{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T12:40:01Z","timestamp":1775565601190,"version":"3.50.1"},"reference-count":206,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EU Recovery and Resilience Plan (PRR), under the project: CASEUS: Combined use of renewable energy sources to improve energy efficiency in cheese industry","award":["PRR-C05-i03-I000249"],"award-info":[{"award-number":["PRR-C05-i03-I000249"]}]},{"name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PRR-C05-i03-I000249"],"award-info":[{"award-number":["PRR-C05-i03-I000249"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>The Clean Label concept has gained significant traction in the cheese industry due to consumer preferences for minimally processed cheeses free from synthetic additives. This review explores different approaches for applying Clean Label principles to the cheese industry while maintaining food safety, sensory quality, and shelf life. Non-thermal technologies, such as high-pressure processing (HPP), pulsed electric fields (PEF), ultra-violet (UV), and visible light (VL), are among the most promising methods that effectively control microbial growth while preserving the nutritional and functional properties of cheese. Protective cultures, postbiotics, and bacteriophages represent microbiological strategies that are natural alternatives to conventional preservatives. Another efficient approach involves plant extracts, which contribute to microbial control, and enhance cheese functionality and potential health benefits. Edible coatings, either alone or combined with other methods, also show promising applications. Despite these advantages, several challenges persist: higher costs of production and technical limitations, possible shorter shelf-life, and regulatory challenges, such as the absence of standardized Clean Label definitions and compliance complexities. Further research is needed to develop and refine Clean Label formulations, especially regarding bioactive peptides, sustainable packaging, and advanced microbial control techniques. Addressing these challenges will be essential for expanding Clean Label cheese availability while ensuring product quality and maintaining consumer acceptance.<\/jats:p>","DOI":"10.3390\/foods14050805","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T08:04:44Z","timestamp":1740643484000},"page":"805","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clean Label Approaches in Cheese Production: Where Are We?"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0505-1443","authenticated-orcid":false,"given":"Jaime","family":"Fernandes","sequence":"first","affiliation":[{"name":"UTI\u2014Unidade de Tecnologia e Inova\u00e7\u00e3o, Instituto Nacional de Investiga\u00e7\u00e3o Agr\u00e1ria e Veterin\u00e1ria IP, Quinta do Marqu\u00eas, 2780-157 Oeiras, Portugal"},{"name":"NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-5367","authenticated-orcid":false,"given":"Sandra","family":"Gomes","sequence":"additional","affiliation":[{"name":"UTI\u2014Unidade de Tecnologia e Inova\u00e7\u00e3o, Instituto Nacional de Investiga\u00e7\u00e3o Agr\u00e1ria e Veterin\u00e1ria IP, Quinta do Marqu\u00eas, 2780-157 Oeiras, Portugal"},{"name":"NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3906-4349","authenticated-orcid":false,"given":"Fernando H.","family":"Reboredo","sequence":"additional","affiliation":[{"name":"NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"},{"name":"GeoBioTec Research Center, NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0760-3184","authenticated-orcid":false,"given":"Manuela E.","family":"Pintado","sequence":"additional","affiliation":[{"name":"CBQF\u2014Centro de Biotecnologia e Qu\u00edmica Fina, Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"given":"Olga","family":"Amaral","sequence":"additional","affiliation":[{"name":"GeoBioTec Research Center, NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"},{"name":"School of Agriculture, Polytechnic University of Beja, Rua Pedro Soares, 7800-295 Beja, Portugal"},{"name":"MED\u2014Mediterranean Institute for Agriculture, Environment and Development, University of \u00c9vora, 7006-554 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5108-0018","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Dias","sequence":"additional","affiliation":[{"name":"GeoBioTec Research Center, NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"},{"name":"School of Agriculture, Polytechnic University of Beja, Rua Pedro Soares, 7800-295 Beja, Portugal"},{"name":"MED\u2014Mediterranean Institute for Agriculture, Environment and Development, University of \u00c9vora, 7006-554 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0625-0687","authenticated-orcid":false,"given":"Nuno","family":"Alvarenga","sequence":"additional","affiliation":[{"name":"UTI\u2014Unidade de Tecnologia e Inova\u00e7\u00e3o, Instituto Nacional de Investiga\u00e7\u00e3o Agr\u00e1ria e Veterin\u00e1ria IP, Quinta do Marqu\u00eas, 2780-157 Oeiras, Portugal"},{"name":"GeoBioTec Research Center, NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"ref_1","first-page":"687","article-title":"Agri-Food Systems and the Anthropocene","volume":"111","author":"Reisman","year":"2021","journal-title":"Ann. 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