{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T02:49:01Z","timestamp":1769741341956,"version":"3.49.0"},"reference-count":40,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT, Lisbon, Portugal)","award":["PTDC\/BTM-SAL\/28977\/2017"],"award-info":[{"award-number":["PTDC\/BTM-SAL\/28977\/2017"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT, Lisbon, Portugal)","award":["UIDB\/04138\/2020"],"award-info":[{"award-number":["UIDB\/04138\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT, Lisbon, Portugal)","award":["UIDP\/04138\/2020"],"award-info":[{"award-number":["UIDP\/04138\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT, Lisbon, Portugal)","award":["2022.06601.PTDC"],"award-info":[{"award-number":["2022.06601.PTDC"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT, Lisbon, Portugal)","award":["project UIDB\/00276\/2020"],"award-info":[{"award-number":["project UIDB\/00276\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT, Lisbon, Portugal)","award":["LA\/P\/0059\/2020"],"award-info":[{"award-number":["LA\/P\/0059\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT, Lisbon, Portugal)","award":["DL57\/2016\/CP1438\/CT0007"],"award-info":[{"award-number":["DL57\/2016\/CP1438\/CT0007"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT, Lisbon, Portugal)","award":["CEEC, 2022.03691.CEECIND"],"award-info":[{"award-number":["CEEC, 2022.03691.CEECIND"]}]},{"name":"FCT through the FCT Stimulus of Scientific Employment Program","award":["PTDC\/BTM-SAL\/28977\/2017"],"award-info":[{"award-number":["PTDC\/BTM-SAL\/28977\/2017"]}]},{"name":"FCT through the FCT Stimulus of Scientific Employment Program","award":["UIDB\/04138\/2020"],"award-info":[{"award-number":["UIDB\/04138\/2020"]}]},{"name":"FCT through the FCT Stimulus of Scientific Employment Program","award":["UIDP\/04138\/2020"],"award-info":[{"award-number":["UIDP\/04138\/2020"]}]},{"name":"FCT through the FCT Stimulus of Scientific Employment Program","award":["2022.06601.PTDC"],"award-info":[{"award-number":["2022.06601.PTDC"]}]},{"name":"FCT through the FCT Stimulus of Scientific Employment Program","award":["project UIDB\/00276\/2020"],"award-info":[{"award-number":["project UIDB\/00276\/2020"]}]},{"name":"FCT through the FCT Stimulus of Scientific Employment Program","award":["LA\/P\/0059\/2020"],"award-info":[{"award-number":["LA\/P\/0059\/2020"]}]},{"name":"FCT through the FCT Stimulus of Scientific Employment Program","award":["DL57\/2016\/CP1438\/CT0007"],"award-info":[{"award-number":["DL57\/2016\/CP1438\/CT0007"]}]},{"name":"FCT through the FCT Stimulus of Scientific Employment Program","award":["CEEC, 2022.03691.CEECIND"],"award-info":[{"award-number":["CEEC, 2022.03691.CEECIND"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Pancreatic cancer is anticipated to be the second leading cause of cancer-related death by 2030. Aquaporins (AQPs), a family of water channel proteins, have been linked to carcinogenesis. The aim of this study was to determine AQP gene expression in pancreatic cancer tissues and to validate aquaporins as possible diagnosis and\/or prognosis genes. The relative gene expression levels of AQP1, AQP3, AQP5, and AQP9 were analyzed using real-time quantitative PCR (RT-qPCR) in 24 paired pancreatic tumors and adjacent healthy tissues according to variables such as age, gender, and tumor invasiveness and aggressiveness. AQPs transcripts were detected in both healthy and tumor tissues. While AQP1 was downregulated in the tumor samples, AQP3 was particularly overexpressed in low-grade invasive tumors. Interestingly, most of the strong positive Pearson correlation coefficients found between AQPs in healthy tissues were lost when analyzing the tumor tissues, suggesting disruption of the coordinated AQP-gene expression in pancreatic cancer.<\/jats:p>","DOI":"10.3390\/genes14091694","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T02:23:25Z","timestamp":1693189405000},"page":"1694","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Aquaporins Transcripts with Potential Prognostic Value in Pancreatic Cancer"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6755-4572","authenticated-orcid":false,"given":"Paula A.","family":"Lopes","sequence":"first","affiliation":[{"name":"CIISA\u2014Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade de Lisboa, 1300-477 Lisbon, Portugal"},{"name":"Laborat\u00f3rio Associado para Ci\u00eancia Animal e Veterin\u00e1ria (AL4AnimalS), Faculdade de Medicina Veterin\u00e1ria, Universidade de Lisboa, 1300-477 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0664-5542","authenticated-orcid":false,"given":"Elisabete","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, 1649-003 Lisbon, Portugal"},{"name":"Department of Pharmaceutical Sciences and Medicines, Faculdade de Farm\u00e1cia, Universidade de Lisboa, 1649-003 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2916-4848","authenticated-orcid":false,"given":"In\u00eas V.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, 1649-003 Lisbon, Portugal"},{"name":"Department of Pharmaceutical Sciences and Medicines, Faculdade de Farm\u00e1cia, Universidade de Lisboa, 1649-003 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4525-9062","authenticated-orcid":false,"given":"Emanuel","family":"Vigia","sequence":"additional","affiliation":[{"name":"Hepatobiliopancreatic and Transplantation Center, Hospital de Curry Cabral-CHULC, 1050-099 Lisbon, Portugal"},{"name":"NOVA Medical School, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8491-2802","authenticated-orcid":false,"given":"Jorge","family":"Paulino","sequence":"additional","affiliation":[{"name":"NOVA Medical School, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal"},{"name":"Hospital da Luz, 1500-650 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-110X","authenticated-orcid":false,"given":"Gra\u00e7a","family":"Soveral","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, 1649-003 Lisbon, Portugal"},{"name":"Department of Pharmaceutical Sciences and Medicines, Faculdade de Farm\u00e1cia, Universidade de Lisboa, 1649-003 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA A Cancer J. 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