{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T13:51:43Z","timestamp":1775051503795,"version":"3.50.1"},"reference-count":90,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:00:00Z","timestamp":1631923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI\u201401-0145-FEDER-007688 (Reference UID\/CTM\/50025)"],"award-info":[{"award-number":["POCI\u201401-0145-FEDER-007688 (Reference UID\/CTM\/50025)"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/CTMCTM\/30623\/2017"],"award-info":[{"award-number":["PTDC\/CTMCTM\/30623\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/144986\/2019"],"award-info":[{"award-number":["SFRH\/BD\/144986\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Engineering drug delivery systems (DDS) aim to release bioactive cargo to a specific site within the human body safely and efficiently. Hydrogels have been used as delivery matrices in different studies due to their biocompatibility, biodegradability, and versatility in biomedical purposes. Microparticles have also been used as drug delivery systems for similar reasons. The combination of microparticles and hydrogels in a composite system has been the topic of many research works. These composite systems can be injected in loco as DDS. The hydrogel will serve as a barrier to protect the particles and retard the release of any bioactive cargo within the particles. Additionally, these systems allow different release profiles, where different loads can be released sequentially, thus allowing a synergistic treatment. The reported advantages from several studies of these systems can be of great use in biomedicine for the development of more effective DDS. This review will focus on in situ injectable microparticles in hydrogel composite DDS for biomedical purposes, where a compilation of different studies will be analysed and reported herein.<\/jats:p>","DOI":"10.3390\/gels7030147","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T03:47:35Z","timestamp":1632282455000},"page":"147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Injectable Composite Systems Based on Microparticles in Hydrogels for Bioactive Cargo Controlled Delivery"],"prefix":"10.3390","volume":"7","author":[{"given":"Henrique","family":"Carr\u00ealo","sequence":"first","affiliation":[{"name":"CENIMAT\/i3N, Departamento de Ci\u00eancia dos Materiais, NOVA School of Science and Technology, 2829-516 Caparica, Portugal"}]},{"given":"Paula I. P.","family":"Soares","sequence":"additional","affiliation":[{"name":"CENIMAT\/i3N, Departamento de Ci\u00eancia dos Materiais, NOVA School of Science and Technology, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3996-6545","authenticated-orcid":false,"given":"Jo\u00e3o Paulo","family":"Borges","sequence":"additional","affiliation":[{"name":"CENIMAT\/i3N, Departamento de Ci\u00eancia dos Materiais, NOVA School of Science and Technology, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8261-6754","authenticated-orcid":false,"given":"Maria Teresa","family":"Cidade","sequence":"additional","affiliation":[{"name":"CENIMAT\/i3N, Departamento de Ci\u00eancia dos Materiais, NOVA School of Science and Technology, 2829-516 Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,18]]},"reference":[{"key":"ref_1","unstructured":"Wagner, W.R., Sakiyama-Elbert, S.E., Zhang, G., and Yaszemski, M.J. 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