{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:06:47Z","timestamp":1775135207093,"version":"3.50.1"},"reference-count":113,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:00:00Z","timestamp":1633737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT","award":["UIDB\/04292\/2020"],"award-info":[{"award-number":["UIDB\/04292\/2020"]}]},{"name":"Operational Programme MAR2020","award":["MAR-04.03.01-FEAMP-0101 \u2013 Limo do Cais"],"award-info":[{"award-number":["MAR-04.03.01-FEAMP-0101 \u2013 Limo do Cais"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Gelidium corneum is a well-known agarophyte, harvested worldwide for its high agar quality. However, the species also exhibits an interesting nutritional profile, but with seasonal variations. Therefore, to evaluate the nutritional value of G. corneum, ash, crude protein, total lipids, and carbohydrates were analyzed at different times of the year. The heavy metals mercury, arsenic, lead, cadmium, and tin, as well as iodine were also measured. Finally, the seasonal antioxidant capacity of G. corneum extracts was evaluated. Our results indicate that the biomass is rich in protein (up to 16.25 \u00b1 0.33%) and carbohydrates (up to 39.5 \u00b1 3.29%), and low in lipids (up to 2.75 \u00b1 0.28%), and especially in the summer, the AI, TI indexes, n-6\/n-3 and h\/H ratios (0.93, 0.6, 0.88 and 1.08, respectively) are very interesting. None of the contaminants exceeded the legally established limits, and the iodine values were adequate for a healthy diet. Finally, the antioxidant capacity is fair, with the DPPH \u2264 10.89 \u00b1 1.46%, and ABTS \u2264 13.90 \u00b1 1.54% inhibition, FRAP \u2264 0.91 \u00b1 0.22 AAE.g\u22121, and TPC \u2264 6.82 \u00b1 0.26 GAE.g\u22121. The results show that G. corneum is an attractive resource, with potential use as food or as a food supplement.<\/jats:p>","DOI":"10.3390\/foods10102394","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T21:19:32Z","timestamp":1633900772000},"page":"2394","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Seasonal Nutritional Profile of Gelidium corneum (Rhodophyta, Gelidiaceae) from the Center of Portugal"],"prefix":"10.3390","volume":"10","author":[{"given":"M\u00e1rio","family":"Cavaco","sequence":"first","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Centre, ESTM, Polytechnic of Leiria, Edif\u00edcio CETEMARES, Av. Porto de Pesca, 2520-641 Peniche, Portugal"}]},{"given":"Adriana","family":"Duarte","sequence":"additional","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Centre, ESTM, Polytechnic of Leiria, Edif\u00edcio CETEMARES, Av. Porto de Pesca, 2520-641 Peniche, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1164-224X","authenticated-orcid":false,"given":"Marta V.","family":"Freitas","sequence":"additional","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Centre, ESTM, Polytechnic of Leiria, Edif\u00edcio CETEMARES, Av. Porto de Pesca, 2520-641 Peniche, Portugal"},{"name":"MARE\u2014Marine and Environmental Sciences Centre, Department of Life Sciences, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4167-5237","authenticated-orcid":false,"given":"Cl\u00e9lia","family":"Afonso","sequence":"additional","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Centre, ESTM, Polytechnic of Leiria, Edif\u00edcio CETEMARES, Av. Porto de Pesca, 2520-641 Peniche, Portugal"}]},{"given":"Susana","family":"Bernardino","sequence":"additional","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Centre, ESTM, Polytechnic of Leiria, Edif\u00edcio CETEMARES, Av. Porto de Pesca, 2520-641 Peniche, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6819-0619","authenticated-orcid":false,"given":"Leonel","family":"Pereira","sequence":"additional","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Centre, Department of Life Sciences, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]},{"given":"Mendelson","family":"Martins","sequence":"additional","affiliation":[{"name":"ESTM\u2014School of Tourism and Maritime Technology, Polytechnic of Leiria, Rua do Conhecimento 4, 2520-614 Peniche, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4849-8840","authenticated-orcid":false,"given":"Teresa","family":"Mouga","sequence":"additional","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Centre, ESTM, Polytechnic of Leiria, Edif\u00edcio CETEMARES, Av. Porto de Pesca, 2520-641 Peniche, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.3390\/md9101860","article-title":"Cnidarians as a source of new marine bioactive compounds\u2014An overview of the last decade and future steps for bio-prospecting","volume":"9","author":"Rocha","year":"2011","journal-title":"Mar. Drugs"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1529-8817.2012.01222.x","article-title":"How many species of algae are there?","volume":"48","author":"Guiry","year":"2012","journal-title":"J. Phycol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4319\/lo.2014.59.1.0156","article-title":"Sea temperature shapes seasonal fluctuations in seaweed biomass within the Ningaloo coral reef ecosystem","volume":"59","author":"Fulton","year":"2014","journal-title":"Limnol. Oceanogr."},{"key":"ref_4","first-page":"1","article-title":"Bioactive compounds and properties of seaweeds\u2014A review","volume":"1","author":"Pal","year":"2014","journal-title":"Open Access Libr. J."},{"key":"ref_5","first-page":"1","article-title":"Seaweed assemblages under a climate change scenario: Functional responses to temperature of eight intertidal seaweeds match recent abundance shifts","volume":"8","author":"Barreiro","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_6","unstructured":"Rao, P.S., Periyasamy, C., Kumar, K.S., Rao, A.S., and Anantharaman, P. (2019). Seaweeds: Distribution, Production and Uses. Bioprospecting of Algae, Society for Plant Research India. Available online: https:\/\/www.researchgate.net\/publication\/329504187."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsps.2009.12.001","article-title":"Biological importance of marine algae","volume":"18","author":"Gamal","year":"2010","journal-title":"Saudi Pharm. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1574-6976.2011.00304.x","article-title":"Microalgae in the postgenomic era: A blooming reservoir for new natural products","volume":"36","author":"Sasso","year":"2012","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.algal.2017.05.019","article-title":"Cosmetic attributes of algae\u2014A review","volume":"25","author":"Ariede","year":"2017","journal-title":"Algal Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9347","DOI":"10.1016\/S0040-4020(01)00931-0","article-title":"Marine cyanobacteria\u2014A prolific source of natural products","volume":"57","author":"Burja","year":"2001","journal-title":"Tetrahedron"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1055\/s-0034-1383001","article-title":"Exploring marine resources for bioactive compounds","volume":"80","author":"Kiuru","year":"2014","journal-title":"Planta Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0304-3835(99)00047-6","article-title":"Potent suppressive effect of a Japanese edible seaweed, Enteromorpha prolifera (Sujiao-nori) on initiation and promotion phases of chemically induced mouse skin tumorigenesis","volume":"140","author":"Otani","year":"1999","journal-title":"Cancer Lett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1016\/j.carres.2008.09.014","article-title":"Chemical structure and antiviral activity of the sulfated heterorhamnan isolated from the green seaweed Gayralia oxysperma","volume":"343","author":"Cassolato","year":"2008","journal-title":"Carbohydr. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4490\/algae.2010.25.4.155","article-title":"Antioxidants from macroalgae: Potential applications in human health and nutrition","volume":"25","author":"Cornish","year":"2010","journal-title":"Algae"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.3390\/md8072038","article-title":"Prebiotics from marine macroalgae for human and animal health applications","volume":"8","author":"Murphy","year":"2010","journal-title":"Mar. Drugs"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Afonso, N.C., Catarino, M.D., Silva, A., and Cardoso, S.M. (2019). Brown macroalgae as valuable food ingredients. Antioxidants, 8.","DOI":"10.3390\/antiox8090365"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Pereira, L. (2016). Edible Seaweeds of the World, CRC Press. [1st ed.].","DOI":"10.1201\/b19970"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/nutrit\/nuy066","article-title":"Risks and benefits of consuming edible seaweeds","volume":"77","author":"Cherry","year":"2019","journal-title":"Nutr. Rev."},{"key":"ref_19","unstructured":"Pereira, L. (2011). A review of the nutrient composition of selected edible seaweeds. Seaweed: Ecology, Nutrient Composition and Medicinal Uses, Nova Science Publishers, Inc.. Available online: https:\/\/www.researchgate.net\/publication\/235767788_A_review_of_the_nutrient_composition_of_selected_edible_seaweeds."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"de Jesus Raposo, M.F., De Morais, A.M.M.B., and De Morais, R.M.S.C. (2016). Emergent sources of prebiotics: Seaweeds and microalgae. Mar. Drugs, 14.","DOI":"10.3390\/md14020027"},{"key":"ref_21","first-page":"1","article-title":"Pharmacological importance of seaweeds: A review","volume":"6","author":"Kolanjinathan","year":"2014","journal-title":"World J. Fish Mar. Sci."},{"key":"ref_22","first-page":"38","article-title":"DHA concentration and purification from the marine heterotrophic microalga Crypthecodinium cohnii CCMP 316 by winterization and urea complexation","volume":"45","author":"Mendes","year":"2007","journal-title":"Food Technol. Biotechnol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ifset.2011.07.004","article-title":"Recent developments in the application of seaweeds or seaweed extracts as a means for enhancing the safety and quality attributes of foods","volume":"12","author":"Gupta","year":"2011","journal-title":"Innovative Food Sci. Emerg. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1515\/BOT.2002.003","article-title":"Fatty acids of marine algae from the Pacific coast of North California","volume":"45","author":"Khotimchenko","year":"2002","journal-title":"Bot. Mar."},{"key":"ref_25","first-page":"133","article-title":"Omega-3 fatty acids","volume":"70","author":"Covington","year":"2004","journal-title":"Am. Fam. Physician"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1183\/09031936.98.11020361","article-title":"Effect of dietary intake of omega-3 and omega-6 fatty acids on severity of asthma in children","volume":"11","author":"Hodge","year":"1998","journal-title":"Eur. Respir. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"931","DOI":"10.17219\/acem\/31243","article-title":"PUFAs: Structures, metabolism and functions","volume":"24","author":"Berezinska","year":"2015","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.foodchem.2009.10.028","article-title":"Lipid, fatty acid, protein, amino acid and ash contents in four Brazilian red algae species","volume":"120","author":"Gressler","year":"2010","journal-title":"Food Chem."},{"key":"ref_29","first-page":"74","article-title":"Fatty acid profiles of marine red alga Gracilaria spp. (Rhodophyta, Gigar-tinales)","volume":"28","author":"Jayasankar","year":"1999","journal-title":"Indian J. Mar. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s10499-020-00633-x","article-title":"European Union legislation on macroalgae products","volume":"29","author":"Rahikainen","year":"2021","journal-title":"Aquac. Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"896","DOI":"10.2174\/138527281807140515154116","article-title":"Bioproducts from seaweeds: A review with special focus on the Iberian Peninsula","volume":"18","author":"Cardoso","year":"2014","journal-title":"Curr. Org. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1023\/B:JAPH.0000004345.31686.7f","article-title":"Nutritional composition of edible Hawaiian seaweeds","volume":"15","author":"McDermid","year":"2003","journal-title":"J. Appl. Phycol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0308-8146(99)00161-2","article-title":"Nutritional composition of edible seaweed Gracilaria changgi","volume":"68","author":"Norziah","year":"2000","journal-title":"Food Chem."},{"key":"ref_34","unstructured":"Guiry, M.D., and Guiry, G.M. (2021). AlgaeBase. World-Wide Electronic Publication, National University of Ireland. Available online: http:\/\/www.algaebase.org."},{"key":"ref_35","unstructured":"Almeida, A.R.G.S.D. (2007). Estudo da Flora Algol\u00f3gica do Intertidal da Praia da Vigia. [Ph.D. Thesis, University of Algarve]."},{"key":"ref_36","unstructured":"Lamouroux, J.V.F. (2021, July 15). Gelidium Corneum (Hudson). Available online: https:\/\/www.algaebase.org\/search\/species\/detail\/?species_id=377."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Cavaco, M., Duarte, A., Bernardino, S., and Afonso, C. (2021). Sustainable Use of Seaweeds from S. Martinho do Porto, Portugal\u2013Past, Present, and Future Perspective, Springer.","DOI":"10.1007\/978-3-030-75315-3_26"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1515\/bot-2019-0012","article-title":"The seaweed resources of Portugal","volume":"62","author":"Gaspar","year":"2019","journal-title":"Bot. Mar."},{"key":"ref_39","unstructured":"Rahikainen, M., and Yang, B. (2021, July 16). Macroalgae as food and feed ingredients in the Baltic Sea region\u2013regulation by the European Union. Available online: https:\/\/www.submariner-network.eu\/images\/grass\/GRASS_O3.4a_EU_regulation_of_seaweed_food_and_feed.pdf."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Hegde, M.V., Zanwar, A.A., and Adekar, S.P. (2016). Omega-3 Fatty Acids: Keys to Nutritional, Springer International Publishing.","DOI":"10.1007\/978-3-319-40458-5"},{"key":"ref_41","unstructured":"FDA, Food and Drug Administration (2021, June 21). National Institutes of Health, Health and Hunan Services, Available online: https:\/\/fdasis.nlm.nih.gov\/srs\/auto\/gelidium%20corneum."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.2174\/138920112804724828","article-title":"The potential of microalgae for the production of bioactive molecules of pharmaceutical interest","volume":"13","author":"Mimouni","year":"2012","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0028-3908(01)00019-3","article-title":"Oxidative stress induced-neurodegenerative diseases: The need for antioxidants that penetrate the blood brain barrier","volume":"40","author":"Melamed","year":"2001","journal-title":"Neuropharmacology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00217-010-1295-6","article-title":"Antioxidant compounds in edible brown seaweeds","volume":"231","year":"2010","journal-title":"Eur. Food Res. Technol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1089\/jmf.2008.0151","article-title":"Characteristics and nutritional and cardiovascular-health properties of seaweeds","volume":"12","author":"Bocanegra","year":"2009","journal-title":"J. Med. Food"},{"key":"ref_47","first-page":"e13389","article-title":"Hypoglycemic and antioxidant effects of five commercial turmeric (Curcuma longa) supplements","volume":"44","year":"2020","journal-title":"J. Food Biochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.aquaculture.2015.08.010","article-title":"Therapeutic efficiency of Portieria hornemannii (Rhodophyta) against Vibrio parahaemolyticus in experimentally infected Oreochromis mossambicus","volume":"450","author":"Fatima","year":"2016","journal-title":"Aquaculture"},{"key":"ref_49","unstructured":"Latimer, G.W. (2016). Appendix D, Guidelines for collaborative study procedures to validate characteristics of a method of analysis. Official Methods of Analysis of AOAC International, Association of Official Analytical Chemists. [20th ed.]."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10811-015-0650-1","article-title":"The protein content of seaweeds: A universal nitrogen-to-protein conversion factor of five","volume":"28","author":"Angell","year":"2016","journal-title":"J. Appl. Phycol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1021\/ac60111a017","article-title":"Colorimetric method for determination of sugars and related substances","volume":"28","author":"Dubois","year":"1956","journal-title":"Anal. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0022-2275(20)38861-1","article-title":"Direct transesterification of all classes of lipids in a one-step reaction","volume":"27","author":"Lepage","year":"1986","journal-title":"J. Lipid Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0140-6736(91)91846-M","article-title":"Coronary heart disease: Seven dietary factors","volume":"338","author":"Ulbricht","year":"1991","journal-title":"Lancet"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Soares, C., Sousa, S., Machado, S., Vieira, E., Carvalho, A.P., Ramalhosa, M.J., Morais, S., Correia, M., Oliva-Teles, T., and Domingues, V. (2021). Bioactive Lipids of Seaweeds from the Portuguese North Coast: Health Benefits versus Potential Contamination. Foods, 10.","DOI":"10.3390\/foods10061366"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"101420","DOI":"10.1016\/j.algal.2019.101420","article-title":"Production of unpurified agar-based extracts from red seaweed Gelidium sesquipedale by means of simplified extraction protocols","volume":"38","author":"Ballester","year":"2019","journal-title":"Algal Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0023-6438(95)80008-5","article-title":"Use of a free radical method to evaluate antioxidant activity","volume":"28","author":"Cuvelier","year":"1995","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Ad\u00e3o, P., Reboleira, J., Teles, M., Santos, B., Ribeiro, N., Teixeira, C.M., Guedes, M., and Pessoa, J.C. (2021). Bernardino, S. Enhancement of the Antioxidant and Antimicrobial Activities of Porphyran through Chemical Modification with Tyrosine Derivatives. Molecules, 26.","DOI":"10.3390\/molecules26102916"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1021\/jf0400056","article-title":"Estimation of scavenging activity of phenolic compounds using the ABTS\u2022+ assay","volume":"52","author":"Nenadis","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5344\/ajev.1965.16.3.144","article-title":"Colorimetry of total phenolics with phosphomo-lybdic-phosphotungstic acid reagents","volume":"16","author":"Singleton","year":"1965","journal-title":"Am. J. Enol. Vitic."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Figueroa, F.L., and Korbee, N. (2010). Interactive effects of UV radiation and nutrients on ecophysiology: Vulnerability and adaptation to climate change. Seaweeds and Their Role in Globally Changing Environments, Springer.","DOI":"10.1007\/978-90-481-8569-6_10"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e12478","DOI":"10.1111\/maec.12478","article-title":"Depth influence on biochemical performance and thallus size of the red alga Gelidium corneum","volume":"39","author":"Quintano","year":"2018","journal-title":"Mar. Ecol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.seares.2013.05.008","article-title":"Solar radiation (PAR and UVA) and water temperature in relation to biochemical performance of Gelidium corneum (Gelidiales, Rhodophyta) in subtidal bottoms off the Basque coast","volume":"83","author":"Quintano","year":"2013","journal-title":"J. Sea Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14710\/ik.ijms.24.1.1-6","article-title":"Nutrient composition of dried seaweed Gracilaria gracilis","volume":"24","author":"Rasyid","year":"2019","journal-title":"Indones. J. Mar. Sci."},{"key":"ref_65","first-page":"601","article-title":"Evaluation of the biochemical composition of tropical red seaweeds Galaxaura rugosa and Gelidiella acerosa from Ujung Genteng waters, Indonesia","volume":"12","author":"Rasyid","year":"2019","journal-title":"Aquac. Aquar. Conserv. Legis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.lwt.2010.05.010","article-title":"Enzyme-enhanced extraction of antioxidant ingredients from red algae Palmaria palmata","volume":"43","author":"Wang","year":"2010","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"116830","DOI":"10.1016\/j.carbpol.2020.116830","article-title":"Tailoring hybrid carrageenans from Mastocarpus stellatus red seaweed using microwave hydrodiffusion and gravity","volume":"248","author":"Torres","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"431","DOI":"10.12691\/jfnr-8-8-7","article-title":"Nutritional Composition and Bioactive Compounds of Red Seaweed: A Mini-Review","volume":"8","author":"Quitral","year":"2020","journal-title":"J. Food Nutr. Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Afonso, C., Correia, A.P., Freitas, M.V., Baptista, T., Neves, M., and Mouga, T. (2021). Seasonal Changes in the Nutritional Composition of Agarophyton vermiculophyllum (Rhodophyta, Gracilariales) from the Center of Portugal. Foods, 10.","DOI":"10.3390\/foods10051145"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1016\/j.bmcl.2008.05.008","article-title":"Monoglycerides from the brown alga Sargassum sagamianum: Isolation, synthesis, and biological activity","volume":"18","author":"Chang","year":"2008","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ab.2011.04.010","article-title":"Comparative evaluation and selection of a method for lipid and fatty acid ex-traction from macroalgae","volume":"415","author":"Kumari","year":"2011","journal-title":"Anal. Biochem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10811-012-9876-3","article-title":"Seasonal composition of lipids, fatty acids, and sterols in the edible red alga Grateloupia turuturu","volume":"25","author":"Kendel","year":"2013","journal-title":"J. Appl. Phycol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1515\/BOT.2002.007","article-title":"Seasonal lipid composition in macroalgae of the northeastern Pacific Ocean","volume":"45","author":"Nelson","year":"2002","journal-title":"Bot. Mar."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Liang, Y., and Wen, Z. (2014). Bio-based nutraceuticals from biorefining. Advances in Biorefineries, Woodhead Publishing.","DOI":"10.1533\/9780857097385.2.596"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.foodchem.2003.08.001","article-title":"Fatty acids, total lipid, protein and ash contents of processed edible seaweeds","volume":"85","year":"2004","journal-title":"Food Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.foodchem.2009.07.047","article-title":"Study of the chemical composition of edible red macroalgae Grateloupia turuturu from Brittany (France)","volume":"119","author":"Denis","year":"2010","journal-title":"Food Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1007\/s13197-014-1372-0","article-title":"Seasonal variation in nutritional composition of Kappaphycus alvarezii (Doty) Doty\u2014An edible seaweed","volume":"52","author":"Kumar","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0304-3770(80)90013-3","article-title":"Seasonal growth and reproduction of intertidal algae in the Townsville region (Queensland, Australia)","volume":"9","author":"Ngan","year":"1980","journal-title":"Aquat. Bot."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Chen, J., and Liu, H. (2020). Nutritional indices for assessing fatty acids: A mini-review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165695"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s10811-010-9578-7","article-title":"Minerals, PUFAs and antioxidant properties of some tropical seaweeds from Saurashtra coast of India","volume":"23","author":"Kumar","year":"2011","journal-title":"J. Appl. Phycol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1476-511X-10-104","article-title":"Polyunsaturated fatty acids in various macroalgal species from north Atlantic and tropical seas","volume":"10","author":"Helsper","year":"2011","journal-title":"Lipids Health Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.3390\/md11103754","article-title":"The red seaweed Gracilaria gracilis as a multi products source","volume":"11","author":"Francavilla","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/jpy.12326","article-title":"Prospects and challenges for industrial production of seaweed bioactives","volume":"51","author":"Hafting","year":"2015","journal-title":"J. Phycol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s10811-018-1596-x","article-title":"Combined effects of seasonal variation and drying methods on the physicochemical properties and antioxidant activity of sugar kelp (Saccharina latissima)","volume":"31","author":"Sappati","year":"2019","journal-title":"J. Appl. Phycol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10811-010-9556-0","article-title":"Nutritional value of selected macroalgae","volume":"23","author":"Patarra","year":"2011","journal-title":"J. Appl. Phycol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1111\/1750-3841.13778","article-title":"Nutritional and functional bioactivity value of selected Azorean macroalgae: Ulva compressa, Ulva rigida, Gelidium microdon, and Pterocladiella capillacea","volume":"82","author":"Paiva","year":"2017","journal-title":"J. Food Sci."},{"key":"ref_87","first-page":"347","article-title":"Co-occurrence and antioxidant activities of fucol and fucophlorethol classes of polymeric phenols in Fucus spiralis","volume":"49","author":"Breton","year":"2006","journal-title":"Bot. Mar."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"94884","DOI":"10.1039\/C6RA16862K","article-title":"Application of Hansen solubility approach for the subcritical and supercritical selective extraction of phlorotannins from Cystoseira abies-marina","volume":"6","author":"Montero","year":"2016","journal-title":"RSC Adv."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Patarra, R.F., Iha, C., Pereira, L., and Neto, A.I. (2019). Concise review of the species Pterocladiella capillacea (SG Gmelin) Santelices Hommersand. J. Appl. Phycol., 1\u201322.","DOI":"10.1007\/s10811-019-02009-y"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1007\/s10811-020-02183-4","article-title":"Concise review of Osmundea pinnatifida (Hudson) Stackhouse","volume":"32","author":"Silva","year":"2020","journal-title":"J. Appl. Phycol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1046\/j.1529-8817.2002.01217.x","article-title":"Seasonal variation of p content and major n pools in Palmaria palmata (Rhodophyta) 1","volume":"38","author":"Rico","year":"2002","journal-title":"J. Phycol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0955-2863(99)00014-5","article-title":"Nutritional value of proteins from edible seaweed Palmaria palmata (Dulse)","volume":"10","author":"Fleurence","year":"1999","journal-title":"J. Nutr. Biochem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0268-005X(09)80105-7","article-title":"Agar yield, quality and standing crop biomass of Gelidium serrulatum, Gelidium floridanum and Pterocladia capillacea in Venezuela","volume":"5","author":"Lemus","year":"1991","journal-title":"Food Hydrocoll."},{"key":"ref_94","first-page":"53","article-title":"Productivity, biochemical composition and biofiltering performance of agarophytic seaweed, Gelidium elegans (Red algae) grown in shrimp hatchery effluents in Malaysia, Iran","volume":"15","author":"Rabiei","year":"2016","journal-title":"J. Fish. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"106905","DOI":"10.1016\/j.foodhyd.2021.106905","article-title":"Investigation of enzyme-assisted methods combined with ultra-sonication under a controlled alkali pretreatment for agar extraction from Gelidium sesquipedale","volume":"120","author":"Li","year":"2021","journal-title":"Food Hydrocoll."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Arvizu-Higuera, D.L., Rodr\u00edguez-Montesinos, Y.E., Murillo-\u00c1lvarez, J.I., Mu\u00f1oz-Ochoa, M., and Hern\u00e1ndez-Carmona, G. (2007). Effect of alkali treatment time and ex-traction time on agar from Gracilaria vermiculophylla. Nineteenth International Seaweed Symposium, Springer.","DOI":"10.1007\/s10811-007-9258-4"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.carbpol.2009.07.001","article-title":"Agar extraction process for Gracilaria cliftonii (Withell, Millar, Kraft, 1994)","volume":"78","author":"Kumar","year":"2009","journal-title":"Carbohydr. Polym."},{"key":"ref_98","first-page":"533","article-title":"Influence of alkali treatment on agar from Gracilaria cornea from Yucatan, Mexico","volume":"9","author":"Robledo","year":"1997","journal-title":"J. Appl. Phycol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.biotechadv.2018.02.006","article-title":"Marine algal carbohydrates as carbon sources for the production of biochemicals and biomaterials","volume":"36","author":"Marques","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Kim, J.H., Lee, J.E., Kim, K.H., and Kang, N.J. (2018). Beneficial effects of marine algae-derived carbohydrates for skin health. Mar. Drugs, 16.","DOI":"10.20944\/preprints201810.0772.v1"},{"key":"ref_101","first-page":"125","article-title":"Seasonal and geographical variation in the chemical composition of the red alga Palmaria palmata (L.) Kuntze","volume":"47","author":"Larsen","year":"2004","journal-title":"Bot. Mar."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1515\/botm.1997.40.1-6.301","article-title":"Chemical and mineral composition of six potentially edible seaweed species of Yucatan","volume":"40","author":"Robledo","year":"1997","journal-title":"Bot. Mar."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11027-010-9275-5","article-title":"Mass-cultivation of carbohydrate rich macroalgae, a possible solution for sustainable biofuel production","volume":"18","author":"Kraan","year":"2013","journal-title":"Mitig. Adapt. Strateg. Glob. Chang."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Santelices, B. (1991). Production ecology of Gelidium. International Workshop on Gelidium, Springer.","DOI":"10.1007\/978-94-011-3610-5_3"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.29121\/granthaalayah.v3.i9SE.2015.3282","article-title":"Effects of heavy metals on human health","volume":"3","author":"Mahurpawar","year":"2015","journal-title":"Int. J. Res.-Granthaalayah"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/1541-4337.12523","article-title":"Food safety hazards in the European seaweed chain","volume":"19","author":"Banach","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jfda.2014.01.014","article-title":"Analysis of iodine content in seaweed by GC-ECD and estimation of iodine intake","volume":"22","author":"Yeh","year":"2014","journal-title":"J. Food Drug Anal."},{"key":"ref_108","first-page":"213","article-title":"Commercial Red Seaweed in Portugal (Gelidium sesquipedale and Pterocladiella capillacea, Florideophyceae): Going beyond a single-purpose product approach by valorizing bioactivity","volume":"36","author":"Matos","year":"2020","journal-title":"Thalass. Int. J. Mar. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4490\/ALGAE.2006.21.1.149","article-title":"Antioxidant activities of red algae from Jeju Island","volume":"21","author":"Heo","year":"2006","journal-title":"Algae"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s11626-013-9603-7","article-title":"Differential growth inhibition of cancer cell lines and antioxidant activity of extracts of red, brown, and green marine algae","volume":"49","author":"Murugan","year":"2013","journal-title":"Vitro Cell. Dev. Biol.-Anim."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3390\/md10020403","article-title":"Antioxidant activity of Hawaiian marine algae","volume":"10","author":"Kelman","year":"2012","journal-title":"Mar. Drugs"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Nishida, Y., Kumagai, Y., Michiba, S., Yasui, H., and Kishimura, H. (2020). Efficient ex-traction and antioxidant capacity of mycosporine-like amino acids from red alga Dulse Palmaria palmata in Japan. Mar. Drugs, 18.","DOI":"10.3390\/md18100502"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.sajb.2013.11.006","article-title":"Ultra-violet radiation-induced generation of reactive oxygen species, DNA damage and in-duction of UV-absorbing compounds in the cyanobacterium Rivularia sp. HKAR-4","volume":"90","author":"Rastogi","year":"2014","journal-title":"S. Afr. J. Bot."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/10\/10\/2394\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:10:58Z","timestamp":1760166658000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/10\/10\/2394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,9]]},"references-count":113,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["foods10102394"],"URL":"https:\/\/doi.org\/10.3390\/foods10102394","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,9]]}}}