{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T03:19:29Z","timestamp":1777087169635,"version":"3.51.4"},"reference-count":500,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Minister of University and Research","award":["MUR, D.M. 1062 del 10.08.2021"],"award-info":[{"award-number":["MUR, D.M. 1062 del 10.08.2021"]}]},{"name":"Italian Minister of University and Research","award":["D.R. 1447\/2022 del 13.10\/2022"],"award-info":[{"award-number":["D.R. 1447\/2022 del 13.10\/2022"]}]},{"name":"Italian Minister of University and Research","award":["J82C22000580005"],"award-info":[{"award-number":["J82C22000580005"]}]},{"name":"Incentivazione della produzione di Aloe vera per lo sviluppo di una filiera agroalimentare di settore","award":["MUR, D.M. 1062 del 10.08.2021"],"award-info":[{"award-number":["MUR, D.M. 1062 del 10.08.2021"]}]},{"name":"Incentivazione della produzione di Aloe vera per lo sviluppo di una filiera agroalimentare di settore","award":["D.R. 1447\/2022 del 13.10\/2022"],"award-info":[{"award-number":["D.R. 1447\/2022 del 13.10\/2022"]}]},{"name":"Incentivazione della produzione di Aloe vera per lo sviluppo di una filiera agroalimentare di settore","award":["J82C22000580005"],"award-info":[{"award-number":["J82C22000580005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Since ancient times, Aloe vera L. (AV) has attracted scientific interest because of its multiple cosmetic and medicinal properties, attributable to compounds present in leaves and other parts of the plant. The collected literature data show that AV and its products have a beneficial influence on human health, both by topical and oral use, as juice or an extract. Several scientific studies demonstrated the numerous biological activities of AV, including, for instance, antiviral, antimicrobial, antitumor, and antifungal. Moreover, its important antidepressant activity in relation to several diseases, including skin disorders (psoriasis, acne, and so on) and prediabetes, is a growing field of research. This comprehensive review intends to present the most significant and recent studies regarding the plethora of AV\u2019s biological activities and an in-depth analysis exploring the component\/s responsible for them. Moreover, its morphology and chemical composition are described, along with some studies regarding the single components of AV available in commerce. Finally, valorization studies and a discussion about the metabolism and toxicological aspects of this \u201cWonder Plant\u201d are reported.<\/jats:p>","DOI":"10.3390\/foods13132155","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T09:01:19Z","timestamp":1720429279000},"page":"2155","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Aloe vera\u2015An Extensive Review Focused on Recent Studies"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7420-4706","authenticated-orcid":false,"given":"Alessia","family":"Catalano","sequence":"first","affiliation":[{"name":"Department of Pharmacy-Drug Sciences, University of Bari \u201cAldo Moro\u201d, Via Orabona 4, 70126 Bari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1386-3601","authenticated-orcid":false,"given":"Jessica","family":"Ceramella","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-7118","authenticated-orcid":false,"given":"Domenico","family":"Iacopetta","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}]},{"given":"Maria","family":"Marra","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6699-005X","authenticated-orcid":false,"given":"Filomena","family":"Conforti","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1776-0271","authenticated-orcid":false,"given":"Francesca R.","family":"Lupi","sequence":"additional","affiliation":[{"name":"Department of Information, Modeling, Electronics and System Engineering, (D.I.M.E.S.), University of Calabria, Via P. Bucci, Cubo 39C, CS, 87036 Rende, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6962-5648","authenticated-orcid":false,"given":"Domenico","family":"Gabriele","sequence":"additional","affiliation":[{"name":"Department of Information, Modeling, Electronics and System Engineering, (D.I.M.E.S.), University of Calabria, Via P. Bucci, Cubo 39C, CS, 87036 Rende, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1050-2402","authenticated-orcid":false,"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[{"name":"CIQUP-IMS\u2014Centro de Investiga\u00e7\u00e3o em Qu\u00edmica da Universidade do Porto, Institute of Molecular Sciences, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2435-8931","authenticated-orcid":false,"given":"Maria Stefania","family":"Sinicropi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.tifs.2016.12.005","article-title":"Aloe vera: Ancient Knowledge with New Frontiers","volume":"61","year":"2017","journal-title":"Trends Food Sci. 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