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In contrast to intravenous administration, local treatments using intratumoral or peritumoral injections are independent of tumor vasculature and allow high concentrations of therapeutic agents to reach the tumor site with minimal systemic toxicity. Injectable biodegradable hydrogels offer a clear advantage over other delivery systems because the former requires no surgical procedures and promotes drug retention at the tumor site. More precisely, in situ gelling systems based on poloxamers have garnered considerable attention due to their thermoresponsive behavior, biocompatibility, ease of preparation, and possible incorporation of different anticancer agents. Therefore, this review focuses on the use of injectable thermoresponsive hydrogels based on poloxamers and their physicochemical and biological characterization. It also includes a summary of these hydrogel applications in local cancer therapies using chemotherapy, phototherapy, immunotherapy, and gene therapy.<\/jats:p>","DOI":"10.3390\/gels9070593","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T01:15:45Z","timestamp":1690161345000},"page":"593","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Injectable Poloxamer Hydrogels for Local Cancer Therapy"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1247-6738","authenticated-orcid":false,"given":"Ana Camila","family":"Marques","sequence":"first","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1152-3398","authenticated-orcid":false,"given":"Paulo Cardoso","family":"Costa","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"}]},{"given":"S\u00e9rgia","family":"Velho","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, University of Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"IPATIMUP\u2014Institute of Molecular Pathology and Immunology of the University of Porto, R. J\u00falio Amaral de Carvalho 45, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3209-3366","authenticated-orcid":false,"given":"Maria Helena","family":"Amaral","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jconrel.2015.11.014","article-title":"Engineered in-situ depot-forming hydrogels for intratumoral drug delivery","volume":"220","author":"Fakhari","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.drudis.2021.04.012","article-title":"Stimuli-responsive hydrogels for intratumoral drug delivery","volume":"26","author":"Marques","year":"2021","journal-title":"Drug Discov. Today"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1177\/019459989811800412","article-title":"Intratumoral cisplatin\/epinephrine-injectable gel as a palliative treatment for accessible solid tumors: A multicenter pilot study","volume":"118","author":"Burris","year":"1998","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"23838","DOI":"10.1039\/D0NR05053A","article-title":"Intratumoral injection of hydrogel-embedded nanoparticles enhances retention in glioblastoma","volume":"12","author":"Brachi","year":"2020","journal-title":"Nanoscale"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1021\/acsbiomaterials.7b00734","article-title":"Methods To Assess Shear-Thinning Hydrogels for Application As Injectable Biomaterials","volume":"3","author":"Chen","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jconrel.2017.08.006","article-title":"Injectable hydrogels for sustained release of therapeutic agents","volume":"267","author":"Thambi","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1080\/03602559.2017.1364383","article-title":"Recent Progress in Smart Polymers: Behavior, Mechanistic Understanding and Application","volume":"57","author":"Chakraborty","year":"2017","journal-title":"Polym. Plast. Technol. Eng."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1039\/C7MH00016B","article-title":"Thermoresponsive polymers with lower critical solution temperature: From fundamental aspects and measuring techniques to recommended turbidimetry conditions","volume":"4","author":"Zhang","year":"2017","journal-title":"Mater. Horiz."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Fan, R., Cheng, Y., Wang, R., Zhang, T., Zhang, H., Li, J., Song, S., and Zheng, A. (2022). Thermosensitive Hydrogels and Advances in Their Application in Disease Therapy. Polymers, 14.","DOI":"10.3390\/polym14122379"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.colsurfb.2018.03.009","article-title":"Intratumoral administration of carboplatin bearing poly (\u03b5-caprolactone) nanoparticles amalgamated with in situ gel tendered augmented drug delivery, cytotoxicity, and apoptosis in melanoma tumor","volume":"166","author":"Bragta","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1111\/jphp.13006","article-title":"Paclitaxel delivery system based on poly(lactide-co-glycolide) microparticles and chitosan thermo-sensitive gel for mammary adenocarcinoma treatment","volume":"70","author":"Pesoa","year":"2018","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Fong, Y.T., Chen, C.-H., and Chen, J.-P. (2017). Intratumoral Delivery of Doxorubicin on Folate-Conjugated Graphene Oxide by In-Situ Forming Thermo-Sensitive Hydrogel for Breast Cancer Therapy. Nanomaterials, 7.","DOI":"10.3390\/nano7110388"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2001442","DOI":"10.1002\/advs.202001442","article-title":"Injectable Thermosensitive Hydrogel Containing Erlotinib-Loaded Hollow Mesoporous Silica Nanoparticles as a Localized Drug Delivery System for NSCLC Therapy","volume":"7","author":"Zhou","year":"2020","journal-title":"Adv. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101885","DOI":"10.1016\/j.jddst.2020.101885","article-title":"Thermosensitive composite hydrogel incorporated with curcumin-loaded nanopolymersomes for prolonged and localized treatment of glioma","volume":"59","author":"Babaei","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Russo, E., and Villa, C. (2019). Poloxamer Hydrogels for Biomedical Applications. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11120671"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Giuliano, E., Paolino, D., Fresta, M., and Cosco, D. (2018). Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics10030159"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.drudis.2019.05.036","article-title":"Poloxamer-based in situ gelling thermoresponsive systems for ocular drug delivery applications","volume":"24","author":"Soliman","year":"2019","journal-title":"Drug Discov. Today"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Bodratti, A.M., and Alexandridis, P. (2018). Formulation of Poloxamers for Drug Delivery. J. Funct. Biomater., 9.","DOI":"10.3390\/jfb9010011"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.msec.2017.07.040","article-title":"Development and characterization of miltefosine-loaded polymeric micelles for cancer treatment","volume":"81","author":"Feitosa","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e1133","DOI":"10.1002\/cnr2.1133","article-title":"Pluronic micelles encapsulated curcumin manifests apoptotic cell death and inhibits pro-inflammatory cytokines in human breast adenocarcinoma cells","volume":"2","author":"Vaidya","year":"2018","journal-title":"Cancer Rep."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Kotta, S., Aldawsari, H.M., Badr-Eldin, S.M., Nair, A.B., Kaleem, M., and Dalhat, M.H. (2022). Thermosensitive Hydrogels Loaded with Resveratrol Nanoemulsion: Formulation Optimization by Central Composite Design and Evaluation in MCF-7 Human Breast Cancer Cell Lines. Gels, 8.","DOI":"10.3390\/gels8070450"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/open.202000040","article-title":"Preparation of Injectable Composite Hydrogels by Blending Poloxamers with Calcium Carbonate-Crosslinked Sodium Alginate","volume":"9","author":"Xu","year":"2020","journal-title":"Chemistryopen"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1104126","DOI":"10.3389\/fbioe.2023.1104126","article-title":"Smart stimuli-responsive injectable gels and hydrogels for drug delivery and tissue engineering applications: A review","volume":"11","author":"Salehi","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3109\/10717544.2014.891272","article-title":"Poloxamer-based in situ hydrogels for controlled delivery of hydrophilic macromolecules after intramuscular injection in rats","volume":"22","author":"Zhang","year":"2014","journal-title":"Drug Deliv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/jbm.b.34703","article-title":"Autoclaving of Poloxamer 407 hydrogel and its use as a drug delivery vehicle","volume":"109","author":"Beard","year":"2020","journal-title":"J. Biomed. Mater. Res. Part B: Appl. Biomater."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e00390","DOI":"10.1016\/j.heliyon.2017.e00390","article-title":"Thermogelling properties of purified poloxamer 407","volume":"3","author":"Fakhari","year":"2017","journal-title":"Heliyon"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.apsb.2017.03.002","article-title":"Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties: Preparation, characterization and application in a vaginal drug delivery system","volume":"7","author":"Ci","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jconrel.2013.10.026","article-title":"Novel thermo-sensitive hydrogel system with paclitaxel nanocrystals: High drug-loading, sustained drug release and extended local retention guaranteeing better efficacy and lower toxicity","volume":"174","author":"Lin","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.2147\/IJN.S308057","article-title":"Intratumoral Administration of Thermosensitive Hydrogel Co-Loaded with Norcantharidin Nanoparticles and Doxorubicin for the Treatment of Hepatocellular Carcinoma","volume":"16","author":"Gao","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ajps.2018.05.004","article-title":"Evaluation of micelles incorporated into thermosensitive hydrogels for intratumoral delivery and controlled release of docetaxel: A dual approach for in situ treatment of tumors","volume":"13","author":"Xu","year":"2018","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jddst.2016.05.007","article-title":"In situ thermosensitive Tamoxifen citrate loaded hydrogels: An effective tool in breast cancer loco-regional therapy","volume":"35","author":"Shaker","year":"2016","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1081\/PDT-120003487","article-title":"Intratumoral Administration of Paclitaxel in an In Situ Gelling Poloxamer 407 Formulation","volume":"7","author":"Amiji","year":"2002","journal-title":"Pharm. Dev. Technol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"110613","DOI":"10.1016\/j.colsurfb.2019.110613","article-title":"Gallic acid loaded poloxamer gel as new adjuvant strategy for melanoma: A preliminary study","volume":"185","author":"Sguizzato","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2174\/156720110791560928","article-title":"Design and Development of Thermoreversible Ophthalmic In Situ Hydrogel of Moxifloxacin HCl","volume":"7","author":"Shastri","year":"2010","journal-title":"Curr. Drug Deliv."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Chen, Y., Lee, J.-H., Meng, M., Cui, N., Dai, C.-Y., Jia, Q., Lee, E.-S., and Jiang, H.-B. (2021). An Overview on Thermosensitive Oral Gel Based on Poloxamer 407. Materials, 14.","DOI":"10.3390\/ma14164522"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.carbpol.2016.08.068","article-title":"Thermo-sensitive injectable hydrogel based on the physical mixing of hyaluronic acid and Pluronic F-127 for sustained NSAID delivery","volume":"156","author":"Jung","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4155\/tde-2020-0099","article-title":"Understanding the burst release phenomenon: Toward designing effective nanoparticulate drug-delivery systems","volume":"12","author":"Bhattacharjee","year":"2021","journal-title":"Ther. Deliv."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.ijbiomac.2022.11.285","article-title":"Ajazuddin Exploration of hemocompatibility and intratumoral accumulation of paclitaxel after loco-regional administration of thermoresponsive hydrogel composed of poloxamer and xanthan gum: An application to dose-dense chemotherapy","volume":"226","author":"Jeswani","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1021\/la400268p","article-title":"Injectable and Thermoresponsive Self-Assembled Nanocomposite Hydrogel for Long-Term Anticancer Drug Delivery","volume":"29","author":"Chen","year":"2013","journal-title":"Langmuir"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.carbpol.2018.09.065","article-title":"N,N,N-trimethyl chitosan embedded in situ Pluronic F127 hydrogel for the treatment of brain tumor","volume":"203","author":"Turabee","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ejpb.2020.10.011","article-title":"Thermosensitive hydrogels for local delivery of 5-fluorouracil as neoadjuvant or adjuvant therapy in colorectal cancer","volume":"157","author":"Seguin","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1002\/jps.23649","article-title":"Thermosensitive Micelles\u2013Hydrogel Hybrid System Based on Poloxamer 407 for Localized Delivery of Paclitaxel","volume":"102","author":"Ju","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"ref_43","unstructured":"Kelly, H., Duffy, G., Rossi, S., and Hastings, C. (2018). A Thermo-Responsive Hydrogel for Intratumoral Administration as a Treatment in Solid Tumor Cancers. (WO2019092049A1)."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e53362","DOI":"10.1002\/app.53362","article-title":"Recent advances on injectable nanocomposite hydrogels towards bone tissue rehabilitation","volume":"140","author":"Phogat","year":"2022","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3109\/10837450.2013.819014","article-title":"High encapsulation efficiency of poloxamer-based injectable thermoresponsive hydrogels of etoposide","volume":"19","author":"Soni","year":"2014","journal-title":"Pharm. Dev. Technol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00270-018-2103-0","article-title":"A Custom Radiopaque Thermoresponsive Chemotherapy-Loaded Hydrogel for Intratumoural Injection: An In Vitro and Ex Vivo Assessment of Imaging Characteristics and Material Properties","volume":"42","author":"Rossi","year":"2018","journal-title":"Cardiovasc. Interv. Radiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"120316","DOI":"10.1016\/j.ijpharm.2021.120316","article-title":"Salinomycin-loaded injectable thermosensitive hydrogels for glioblastoma therapy","volume":"598","author":"Norouzi","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2020.03.050","article-title":"Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies","volume":"323","author":"Chung","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/jps.24693","article-title":"Thermosensitive Hydrogel System With Paclitaxel Liposomes Used in Localized Drug Delivery System for In Situ Treatment of Tumor: Better Antitumor Efficacy and Lower Toxicity","volume":"105","author":"Mao","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1002\/jbm.b.34048","article-title":"Sterilization of hydrogels for biomedical applications: A review","volume":"106","author":"Galante","year":"2017","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Ferreira, I., Marques, A.C., Costa, P.C., and Amaral, M.H. (2023). Effects of Steam Sterilization on the Properties of Stimuli-Responsive Polymer-Based Hydrogels. Gels, 9.","DOI":"10.3390\/gels9050385"},{"key":"ref_52","first-page":"471","article-title":"Impact of sterilisation conditions on the rheological properties of thermoresponsive pluronic F-127-based gels for the ophthalmic use","volume":"75","author":"Burak","year":"2018","journal-title":"Acta Pol. Pharm.\u2014Drug Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1021\/acs.accounts.9b00228","article-title":"Survey of Clinical Translation of Cancer Nanomedicines\u2014Lessons Learned from Successes and Failures","volume":"52","author":"He","year":"2019","journal-title":"Accounts Chem. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.2147\/OTT.S214024","article-title":"A temperature-sensitive phase-change hydrogel of topotecan achieves a long-term sustained antitumor effect on retinoblastoma cells","volume":"12","author":"Huo","year":"2019","journal-title":"OncoTargets Ther."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Chung, C.K., Garc\u00eda-Couce, J., Campos, Y., Kralisch, D., Bierau, K., Chan, A., Ossendorp, F., and Cruz, L.J. (2020). Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation. Molecules, 25.","DOI":"10.3390\/molecules25092219"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2147\/IJN.S15057","article-title":"Thermoreversible Pluronic\u00ae F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: In vitro drug release, cell cytotoxicity, and uptake studies","volume":"6","author":"Yang","year":"2011","journal-title":"Int. J. Nanomed."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.canlet.2018.11.011","article-title":"Intratumoral injection of gels containing losartan microspheres and (PLG-g-mPEG)-cisplatin nanoparticles improves drug penetration, retention and anti-tumor activity","volume":"442","author":"Yu","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.colsurfb.2015.12.057","article-title":"Evaluation of TPGS-modified thermo-sensitive Pluronic PF127 hydrogel as a potential carrier to reverse the resistance of P-gp-overexpressing SMMC-7721 cell lines","volume":"140","author":"Gao","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jconrel.2015.10.018","article-title":"A novel localized co-delivery system with lapatinib microparticles and paclitaxel nanoparticles in a peritumorally injectable in situ hydrogel","volume":"220","author":"Hu","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ijpharm.2012.05.008","article-title":"Smart design of intratumoral thermosensitive \u03b2-lapachone hydrogels by Artificial Neural Networks","volume":"433","author":"Landin","year":"2012","journal-title":"Int. J. Pharm."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ejpb.2012.12.019","article-title":"Administration of the optimized \u03b2-Lapachone\u2013poloxamer\u2013cyclodextrin ternary system induces apoptosis, DNA damage and reduces tumor growth in a human breast adenocarcinoma xenograft mouse model","volume":"84","author":"Seoane","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.2217\/nnm.14.211","article-title":"Novel injectable thermosensitive hydrogels for delivering hyaluronic acid\u2013doxorubicin nanocomplexes to locally treat tumors","volume":"10","author":"Jhan","year":"2015","journal-title":"Nanomedicine"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.colsurfb.2016.03.054","article-title":"Codelivery of doxorubicin-containing thermosensitive hydrogels incorporated with docetaxel-loaded mixed micelles enhances local cancer therapy","volume":"143","author":"Sheu","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jconrel.2009.01.007","article-title":"A novel mixed micelle gel with thermo-sensitive property for the local delivery of docetaxel","volume":"135","author":"Yang","year":"2009","journal-title":"J. Control. Release"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.3109\/03639045.2013.838579","article-title":"Preparation and characterization of curcumin thermosensitive hydrogels for intratumoral injection treatment","volume":"40","author":"Gao","year":"2013","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/10837450.2017.1391287","article-title":"Liposome-loaded thermo-sensitive hydrogel for stabilization of SN-38 via intratumoral injection: Optimization, characterization, and antitumor activity","volume":"23","author":"Bai","year":"2017","journal-title":"Pharm. Dev. Technol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Basso, J., Miranda, A., Nunes, S., Cova, T., Sousa, J., Vitorino, C., and Pais, A. (2018). Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors. Gels, 4.","DOI":"10.3390\/gels4030062"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"20530","DOI":"10.1021\/acsami.5b06043","article-title":"Preparation of a Thermosensitive Gel Composed of a mPEG-PLGA-PLL-cRGD Nanodrug Delivery System for Pancreatic Tumor Therapy","volume":"7","author":"Shen","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/10837450.2018.1550788","article-title":"In-vivo anti-tumor activity of a novel poloxamer-based thermosensitive in situ gel for sustained delivery of norcantharidin","volume":"24","author":"Xie","year":"2018","journal-title":"Pharm. Dev. Technol."},{"key":"ref_70","first-page":"126723","article-title":"Temperature-Sensitive Gels for Intratumoral Delivery of \u03b2-Lapachone: Effect of Cyclodextrins and Ethanol","volume":"2012","author":"Landin","year":"2012","journal-title":"Sci. World J."},{"key":"ref_71","unstructured":"Jhan, H.J., Ho, H.O., Sheu, M.T., Shen, S.C., Ho, Y.S., and Liu, J.J. (2016). Thermosensitive Injectable Hydrogel for Drug Delivery. (9,364,545), U.S. Patent."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4103\/1735-5362.228918","article-title":"Preparation and characterization of an injectable thermosensitive hydrogel for simultaneous delivery of paclitaxel and doxorubicin","volume":"13","author":"Emami","year":"2018","journal-title":"Res. Pharm. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijbiomac.2019.05.031","article-title":"The utilization of low molecular weight heparin-poloxamer associated Laponite nanoplatform for safe and efficient tumor therapy","volume":"134","author":"Li","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1208\/s12248-015-9828-3","article-title":"Thermosensitive Hydrogel Co-loaded with Gold Nanoparticles and Doxorubicin for Effective Chemoradiotherapy","volume":"18","author":"Li","year":"2015","journal-title":"AAPS J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"111333","DOI":"10.1016\/j.biopha.2021.111333","article-title":"Polymer-based hydrogels with local drug release for cancer immunotherapy","volume":"137","author":"Xie","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"7979","DOI":"10.1021\/acsnano.3c00891","article-title":"Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine","volume":"17","author":"Overchuk","year":"2023","journal-title":"ACS Nano"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1021\/acs.molpharmaceut.8b00624","article-title":"CuS Nanodot-Loaded Thermosensitive Hydrogel for Anticancer Photothermal Therapy","volume":"15","author":"Fu","year":"2018","journal-title":"Mol. Pharm."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.apsb.2018.12.005","article-title":"Prussian blue nanosphere-embedded in situ hydrogel for photothermal therapy by peritumoral administration","volume":"9","author":"Fu","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"120123","DOI":"10.1016\/j.carbpol.2022.120123","article-title":"Iota carrageenan gold-silver NPs photothermal hydrogel for tumor postsurgical anti-recurrence and wound healing","volume":"298","author":"Chen","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"791891","DOI":"10.3389\/fbioe.2021.791891","article-title":"Injectable and Temperature-Sensitive Titanium Carbide-Loaded Hydrogel System for Photothermal Therapy of Breast Cancer","volume":"9","author":"Yao","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ijpharm.2015.11.032","article-title":"Nanocomposite hydrogel incorporating gold nanorods and paclitaxel-loaded chitosan micelles for combination photothermal\u2013chemotherapy","volume":"497","author":"Zhang","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jcis.2019.08.058","article-title":"Black phosphorus nanosheets and gemcitabine encapsulated thermo-sensitive hydrogel for synergistic photothermal-chemotherapy","volume":"556","author":"Qin","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1039\/D2TB00044J","article-title":"An injectable thermosensitive hydrogel loaded with a theranostic nanoprobe for synergistic chemo\u2013photothermal therapy for multidrug-resistant hepatocellular carcinoma","volume":"10","author":"Huang","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Correia, J.H., Rodrigues, J.A., Pimenta, S., Dong, T., and Yang, Z. (2021). Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13091332"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jconrel.2019.01.019","article-title":"Thermosensitive nanocomposite gel for intra-tumoral two-photon photodynamic therapy","volume":"298","author":"Luo","year":"2019","journal-title":"J. Control. Release"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s13346-020-00836-y","article-title":"Black phosphorus nanosheets and docetaxel micelles co-incorporated thermoreversible hydrogel for combination chemo-photodynamic therapy","volume":"11","author":"Li","year":"2021","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.3747\/co.27.5223","article-title":"A Review of Cancer Immunotherapy: From the Past, to the Present, to the Future","volume":"27","author":"Esfahani","year":"2020","journal-title":"Curr. Oncol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41573-018-0006-z","article-title":"Delivery technologies for cancer immunotherapy","volume":"18","author":"Riley","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.xphs.2017.04.041","article-title":"Thermosensitive Gel\u2013Based Formulation for Intratumoral Delivery of Toll-Like Receptor 7\/8 Dual Agonist, MEDI9197","volume":"106","author":"Fakhari","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Tsai, H.-C., Chou, H.-Y., Chuang, S.-H., Lai, J.-Y., Chen, Y.-S., Wen, Y.-H., Yu, L.-Y., and Lo, C.-L. (2019). Preparation of Immunotherapy Liposomal-Loaded Thermal-Responsive Hydrogel Carrier in the Local Treatment of Breast Cancer. Polymers, 11.","DOI":"10.3390\/polym11101592"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jconrel.2019.10.041","article-title":"Extracellular pH modulating injectable gel for enhancing immune checkpoint inhibitor therapy","volume":"315","author":"Jin","year":"2019","journal-title":"J. Control. Release"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jconrel.2023.04.028","article-title":"Sustained release hydrogel for durable locoregional chemoimmunotherapy for BRAF-mutated melanoma","volume":"357","author":"Kim","year":"2023","journal-title":"J. Control. Release"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"686544","DOI":"10.3389\/fcell.2021.686544","article-title":"Insights Into Dendritic Cells in Cancer Immunotherapy: From Bench to Clinical Applications","volume":"9","author":"Salah","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"118421","DOI":"10.1016\/j.ijpharm.2019.06.012","article-title":"Mucoadhesive thermosensitive hydrogel for the intra-tumoral delivery of immunomodulatory agents, in vivo evidence of adhesion by means of non-invasive imaging techniques","volume":"567","author":"Lemdani","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1016\/j.biomaterials.2009.05.051","article-title":"Synergistic anti-tumor activity of paclitaxel-incorporated conjugated linoleic acid-coupled poloxamer thermosensitive hydrogel in vitro and in vivo","volume":"30","author":"Guo","year":"2009","journal-title":"Biomaterials"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/j.biomaterials.2011.12.011","article-title":"Synergistic effects of Akt1 shRNA and paclitaxel-incorporated conjugated linoleic acid-coupled poloxamer thermosensitive hydrogel on breast cancer","volume":"33","author":"Guo","year":"2012","journal-title":"Biomaterials"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ejps.2019.03.021","article-title":"Novel facile thermosensitive hydrogel as sustained and controllable gene release vehicle for breast cancer treatment","volume":"134","author":"Zhao","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_98","first-page":"100016","article-title":"In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats","volume":"1","author":"Dewulf","year":"2019","journal-title":"Int. J. Pharm. X"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Alonso, J.M., del Olmo, J.A., Gonzalez, R.P., and Saez-Martinez, V. (2021). Injectable Hydrogels: From Laboratory to Industrialization. Polymers, 13.","DOI":"10.3390\/polym13040650"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Cui, N., Dai, C.-Y., Mao, X., Lv, X., Gu, Y., Lee, E.-S., Jiang, H.-B., and Sun, Y. (2022). Poloxamer-Based Scaffolds for Tissue Engineering Applications: A Review. Gels, 8.","DOI":"10.3390\/gels8060360"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/21691401.2018.1452752","article-title":"ECM based injectable thermo-sensitive hydrogel on the recovery of injured cartilage induced by osteoarthritis","volume":"46","author":"Li","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Chen, I.-C., Su, C.-Y., Chen, P.-Y., Hoang, T.C., Tsou, Y.-S., and Fang, H.-W. (2022). Investigation and Characterization of Factors Affecting Rheological Properties of Poloxamer-Based Thermo-Sensitive Hydrogel. Polymers, 14.","DOI":"10.3390\/polym14245353"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"20210172","DOI":"10.1002\/EXP.20210172","article-title":"Drug-grafted DNA as a novel chemogene for targeted combinatorial cancer therapy","volume":"2","author":"Liu","year":"2022","journal-title":"Exploration"}],"container-title":["Gels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2310-2861\/9\/7\/593\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:17:40Z","timestamp":1760127460000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2310-2861\/9\/7\/593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,24]]},"references-count":103,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["gels9070593"],"URL":"https:\/\/doi.org\/10.3390\/gels9070593","relation":{},"ISSN":["2310-2861"],"issn-type":[{"value":"2310-2861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,24]]}}}