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The use of dietary fibers as binders of four mycotoxins (zearalenone (ZEA), deoxynivalenol (DON), HT-2, and T-2 toxins) to reduce their bioaccessibility was investigated by in vitro digestion of biscuits enriched with fibers. K-carrageenan is a promising fiber to reduce the bioaccessibility of ZEA, obtaining values lower than 20%, while with pectin a higher reduction of DON, HT-2, and T-2 (50\u201388%) was achieved. Three metabolites of mycotoxins were detected, of which the most important was T-2-triol, which was detected at higher levels compared to T-2. This work has demonstrated the advantages of incorporating dietary fibers into a biscuit recipe to reduce the bioaccessibility of mycotoxins and to obtain healthier biscuits than when a conventional recipe is performed due to its high content of fiber.<\/jats:p>","DOI":"10.3390\/foods12173175","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:09:53Z","timestamp":1692871793000},"page":"3175","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Investigating the Impact of Dietary Fibers on Mycotoxin Bioaccessibility during In Vitro Biscuit Digestion and Metabolites Identification"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0806-9013","authenticated-orcid":false,"given":"Rosal\u00eda","family":"L\u00f3pez-Ruiz","sequence":"first","affiliation":[{"name":"LAQV\/REQUIMTE, Laboratory of Bromatology and Hydrology, Department of Chemical Sciences, Porto University, 4050-313 Porto, Portugal"},{"name":"Research Group \u201cAnalytical Chemistry of Contaminants\u201d, Department of Chemistry and Physics, Research Centre for Mediterranean Intensive Agrosystems and Agri-Food Biotechnology (CIAIMBITAL), University of Almeria, Agrifood Campus of International Excellence, ceiA3, E-04120 Almeria, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4153-9788","authenticated-orcid":false,"given":"Jes\u00fas","family":"Marin-Saez","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, Laboratory of Bromatology and Hydrology, Department of Chemical Sciences, Porto University, 4050-313 Porto, Portugal"},{"name":"Research Group \u201cAnalytical Chemistry of Contaminants\u201d, Department of Chemistry and Physics, Research Centre for Mediterranean Intensive Agrosystems and Agri-Food Biotechnology (CIAIMBITAL), University of Almeria, Agrifood Campus of International Excellence, ceiA3, E-04120 Almeria, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4320-2318","authenticated-orcid":false,"given":"Sara. C.","family":"Cunha","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, Laboratory of Bromatology and Hydrology, Department of Chemical Sciences, Porto University, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3914-6117","authenticated-orcid":false,"given":"Ana","family":"Fernandes","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, Department of Chemistry and Biochemistry, Science Faculty, Porto University, 4169-007 Porto, Portugal"}]},{"given":"Victor","family":"de Freitas","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, Department of Chemistry and Biochemistry, Science Faculty, Porto University, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0189-1357","authenticated-orcid":false,"given":"Olga","family":"Viegas","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, Laboratory of Bromatology and Hydrology, Department of Chemical Sciences, Porto University, 4050-313 Porto, Portugal"},{"name":"Faculty of Nutrition and Food Sciences, University of Porto, 4150-180 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-1431","authenticated-orcid":false,"given":"Isabel M. P. L. V. O.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, Laboratory of Bromatology and Hydrology, Department of Chemical Sciences, Porto University, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tran, V.N., Viktorov\u00e1, J., and Ruml, T. (2020). Mycotoxins: Biotransformation and Bioavailability Assessment Using Caco-2 Cell Monolayer. Toxins, 12.","DOI":"10.3390\/toxins12100628"},{"key":"ref_2","unstructured":"Sobral, M.M.C., Cunha, S.C., Faria, M.A., and Ferreira, I.M.P.L.V.O. (2019). Aflatoxins: Biochemistry, Toxicology, Public Health, Policies and Modern Methods of Analysis, Ed. Nova Science Publishers, Inc."},{"key":"ref_3","unstructured":"Miranda-Castro, S.P. (2013). Aflatoxins, IntechOpen."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Bui-Klimke, T.R., Guclu, H., Kensler, T.W., Yuan, J.M., and Wu, F. 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