{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T10:04:09Z","timestamp":1775556249012,"version":"3.50.1"},"reference-count":70,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/108890\/2015"],"award-info":[{"award-number":["SFRH\/BD\/108890\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04501\/2020 (POCI-01-0145-FEDER-007628)"],"award-info":[{"award-number":["UIDB\/04501\/2020 (POCI-01-0145-FEDER-007628)"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00127\/2020"],"award-info":[{"award-number":["UIDB\/00127\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04279\/2020"],"award-info":[{"award-number":["UIDB\/04279\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>The nicotinate phosphoribosyltransferase (NAPRT) gene has gained relevance in the research of cancer therapeutic strategies due to its main role as a NAD biosynthetic enzyme. NAD metabolism is an attractive target for the development of anti-cancer therapies, given the high energy requirements of proliferating cancer cells and NAD-dependent signaling. A few studies have shown that NAPRT expression varies in different cancer types, making it imperative to assess NAPRT expression and functionality status prior to the application of therapeutic strategies targeting NAD. In addition, the recent finding of NAPRT extracellular form (eNAPRT) suggested the involvement of NAPRT in inflammation and signaling. However, the mechanisms regulating NAPRT gene expression have never been thoroughly addressed. In this study, we searched for NAPRT gene expression regulatory mechanisms in transcription factors (TFs), RNA binding proteins (RBPs) and microRNA (miRNAs) databases. We identified several potential regulators of NAPRT transcription activation, downregulation and alternative splicing and performed GO and expression analyses. The results of the functional analysis of TFs, RBPs and miRNAs suggest new, unexpected functions for the NAPRT gene in cell differentiation, development and neuronal biology.<\/jats:p>","DOI":"10.3390\/genes12122022","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T02:50:18Z","timestamp":1639968618000},"page":"2022","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["NAPRT Expression Regulation Mechanisms: Novel Functions Predicted by a Bioinformatics Approach"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5244-068X","authenticated-orcid":false,"given":"Sara","family":"Duarte-Pereira","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, iBiMED\u2014Institute of Biomedicine, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"IEETA\u2014Institute of Electronics and Informatics Engineering of Aveiro, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1957-4947","authenticated-orcid":false,"given":"Olga","family":"Fajarda","sequence":"additional","affiliation":[{"name":"IEETA\u2014Institute of Electronics and Informatics Engineering of Aveiro, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-3983","authenticated-orcid":false,"given":"S\u00e9rgio","family":"Matos","sequence":"additional","affiliation":[{"name":"IEETA\u2014Institute of Electronics and Informatics Engineering of Aveiro, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"DETI\u2014Department of Electronics, Telecommunications and Informatics, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Jos\u00e9","family":"Lu\u00eds Oliveira","sequence":"additional","affiliation":[{"name":"IEETA\u2014Institute of Electronics and Informatics Engineering of Aveiro, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"DETI\u2014Department of Electronics, Telecommunications and Informatics, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5926-8042","authenticated-orcid":false,"given":"Raquel Monteiro","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, iBiMED\u2014Institute of Biomedicine, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Universidade Cat\u00f3lica Portuguesa, Faculty of Dental Medicine, Center for Interdisciplinary Research in Health (CIIS), 3504-505 Viseu, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5872","DOI":"10.1128\/MCB.00112-09","article-title":"The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: Strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors","volume":"29","author":"Watson","year":"2009","journal-title":"Mol. 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