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Developing new and more personalized treatment options is crucial to decreasing the cancer burden. In this study, we combined magnetic polysaccharide microparticles with a Pluronic thermoresponsive hydrogel to develop a multifunctional, injectable drug delivery system (DDS) for magnetic hyperthermia applications. Gellan gum and alginate microparticles were loaded with superparamagnetic iron oxide nanoparticles (SPIONs) with and without coating. The magnetic microparticles\u2019 registered temperature increases up to 4 \u00b0C upon the application of an alternating magnetic field. These magnetic microparticles were mixed with drug-loaded microparticles, and, subsequently, this mixture was embedded within a Pluronic thermoresponsive hydrogel that is capable of being in the gel state at 37 \u00b0C. The proposed DDS was capable of slowly releasing methylene blue, used as a model drug, for up to 9 days. The developed hydrogel\/microparticle system had a smaller rate of drug release compared with microparticles alone. This system proved to be a potential thermoresponsive DDS suitable for magnetic hyperthermia applications, thus enabling a synergistic treatment for cancer.<\/jats:p>","DOI":"10.3390\/gels9120982","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T11:28:07Z","timestamp":1702898887000},"page":"982","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Injectable Thermoresponsive Microparticle\/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications"],"prefix":"10.3390","volume":"9","author":[{"given":"Henrique","family":"Carrelo","sequence":"first","affiliation":[{"name":"CENIMAT\/i3N, Department of Materials Science, NOVA School of Science and Technology (FCT NOVA), Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"given":"Andr\u00e9 R.","family":"Escoval","sequence":"additional","affiliation":[{"name":"CENIMAT\/i3N, Department of Materials Science, NOVA School of Science and Technology (FCT NOVA), Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"given":"T\u00e2nia","family":"Vieira","sequence":"additional","affiliation":[{"name":"CENIMAT\/i3N, Department of Physics, NOVA School of Science and Technology (FCT NOVA), Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5164-838X","authenticated-orcid":false,"given":"Mercedes","family":"Jim\u00e9nez-Rosado","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry and Physics, Universidad de Le\u00f3n, 24007 Leon, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9959-4272","authenticated-orcid":false,"given":"Jorge Carvalho","family":"Silva","sequence":"additional","affiliation":[{"name":"CENIMAT\/i3N, Department of Physics, NOVA School of Science and Technology (FCT NOVA), Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6323-9938","authenticated-orcid":false,"given":"Alberto","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Facultad de Qu\u00edmica, Universidad de Sevilla, 41012 Sevilla, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4975-7480","authenticated-orcid":false,"given":"Paula Isabel P.","family":"Soares","sequence":"additional","affiliation":[{"name":"CENIMAT\/i3N, Department of Materials Science, NOVA School of Science and Technology (FCT NOVA), Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3996-6545","authenticated-orcid":false,"given":"Jo\u00e3o Paulo","family":"Borges","sequence":"additional","affiliation":[{"name":"CENIMAT\/i3N, Department of Materials Science, NOVA School of Science and Technology (FCT NOVA), Campus de Caparica, 2829-516 Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.colsurfb.2014.09.011","article-title":"Synthesis and characterization of CaCO3 \u2013biopolymer hybrid nanoporous microparticles for controlled release of doxorubicin","volume":"123","author":"Bosio","year":"2014","journal-title":"Colloids Surf. 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