{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T01:11:42Z","timestamp":1768612302791,"version":"3.49.0"},"reference-count":159,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Lignans are naturally occurring compounds found in a wide variety of plant species, including flaxseed, soybean, pumpkin seed, broccoli, sesame seed, and some berries. Lignans have been used for centuries in both food and traditional herbal medicine. Recently, numerous new lignans and lignan derivatives with diverse biological properties have been identified. Lignans are considered promising for human health due to their hydrogen-donating antioxidant activity together with their ability to complex divalent transition metal cations. They have demonstrated beneficial effects for cardiovascular disease, as well as in maintaining blood glucose levels, supporting cardiac health, promoting anti-obesity effects, decreasing the risk of renal diseases, enhancing brain function, improving skin and gut health, among others. This review explores the biosynthesis and biological effects of lignans, with a particular focus on their antihypertensive and anti-obesity properties, as well as the molecular mechanisms involved. It also highlights recent advances in sustainable lignan extraction techniques that are suitable for human use. The mechanisms underlying these bioactivities are thought to involve hormonal metabolism and availability, antioxidant action, modulation of angiogenesis, and more. However, further research is needed to fully elucidate the molecular pathways through which lignans exert their therapeutic effects. Overall, lignans from various plant sources hold significant potential for application in functional foods, dietary supplements, and pharmaceutical products aimed at preventing and managing a range of health conditions, including hypertension and obesity.<\/jats:p>","DOI":"10.3390\/foods15020336","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:46:33Z","timestamp":1768574793000},"page":"336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Mechanisms of Lignans in Lowering Blood Pressure and Anti-Obesity Effects: A Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5676-0768","authenticated-orcid":false,"given":"Gitishree","family":"Das","sequence":"first","affiliation":[{"name":"Department of Food Science and Biotechnology, College of Life Science and Biotechnology, Dongguk University-Seoul, Goyang-si 10326, Republic of Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3038-4434","authenticated-orcid":false,"given":"Sandra","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"MED\u2014Mediterranean Institute for Agriculture, Environment and Development & CHANGE\u2014Global Change and Sustainability Institute, Faculdade de Ci\u00eancias e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1017-957X","authenticated-orcid":false,"given":"Jos\u00e9 Basilio","family":"Heredia","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo, A.C. Subsede Culiac\u00e1n, Carretera a Eldorado Km.  5.5, Col. Campo El Diez, Culiac\u00e1n 80110, Sinaloa, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-6169","authenticated-orcid":false,"given":"Nayely","family":"Leyva-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo, A.C. Subsede Culiac\u00e1n, Carretera a Eldorado Km.  5.5, Col. Campo El Diez, Culiac\u00e1n 80110, Sinaloa, Mexico"},{"name":"Posdoc SECIHTI\u2014Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo, A.C. Unidad Culiac\u00e1n, Carretera a Eldorado Km.  5.5, Col. Campo El Diez, Culiac\u00e1n 80110, Sinaloa, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7204-7428","authenticated-orcid":false,"given":"Anabela","family":"Romano","sequence":"additional","affiliation":[{"name":"MED\u2014Mediterranean Institute for Agriculture, Environment and Development & CHANGE\u2014Global Change and Sustainability Institute, Faculdade de Ci\u00eancias e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5112-974X","authenticated-orcid":false,"given":"Spiros","family":"Paramithiotis","sequence":"additional","affiliation":[{"name":"Department of Biological Applications and Technology, University of Ioannina, 45110 Ioannina, Greece"}]},{"given":"Han-Seung","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, College of Life Science and Biotechnology, Dongguk University-Seoul, Goyang-si 10326, Republic of Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4118-4355","authenticated-orcid":false,"given":"Jayanta Kumar","family":"Patra","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, College of Life Science and Biotechnology, Dongguk University-Seoul, Goyang-si 10326, Republic of Korea"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S1572-5995(00)80054-X","article-title":"Recent advances in the chemistry of lignans","volume":"24","author":"Ward","year":"2000","journal-title":"Stud. 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