{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:20:40Z","timestamp":1774380040553,"version":"3.50.1"},"reference-count":190,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Cardoon (Cynara cardunculus L.) is a Mediterranean plant and member of the Asteraceae family that includes three botanical taxa, the wild perennial cardoon (C. cardunculus L. var. sylvestris (Lamk) Fiori), globe artichoke (C. cardunculus L. var. scolymus L. Fiori), and domesticated cardoon (C. cardunculus L. var. altilis DC.). Cardoon has been widely used in the Mediterranean diet and folk medicine since ancient times. Today, cardoon is recognized as a plant with great industrial potential and is considered as a functional food, with important nutritional value, being an interesting source of bioactive compounds, such as phenolics, minerals, inulin, fiber, and sesquiterpene lactones. These bioactive compounds have been vastly described in the literature, exhibiting a wide range of beneficial effects, such as antimicrobial, anti-inflammatory, anticancer, antioxidant, lipid-lowering, cytotoxic, antidiabetic, antihemorrhoidal, cardiotonic, and choleretic activity. In this review, an overview of the cardoon nutritional and phytochemical composition, as well as its biological potential, is provided, highlighting the main therapeutic effects of the different parts of the cardoon plant on metabolic disorders, specifically associated with hepatoprotective, hypolipidemic, and antidiabetic activity.<\/jats:p>","DOI":"10.3390\/foods11030336","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T20:38:58Z","timestamp":1643143138000},"page":"336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5264-3516","authenticated-orcid":false,"given":"Lu\u00eds R.","family":"Silva","sequence":"first","affiliation":[{"name":"CPIRN-UDI\/IPG\u2014Centro de Potencial e Inova\u00e7\u00e3o em Recursos Naturais, Unidade de Investiga\u00e7\u00e3o para o Desenvolvimento do Interior do Instituto Polit\u00e9cnico da Guarda, 6300-559 Guarda, Portugal"},{"name":"CICS-UBI\u2014Health Sciences Research Centre, University of Beira Interior, 6201-506 Covilh\u00e3, Portugal"}]},{"given":"Telma A.","family":"Jacinto","sequence":"additional","affiliation":[{"name":"CPIRN-UDI\/IPG\u2014Centro de Potencial e Inova\u00e7\u00e3o em Recursos Naturais, Unidade de Investiga\u00e7\u00e3o para o Desenvolvimento do Interior do Instituto Polit\u00e9cnico da Guarda, 6300-559 Guarda, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6832-3082","authenticated-orcid":false,"given":"Paula","family":"Coutinho","sequence":"additional","affiliation":[{"name":"CPIRN-UDI\/IPG\u2014Centro de Potencial e Inova\u00e7\u00e3o em Recursos Naturais, Unidade de Investiga\u00e7\u00e3o para o Desenvolvimento do Interior do Instituto Polit\u00e9cnico da Guarda, 6300-559 Guarda, Portugal"},{"name":"CICS-UBI\u2014Health Sciences Research Centre, University of Beira Interior, 6201-506 Covilh\u00e3, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13002-019-0309-0","article-title":"The use of medicinal plants by the population from the Protected Landscape of \u201cSerra de Montejunto\u201d, Portugal","volume":"15","author":"Vinagre","year":"2019","journal-title":"J. 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