Phloroglucinol attenuates motor functional deficits in an animal model of Parkinson\u2019s disease by enhancing Nrf2 activity. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0071178"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s12562-012-0511-7","article-title":"Inhibitory activity of Ecklonia stolonifera and its isolated phlorotannins against Cu2+-induced low-density lipoprotein oxidation","volume":"78","author":"Moon","year":"2012","journal-title":"Fish. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF02974279","article-title":"An antioxidative and antiinflammatory agent for potential treatment of osteoarthritis from Ecklonia cava","volume":"29","author":"Shin","year":"2006","journal-title":"Arch. Pharm. Res."},{"key":"ref_78","first-page":"515","article-title":"Phlorotannins","volume":"3","author":"Venkatesan","year":"2018","journal-title":"Encycl. Food Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1016\/j.fct.2012.03.082","article-title":"Vascular barrier protective effects of phlorotannins on HMGB1-mediated proinflammatory responses in vitro and in vivo","volume":"50","author":"Kim","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.etap.2013.01.009","article-title":"Protective effect of phlorotannins from Eisenia bicyclis against lipopolysaccharide-stimulated inflammation in HepG2 cells","volume":"35","author":"Kang","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1021\/jf9003913","article-title":"Inhibitory effects and molecular mechanism of dieckol isolated from marine brown alga on COX-2 and iNOS in microglial cells","volume":"57","author":"Jung","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/odi.12266","article-title":"Eckols reduce dental pulp inflammation through the ERK1\/2 pathway independent of COX-2 inhibition","volume":"20","author":"Paudel","year":"2014","journal-title":"Oral Dis."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Kim, S., Choi, S., Kim, G., and Imm, J. (2019). Anti-Inflammatory Effect of Ecklonia cava Extract on Porphyromonas gingivalis Lipopolysaccharide-Stimulated Macrophages and a Periodontitis Rat Model. Nutrients, 11.","DOI":"10.3390\/nu11051143"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.fct.2008.11.041","article-title":"Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-\u03baB pathways","volume":"47","author":"Jung","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"362","DOI":"10.2478\/s11756-010-0027-5","article-title":"Ecklonia stolonifera inhibits lipopolysaccharide-induced production of nitric oxide, prostaglandin E2, and proinflammatory cytokines in RAW264.7 macrophages","volume":"65","author":"Yang","year":"2010","journal-title":"Biologia"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"9120","DOI":"10.1021\/jf3022018","article-title":"Anti-inflammatory activities of an ethanol extract of Ecklonia stolonifera in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells","volume":"60","author":"Lee","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1007\/s10811-019-01781-1","article-title":"Biosprospecting potential of kelp (Laminariales, Phaeophyceae) from Baja California Peninsula: Phenolic content, antioxidant properties, anti-inflammatory, and cell viability","volume":"31","author":"Ascencio","year":"2019","journal-title":"J. Appl. Phycol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"6509212","DOI":"10.1155\/2016\/6509212","article-title":"Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK\/NF-kappa B Signaling Pathway","volume":"2016","author":"Lee","year":"2016","journal-title":"J. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.intimp.2012.01.005","article-title":"6,6\u2032-Bieckol, isolated from marine alga Ecklonia cava, suppressed LPS-induced nitric oxide and PGE 2 production and inflammatory cytokine expression in macrophages: The inhibition of NF\u03baB","volume":"12","author":"Yang","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.algal.2017.09.009","article-title":"Phlorotannin extracts from Fucales: Marine polyphenols as bioregulators engaged in inflammation-related mediators and enzymes","volume":"28","author":"Barbosa","year":"2017","journal-title":"Algal Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/08820139.2014.942459","article-title":"Anti-inflammatory effects of ethanolic extract from Sargassum horneri (Turner) C. Agardh on lipopolysaccharide-stimulated macrophage activation via NF-\u03baB pathway regulation","volume":"44","author":"Kim","year":"2015","journal-title":"Immunol. Investig."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s10068-013-0191-9","article-title":"Anti-inflammatory activity of ethanolic extract of Sargassum sagamianum in RAW 264.7 cells","volume":"22","author":"Kim","year":"2013","journal-title":"Food Sci. Biotechnol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3923\/ijp.2013.524.532","article-title":"Inhibitory effect of Sargassum patens on inflammation and melanogenesis","volume":"9","author":"Kim","year":"2013","journal-title":"Int. J. Pharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"747846","DOI":"10.1155\/2013\/747846","article-title":"Sargassum fulvellum protects HaCaT cells and BALB\/c mice from UVB-induced proinflammatory responses","volume":"2013","author":"Lee","year":"2013","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.intimp.2014.06.009","article-title":"Hemeoxygenase 1 partly mediates the anti-inflammatory effect of dieckol in lipopolysaccharide stimulated murine macrophages","volume":"22","author":"Yayeh","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.tiv.2011.09.012","article-title":"Phlorofucofuroeckol A inhibits the LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-\u03baB, Akt, and p38 MAPK","volume":"25","author":"Kim","year":"2011","journal-title":"Toxicol. In Vitro"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3109\/08923973.2016.1173060","article-title":"6,6\u2032-Bieckol suppresses inflammatory responses by down-regulating nuclear factor-\u03baB activation via Akt, JNK, and p38 MAPK in LPS-stimulated microglial cells","volume":"38","author":"Kim","year":"2016","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s10126-017-9787-z","article-title":"Phytochemical Analysis and Evaluation of the Antioxidant, Anti-Inflammatory, and Antinociceptive Potential of Phlorotannin-Rich Fractions from Three Mediterranean Brown Seaweeds","volume":"20","author":"Abdelhamid","year":"2018","journal-title":"Mar. Biotechnol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"7995","DOI":"10.1039\/C9FO02068C","article-title":"The protective effect of Sargassum horneri against particulate matter-induced inflammation in lung tissues of an in vivo mouse asthma model","volume":"10","author":"Sanjeewa","year":"2019","journal-title":"Food Funct."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Joung, E.J., Lee, M.S., Choi, J.W., Kim, J.S., Shin, T., Jung, B.M., Yoon, N.Y., Lim, C.W., Kim, J.I., and Kim, H.R. (2012). Anti-inflammatory effect of ethanolic extract from Myagropsis myagroides on murine macrophages and mouse ear edema. BMC Complement. Altern. Med., 12.","DOI":"10.1186\/1472-6882-12-171"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1021\/acs.jafc.5b04482","article-title":"Protective Effect of Brown Alga Phlorotannins against Hyper-inflammatory Responses in Lipopolysaccharide-Induced Sepsis Models","volume":"64","author":"Yang","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1017\/S0007114516000210","article-title":"Gastrointestinal modifications and bioavailability of brown seaweed phlorotannins and effects on inflammatory markers","volume":"15","author":"Corona","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3136\/fstr.23.475","article-title":"Anti-inflammatory effects of 6,6\u2032-bieckol and 6,8\u2032-bieckol from Eisenia arborea on mouse ear swelling","volume":"23","author":"Sugiura","year":"2017","journal-title":"Food Sci. Technol. Res."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Sugiura, Y., Usui, M., Katsuzaki, H., Imai, K., Kakinuma, M., Amano, H., and Miyata, M. (2018). Orally Administered Phlorotannins from Eisenia arborea Suppress Chemical Mediator Release and Cyclooxygenase-2 Signaling to Alleviate Mouse Ear Swelling. Mar. Drugs, 16.","DOI":"10.3390\/md16080267"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.jff.2013.08.010","article-title":"The anti-inflammatory effects of phlorotannins from Eisenia arborea on mouse ear edema by inflammatory inducers","volume":"5","author":"Sugiura","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3109\/01480545.2014.928719","article-title":"Protective effect of dieckol against chemical hypoxia-induced cytotoxicity in primary cultured mouse hepatocytes","volume":"38","author":"Jeon","year":"2015","journal-title":"Drug Chem. Toxicol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-3164.2011.01009.x","article-title":"Protective effects of phlorotannins against ultraviolet B radiation in zebrafish (Danio rerio)","volume":"23","author":"Cha","year":"2012","journal-title":"Vet. Dermatol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"5508","DOI":"10.1021\/acs.jafc.6b01945","article-title":"MicroRNA134 Mediated Upregulation of JNK and Downregulation of NFkB Signalings Are Critically Involved in Dieckol Induced Antihepatic Fibrosis","volume":"64","author":"Lee","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s12562-011-0379-y","article-title":"Potential effect of phloroglucinol derivatives from Ecklonia cava on matrix metalloproteinase expression and the inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages","volume":"77","author":"Kong","year":"2011","journal-title":"Fish. Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.tiv.2009.11.002","article-title":"Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells","volume":"24","author":"Lee","year":"2010","journal-title":"Toxicol. In Vitro"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.cbi.2009.01.006","article-title":"Differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: Implication for chronic articular disease","volume":"179","author":"Ryu","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.intimp.2014.09.019","article-title":"8,8\u2032-Bieckol, isolated from edible brown algae, exerts its anti-inflammatory effects through inhibition of NF-\u03baB signaling and ROS production in LPS-stimulated macrophages","volume":"23","author":"Yang","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"ref_113","first-page":"207","article-title":"Antioxidant, anti-inflammatory and antiproliferative effects of aqueous extracts of three mediterranean brown seaweeds of the Genus Cystoseira","volume":"13","author":"Mhadhebi","year":"2014","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00432-014-1819-8","article-title":"Dieckol, isolated from the edible brown algae Ecklonia cava, induces apoptosis of ovarian cancer cells and inhibits tumor xenograft growth","volume":"141","author":"Ahn","year":"2014","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s00343-013-2321-x","article-title":"Optimization of the microwave-assisted extraction of phlorotannins from Saccharina japonica Aresch and evaluation of the inhibitory effects of phlorotannin-containing extracts on HepG2 cancer cells","volume":"31","author":"He","year":"2013","journal-title":"Chin. J. Oceanol. Limnol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1080\/10498850.2019.1662865","article-title":"Optimized Extraction, Preliminary Characterization and Evaluation of the In Vitro Anticancer Activity of Phlorotannin-Rich Fraction from the Brown Seaweed, Cystoseira sedoides","volume":"28","author":"Abdelhamid","year":"2019","journal-title":"J. Aquat. Food Prod. Technol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1134\/S1063074009020084","article-title":"Comparative study of chemical composition and antitumor activity of aqueous-ethanol extracts of brown algae Laminaria cichorioides, Costaria costata, and Fucus evanescens","volume":"35","author":"Imbs","year":"2009","journal-title":"Russ. J. Mar. Biol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.fct.2006.02.002","article-title":"Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds","volume":"44","author":"Yuan","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.chroma.2015.07.053","article-title":"Anti-proliferative activity and chemical characterization by comprehensive two-dimensional liquid chromatography coupled to mass spectrometry of phlorotannins from the brown macroalga Sargassum muticum collected on North-Atlantic coasts","volume":"1428","author":"Montero","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.3390\/md13074470","article-title":"Molecular mechanisms by which a Fucus vesiculosus extract mediates cell cycle inhibition and cell death in pancreatic cancer cells","volume":"13","author":"Geisen","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.foodchem.2011.02.005","article-title":"Antimetastatic activity of polyphenol-rich extract of Ecklonia cava through the inhibition of the Akt pathway in A549 human lung cancer cells","volume":"127","author":"Lee","year":"2011","journal-title":"Food Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.lfs.2006.04.022","article-title":"Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity","volume":"79","author":"Kim","year":"2006","journal-title":"Life Sci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10811-017-1228-x","article-title":"Solvent-partitioned fractions from Ishige okamurae extract inhibit MMP-2 and MMP-9 activities in human fibrosarcoma cells in vitro","volume":"30","author":"Karadeniz","year":"2018","journal-title":"J. Appl. Phycol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5483\/BMBRep.2010.43.1.062","article-title":"Inhibition of the expression on MMP-2, 9 and morphological changes via human fibrosarcoma cell line by 6,6\u2032-bieckol from marine alga Ecklonia cava","volume":"43","author":"Zhang","year":"2010","journal-title":"BMB Rep."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e22346","DOI":"10.1002\/jbt.22346","article-title":"Dieckol inhibits non-small-cell lung cancer cell proliferation and migration by regulating the PI3K\/AKT signaling pathway","volume":"33","author":"Wang","year":"2019","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11010-017-3027-8","article-title":"Modulatory efficacy of dieckol on xenobiotic-metabolizing enzymes, cell proliferation, apoptosis, invasion and angiogenesis during NDEA-induced rat hepatocarcinogenesis","volume":"433","author":"Sadeeshkumar","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.3390\/md13041785","article-title":"First evidence that Ecklonia cava-derived dieckol attenuates MCF-7 human breast carcinoma cell migration","volume":"13","author":"Kim","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3839\/jksabc.2011.059","article-title":"Dieckol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced SK-Hep1 human hepatoma cell motility through suppression of matrix metalloproteinase-9 activity","volume":"54","author":"Oh","year":"2011","journal-title":"J. Korean Soc. Appl. Biol. Chem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10811-019-01899-2","article-title":"Dieckol or phlorofucofuroeckol extracted from Ecklonia cava suppresses lipopolysaccharide-mediated human breast cancer cell migration and invasion","volume":"32","author":"Lee","year":"2020","journal-title":"J. Appl. Phycol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s11418-012-0709-0","article-title":"Dieckol, isolated from Ecklonia stolonifera, induces apoptosis in human hepatocellular carcinoma Hep3B cells","volume":"67","author":"Yoon","year":"2013","journal-title":"J. Nat. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1039\/C9FO00865A","article-title":"An in vivo anti-tumor effect of eckol from marine brown algae by improving the immune response","volume":"10","author":"Zhang","year":"2019","journal-title":"Food Funct."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.fct.2009.04.013","article-title":"Induction of apoptosis by phloroglucinol derivative from Ecklonia cava in MCF-7 human breast cancer cells","volume":"47","author":"Kong","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.3892\/or.2014.3355","article-title":"Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells","volume":"32","author":"Kang","year":"2014","journal-title":"Oncol. Rep."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.3892\/ijo.2014.2521","article-title":"Phloroglucinol induces apoptosis through the regulation of insulin-like growth factor 1 receptor signaling pathways in human colon cancer HT-29 cells","volume":"45","author":"Kang","year":"2014","journal-title":"Int. J. Oncol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Eo, H.J., Kwon, T.H., Park, G.H., Song, H.M., Lee, S.J., Park, N.H., and Jeong, J.B. (2016). In Vitro Anticancer Activity of Phlorofucofuroeckol A via Upregulation of Activating Transcription Factor 3 against Human Colorectal Cancer Cells. Mar. Drugs, 14.","DOI":"10.3390\/md14040069"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.critrevonc.2019.02.010","article-title":"Matrix metalloproteinases participation in the metastatic process and their diagnostic and therapeutic applications in cancer","volume":"137","author":"Sommer","year":"2019","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_137","unstructured":"Byun, S.Y., Ham, Y.M., Jeong, D.J., Kim, H.B., Kim, J.H., Song, Y.K., and Yoo, B.S. (2013). Ecklonia cava Extract with High Antioxidant Activity and Process for Preparing the Same Using Supercritical Carbon Dioxide Extraction. (KR101217472B1)."},{"key":"ref_138","unstructured":"Garcia, M.J.N., Guerrero, M.S., and Torres, J.S. (2016). Antioxidant Extract from Brown Macroalgae and Method for Obtaining Same. (US20160074317A1)."},{"key":"ref_139","unstructured":"Choi, J.S., Jung, H.Y., Jung, J.H., Kang, H.S., and Son, B.H. (2005). Composition Comprising Phlorotannins Isolated from the Extract of Ecklonia stolonifera Okamura Having Anti-Oxidative Activity. (KR100512482B1)."},{"key":"ref_140","unstructured":"Kim, M.M., Kim, S.K., Lee, S.H., and Yanping, Z. (2010). An Anti-Oxidant Active Composition Containing Compounds from Ishige okamurae. (KR20100039104A)."},{"key":"ref_141","unstructured":"Choi, J.S., Kim, A.R., Kim, H.R., Kwon, M.S., Shin, T.S., and Woo, H.C. (2011). Anti-Inflammatory Composition Containing Phlorotannins from Ecklonia stolonifera and Ecklonia cava Extract as an Effective Component. (KR20110035127A)."},{"key":"ref_142","unstructured":"Besnard, M., Grandieu, P., Inisan, C., Lerat, Y., Megard, D., Mitjavila, M.T., Rousseau, I., and Simonetti, P. (2008). Algae Extract Containing Polyphenols. (EP1977756A1)."},{"key":"ref_143","unstructured":"Kim, M.M., and Kim, S.K. (2008). Composition Containing Phlorotannin for Inhibition of Matrix Metalloproteinase Activities. (KR100858847B1)."},{"key":"ref_144","unstructured":"Hyun, J.W., Hyun, K.H., Kim, M.J., Lee, N.H., and Lee, S.J. (2013). A Composition Containing Eckol for Inhibiting a Growth of Cancer Stem Cells. (KR20120053265A)."},{"key":"ref_145","unstructured":"Hyiun, J.W., Kim, R.K., Lee, S.J., and Yoon, C.H. (2016). An Anti-Cancer Composition Containing Eckol for Cancer Expressing k-Ras. (KR101596989B1)."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/10\/7\/1478\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:24:09Z","timestamp":1760163849000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/10\/7\/1478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,25]]},"references-count":145,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["foods10071478"],"URL":"https:\/\/doi.org\/10.3390\/foods10071478","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,25]]}}}