{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:13:23Z","timestamp":1776708803923,"version":"3.51.2"},"publisher-location":"Basel Switzerland","reference-count":13,"publisher":"MDPI","license":[{"start":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T00:00:00Z","timestamp":1697241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT\/Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior (MCTES)","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"FCT\/Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior (MCTES)","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"FCT\/Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior (MCTES)","award":["C644915664-00000026"],"award-info":[{"award-number":["C644915664-00000026"]}]},{"name":"NextGenerationEU","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"NextGenerationEU","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"NextGenerationEU","award":["C644915664-00000026"],"award-info":[{"award-number":["C644915664-00000026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.3390\/foods2023-15026","type":"proceedings-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T10:51:18Z","timestamp":1700045478000},"page":"13","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Bioactive Potential of Gracilaria gracilis: An Extraction Optimization Study Using Response Surface Methodology"],"prefix":"10.3390","author":[{"given":"C\u00e1tia","family":"Neves","sequence":"first","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"},{"name":"Ci\u00eancias Qu\u00edmicas e das Biomol\u00e9culas\/CISA, Escola Superior de Sa\u00fade\u2014Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 400, 4200-072 Porto, Portugal"}]},{"given":"Stephanie","family":"Morais","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]},{"given":"Tiago","family":"Vale","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0924-9681","authenticated-orcid":false,"given":"Cristina","family":"Soares","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]},{"given":"Clara","family":"Grosso","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3472-849X","authenticated-orcid":false,"given":"Valentina F.","family":"Domingues","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8687-4811","authenticated-orcid":false,"given":"M\u00f3nica","family":"Vieira","sequence":"additional","affiliation":[{"name":"Ci\u00eancias Qu\u00edmicas e das Biomol\u00e9culas\/CISA, Escola Superior de Sa\u00fade\u2014Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 400, 4200-072 Porto, Portugal"},{"name":"TBIO, Center for Translational Health and Medical Biotechnology, Rua Dr. Ant\u00f3nio Bernardino de Almeida 400, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-776X","authenticated-orcid":false,"given":"Cristina","family":"Delerue-Matos","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"R590","DOI":"10.1016\/j.cub.2014.05.039","article-title":"Algae","volume":"24","author":"Raven","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/B978-0-12-387669-0.00002-8","article-title":"Nutritional and Digestive Health Benefits of Seaweed","volume":"64","author":"Rajapakse","year":"2011","journal-title":"Adv. Food Nutr. Res."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Quit\u00e9rio, E., Soares, C., Ferraz, R., Delerue-Matos, C., and Grosso, C. (2021). Marine Health-Promoting Compounds: Recent Trends for Their Characterization and Human Applications. Foods, 10.","DOI":"10.3390\/foods10123100"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Pangestuti, R., Siahaan, E., and Kim, S.-K. (2018). Photoprotective Substances Derived from Marine Algae. Mar. Drugs, 16.","DOI":"10.3390\/md16110399"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1007\/s13197-019-03952-x","article-title":"The Importance of Antioxidants and Place in Today\u2019s Scientific and Technological Studies","volume":"56","author":"Zehiroglu","year":"2019","journal-title":"J. Food Sci. Technol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Reboleira, J., Ganh\u00e3o, R., Mendes, S., Ad\u00e3o, P., Andrade, M., Vilarinho, F., Sanches-Silva, A., Sousa, D., Mateus, A., and Bernardino, S. (2020). Optimization of Extraction Conditions for Gracilaria Gracilis Extracts and Their Antioxidative Stability as Part of Microfiber Food Coating Additives. Molecules, 25.","DOI":"10.3390\/molecules25184060"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.3390\/md11103754","article-title":"The Red Seaweed Gracilaria Gracilis as a Multi Products Source","volume":"11","author":"Francavilla","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Quit\u00e9rio, E., Grosso, C., Ferraz, R., Delerue-Matos, C., and Soares, C. (2022). A Critical Comparison of the Advanced Extraction Techniques Applied to Obtain Health-Promoting Compounds from Seaweeds. Marine Drugs, 20.","DOI":"10.3390\/md20110677"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.talanta.2008.05.019","article-title":"Response Surface Methodology (RSM) as a Tool for Optimization in Analytical Chemistry","volume":"76","author":"Bezerra","year":"2008","journal-title":"Talanta"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"745","DOI":"10.12944\/CRNFSJ.9.3.03","article-title":"An Overview on the Use of Response Surface Methodology to Model and Optimize Extraction Processes in the Food Industry","volume":"9","year":"2021","journal-title":"Curr. Res. Nutr. Food Sci. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.aca.2007.07.011","article-title":"Box-Behnken Design: An Alternative for the Optimization of Analytical Methods","volume":"597","author":"Ferreira","year":"2007","journal-title":"Anal. Chim. Acta"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s13201-020-01213-3","article-title":"Optimization Using Central Composite Design (CCD) of Response Surface Methodology (RSM) for Biosorption of Hexavalent Chromium from Aqueous Media","volume":"10","author":"Bayuo","year":"2020","journal-title":"Appl. Water Sci."},{"key":"ref_13","unstructured":"Ait-Amir, B., Pougnet, P., and El Hami, A. (2020). Embedded Mechatronic Systems 2: Analysis of Failures, Modeling, Simulation and Optimization, ISTE."}],"event":{"name":"Foods 2023","acronym":"Foods 2023"},"container-title":["Foods 2023"],"original-title":[],"link":[{"URL":"https:\/\/www.mdpi.com\/2673-9976\/26\/1\/13\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:23:21Z","timestamp":1760131401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2673-9976\/26\/1\/13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,14]]},"references-count":13,"alternative-id":["Foods2023-15026"],"URL":"https:\/\/doi.org\/10.3390\/foods2023-15026","relation":{},"subject":[],"published":{"date-parts":[[2023,10,14]]}}}