{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:31:14Z","timestamp":1760146274397,"version":"build-2065373602"},"reference-count":248,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian Research Councils: Conselho Nacional do Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["PQ\u20132022","308411\/2022-6","CAPES-PROEX, 001","UIDB\/00313\/2020","UIDP\/00313\/2020"],"award-info":[{"award-number":["PQ\u20132022","308411\/2022-6","CAPES-PROEX, 001","UIDB\/00313\/2020","UIDP\/00313\/2020"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["PQ\u20132022","308411\/2022-6","CAPES-PROEX, 001","UIDB\/00313\/2020","UIDP\/00313\/2020"],"award-info":[{"award-number":["PQ\u20132022","308411\/2022-6","CAPES-PROEX, 001","UIDB\/00313\/2020","UIDP\/00313\/2020"]}]},{"name":"Portuguese Agency for Scientific Research, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)","award":["PQ\u20132022","308411\/2022-6","CAPES-PROEX, 001","UIDB\/00313\/2020","UIDP\/00313\/2020"],"award-info":[{"award-number":["PQ\u20132022","308411\/2022-6","CAPES-PROEX, 001","UIDB\/00313\/2020","UIDP\/00313\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Future Pharmacology"],"abstract":"<jats:p>Metallodrugs represent a critical area of medicinal chemistry with the potential to address a wide range of diseases. Their design requires a multidisciplinary approach, combining principles of inorganic chemistry, pharmacology, and molecular biology to create effective and safe therapeutic agents. Vanadium, the element of the fifth group of the first transition series (3d metals), has been already detected as a crucial species in the biological action of some enzymes, e.g., nitrogenases and chloroperoxidase; furthermore, vanadium-based compounds have recently been described as physiologically stable with therapeutic behavior, e.g., having anticancer, antidiabetic (insulin-mimicking), antiprotozoal, antibacterial, antiviral, and inhibition of neurodegenerative disease properties. Since the binding of metallodrugs to serum albumin influences the distribution, stability, toxicity (intended and off-target interactions), and overall pharmacological properties, the biophysical characterization between serum albumin and vanadium-based compounds is one of the hot topics in pharmacology. Overall, since vanadium complexes offer new possibilities for the design of novel metallodrugs, this review summarized some up-to-date biological and medicinal aspects, highlighting proteins as the main targets for the inorganic complexes based on this transition metal.<\/jats:p>","DOI":"10.3390\/futurepharmacol4040040","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T10:50:08Z","timestamp":1729853408000},"page":"743-774","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Role of Vanadium in Metallodrugs Design and Its Interactive Profile with Protein Targets"],"prefix":"10.3390","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6211-7659","authenticated-orcid":false,"given":"Ot\u00e1vio Augusto","family":"Chaves","sequence":"first","affiliation":[{"name":"Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Sciences (CQC-IMS), University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7621-3964","authenticated-orcid":false,"given":"Francisco Mainardi","family":"Martins","sequence":"additional","affiliation":[{"name":"Laboratory of Inorganic Materials, Department of Chemistry, Center for Natural and Exact Sciences (CCNE), Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7004-0110","authenticated-orcid":false,"given":"Carlos","family":"Serpa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Sciences (CQC-IMS), University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal"}]},{"given":"Davi Fernando","family":"Back","sequence":"additional","affiliation":[{"name":"Laboratory of Inorganic Materials, Department of Chemistry, Center for Natural and Exact Sciences (CCNE), Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hernandez, L., Araujo, M.L., Madden, W., Del Carpio, E., Lubes, V., and Lubes, G. 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