{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T16:15:13Z","timestamp":1760890513401,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"],"award-info":[{"award-number":["UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ARDITI\u2014Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o Tecnologia e Inova\u00e7\u00e3o","award":["UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"],"award-info":[{"award-number":["UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"]}]},{"name":"Portuguese Mass Spectrometry Network","award":["UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"],"award-info":[{"award-number":["UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"]}]},{"name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cA. Avogadro\u201d","award":["UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"],"award-info":[{"award-number":["UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>The aim of the current study was to provide a useful platform to identify characteristic molecular markers related to the authenticity of Italian fortified wines. For this purpose, the volatilomic fingerprint of the most popular Italian fortified wines was established using headspace solid-phase microextraction combined with gas chromatography\u2013mass spectrometry (HS-SPME\/GC-MS). Several volatile organic compounds (VOCs), belonging with distinct chemical groups, were identified, ten of which are common to all the analyzed fortified Italian wines. Terpenoids were the most abundant chemical group in Campari bitter wines due to limonene\u2019s high contribution to the total volatilomic fingerprint, whereas for Marsala wines, alcohols and esters were the most predominant chemical groups. The fortified Italian wines VOCs network demonstrated that the furanic compounds 2-furfural, ethyl furoate, and 5-methyl-2-furfural, constitute potential molecular markers of Marsala wines, while the terpenoids nerol, \u03b1-terpeniol, limonene, and menthone isomers, are characteristic of Vermouth wines. In addition, butanediol was detected only in Barolo wines, and \u03b2-phellandrene and \u03b2-myrcene only in Campari wines. The obtained data reveal an adequate tool to establish the authenticity and genuineness of Italian fortified wines, and at the same time constitute a valuable contribution to identify potential cases of fraud or adulteration to which they are subject, due to the high commercial value associated with these wines. In addition, they contribute to the deepening of scientific knowledge that supports its valorization and guarantee of quality and safety for consumers.<\/jats:p>","DOI":"10.3390\/foods12102058","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T09:23:10Z","timestamp":1684488190000},"page":"2058","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tracing the Volatilomic Fingerprint of the Most Popular Italian Fortified Wines"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7775-3946","authenticated-orcid":false,"given":"Gon\u00e7alo","family":"Jasmins","sequence":"first","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-1022","authenticated-orcid":false,"given":"Rosa","family":"Perestrelo","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-0711","authenticated-orcid":false,"given":"Jean Daniel","family":"Co\u00efsson","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universit\u00e0 degli Studi del Piemonte Orientale \u201cA. Avogadro\u201d, Largo Donegani 2, 28100 Novara, Italy"}]},{"given":"Patr\u00edcia","family":"Sousa","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4918-3704","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"CEB\u2014Centre of Biological Engineering, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal"},{"name":"LABBELS-Associate Laboratory, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6587-9843","authenticated-orcid":false,"given":"Matteo","family":"Bordiga","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universit\u00e0 degli Studi del Piemonte Orientale \u201cA. Avogadro\u201d, Largo Donegani 2, 28100 Novara, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1965-3151","authenticated-orcid":false,"given":"Jos\u00e9 S.","family":"C\u00e2mara","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"},{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias Exatas e Engenharia, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Abreu, T., Perestrelo, R., Bordiga, M., Locatelli, M., Co\u00efsson, J.D., and C\u00e2mara, J.S. (2021). The Flavor Chemistry of Fortified Wines-A Comprehensive Approach. Foods, 10.","DOI":"10.3390\/foods10061239"},{"key":"ref_2","unstructured":"Tredoux, A.G.J., and Silva Ferreira, A.C. (2012). Alcoholic Beverages, Elsevier."},{"key":"ref_3","unstructured":"Reader, H.P., and Dominguez, M. (2003). Fermented Beverage Production, Springer."},{"key":"ref_4","unstructured":"Ferreira, I.M.P.L.V.O., and P\u00e9rez-Palacios, M.T. (2014). Processing and Impact on Antioxidants in Beverages, Elsevier Inc."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Zanfi, A., and Mencarelli, S. (2013). Sweet, Reinforced and Fortified Wines, John Wiley & Sons, Ltd.","DOI":"10.1002\/9781118569184"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.foodchem.2008.02.071","article-title":"Classification of Marsala Wines According to Their Polyphenol, Carbohydrate and Heavy Metal Levels Using Canonical Discriminant Analysis","volume":"110","author":"Rando","year":"2008","journal-title":"Food Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/B978-0-12-384927-4.00008-7","article-title":"Vermouth: Technology of Production and Quality Characteristics","volume":"Volume 63","author":"Panesar","year":"2011","journal-title":"Advances in Food and Nutrition Research"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ffj.2001","article-title":"Aromatic Plants in Alcoholic Beverages. A Review","volume":"25","author":"Tonutti","year":"2010","journal-title":"Flavour Fragr. J."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Kosseva, M.R., Joshi, V.K., and Panesar, P.S. (2017). Science and Technology of Fruit Wine Production, Elsevier.","DOI":"10.1016\/B978-0-12-800850-8.00011-9"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Buglass, A.J. (2011). Handbook of Alcoholic Beverages: Technical, Analytical and Nutritional Aspects, John Wiley & Sons Ltd.. [1st ed.].","DOI":"10.1002\/9780470976524"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.aca.2013.12.018","article-title":"Rapid and Sensitive Methodology for Determination of Ethyl Carbamate in Fortified Wines Using Microextraction by Packed Sorbent and Gas Chromatography with Mass Spectrometric Detection","volume":"811","author":"Pereira","year":"2014","journal-title":"Anal. Chim. Acta"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1021\/jf104219t","article-title":"In-Depth Search Focused on Furans, Lactones, Volatile Phenols, and Acetals as Potential Age Markers of Madeira Wines by Comprehensive Two-Dimensional Gas Chromatography with Time-of-Flight Mass Spectrometry Combined with Solid Phase Microextraction","volume":"59","author":"Perestrelo","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Perestrelo, R., Silva, C., and C\u00e2mara, J.S. (2019). Madeira Wine Volatile Profile. A Platform to Establish Madeirawine Aroma Descriptors. Molecules, 24.","DOI":"10.3390\/molecules24173028"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.talanta.2009.05.019","article-title":"Comparison of Extraction Methods for Volatile Compounds of Muscat Grape Juice","volume":"79","year":"2009","journal-title":"Talanta"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.talanta.2009.07.038","article-title":"Potentialities of Two Solventless Extraction Approaches-Stir Bar Sorptive Extraction and Headspace Solid-Phase Microextraction for Determination of Higher Alcohol Acetates, Isoamyl Esters and Ethyl Esters in Wines","volume":"80","author":"Perestrelo","year":"2009","journal-title":"Talanta"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Saha, B., Longo, R., Torley, P., Saliba, A., and Schmidtke, L. (2018). SPME Method Optimized by Box-Behnken Design for Impact Odorants in Reduced Alcohol Wines. Foods, 7.","DOI":"10.20944\/preprints201807.0394.v1"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Pati, S., Tufariello, M., Crupi, P., Coletta, A., Grieco, F., and Losito, I. (2021). Quantification of Volatile Compounds in Wines by HS-SPME-GC\/MS: Critical Issues and Use of Multivariate Statistics in Method Optimization. Processes, 9.","DOI":"10.3390\/pr9040662"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s12161-019-01491-x","article-title":"Characterization of Volatile Compounds of Dry-Cured Meat Products Using HS-SPME-GC\/MS Technique","volume":"12","author":"Pateiro","year":"2019","journal-title":"Food Anal. Methods"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zeng, L., Fu, Y., Huang, J., Wang, J., Jin, S., Yin, J., and Xu, Y. (2022). Comparative Analysis of Volatile Compounds in Tieguanyin with Different Types Based on HS-SPME-GC-MS. Foods, 11.","DOI":"10.3390\/foods11111530"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s11947-011-0760-y","article-title":"Volatile Composition of Macedonian and Hungarian Wines Assessed by GC\/MS","volume":"6","author":"Ivanova","year":"2013","journal-title":"Food Bioprocess Technol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jchromb.2013.11.032","article-title":"Characterization of Aroma Compounds of Chinese Famous Liquors by Gas Chromatography\u2013Mass Spectrometry and Flash GC Electronic-Nose","volume":"945\u2013946","author":"Xiao","year":"2014","journal-title":"J. Chromatogr. B"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.foodchem.2018.07.093","article-title":"Development and Optimization of a HS-SPME-GC-MS Methodology to Quantify Volatile Carbonyl Compounds in Port Wines","volume":"270","author":"Moreira","year":"2019","journal-title":"Food Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"W388","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: Narrowing the Gap between Raw Spectra and Functional Insights","volume":"49","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Adam, Z.R., Fahrenbach, A.C., Jacobson, S.M., Kacar, B., and Zubarev, D.Y. (2021). Radiolysis Generates a Complex Organosynthetic Chemical Network. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-81293-6"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Perestrelo, R., Silva, C., Gon\u00e7alves, C., Castillo, M., and C\u00e2mara, J.S. (2020). An Approach of the Madeira Wine Chemistry. Beverages, 6.","DOI":"10.3390\/beverages6010012"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.aca.2005.10.023","article-title":"Analytical Characterization of the Aroma of Tinta Negra Mole Red Wine: Identification of the Main Odorants Compounds","volume":"563","author":"Perestrelo","year":"2006","journal-title":"Anal. Chim. Acta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.1021\/jf500947x","article-title":"Quantifying the Contribution of Grape Hexoses to Wine Volatiles by High-Precision [U13C]-Glucose Tracer Studies","volume":"62","author":"Nisbet","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1080\/10942912.2018.1479860","article-title":"Volatile Composition and Aromatic Attributes of Wine Made with Vitisvinifera l.Cv Cabernet Sauvignon Grapes in the Xinjiang Region of China: Effect of Different Commercial Yeasts","volume":"21","author":"Duan","year":"2018","journal-title":"Int. J. Food Prop."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.foodchem.2013.07.061","article-title":"Elucidation of the Volatile Composition of Marsala Wines by Using Comprehensive Two-Dimensional Gas Chromatography","volume":"142","author":"Dugo","year":"2014","journal-title":"Food Chem."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zhao, P., Gao, J., Qian, M., and Li, H. (2017). Characterization of the Key Aroma Compounds in Chinese Syrah Wine by Gas Chromatography-Olfactometry-Mass Spectrometry and Aroma Reconstitution Studies. Molecules, 22.","DOI":"10.3390\/molecules22071045"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00005-007-0039-1","article-title":"Terpenes: Substances Useful in Human Healthcare","volume":"55","author":"Paduch","year":"2007","journal-title":"Arch. Immunol. Ther. Exp."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/12\/10\/2058\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:38:39Z","timestamp":1760125119000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/12\/10\/2058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,19]]},"references-count":31,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["foods12102058"],"URL":"https:\/\/doi.org\/10.3390\/foods12102058","relation":{},"ISSN":["2304-8158"],"issn-type":[{"type":"electronic","value":"2304-8158"}],"subject":[],"published":{"date-parts":[[2023,5,19]]}}}