{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:39:20Z","timestamp":1771551560541,"version":"3.50.1"},"reference-count":96,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia, Portugal","award":["UID\/MAR\/04292\/2019"],"award-info":[{"award-number":["UID\/MAR\/04292\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Type 2 Diabetes Mellitus (T2DM) is a chronic disease which corresponds to 90% of the worldwide cases of diabetes, mainly due to epigenetic factors such as unhealthy lifestyles. First line therapeutic approaches are based on lifestyle changes, most of the time complemented with medication mostly associated with several side effects and high costs. As a result, the scientific community is constantly working for the discovery and development of natural therapeutic strategies that provide lower financial impact and minimize side effects. This review focus on these nature-based therapeutic strategies for prevention and control of T2DM, with a special emphasis on natural compounds that present pharmacological activity as dipeptidyl peptidase-4 (DPP4), alpha-amylase, alpha-glucosidase, lipase, and protein tyrosine phosphatase 1B (PTP1B) inhibitors.<\/jats:p>","DOI":"10.3390\/foods9030271","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T13:06:23Z","timestamp":1583240783000},"page":"271","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Phytopharmacological Strategies in the Management of Type 2 Diabetes Mellitus"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7103-3924","authenticated-orcid":false,"given":"Ana M.","family":"Duarte","sequence":"first","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Center, Polit\u00e9cnico de Leiria, 2520-630 Peniche, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6079-1105","authenticated-orcid":false,"given":"Maria P.","family":"Guarino","sequence":"additional","affiliation":[{"name":"ciTechCare\u2014Center for Innovative Care and Health Technology, Polit\u00e9cnico de Leiria, 2410-541 Leiria, Portugal"}]},{"given":"S\u00f3nia","family":"Barroso","sequence":"additional","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Center, Polit\u00e9cnico de Leiria, 2520-630 Peniche, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8008-9839","authenticated-orcid":false,"given":"Maria M.","family":"Gil","sequence":"additional","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Center, Polit\u00e9cnico de Leiria, 2520-630 Peniche, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.3390\/md13085447","article-title":"Potencial bioactive compounds from seaweed for diabetes management","volume":"13","author":"Sharifuddin","year":"2015","journal-title":"Mar. 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