{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T22:12:23Z","timestamp":1776377543803,"version":"3.51.2"},"reference-count":112,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014439","name":"Partnership for Research and Innovation in the Mediterranean Area","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014439","id-type":"DOI","asserted-by":"crossref"}]},{"name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["PRIMA\/0014\/2019"],"award-info":[{"award-number":["PRIMA\/0014\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Background\/Objectives: Orange peels (OP), a major by-product of the juice industry, are rich in bioactive compounds (phenolic compounds, pectin, carotenoids, and essential oils). Its valorization represents a promising route to reduce food waste and foster a circular bioeconomy. This review aimed to map scientific progress in OP upcycling, focusing on the extraction of bioactive ingredients for human nutrition and integrated biorefinery approaches aligned with zero-waste principles. Methods: A bibliometric analysis and a scoping review were conducted covering studies published between 2003 and 2023. Scopus database and VOSviewer was usedto identify research trends, hotspots, and gaps. Conventional and emerging green extraction methods were critically compared, and integrated biorefinery strategies for maximizing OP valorization were systematically assessed. Results: The analysis revealed an exponential rise in OP research over the past decade, reflecting growing interest in sustainable food waste valorization. Polyphenol- and pectin-rich extracts are currently the focus of research and applications, driven by their high economic and nutritional value. Innovative multi-extraction and zero-waste biorefinery models have emerged, yet most remain at low technological readiness levels. Carotenoids and other bioactive compounds remain underexplored, and challenges persist regarding standardization and scalability. Conclusions: OP valorization is shifting towards integrated green extraction and biorefinery frameworks that address clean-label demands, promote circular economy goals, and align with the Sustainable Development Goals. Future research should prioritize (i) standardized protocols, (ii) scalable green extraction technologies, (iii) the inclusion of underutilized compounds such as carotenoids, and (iv) regulatory pathways to accelerate industrial translation.<\/jats:p>","DOI":"10.3390\/foods14213766","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T14:40:48Z","timestamp":1762180848000},"page":"3766","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Upcycled Orange Peel Ingredients: A Scoping Review on Phytochemical Composition, Extraction Techniques, and Biorefinery Strategies"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9051-8123","authenticated-orcid":false,"given":"Ana A.","family":"Vilas-Boas","sequence":"first","affiliation":[{"name":"CBQF\u2014Centro de Biotecnologia e Qu\u00edmica Fina\u2014Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Arquiteto Lob\u00e3o Vital 172, 4200-374 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9728-1635","authenticated-orcid":false,"given":"Daniela","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"CBQF\u2014Centro de Biotecnologia e Qu\u00edmica Fina\u2014Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Arquiteto Lob\u00e3o Vital 172, 4200-374 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6431-7336","authenticated-orcid":false,"given":"Ricardo","family":"G\u00f3mez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"CBQF\u2014Centro de Biotecnologia e Qu\u00edmica Fina\u2014Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Arquiteto Lob\u00e3o Vital 172, 4200-374 Porto, Portugal"},{"name":"CIICYT\u2014Centro de Investigaci\u00f3n e Innovaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica, Universidad Aut\u00f3noma de Coahuila, Avenida 3, Esquina con Avenida 16, Colonia Lourdes, Saltillo 25070, Coahuila, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0174-6640","authenticated-orcid":false,"given":"D\u00e9bora A.","family":"Campos","sequence":"additional","affiliation":[{"name":"CBQF\u2014Centro de Biotecnologia e Qu\u00edmica Fina\u2014Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Arquiteto Lob\u00e3o Vital 172, 4200-374 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5040-735X","authenticated-orcid":false,"given":"Marta","family":"Correia","sequence":"additional","affiliation":[{"name":"CBQF\u2014Centro de Biotecnologia e Qu\u00edmica Fina\u2014Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Arquiteto Lob\u00e3o Vital 172, 4200-374 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0760-3184","authenticated-orcid":false,"given":"Manuela","family":"Pintado","sequence":"additional","affiliation":[{"name":"CIICYT\u2014Centro de Investigaci\u00f3n e Innovaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica, Universidad Aut\u00f3noma de Coahuila, Avenida 3, Esquina con Avenida 16, Colonia Lourdes, Saltillo 25070, Coahuila, Mexico"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/ijfs.13987","article-title":"Recent Advances in Orange Oil Extraction: An Opportunity for the Valorisation of Orange Peel Waste a Review","volume":"54","author":"Gavahian","year":"2019","journal-title":"Int. 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