{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T05:16:38Z","timestamp":1766034998907,"version":"3.48.0"},"reference-count":42,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0037\/2020, UIDP\/50025\/2020, and UIDB\/50025\/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling, and Nanofabrication-i3N"],"award-info":[{"award-number":["LA\/P\/0037\/2020, UIDP\/50025\/2020, and UIDB\/50025\/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling, and Nanofabrication-i3N"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["Center for Innovative Biomedicine and Biotechnology (CIBB) through the Strategic Projects UIDB\/04539\/2020 (https:\/\/doi.org\/10.54499\/UIDB\/04539\/2020) and UIDP\/04539\/2020 (https:\/\/doi.org\/10.54499\/UIDP\/04539\/2020) and the Associated Laboratory funding LA\/P\/"],"award-info":[{"award-number":["Center for Innovative Biomedicine and Biotechnology (CIBB) through the Strategic Projects UIDB\/04539\/2020 (https:\/\/doi.org\/10.54499\/UIDB\/04539\/2020) and UIDP\/04539\/2020 (https:\/\/doi.org\/10.54499\/UIDP\/04539\/2020) and the Associated Laboratory funding LA\/P\/"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Diabetes mellitus is a serious public health problem, mainly due to the difficulty in healing chronic wounds, which present an inflammatory response for long periods of time and are more vulnerable to infections. Hydrogels are a promising therapeutic solution due to their biocompatibility, biodegradability, and ability to allow controlled release of therapeutic agents. The addition of bioactive glasses doped with therapeutic ions to hydrogels can also provide specific biological responses to the system and thus improve tissue regeneration. In this study, a hydrogel based on carboxymethylcellulose and polyethylene glycol with different degrees of crosslinking and enriched with 10% by weight of CeO2-doped Bioglass 45S5 was developed. Structural, morphological, mechanical, and biological characterizations were performed on bioactive glass, hydrogels, and hydrogels enriched with bioactive glass. Structural analyses confirmed the preservation of the typical amorphous structure of Bioglass 45S5, even after the incorporation of 5% molar CeO2, as well as the effectiveness of the polymer matrix crosslinking process. Structural analyses demonstrated the preservation of the typical amorphous structure of Bioglass 45S5, even after the incorporation of 5 mol% CeO2, as well as the effectiveness of the polymer matrix cross-linking process. The hydrogels exhibited distinct behaviours in terms of water absorption and degradation, showing that the sample with the lowest concentration of crosslinkers and bioactive glass allowed for a higher expansion rate and a higher degradation rate. The hydrogel with 10 wt% BG did not compromise cell viability and showed structural integrity after being subjected to cyclic flexible deformations, indicating its safety and suitability for use in tissue engineering.<\/jats:p>","DOI":"10.3390\/gels11121010","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T15:41:12Z","timestamp":1765899672000},"page":"1010","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of CeO2-Doped Bioactive Glass on the Properties of CMC\/PEG Hydrogels Intended for Wound Treatment"],"prefix":"10.3390","volume":"11","author":[{"given":"Sofia","family":"Pacheco","sequence":"first","affiliation":[{"name":"i3N and Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5690-3020","authenticated-orcid":false,"given":"In\u00eas Alexandra","family":"Marques","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Rua Larga, 3004-504 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-4650","authenticated-orcid":false,"given":"Ana Salom\u00e9","family":"Pires","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Rua Larga, 3004-504 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), Praceta Professor Mota Pinto, 3004-561 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-1650","authenticated-orcid":false,"given":"Maria Filomena","family":"Botelho","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Rua Larga, 3004-504 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), Praceta Professor Mota Pinto, 3004-561 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4084-5764","authenticated-orcid":false,"given":"S\u00edlvia Soreto","family":"Teixeira","sequence":"additional","affiliation":[{"name":"i3N and Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6858-9507","authenticated-orcid":false,"given":"Manuel","family":"Gra\u00e7a","sequence":"additional","affiliation":[{"name":"i3N and Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6216-3735","authenticated-orcid":false,"given":"S\u00edlvia","family":"Gavinho","sequence":"additional","affiliation":[{"name":"i3N and Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9786","DOI":"10.1038\/s41467-024-54075-7","article-title":"A Microenvironment-Modulating Dressing with Proliferative Degradants for the Healing of Diabetic Wounds","volume":"15","author":"Cheng","year":"2024","journal-title":"Nat. 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